Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Rink TJ | Stimulus-response coupling mechanisms in human platelets. | 1986 | Agents Actions Suppl. | pmid:3028101 |
Baroggi N et al. | Changes in cytosolic free calcium induced by platelet-activating factor in rabbit platelets: specific inhibition by BN 52021 and structurally related compounds. | 1986 | Agents Actions Suppl. | pmid:3028108 |
Biftu T et al. | Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. | 1986 | J. Med. Chem. | pmid:3020247 |
Bush LR and Smith SG | Antagonism of U46619-induced aggregation of human and canine platelets by four TXA2 receptor antagonists. | 1986 | Thromb. Res. | pmid:2948294 |
Valone FH and Ruis NM | Platelet-activating factor binding to human platelet membranes. | 1986 | Biotechnol. Appl. Biochem. | pmid:3021183 |
Braquet P | Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949548 |
Naccache PH et al. | Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. | 1986 | J. Leukoc. Biol. | pmid:3021882 |
Chamone DF et al. | Increased levels of eosinophil-derived PAF-acether activity in a patient with idiopathic hypereosinophilic syndrome. | 1986 | Braz. J. Med. Biol. Res. | pmid:3801724 |
Toth PD and Mikulaschek AW | Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat. | 1986 | Circ. Shock | pmid:3802423 |
Schlondorff D et al. | Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. | 1986 | Am. J. Physiol. | pmid:3087218 |
Coëffier E et al. | Effects of PAF-acether and structural analogues on platelet activation and bronchoconstriction in guinea-pigs. | 1986 | Eur. J. Pharmacol. | pmid:3816952 |
Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
Oda M et al. | Polymorphonuclear leukocyte-platelet interactions: acetylglyceryl ether phosphocholine-induced platelet activation under stimulation with chemotactic peptide. | 1986 | J. Biochem. | pmid:3818574 |
Lynch JM and Henson PM | The intracellular retention of newly synthesized platelet-activating factor. | 1986 | J. Immunol. | pmid:3093579 |
McMurtry IF and Morris KG | Platelet-activating factor causes pulmonary vasodilation in the rat. | 1986 | Am. Rev. Respir. Dis. | pmid:3094417 |
Viero P et al. | Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. | 1986 | Ann. Intern. Med. | pmid:3946966 |
Siafaka-Kapadai A et al. | Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. | 1986 | Biochem. Int. | pmid:3947373 |
McNamara PJ et al. | Autacoid binding to serum proteins. Interaction of platelet activating factor (PAF) with human serum alpha-1-acid glycoprotein (AAG). | 1986 | Biochem. Pharmacol. | pmid:3947392 |
Piper PJ and Stewart AG | Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4. | 1986 | Br. J. Pharmacol. | pmid:3091131 |
Hanahan DJ | Platelet activating factor: a biologically active phosphoglyceride. | 1986 | Annu. Rev. Biochem. | pmid:3017194 |
Bette-Bobillo P et al. | Interaction between blood components and a spin-labeled analogue of PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3017416 |
Levesque JP et al. | Fibrinogen mitogenic effect on hemopoietic cell lines: control via receptor modulation. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3018735 |
Foegh ML et al. | Fatty acids and eicosanoids in organ transplantation. | 1986 | Prog. Lipid Res. | pmid:3321095 |
First International Alexis Carrel Conference on Lipid Mediators in Organ Transplantation. April 8-10, 1986, Washington, DC. | 1986 | Transplant. Proc. | pmid:3765055 | |
Satoh K and Takamatsu S | [Inactivation by plasma of platelet-activating factor]. | 1986 | Nippon Ketsueki Gakkai Zasshi | pmid:3766067 |
Gordeev KIu et al. | [Synthesis of thioanalogs of platelet activating factor (PAF)]. | 1986 | Bioorg. Khim. | pmid:3768051 |
Hsueh W et al. | Release of leukotriene C4 by isolated, perfused rat small intestine in response to platelet-activating factor. | 1986 | J. Clin. Invest. | pmid:3459734 |
Thomas Y et al. | [Synthesis of paf-acether by E. coli K12]. | 1986 | C. R. Acad. Sci. III, Sci. Vie | pmid:3101984 |
Rosam AC et al. | Potent ulcerogenic actions of platelet-activating factor on the stomach. | 1986 Jan 2-8 | Nature | pmid:3510396 |
Kako KJ | Membrane phospholipids and plasmalogens in the ischemic myocardium. | 1986 May-Jun | Can J Cardiol | pmid:2424580 |
