Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Ventricular Remodeling D020257 28 associated lipids
Gliosis D005911 6 associated lipids
Neuralgia D009437 28 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Amnesia D000647 12 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Sneezing D012912 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Helicobacter Infections D016481 21 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Mucositis D052016 7 associated lipids
Ileitis D007079 2 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Zang BX et al. [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15506296
Bankers-Fulbright JL et al. Platelet-activating factor stimulates cytoplasmic alkalinization and granule acidification in human eosinophils. 2004 J. Cell. Sci. pmid:15507482
Hertelendy F and Zakár T Prostaglandins and the myometrium and cervix. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14683694
Diez-Fraile A et al. Effect of proinflammatory mediators and glucocorticoids on L-selectin expression in peripheral blood neutrophils from dairy cows in various stages of lactation. 2004 Am. J. Vet. Res. pmid:15524330
Mangan NE et al. Helminth infection protects mice from anaphylaxis via IL-10-producing B cells. 2004 J. Immunol. pmid:15528374
Jung TT et al. Effect of inhibitors of leukotriene and/or platelet activating factor on killed H. influenzae induced experimental otitis media with effusion. 2004 Int. J. Pediatr. Otorhinolaryngol. pmid:14687688
Barbanoj MJ et al. Central and peripheral evaluation of rupatadine, a new antihistamine/platelet-activating factor antagonist, at different doses in healthy volunteers. 2004 Neuropsychobiology pmid:15539863
Fujii S et al. Chromogenic assay for the activity of sphingomyelinase from Bacillus cereus and its application to the enzymatic hydrolysis of lysophospholipids. 2004 Biol. Pharm. Bull. pmid:15516713
Hla T Prostaglandins & other lipid mediators: a new phase, a new team. 2004 Prostaglandins Other Lipid Mediat. pmid:15165026
Ruan Z et al. Effects of platelet-activating factor and thromboxane A2 on isolated perfused guinea pig liver. 2004 Prostaglandins Other Lipid Mediat. pmid:15165033
Nomikos TN et al. Application of a TCA-precipitation method for the determination of 1-alkyl-sn-glycero-3-phosphate: Acetyl-CoA acetyltransferase in human renal tissue. 2004 Prostaglandins Other Lipid Mediat. pmid:15165037
Kato M et al. Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating factor. 2004 Int. Arch. Allergy Immunol. pmid:15166482
Besana A et al. Activation of protein kinase C epsilon inhibits the two-pore domain K+ channel, TASK-1, inducing repolarization abnormalities in cardiac ventricular myocytes. 2004 J. Biol. Chem. pmid:15184378
Michail S and Abernathy F A new model for studying eosinophil migration across cultured intestinal epithelial monolayers. 2004 J. Pediatr. Gastroenterol. Nutr. pmid:15187782
Amer MD et al. Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis. 2004 Biol. Neonate pmid:14646336
Wang Y et al. Opposing effect of angiopoietin-1 on VEGF-mediated disruption of endothelial cell-cell interactions requires activation of PKC beta. 2004 J. Cell. Physiol. pmid:14584044
Takeda K [Role of increase in permeability and circulatory failure in the development of organ dysfunction in severe acute pancreatitis]. 2004 Nippon Rinsho pmid:15552880
Takase K et al. [New aspects of pharmaco-therapy for acute pancreatitis]. 2004 Nippon Rinsho pmid:15552891
Rothhut B Benveniste's reputation was not written in water. 2004 Nature pmid:15565124
Serradji N et al. Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity. 2004 J. Med. Chem. pmid:15566310
Roudebush WE et al. Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility. 2004 Fertil. Steril. pmid:15236989
Alloatti G et al. Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. 2004 Biochem. Soc. Trans. pmid:15046613
Shio MT et al. PAF is involved in the Mycoplasma arthritidis superantigen-triggering pathway for iNOS and COX-2 expression in murine peritoneal cells. 2004 Exp. Cell Res. pmid:15242784
Naoki K et al. PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. 2004 Biochem. Biophys. Res. Commun. pmid:15047169
Al-Darmaki S et al. Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response. 2004 Clin. Diagn. Lab. Immunol. pmid:15242947
Sugatani J et al. Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation. 2004 Int. Arch. Allergy Immunol. pmid:15051936
Tsironis LD et al. Effect of lipoprotein (a) on platelet activation induced by platelet-activating factor: role of apolipoprotein (a) and endogenous PAF-acetylhydrolase. 2004 Cardiovasc. Res. pmid:15194469
