Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Fujii E et al. | Role of nitric oxide and prostaglandins in lipopolysaccharide-induced increase in vascular permeability in mouse skin. | 1996 | Eur. J. Pharmacol. | pmid:8666058 |
Goudevenos J et al. | Platelet aggregability to platelet activating factor at rest and after exercise in patients with coronary artery disease. | 1995 | Eur. Heart J. | pmid:8665964 |
Nathan N et al. | Effects of a paf-receptor antagonist on hemodynamics during and after cardiopulmonary bypass. | 1995 | J. Cardiothorac. Vasc. Anesth. | pmid:8664454 |
Ettinger SL et al. | Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation. | 1996 | J. Biol. Chem. | pmid:8663229 |
Ferby IM et al. | Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase. | 1996 | J. Biol. Chem. | pmid:8662643 |
Ganbo T et al. | Effects of platelet activating factor on mucociliary clearance of the eustachian tube. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8659935 |
Leont'ev VK and Kankanian AP | [The local activation of leukocytes and thrombocytes in periodontal diseases: the role of thrombocyte-activating factor]. | 1996 | Stomatologiia (Mosk) | pmid:8658569 |
Sheen WS et al. | Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. | 1996 | Planta Med. | pmid:8657756 |
Franciose RJ et al. | Hypoxia/reoxygenation of human endothelium activates PMNs to detach endothelial cells via a PAF mechanism. | 1996 | J. Surg. Res. | pmid:8656625 |
Zimmerman GA et al. | Platelet-activating factor: antagonists, terminators, molecular mimics, and microbial opportunism. | 1996 | J. Intern. Med. | pmid:8656138 |
Das AK and Hajra AK | A simple chemical synthesis of the ether analog of lysophosphatidylcholine and platelet-activating factor. | 1995 | J. Lipid Res. | pmid:8656084 |
Miadonna A et al. | Nasal neutrophilia and release of myeloperoxidase induced by nasal challenge with platelet activating factor: different degrees of responsiveness in atopic and nonatopic subjects. | 1996 | J. Allergy Clin. Immunol. | pmid:8655890 |
Iatrou C et al. | The production of platelet-activating factor (PAF) during hemodialysis with cuprophane membrane. Does the calcium concentration in the dialysate play any role on it? | 1995 | Int J Artif Organs | pmid:8655220 |
Im SY et al. | Augmentation of tumor metastasis by platelet-activating factor. | 1996 | Cancer Res. | pmid:8653713 |
Resink T et al. | Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8651917 |
Nikolelis DP and Siontorou CG | Ammonium ion minisensors form self-assembled bilayer lipid membranes using gramicidin as an ionophore. Modulation of ammonium selectivity by platelet-activating factor. | 1996 | Anal. Chem. | pmid:8651482 |
Aïssa J et al. | Tissue levels of histamine, PAF-acether and lysopaf-acether in carrageenan-induced granuloma in rats. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645997 |
Korth RM | Specific high affinity binding of platelet activating factor to intact human blood neutrophils and eosinophils. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645989 |
Ikemura T et al. | KW-4679, an antiallergic drug, inhibits the production of inflammatory lipids in human polymorphonuclear leukocytes and guinea pig eosinophils. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645979 |
Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
Parent JL et al. | Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8645288 |
Reddy DS and Singh M | Antiperoxidative effects of platelet activating factor antagonists against iron-dependent lipid peroxidation in murine ventricular membranes. | 1995 Jul-Aug | Methods Find Exp Clin Pharmacol | pmid:8642899 |
Mori M et al. | Predominant expression of platelet-activating factor receptor in the rat brain microglia. | 1996 | J. Neurosci. | pmid:8642404 |
Isogai E et al. | Platelet-activating-factor-mediated pathogenesis in Lyme disease. | 1996 | Infect. Immun. | pmid:8641753 |
Giannini S et al. | Platelet-activating factor enhances production of insulin-like growth factor binding proteins in a human adenocarcinoma cell line (HEC-1A) | 1996 | Gynecol. Oncol. | pmid:8641611 |