von Tscharner V et al. | Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. | 1986 Nov 27-Dec 3 | Nature | pmid:2431318 |
Benhamou M and Mencia-Huerta JM | Effect of glucocorticosteroids on the expression of Fc epsilon R1 and on mediator release from mast cells. | 1986 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:2948525 |
Morley J | Theophylline in asthma. | 1986 Sep-Oct | Bull Eur Physiopathol Respir | pmid:3801711 |
Pritchard PH | The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration. | 1987 | Biochem. J. | pmid:3689334 |
Hill CE and Olson MS | Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. | 1987 | Biochem. J. | pmid:3689345 |
Bolin RW et al. | Lung endothelial and epithelial permeability after platelet-activating factor. | 1987 | J. Appl. Physiol. | pmid:3693212 |
Sugiyama T et al. | A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. | 1987 | Blood | pmid:3580576 |
Agrawal DK and Townley RG | Effect of platelet-activating factor on beta-adrenoceptors in human lung. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030311 |
McFall TL et al. | Effect of group B streptococcal type-specific antigen on polymorphonuclear leukocyte function and polymorphonuclear leukocyte-endothelial cell interaction. | 1987 | Pediatr. Res. | pmid:3037472 |
Hébert RL et al. | Hemodynamic effects of PAF-acether on the dog kidney. | 1987 | Prostaglandins Leukot Med | pmid:3033688 |
Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
Barnes PJ et al. | The effect of platelet activating factor on pulmonary beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:3034367 |
Davenas E et al. | Effect of mouse peritoneal macrophages of orally administered very high dilutions of silica. | 1987 | Eur. J. Pharmacol. | pmid:3034632 |
Barrio V et al. | Atrial natriuretic peptide inhibits glomerular contraction induced by angiotensin II and platelet activating factor. | 1987 | Eur. J. Pharmacol. | pmid:2952517 |
Kawasaki T and Snyder F | The metabolism of lyso-platelet-activating factor (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by a calcium-dependent lysophospholipase D in rabbit kidney medulla. | 1987 | Biochim. Biophys. Acta | pmid:3036238 |
Camussi G et al. | Receptor antagonist of platelet activating factor inhibits inflammatory injury induced by in situ formation of immune complexes in renal glomeruli and in the skin. | 1987 | J. Lab. Clin. Med. | pmid:2955066 |
Foegh ML et al. | Leukotrienes, thromboxane, and platelet activating factor in organ transplantation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959038 |
Robertson DN and Smith GM | Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959049 |
d'Humieres S et al. | Platelet activating factor acether is involved in thrombin-induced synthesis of prostacyclin by human endothelial cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959051 |
Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
Myers AK and Bader TJ | Role of adrenal steroids in the recovery from platelet activating factor challenge. | 1987 | Circ. Shock | pmid:3677334 |
Hsueh W et al. | Platelet-activating factor: an endogenous mediator for bowel necrosis in endotoxemia. | 1987 | FASEB J. | pmid:3678700 |
Terasawa M et al. | Antagonistic activity of etizolam on platelet-activating factor in vivo experiments. | 1987 | Jpn. J. Pharmacol. | pmid:3682404 |
Bittman R et al. | Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone. | 1987 | J. Lipid Res. | pmid:3611974 |
Terashita Z et al. | CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3612533 |
Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
Huber M and Keppler D | Inhibition of leukotriene D4 catabolism by D-penicillamine. | 1987 | Eur. J. Biochem. | pmid:3622511 |
Egido J et al. | Role of platelet-activating factor in adriamycin-induced nephropathy in rats. | 1987 | Eur. J. Pharmacol. | pmid:3622604 |
Kawaguchi H and Yasuda H | Effects of platelet-activating factor on conversion of angiotensin I to II. | 1987 | FEBS Lett. | pmid:3622769 |
Purdon AD et al. | Ionophore-stimulated rat basophilic leukemia cells produce PAF-acether. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3100454 |