Aguiari G et al. Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells. 2004 FASEB J. pmid:15001556
Ma YQ et al. P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils. 2004 Blood pmid:15217824
Du YM et al. Effects of platelet activating factor on action potentials and potassium channels in guinea-pig ventricular myocytes. 2004 Sheng Li Xue Bao pmid:15224138
Geromin D et al. Glycoprotein 170 induces platelet-activating factor receptor membrane expression and confers tumor cell hypersensitivity to NK-dependent cell lysis. 2004 J. Immunol. pmid:15004162
McDonagh PF et al. Chronic expression of platelet adhesion proteins is associated with severe ischemic heart disease in type 2 diabetic patients: Chronic platelet activation in diabetic heart patients. 2003 Sep-Oct J. Diabetes Complicat. pmid:12954156
Kerek M et al. Effects of recombinant platelet activating factor acetylhydrolase in obstructive jaundice. 2003 Jul-Aug Hepatogastroenterology pmid:12845989
Baltás E et al. Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. 2003 Jul-Aug Skin Pharmacol. Appl. Skin Physiol. pmid:12784066
Hsueh W et al. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. 2003 Jan-Feb Pediatr. Dev. Pathol. pmid:12424605
Diez-Fraile A et al. Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. 2003 Jan-Feb Vet. Res. pmid:12588684
Tellis C et al. Localization of an alkyl-acetyl-glycerol-CDP-choline: cholinephosphotransferase activity in submitochondrial fractions of Tetrahymena pyriformis. 2003 Eur. J. Cell Biol. pmid:14703014
Stafforini DM et al. Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. 2003 Crit Rev Clin Lab Sci pmid:14708958
Narahara H et al. Platelet-activating factor inhibits the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages. 2003 J. Clin. Endocrinol. Metab. pmid:14671207
Gálvez J et al. The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. 2003 Inflamm. Bowel Dis. pmid:14671485
Saeed SA and Rasheed H Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. 2003 Acta Pharmacol. Sin. pmid:12511226
Ishizuka S et al. Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. 2003 J. Infect. Dis. pmid:14673774
Koyama N Platelet activating factor in surfactant-TA is inhibited by coexisting inhibitors. 2003 Lung pmid:14692561
Russo S et al. Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction. 2003 J. Immunol. pmid:14607955
Zhang Y et al. Antioxidant superoxide dismutase attenuates increased endothelial permeability induced by platelet-activating factor. 2003 J. Soc. Gynecol. Investig. pmid:12517587
Kuo RY et al. Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate. 2003 Bioorg. Med. Chem. Lett. pmid:12873516
Zhu X et al. Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. 2003 Life Sci. pmid:14519449
Gabrijelcic J et al. Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. 2003 Eur. Respir. J. pmid:12952263
Takafuji S et al. Matrix metalloproteinase-9 release from human leukocytes. 2003 J Investig Allergol Clin Immunol pmid:12861851
Bar-Or D et al. Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. 2003 Shock pmid:12865660
Kujiraoka T et al. Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus. 2003 J. Lipid Res. pmid:12867534
D'Andrea D et al. Induction of tissue factor in the arterial wall during recurrent thrombus formation. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12869352
Lupia E et al. The membrane attack complex of complement contributes to plasmin-induced synthesis of platelet-activating factor by endothelial cells and neutrophils. 2003 Immunology pmid:12871223
Fernandes ES et al. Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw. 2003 Br. J. Pharmacol. pmid:12839871
Saruc M et al. An experimental model of hemolysis-induced acute pancreatitis. 2003 Braz. J. Med. Biol. Res. pmid:12845374
Nomikos TN et al. Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue. 2003 Eur. J. Biochem. pmid:12846832
Suzuki M et al. Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils. 2003 J. Allergy Clin. Immunol. pmid:12847489
Brandt EB et al. Mast cells are required for experimental oral allergen-induced diarrhea. 2003 J. Clin. Invest. pmid:14660743
Rhee CK Candidate's thesis: Platelet-activating factor-induced hearing loss: mediated by nitric oxide? 2003 Laryngoscope pmid:14660903
Diaper CM et al. A total synthesis of (+/-)-phomactin A. 2003 Org. Biomol. Chem. pmid:14664384
Beck-Speier I et al. Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. 2003 Prostaglandins Other Lipid Mediat. pmid:14518563
Antonopoulou S et al. Hydroxyl-platelet-activating factor exists in blood of healthy volunteers and periodontal patients. 2003 Mediators Inflamm. pmid:14514473
