| MeSH term | MeSH ID | Detail |
|---|---|---|
| Respiratory Distress Syndrome, Adult | D012128 | 15 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ramesha CS and Pickett WC | Human neutrophil platelet-activating factor: molecular heterogeneity in unstimulated and ionophore-stimulated cells. | 1987 | Biochim. Biophys. Acta | pmid:3113489 |
| Bolin RW et al. | Lung endothelial and epithelial permeability after platelet-activating factor. | 1987 | J. Appl. Physiol. | pmid:3693212 |
| Robertson DA et al. | Negative inotropic effect of platelet-activating factor on human myocardium: a pharmacological study. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3694533 |
| Nomura H | Biological action and structural specificity of diacylglycerol in platelet activation. | 1987 | Kobe J Med Sci | pmid:3695296 |
| Simon MF et al. | Effect of BN 52021, a specific antagonist of platelet activating factor (PAF-acether), on calcium movements and phosphatidic acid production induced by PAF-acether in human platelets. | 1987 | Thromb. Res. | pmid:3576518 |
| Alam I and Silver MJ | Metabolism of 1-alkyl-2-acyl-GPC in human platelets in response to stimulation by thrombin. | 1987 | Thromb. Res. | pmid:3576519 |
| Kusner EJ et al. | Pharmacologic analysis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced increases in cutaneous vascular permeability in the rat. | 1987 | Agents Actions | pmid:3577957 |
| Chesney CM et al. | Triazolobenzodiazepines competitively inhibit the binding of platelet activating factor (PAF) to human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3579913 |
| Kawasaki T and Snyder F | The metabolism of lyso-platelet-activating factor (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by a calcium-dependent lysophospholipase D in rabbit kidney medulla. | 1987 | Biochim. Biophys. Acta | pmid:3036238 |
| Shukla SD et al. | Activation of phospholipase C in platelets by platelet activating factor and thrombin causes hydrolysis of a common pool of phosphatidylinositol 4,5-bisphosphate. | 1987 | Biochim. Biophys. Acta | pmid:3036249 |
| Casals-Stenzel J | Protective effect of WEB 2086, a novel antagonist of platelet activating factor, in endotoxin shock. | 1987 | Eur. J. Pharmacol. | pmid:3582490 |
| Grignani G and Jamieson GA | Tissue factor-dependent activation of platelets by cells and microvesicles of SK-OS-10 human osteogenic sarcoma cell line. | 1987 | Invasion Metastasis | pmid:3036740 |
| Snyder F et al. | Measurement of key enzyme activities involved in the metabolism of platelet activating factor. | 1987 | Meth. Enzymol. | pmid:3037250 |
| d'Humieres S et al. | Platelet activating factor acether is involved in thrombin-induced synthesis of prostacyclin by human endothelial cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959051 |
| Ingraham LM et al. | In vitro and in vivo effects of treatment by platelet-activating factor on N-formyl-met-leu-phe-mediated responses of polymorphonuclear leucocytes. | 1987 | Br. J. Haematol. | pmid:3038160 |
| Whittle BJ et al. | Gastric vascular and mucosal damaging actions of platelet activating factor in the canine stomach. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959063 |
| Wymann MP et al. | Oscillatory motion in human neutrophils responding to chemotactic stimuli. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820398 |
| Handley DA et al. | Inhibition by SRI 63-072 and SRI 63-119 of PAF-acether and immune complex effects in the guinea pig. | 1987 | Eur. J. Pharmacol. | pmid:2959489 |
| Montrucchio G et al. | In vitro oxytocic activity of platelet-activating factor on human myometrium. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960158 |
| Mallet AI et al. | Platelet activating factor in chronic plaque psoriasis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960170 |
| Woodard DS et al. | The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats. | 1987 | J. Biol. Chem. | pmid:3029085 |
| Stafforini DM et al. | Human plasma platelet-activating factor acetylhydrolase. Purification and properties. | 1987 | J. Biol. Chem. | pmid:3558407 |
| Adamson LM et al. | Mechanistic studies of early pregnancy associated thrombocytopenia (EPAT) in the mouse. | 1987 | Am J Reprod Immunol Microbiol | pmid:3605486 |
| Edwards MC et al. | Secretion and properties of a polypeptide factor generated by phorbol ester stimulation of human blood platelets. | 1987 | Biochem. Pharmacol. | pmid:3606649 |
| Sturk A et al. | Age-related deficiency of the synthesis of platelet activating factor by leukocytes from Zellweger patients. | 1987 | Blood | pmid:3607283 |
| Casals-Stenzel J | Effects of WEB 2086, a novel antagonist of platelet activating factor, in active and passive anaphylaxis. | 1987 | Immunopharmacology | pmid:3597059 |
| Handley DA et al. | Biological properties of the antagonist SRI 63-441 in the PAF and endotoxin models of hypotension in the rat and dog. | 1987 | Immunopharmacology | pmid:3597060 |
