| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Gliosis | D005911 | 6 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Tachycardia, Ventricular | D017180 | 9 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Malaria, Falciparum | D016778 | 22 associated lipids |
| Liver Failure | D017093 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Gastroesophageal Reflux | D005764 | 10 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Ileitis | D007079 | 2 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Postoperative Hemorrhage | D019106 | 7 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozaki Y et al. | Potentiation of neutrophil biosynthesis of platelet-activating factor by cytochalasin B: evaluation of acetyltransferase activity. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3687329 |
| Ponpipom MM et al. | Structure-activity relationships of kadsurenone analogues. | 1987 | J. Med. Chem. | pmid:3027330 |
| Hecker G et al. | Potent inhibition of PAF-stimulated human platelets and polymorphonuclear leukocytes by the PGE1 analog OP-1206. | 1987 | Prog. Clin. Biol. Res. | pmid:2444988 |
| Desquand S et al. | Interference of the PAF-acether antagonist BN 52021 with anaphylaxis in the guinea pig. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2445183 |
| Kurosawa M | Effect of platelet activating factor on histamine release from rat mast cells. | 1987 | Agents Actions Suppl. | pmid:2445185 |
| Gerard NP | Characterization of substance P contractile activity on isolated guinea pig lung tissues. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2447271 |
| Beijer L et al. | The involvement of platelet activating factor in endotoxin-induced pulmonary platelet recruitment in the guinea-pig. | 1987 | Br. J. Pharmacol. | pmid:2447993 |
| Belch JJ et al. | Whole blood white cell aggregation: a novel technique. | 1987 | Thromb. Res. | pmid:2448894 |
| Hannun YA et al. | Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. | 1987 | J. Biol. Chem. | pmid:3115982 |
| Martin TR et al. | Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage. | 1987 | J. Clin. Invest. | pmid:2821074 |
| Rylander R and Beijer L | Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3541718 |
| Dejana E et al. | Modulation of endothelial cell functions by different molecular species of interleukin 1. | 1987 | Blood | pmid:3542082 |
| Miwa M et al. | Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver. | 1987 | J. Biol. Chem. | pmid:3804997 |
| Sugiura T et al. | Transacylation of lyso platelet-activating factor and other lysophospholipids by macrophage microsomes. Distinct donor and acceptor selectivities. | 1987 | J. Biol. Chem. | pmid:3805017 |
| Sturk A et al. | Platelet-activating factor: mediator of the third pathway of platelet aggregation? A study in three patients with deficient platelet-activating factor synthesis. | 1987 | J. Clin. Invest. | pmid:3805272 |
| Argyroudi-Akoyunoglou JH and Vakirtzi-Lemonias C | Low-temperature fluorescence emission changes in thylakoids induced by acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | Arch. Biochem. Biophys. | pmid:3813566 |
| Maguire MH and Csonka-Khalifah L | Vinca alkaloids inhibit conversion of arachidonic acid to thromboxane by human platelet microsomes: comparison with other microtubule-active drugs. | 1987 | Biochim. Biophys. Acta | pmid:3117116 |
| Blache D and Ciavatti M | Rat platelet arachidonate metabolism in the presence of Ca2+, Sr2+ and Ba2+: studies using intact platelets and semi-purified phospholipase A2. | 1987 | Biochim. Biophys. Acta | pmid:2444263 |
| Brunelleschi S et al. | Platelet-activating factor-acether-induced relaxation of guinea pig airway muscle: role of prostaglandin E2 and the epithelium. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3478474 |
| Casals-Stenzel J | Triazolodiazepines are potent antagonists of platelet activating factor (PAF) in vitro and in vivo. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3587377 |
| Brambilla A et al. | WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage. | 1987 | Pharmacol Res Commun | pmid:3588650 |
| Jancar S et al. | Comparative effects of platelet activating factor, leukotriene D4 and histamine on guinea pig trachea, bronchus and lung parenchyma. | 1987 | Prostaglandins | pmid:3588970 |