Kusunoki H et al. Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. 2003 Diabetes Care pmid:12766129
Gödecke A PAF, PIP(3) and NO: emerging role in reperfusion injury. 2003 Cardiovasc. Res. pmid:14613846
Strümper D et al. Effects of antidepressants on function and viability of human neutrophils. 2003 Anesthesiology pmid:12766643
Alloatti G et al. Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. 2003 Cardiovasc. Res. pmid:14613853
Pizurki L et al. Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production. 2003 Br. J. Pharmacol. pmid:12770938
Akisu M et al. Supplementation with Saccharomyces boulardii ameliorates hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. 2003 Eur J Pediatr Surg pmid:14618522
Takizawa T et al. Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. 2003 Int. Arch. Allergy Immunol. pmid:12771544
Zhang X et al. Age-related increase of plasma platelet-activating factor concentrations in Chinese. 2003 Clin. Chim. Acta pmid:14568193
Saraf MK et al. Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. 2003 Behav. Brain Res. pmid:12798263
Denizot Y et al. Platelet-activating factor and normal or leukaemic haematopoiesis. 2003 Leuk. Lymphoma pmid:12802913
Olanders K et al. Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. 2003 Scand. J. Gastroenterol. pmid:12825870
Adamson RH et al. PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12649070
Haraldsen P et al. Multimodal management - of value in fulminant acute pancreatitis? 2003 Pancreatology pmid:12649560
Li XG and Luo HM [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15617488
Denizot Y et al. No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis. 2003 Mediators Inflamm. pmid:12775360
Yan W et al. Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12775763
Nie ZG and Wang WJ [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. 2003 Yao Xue Xue Bao pmid:12778742
Fragopoulou E et al. Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties. 2003 Biochim. Biophys. Acta pmid:12782155
Marshall JC Such stuff as dreams are made on: mediator-directed therapy in sepsis. 2003 Nat Rev Drug Discov pmid:12750742
Bayar MA et al. The effect of EGb-761 on morphologic vasospasm in canine basilar artery after subarachnoid hemorrhage. 2003 J. Cardiovasc. Pharmacol. pmid:12960685
Kato M et al. The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis. 2003 J Ocul Pharmacol Ther pmid:12964956
Ishiura Y et al. Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction. 2003 J Investig Allergol Clin Immunol pmid:12968390
Calabresi L et al. Endothelial protection by high-density lipoproteins: from bench to bedside. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12969988
Zhao XY et al. [Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release]. 2003 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:12970925
Izquierdo I et al. Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. A review of pharmacological profile and clinical management of allergic rhinitis. 2003 Drugs Today pmid:12944997
Wu B et al. Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. 2003 FASEB J. pmid:12709415
Ueda Y et al. Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ. 2003 Biol. Pharm. Bull. pmid:14519965
Akisu M et al. The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis. 2003 Ann. Nutr. Metab. pmid:14520021
Bussolati B et al. The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. 2003 J. Immunol. pmid:12538709
Frostegård J et al. Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion. 2003 Am. J. Obstet. Gynecol. pmid:14520236
Ahlemeyer B and Krieglstein J Neuroprotective effects of Ginkgo biloba extract. 2003 Cell. Mol. Life Sci. pmid:14523543
Hirayama K et al. Platelet-activating factor, a critical mediator in the pathogenesis of dextran sulfate sodium-induced colitis in rats. 2003 Dis. Colon Rectum pmid:12544529
Balestrieri ML et al. Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. 2003 J. Lipid Res. pmid:12576520
Lee JM et al. Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. 2003 J. Biol. Chem. pmid:12556532
Handa RK et al. Platelet-activating factor and solute transport processes in the kidney. 2003 Am. J. Physiol. Renal Physiol. pmid:12529272
Zhao H et al. Influence of platelet activating factor on expression of adhesion molecules in experimental pancreatitis. 2003 World J. Gastroenterol. pmid:12532462
Kolko M et al. Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. 2003 Neurosci. Lett. pmid:12566178
Biancone L et al. Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth. 2003 Clin. Cancer Res. pmid:14519648