Watanabe M et al. | Enhancement by cyclo-oxygenase inhibitors of platelet-activating factor production in thapsigargin-stimulated macrophages. | 1995 | Br. J. Pharmacol. | pmid:8640357 |
Saito M et al. | RANTES and platelet-activating factor open Ca2+-activated K+ channels in eosinophils. | 1996 | FASEB J. | pmid:8635697 |
Niwa Y et al. | Role of cytokines, tyrosine kinase, and protein kinase C on production of superoxide and induction of scavenging enzymes in human leukocytes. | 1996 | Clin. Immunol. Immunopathol. | pmid:8635290 |
Francischi JN et al. | Pharmacological characterization of Sephadex-induced oedema in rat paws: predominant role of serotonin and platelet-activating factor. | 1996 | Int. Arch. Allergy Immunol. | pmid:8634526 |
Yin M et al. | The PAF antagonist TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. | 1996 | Transplantation | pmid:8633367 |
Alaei P et al. | Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630058 |
Harris JG et al. | Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630023 |
Parent JL et al. | Mutations of two adjacent amino acids generate inactive and constitutively active forms of the human platelet-activating factor receptor. | 1996 | J. Biol. Chem. | pmid:8626474 |
Komatsu Y et al. | Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury. | 1996 | Dig. Dis. Sci. | pmid:8625746 |
Antonopoulou S et al. | Blood cardiolipin in haemodialysis patients. Its implication in the biological action of platelet-activating factor. | 1996 | Int. J. Biochem. Cell Biol. | pmid:8624843 |
Coceani F et al. | Response of newborn and adult sheep to pyrogens: relation between fever and brain eicosanoid changes. | 1995 | Brain Res. | pmid:8624710 |
Longphre M et al. | PAF-induced airways hyperreactivity is modulated by mast cells in mice. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8624251 |
Nassif A et al. | Role of cytokines and platelet-activating factor in inflammatory bowel disease. Implications for therapy. | 1996 | Dis. Colon Rectum | pmid:8620791 |
Burns AR et al. | Chemotactic factors stimulate CD18-dependent canine neutrophil adherence and motility on lung fibroblasts. | 1996 | J. Immunol. | pmid:8617965 |
Dentan C et al. | Phagocytic activation induces formation of platelet-activating factor in human monocyte-derived macrophages and in macrophage-derived foam cells. Relevance to the inflammatory reaction in atherogenesis. | 1996 | Eur. J. Biochem. | pmid:8617285 |
Silva CL et al. | Formation of a highly stable complex between BN 50730 [tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4',3'-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4] and the platelet-activating factor receptor in rabbit platelet membranes. | 1996 | Biochem. Pharmacol. | pmid:8615889 |
van Willigen G et al. | Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit. | 1996 | Biochem. J. | pmid:8615768 |
Svetlov SI et al. | Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation. | 1996 | Arch. Biochem. Biophys. | pmid:8615681 |
Bailie MB et al. | Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity. | 1996 | Toxicol. Lett. | pmid:8614909 |
Biffl WL et al. | Interleukin-6 delays neutrophil apoptosis via a mechanism involving platelet-activating factor. | 1996 | J Trauma | pmid:8614035 |
Biffl WL et al. | Interleukin-6 stimulates neutrophil production of platelet-activating factor. | 1996 | J. Leukoc. Biol. | pmid:8613706 |
Nishida K and Markey SP | Platelet-activating factor in brain regions after transient ischemia in gerbils. | 1996 | Stroke | pmid:8610322 |
Tan XD et al. | Platelet activating factor and endotoxin increase the enzyme activity and gene expression of type II phospholipase A2 in the rat intestine. Role of polymorphonuclear leukocytes. | 1996 | J. Immunol. | pmid:8609420 |
Gabbeta J et al. | Abnormal inside-out signal transduction-dependent activation of glycoprotein IIb-IIIa in a patient with impaired pleckstrin phosphorylation. | 1996 | Blood | pmid:8608226 |
Comminges C et al. | Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607782 |
Satoh K et al. | Production of platelet-activating factor by porcine brain microvascular endothelial cells in culture. | 1995 | Thromb. Haemost. | pmid:8607119 |