| Casals-Stenzel J et al. | Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3598913 |
| Tokumura A et al. | Platelet aggregation induced by ether-linked phospholipids. 1. Inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor. | 1987 | Thromb. Res. | pmid:3647677 |
| Rola-Pleszczynski M et al. | Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether): reversal by a specific antagonist, BN 52021. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3493773 |
| Dewald B and Baggiolini M | Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay. | 1987 | Biochem. Pharmacol. | pmid:3649232 |
| Knox P et al. | Role of plasminogen, plasmin, and plasminogen activators in the migration of fibroblasts into plasma clots. | 1987 | J. Cell. Physiol. | pmid:2958486 |
| Kudo I et al. | Antitumor activity of synthetic alkylphospholipids with or without PAF activity. | 1987 | Lipids | pmid:3444379 |
| Söling U et al. | Effect of synthetic phospholipids on platelet aggregation and serotonin release. | 1987 | Lipids | pmid:3444380 |
| Schick HD et al. | Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro. | 1987 | Lipids | pmid:3444383 |
| Danhauser S et al. | Structure-cytotoxicity studies on alkyl lysophospholipids and some analogs in leukemic blasts of human origin in vitro. | 1987 | Lipids | pmid:3444384 |
| Grigorian GY and Ryan US | Platelet-activating factor effects on bovine pulmonary artery endothelial cells. | 1987 | Circ. Res. | pmid:3040294 |
| Levin M et al. | Platelet immune complex interaction in the pathogenesis of Kawasaki disease. | 1987 | Prog. Clin. Biol. Res. | pmid:3423040 |
| Violi F et al. | Human platelet aggregation by PAF and thromboxane production. | 1987 | Thromb. Res. | pmid:3424290 |
| Braquet P and Rola-Pleszczynski M | The role of PAF in immunological responses: a review. | 1987 | Prostaglandins | pmid:3313527 |
| Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
| Barnes PJ | New concepts in the pathogenesis of bronchial hyperresponsiveness. | 1987 | Agents Actions Suppl. | pmid:3314413 |
| Mustard JF et al. | Platelet activation--an overview. | 1987 | Agents Actions Suppl. | pmid:3314414 |
| Page CP and Robertson DN | Properties of PAF relevant to asthma. | 1987 | Agents Actions Suppl. | pmid:3314416 |
| Steel G et al. | Failure of prostaglandin E2 and its 16,16-dimethyl analogue to prevent the gastric mucosal damage induced by Paf. | 1987 | Br. J. Pharmacol. | pmid:3470106 |
| Morley J | PAF and airway hyperreactivity; prospects for novel prophylactic anti-asthma drugs. | 1987 | Agents Actions Suppl. | pmid:3314417 |
| Wang J and Dunn MJ | Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. | 1987 | Am. J. Physiol. | pmid:2827506 |
| Panetta T et al. | Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827647 |
| Bazan HE et al. | The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827658 |
| Tamura N et al. | Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030295 |
| Czarnetzki BM | [Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system]. | 1987 | Wien Med Wochenschr Suppl | pmid:3078398 |
| O'Flaherty JT | Phospholipid metabolism and stimulus-response coupling. | 1987 | Biochem. Pharmacol. | pmid:3030324 |
| Korth R and Benveniste J | BN 52021 displaces [3H]paf-acether from, and inhibits its binding to intact human platelets. | 1987 | Eur. J. Pharmacol. | pmid:3428349 |
| Steiger J et al. | Platelet activating factor (PAF) is a potent stimulator of porcine tracheal fluid secretion in vitro. | 1987 | Eur. J. Pharmacol. | pmid:3428351 |
| Karasawa K et al. | Antibody to platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; PAF). | 1987 | J. Biochem. | pmid:3429442 |
| Stahl GL et al. | PAF-acether induced cardiac dysfunction in the isolated perfused guinea pig heart. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3431598 |
| Spinnewyn B et al. | Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils. | 1987 | Prostaglandins | pmid:3432553 |
| Wymann MP et al. | The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process. | 1987 | J. Biol. Chem. | pmid:3040727 |
| Shimokawa H et al. | Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. | 1987 | Circ. Res. | pmid:3113760 |
| Adnot S et al. | Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. | 1987 | Agents Actions | pmid:3115070 |
| Montrucchio G et al. | The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. | 1987 | Agents Actions | pmid:3115072 |
| Evans TW et al. | Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. | 1987 | J. Appl. Physiol. | pmid:3115939 |
| Knudsen BS et al. | Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells. | 1987 | J. Clin. Invest. | pmid:3116043 |
| Bussolino F et al. | Human endothelial cells are target for platelet-activating factor. I. Platelet-activating factor induces changes in cytoskeleton structures. | 1987 | J. Immunol. | pmid:3116081 |