Sha'afi RI and Molski TF | Signalling for increased cytoskeletal actin in neutrophils. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3036146 |
Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
Sperling RI et al. | Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. | 1987 | Arthritis Rheum. | pmid:3663263 |
Siess W and Lapetina EG | Phorbol esters sensitize platelets to activation by physiological agonists. | 1987 | Blood | pmid:3663938 |
Casals-Stenzel J et al. | Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist. | 1987 | Br. J. Pharmacol. | pmid:3664079 |
Robertson DN and Page CP | Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation. | 1987 | Br. J. Pharmacol. | pmid:3664082 |
Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
Haroldsen PE et al. | Metabolism of platelet-activating factor in isolated perfused rat lung. | 1987 | J. Clin. Invest. | pmid:3108322 |
Tahara T et al. | PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines. | 1987 | Chem. Pharm. Bull. | pmid:3664818 |
Brigham KL | Conference summary: lipid mediators in the pulmonary circulation. | 1987 | Am. Rev. Respir. Dis. | pmid:2820285 |
Lamant V et al. | Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. | 1987 | Biochem. Pharmacol. | pmid:2820421 |
Haroldsen PE et al. | Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. | 1987 | J. Lipid Res. | pmid:3104521 |
Bienenstock J et al. | Mast cell involvement in various inflammatory processes. | 1987 | Am. Rev. Respir. Dis. | pmid:3109295 |
Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
Vargaftig BB and Braquet PG | PAF-acether today--relevance for acute experimental anaphylaxis. | 1987 | Br. Med. Bull. | pmid:2825900 |
Kochanek PM et al. | Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. | 1987 | Life Sci. | pmid:2826947 |
Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
Valone FH and Johnson B | Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. | 1987 | Biochem. J. | pmid:3322269 |
Tou JS | Platelet-activating factor modulates phospholipid acylation in human neutrophils. | 1987 | Lipids | pmid:3110533 |
Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
Lianos EA and Zanglis A | Biosynthesis and metabolism of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in rat glomerular mesangial cells. | 1987 | J. Biol. Chem. | pmid:3110152 |
Riedel A et al. | The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity. | 1987 | Pharmacol Res Commun | pmid:3441484 |
Bussolino F et al. | Intravascular release of platelet activating factor in children with sepsis. | 1987 | Thromb. Res. | pmid:3441909 |
Bull HA and Machin SJ | The haemostatic function of the vascular endothelial cell. | 1987 | Blut | pmid:3111566 |
Bossant MJ et al. | Characterization and quantification of PAF-acether (platelet-activating factor) as a heptafluorobutyrate derivative of 1-O-alkyl-2-acetyl-sn-glycerol by capillary column gas chromatography with electron-capture detection. | 1987 | J. Chromatogr. | pmid:3443654 |
Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
Vane J and Botting R | Inflammation and the mechanism of action of anti-inflammatory drugs. | 1987 | FASEB J. | pmid:3111928 |
Riedel A and Mest HJ | The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. | 1987 | Prostaglandins Leukot Med | pmid:3112804 |
Shimokawa H et al. | Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. | 1987 | Circ. Res. | pmid:3113760 |
Adnot S et al. | Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. | 1987 | Agents Actions | pmid:3115070 |
Feuerstein G and Hallenbeck JM | Prostaglandins, leukotrienes, and platelet-activating factor in shock. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3034139 |
Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
Bureau M et al. | Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. | 1987 | Prostaglandins | pmid:3035615 |
Satouchi K et al. | 1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes. | 1987 | Lipids | pmid:3110532 |
Di Marzo V et al. | Neuropeptides and leukotriene release: effect of peptide histidine isoleucine and secretin in platelet activating factor-stimulated rat lung. | 1987 | Neuropeptides | pmid:3031537 |