Novo C et al. | Factors associated with hyperdynamic or hypodynamic circulation and role of platelet-activating factor in hemodynamic alterations in bacterial peritonitis in conscious rats. | 1995 | J. Cardiovasc. Pharmacol. | pmid:8606531 |
Ono S et al. | A clinical study on the significance of platelet-activating factor in the pathophysiology of septic disseminated intravascular coagulation in surgery. | 1996 | Am. J. Surg. | pmid:8604832 |
Schweizer RC et al. | Mechanisms involved in eosinophil migration. Platelet-activating factor-induced chemotaxis and interleukin-5-induced chemokinesis are mediated by different signals. | 1996 | J. Leukoc. Biol. | pmid:8604012 |
Pinckard RN and Prihoda TJ | Alkyl-PAF and acyl-PAF human neutrophil priming for enhanced fMLP- and rC5a-induced superoxide anion production. | 1996 | J. Leukoc. Biol. | pmid:8603994 |
Lombard MN et al. | Liver and plasma concentrations in paf-acether and its precursors after partial hepatectomy. | 1996 | Cell Prolif. | pmid:8603108 |
Dupuis F et al. | PAF and haematopoiesis. X. Macrophage colony-stimulating factor and granulocyte macrophage colony-stimulating factor enhance platelet-activating factor acetylhydrolase production by human blood-derived macrophages. | 1996 | Biochim. Biophys. Acta | pmid:8603099 |
Carter MB et al. | Platelet-activating factor mediates pulmonary macromolecular leak following intestinal ischemia-reperfusion. | 1996 | J. Surg. Res. | pmid:8598677 |
Dentan C et al. | Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase. | 1996 | Biochim. Biophys. Acta | pmid:8597590 |
Klabunde RE and Calvello C | Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor. | 1995 | Shock | pmid:8595525 |
Bazan NG et al. | Mediators of injury in neurotrauma: intracellular signal transduction and gene expression. | 1995 | J. Neurotrauma | pmid:8594208 |
Zhou W et al. | Evidence for altered cellular calcium in the pathogenetic mechanism of acute pancreatitis in rats. | 1996 | J. Surg. Res. | pmid:8592406 |
Hurst JS and Bazan HE | Activation of the phospholipase/cyclooxygenase cascade in the rabbit cornea by platelet-activating factor is challenged by PAF receptor antagonists. | 1995 | J Ocul Pharmacol Ther | pmid:8590265 |
Pettigrew LC et al. | Delayed elevation of platelet activating factor in ischemic hippocampus. | 1995 | Brain Res. | pmid:8590061 |
Suzuki H et al. | Evidence for the production of platelet-activating factor by murine embryos and its putative role in the maternal physiology. | 1995 | Biochem. Mol. Biol. Int. | pmid:8589634 |
Calligerou M et al. | Platelet activating factor and lyso-phosphatidylcholines from strawberry. | 1996 | Phytochemistry | pmid:8588879 |
Myers SI et al. | Platelet activating factor (PAF) stimulates release of PGI2 from inflamed rabbit gallbladder cell cultures. | 1995 | Prostaglandins | pmid:8588069 |
Davis TM et al. | The metabolism of platelet-activating factor in severe and cerebral malaria. | 1995 | J. Infect. | pmid:8586836 |
Cheng D and Chen W | [Distribution of platelet activating factor in the pulmonary tissues of normal rats]. | 1995 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:8586397 |
Tunón H et al. | Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. | 1995 | J Ethnopharmacol | pmid:8583796 |
Komatsu H et al. | Platelet-activating factor induces cell growth through tyrosine phosphorylation pathway in cultured rat mesangial cells. | 1995 | Nihon Jinzo Gakkai Shi | pmid:8583698 |
Arthur JF et al. | Paf antagonists block induction of nitric oxide synthase in cultured macrophages and vascular smooth muscle cells. | 1995 Jun-Jul | Clin. Exp. Pharmacol. Physiol. | pmid:8582100 |
Morris J et al. | Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study. | 1995 Jun-Jul | Clin. Exp. Pharmacol. Physiol. | pmid:8582091 |
Kuwahara M et al. | Synthetic studies on condensed-azole derivatives. IV. Synthesis and anti-asthmatic activities of omega-sulfamoylalkyloxyimidazo[1,2-b]pyridazines. | 1996 | Chem. Pharm. Bull. | pmid:8582031 |
Hilliquin P et al. | Production of PAF-acether by synovial fluid neutrophils in rheumatoid arthritis. | 1995 | Inflamm. Res. | pmid:8581516 |
