Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Cervoni P et al. | Evidence for the lack of interaction between (+/-)-1-O-octadecyl-2-acetylglyceryl-3-phosphorylcholine and alpha-adrenoceptors in vivo and in vitro. | 1984 | Br. J. Pharmacol. | pmid:6091835 |
Fink KL and Gross RW | Modulation of canine myocardial sarcolemmal membrane fluidity by amphiphilic compounds. | 1984 | Circ. Res. | pmid:6091941 |
Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
Fouque F and Vargaftig BB | Triggering by Paf-acether and adrenaline of cyclo-oxygenase-independent platelet aggregation. | 1984 | Br. J. Pharmacol. | pmid:6439269 |
Karlsson G and Pipkorn U | Effect of disodium chromoglycate on changes in nasal airway resistance induced by platelet activating factor. | 1984 | Eur. J. Clin. Pharmacol. | pmid:6439565 |
Sänze JU et al. | On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse. | 1984 | Biomed. Biochim. Acta | pmid:6440544 |
Sills RH | Thrombotic thrombocytopenic purpura. I. Pathophysiology and clinical manifestations. | 1984 | Am J Pediatr Hematol Oncol | pmid:6442830 |
Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |
Kulikov VI et al. | [Incorporation of 1-0-alkyl-2-acetyl-sn-glycerol-3-phosphocholine into human plasma lipoproteins in vitro. Effect of the lecithin:cholesterol acyltransferase activity of plasma]. | 1984 | Biokhimiia | pmid:6542803 |
Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
Pirotzky E et al. | PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. | 1984 | Microcirc Endothelium Lymphatics | pmid:6546141 |
Bussolino F et al. | Platelet-activating factor phosphatidate, but not platelet-activating factor, is a powerful calcium ionophore in the human red cell. | 1984 | Cell Calcium | pmid:6549153 |
Pirotzky E et al. | Biosynthesis of platelet-activating factor. VI. Precursor of platelet-activating factor and acetyltransferase activity in isolated rat kidney cells. | 1984 | Lab. Invest. | pmid:6492758 |
Handley DA et al. | Evaluation of dose and route effects of platelet activating factor-induced extravasation in the guinea pig. | 1984 | Thromb. Haemost. | pmid:6495262 |
Riess H and Hiller E | Heparin and thrombocytopenia. | 1984 | Ann. Intern. Med. | pmid:6497200 |
Smith RJ et al. | Stimulation of the human neutrophil superoxide anion-generating system with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3- phosphorylcholine. | 1984 | Biochem. Pharmacol. | pmid:6324816 |
Buxton DB et al. | Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine. | 1984 | J. Biol. Chem. | pmid:6693418 |
Doebber TW et al. | Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6517949 |
Heinrich J and Zimmermann RE | Compound 48/80 is a potent inhibitor of human platelet aggregation antagonizing the calmodulin-dependent platelet reaction in vitro. | 1984 | Thromb. Res. | pmid:6523451 |
Oxholm P et al. | Lack of evidence for human lymphokines with thrombocyte aggregating activity. An in vitro study. | 1984 | Allergy | pmid:6528957 |
Hwang SB et al. | Effects of nonsteroid antiinflammatory drugs on the specific binding of platelet activating factor to membrane preparations of rabbit platelets. | 1984 | Thromb. Res. | pmid:6429890 |
Colditz IG and Movat HZ | Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens. | 1984 | J. Immunol. | pmid:6470487 |
Patterson R et al. | Airway responses to sequential challenges with platelet-activating factor and leukotriene D4 in rhesus monkeys. | 1984 | J. Lab. Clin. Med. | pmid:6470563 |
Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+. | 1984 | Arch. Biochem. Biophys. | pmid:6430234 |
Söling HD et al. | Acetylcholine-like effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine ('platelet-activating factor') and its analogues in exocrine secretory glands. | 1984 | Eur. J. Biochem. | pmid:6207023 |
Lüthje J and Ogilvie A | Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6704102 |
Clare KA and Scrutton MC | The role of Ca2+ uptake in the response of human platelets to adrenaline and to 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor). | 1984 | Eur. J. Biochem. | pmid:6705791 |
Kumar R et al. | A facile route to semi-synthesis of acetyl glycerylether phosphoethanolamine and its choline analogue. | 1984 | J. Lipid Res. | pmid:6707528 |
Kornecki E et al. | Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines. | 1984 | Science | pmid:6150550 |
Archer CB et al. | Synergistic interaction between prostaglandins and PAF-acether in experimental animals and man. | 1984 | Prostaglandins | pmid:6203139 |
Vargaftig BB et al. | [Platelet aggregation and PAF-acether. Pharmacologic interference]. | 1984 | J Pharmacol | pmid:6374298 |
Ito S et al. | Hyperacute renal allograft rejection in the rabbit. The role of platelet-activating factor and of cationic proteins derived from polymorphonuclear leukocytes and from platelets. | 1984 | Lab. Invest. | pmid:6379289 |
Bult H et al. | Complement derived factors and prostacyclin formation by rabbit isolated peritoneum and cultured mesothelial cells. | 1984 | Agents Actions Suppl. | pmid:6382974 |
Hechtman HB et al. | Role of humoral mediators in adult respiratory distress syndrome. | 1984 | Chest | pmid:6383742 |
Kelton JG et al. | The detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. | 1984 | Ann. Intern. Med. | pmid:6333196 |
Bussolino F et al. | Release of platelet-activating factor (PAF)-like material from human lymphoid cell lines. | 1984 | Exp. Hematol. | pmid:6333353 |
Wodzinowska B and Krajewski T | [Role of blood platelets and their membrane in the process of hemostasis]. | 1984 Jan-Feb | Postepy Hig Med Dosw | pmid:6093087 |
Vemulapalli S et al. | Cardiovascular and renal action of platelet-activating factor in anesthetized dogs. | 1984 Jul-Aug | Hypertension | pmid:6378787 |
Cox CP et al. | VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF). | 1984 Mar-Apr | Peptides | pmid:6206481 |
Leid RW and Potter KA | Inflammation and mediators of lung injury. | 1985 | Vet. Clin. North Am. Food Anim. Pract. | pmid:3907779 |
Roubin R and Benveniste J | Formation of prostaglandins, leukotrienes and paf-acether by macrophages. | 1985 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:3910339 |
Tuffin DP et al. | Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:3834789 |
Parente L and Flower RJ | Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes. | 1985 | Life Sci. | pmid:3838566 |
Tokumura A and Tsukatani H | [Antagonists of platelet activating factor]. | 1985 | Seikagaku | pmid:3009656 |
Chesney CM et al. | Desensitization of human platelets by platelet activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977920 |
Nakayama R et al. | Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977939 |
Aul C et al. | [Thrombotic thrombocytopenic purpura]. | 1985 | Klin. Wochenschr. | pmid:4038757 |
Page CP et al. | Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. | 1985 | Agents Actions | pmid:4003195 |
Oda M et al. | Production of platelet-activating factor by washed rabbit platelets. | 1985 | J. Lipid Res. | pmid:3934305 |
Shen TY et al. | Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2983307 |