| Gomez-Cambronero J et al. | The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2823810 |
| Bertani T et al. | Platelet activating factor (PAF) as a mediator of injury in nephrotoxic nephritis. | 1987 | Kidney Int. | pmid:3039232 |
| PAF, platelets and asthma. Proceedings of a meeting. September 7-9, 1986. | 1987 | Agents Actions Suppl. | pmid:3478993 | |
| Farr RS et al. | Platelet abnormalities in asthma--do they exist in humans? | 1987 | Agents Actions Suppl. | pmid:3478994 |
| Menz G et al. | Lack of PAF release in extrinsic asthma. | 1987 | Agents Actions Suppl. | pmid:3478995 |
| Szczeklik A et al. | Bleeding time and PAF-acether-induced platelet aggregation in atopy. | 1987 | Agents Actions Suppl. | pmid:3478996 |
| Schmitz-Schumann M et al. | Evidence of PAF release and platelet activation in analgesics-asthma-syndrome. | 1987 | Agents Actions Suppl. | pmid:3478999 |
| Liu BN | [Neoplastic membrane-toxic activity as one of the pathogenetic factors in blood cell and tumor growth changes]. | 1987 Jan-Feb | Patol Fiziol Eksp Ter | pmid:3550649 |
| Lurie A et al. | Exercise- and allergen-induced asthma do not change the production of Paf-acether by neutrophils and platelets. | 1987 Jul-Aug | Bull Eur Physiopathol Respir | pmid:3690021 |
| Auriault C et al. | The effector function of platelets is induced and regulated by T lymphocytes. | 1987 Jul-Aug | Ann. Inst. Pasteur Immunol. | pmid:3118905 |
| Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
| Arnoux B et al. | Antigenic release of paf-acether and beta-glucuronidase from alveolar macrophages of asthmatics. | 1987 Mar-Apr | Bull Eur Physiopathol Respir | pmid:3607326 |
| Berdel WE et al. | Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. | 1987 Nov-Dec | Anticancer Res. | pmid:3442414 |
| Lakin KM et al. | [Action of calcium antagonists on thrombocyte aggregation]. | 1987 Sep-Oct | Farmakol Toksikol | pmid:2826225 |
| Kawasaki T and Snyder F | Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. | 1988 | J. Biol. Chem. | pmid:3422635 |
| Terashita Z et al. | Protective effects of a platelet activating factor (PAF) antagonist and its combined treatment with prostaglandin (PG) E1 in traumatic shock. | 1988 | J. Cardiovasc. Pharmacol. | pmid:2468048 |
| Bourdillat B et al. | Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. | 1988 | Eur. J. Pharmacol. | pmid:2836213 |
| Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
| Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
| Fernandez-Gallardo S et al. | Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids. | 1988 | Biochem. J. | pmid:2848496 |
| Handley DA et al. | Biological effects of the orally active platelet activating factor receptor antagonist SDZ 64-412. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3183958 |
| Pirotzky E et al. | Cyclosporine-induced nephrotoxicity: preventive effect of a PAF-acether antagonist, BN 52063. | 1988 | Transplant. Proc. | pmid:3388505 |
| Ward SG and Westwick J | Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells. | 1988 | Br. J. Pharmacol. | pmid:3390650 |
| Demopoulos CA et al. | Abnormal platelet response to PAF and ADP in beta-thalassaemia. | 1988 | Int. J. Biochem. | pmid:3391336 |
| Rola-Pleszczynski M | PAF in cellular immunology. | 1988 | Prog Biochem Pharmacol | pmid:3043437 |
| Baggiolini M et al. | Effects of PAF on neutrophils and mononuclear phagocytes. | 1988 | Prog Biochem Pharmacol | pmid:3043438 |
| Makino S | [Platelet activating factor in allergic reaction]. | 1988 | Arerugi | pmid:3052368 |
| Wasserman SI | Platelet-activating factor as a mediator of bronchial asthma. | 1988 | Hosp. Pract. (Off. Ed.) | pmid:3053741 |
| Cunha FQ et al. | Failure of PAF-acether to induce in vivo neutrophil migration. | 1988 | Agents Actions | pmid:3055873 |
| Nieto ML et al. | Biosynthesis of platelet-activating factor in human polymorphonuclear leukocytes. Involvement of the cholinephosphotransferase pathway in response to the phorbol esters. | 1988 | J. Biol. Chem. | pmid:2828363 |
| Ponpipom MM et al. | (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2829894 |
| Stahl GL et al. | Role of platelet activating factor in propagation of cardiac damage during myocardial ischemia. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3252036 |
| Williams WR et al. | Plates and anti-asthma drugs. | 1988 | Pneumonol Pol | pmid:3254508 |
| Fichelle J et al. | Bronchospasmolytic effects of RU 42173. | 1988 | Fundam Clin Pharmacol | pmid:3240917 |
| Misawa M and Takata T | [Effects of platelet activating factor on the bronchial musculature and vasculature in dogs]. | 1988 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3241511 |
| Perico N et al. | Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney. | 1988 | Lab. Invest. | pmid:3123798 |