Man RY and Kinnaird AA | Similar coronary vascular effects in the rat perfused heart of platelet-activating factor structural analogues with agonist and antagonist properties. | 1995 | Br. J. Pharmacol. | pmid:8581269 |
Iwamoto S et al. | Platelet microparticles: a carrier of platelet-activating factor? | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579618 |
Diserbo M et al. | Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579584 |
Monthly prostaglandin bibliography prepared by the University of Sheffield Biomedical Information Service. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577776 | |
Manning R et al. | Lipid changes in HL-60 cells on differentiation into macrophages by treatment with a phorbol ester. | 1995 | Lipids | pmid:8577224 |
Naz RK and Minhas BS | Enhancement of sperm function for treatment of male infertility. | 1995 Sep-Oct | J. Androl. | pmid:8575977 |
Fukumura D et al. | Oxidative stress in gastric mucosal injury: role of platelet-activating factor-activated granulocytes. | 1995 | J. Gastroenterol. | pmid:8574326 |
Samuelsson J | Impaired activation of phospholipase D in polycythaemia vera-implications for the pathogenesis of the disease? | 1995 | Leuk. Lymphoma | pmid:8574168 |
Muzia GI et al. | [Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist]. | 1995 Jul-Aug | Vopr. Med. Khim. | pmid:8571587 |
Kudolo GB et al. | Differential metabolism of exogenous platelet-activating factor by glandular epithelial and stromal cells of rabbit endometrium. | 1995 | J. Reprod. Fertil. | pmid:8568777 |
Lin CN et al. | Synthesis and antiplatelet effects of omega-aminoalkoxylxanthones. | 1995 | J. Pharm. Pharmacol. | pmid:8568627 |
Kyriacopoulos F et al. | Role of PAF in the late airway microvascular leakage induced by antigen in IgE-sensitized rat. | 1995 | Fundam Clin Pharmacol | pmid:8566934 |
Sasaki Y et al. | [Effect of KW-4679, a novel antiallergic drug, on platelet-activating factor (PAF)-induced bronchoconstriction, airway hyperresponsiveness and pulmonary cell accumulation in guinea pigs]. | 1995 | Nippon Yakurigaku Zasshi | pmid:8566911 |
Costuleanu M et al. | Effects of liposome-entrapped platelet-activating factor in the isolated rat trachea. | 1995 | Eur. J. Pharmacol. | pmid:8566122 |
Dillon AM and Heath MF | Protein tyrosine phosphorylation in equine platelets: the effect of stimulation by thrombin and platelet-activating factor (PAF) | 1995 | Equine Vet. J. | pmid:8565942 |
Yu P et al. | [The roles of platelet activating factor in intestinal mucosal barrier injury after burn]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8565724 |
Wang C et al. | [Inhalation of platelet-activating factor induced guinea pig airway hyperresponsiveness: role of eosinophils activation]. | 1995 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:8565083 |
Lorant DE et al. | Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion. | 1995 | Semin. Cell Biol. | pmid:8562922 |
Kaneko T et al. | Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. | 1995 | Cell. Signal. | pmid:8562314 |
van der Poll T et al. | Interleukin 10 release during endotoxaemia in chimpanzees: role of platelet-activating factor and interleukin 6. | 1996 | Scand. J. Immunol. | pmid:8560191 |
Tetta C et al. | Adherence of human monocytes to haemodialysis membranes: LFA 1 (CD11a/CD18) CR1 (CD35) and CR3 (CD11b/CD18) triggering promotes the biosynthesis of platelet-activating factor and adherence. | 1995 | Nephrol. Dial. Transplant. | pmid:8559489 |
Carceller E et al. | Design, synthesis, and structure-activity relationship studies of novel 1-[(1-acyl-4-piperidyl)methyl]-1H-2- methylimidazo[4,5-c]pyridine derivatives as potent, orally active platelet-activating factor antagonists. | 1996 | J. Med. Chem. | pmid:8558517 |
Endemann G et al. | Novel anti-inflammatory compounds prevent CD11b/CD18, alpha M beta 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8558456 |
Kita H et al. | Extracellular matrix proteins attenuate activation and degranulation of stimulated eosinophils. | 1996 | J. Immunol. | pmid:8557995 |
Patke CL et al. | Differential effects of interleukin-2 and interleukin-4 on immunomodulatory role of platelet-activating factor in human B cells. | 1994 | Clin. Diagn. Lab. Immunol. | pmid:8556480 |