| Malo PE et al. | Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor. | 1987 | Prostaglandins | pmid:3588971 |
| Joseph R et al. | Sensitivity to PAF is increased in migraine patients. | 1987 | Thromb. Haemost. | pmid:3590077 |
| Valone FH | Inhibition of platelet-activating factor binding to human platelets by calcium channel blockers. | 1987 | Thromb. Res. | pmid:3590086 |
| Tokumura A et al. | Platelet aggregation induced by ether-linked phospholipids. 2. Mechanism of desensitization of rabbit platelets by platelet activating factor and reversibility of inhibitory actions of its antagonists. | 1987 | Thromb. Res. | pmid:3590110 |
| Christman BW et al. | Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. | 1987 | Am. Rev. Respir. Dis. | pmid:3592402 |
| Benveniste J | A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? | 1987 | Am. Rev. Respir. Dis. | pmid:3592414 |
| Sugatani J et al. | Platelet-activating factor stimulation of rabbit platelets is blocked by serine protease inhibitor (chymotryptic protease inhibitor). | 1987 | J. Biol. Chem. | pmid:3106343 |
| Ramesha CS and Pickett WC | Fatty acid composition of diacyl, alkylacyl, and alkenylacyl phospholipids of control and arachidonate-depleted rat polymorphonuclear leukocytes. | 1987 | J. Lipid Res. | pmid:3106551 |
| Dallob A et al. | Pharmacological evidence for a role of lipoxygenase products in platelet-activating factor (PAF)-induced hyperalgesia. | 1987 | Biochem. Pharmacol. | pmid:2822047 |
| Coëffier E et al. | Platelet-leukocyte interaction: activation of rabbit platelets by FMLP-stimulated neutrophils. | 1987 | Br. J. Pharmacol. | pmid:3118996 |
| Shigenobu K et al. | Potentiation by bovine serum albumin (BSA) of endothelium-dependent vasodilator response to acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | J. Pharmacobio-dyn. | pmid:3625454 |
| Hirafuji M et al. | Regulation of PAF-acether (platelet-activating factor) biosynthesis in cultured human vascular endothelial cells stimulated with thrombin. | 1987 | Biochim. Biophys. Acta | pmid:2888488 |
| Jensen NJ et al. | FAB MS/MS for phosphatidylinositol, -glycerol, -ethanolamine and other complex phospholipids. | 1987 | Lipids | pmid:3626775 |
| Cox CP and Wood KL | Selective antagonism of platelet-activating factor (PAF)-induced aggregation and secretion in washed rabbit platelets by CV-3988, L-652731, triazolam and alprazolam. | 1987 | Thromb. Res. | pmid:3629553 |
| Ostermann G et al. | Plasma from atherosclerotic patients exerts an increased degradation of platelet-activating factor. | 1987 | Thromb. Res. | pmid:3629555 |
| Pettipher ER et al. | PAF-acether in chronic arthritis. | 1987 | Agents Actions | pmid:3630862 |
| Stenmark KR et al. | Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. | 1987 | Am. Rev. Respir. Dis. | pmid:3631747 |
| O'Donnell SR and Barnett CJ | Microvascular leakage to platelet activating factor in guinea-pig trachea and bronchi. | 1987 | Eur. J. Pharmacol. | pmid:3040440 |
| Nakamura T et al. | Platelet-activating factor in late asthmatic response. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3804454 |
| Ramesha CS and Pickett WC | Species-specific variations in the molecular heterogeneity of the platelet-activating factor. | 1987 | J. Immunol. | pmid:3100641 |
| Beauvais F and Benveniste J | [IgE and anaphylaxis mediators]. | 1987 | Allerg Immunol (Paris) | pmid:2968802 |
| Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
| Schwertschlag U et al. | L-platelet activating factor induces changes on renal vascular resistance, vascular reactivity, and renin release in the isolated perfused rat kidney. | 1987 | Circ. Res. | pmid:3297384 |
| O'Flaherty JT and Nishihira J | Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils. | 1987 | J. Immunol. | pmid:3029224 |
| Page CP | A role for platelet activating factor and platelets in the induction of bronchial hyperreactivity. | 1987 | Int J Tissue React | pmid:3298115 |
| Lian EC | Pathogenesis of thrombotic thrombocytopenic purpura. | 1987 | Semin. Hematol. | pmid:3299722 |
| Camussi G et al. | Release of platelet-activating factor from rabbit heart perfused in vitro by sera with transplantation alloantibodies. | 1987 | Transplantation | pmid:3299910 |
| Zimmerman GA et al. | Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. | 1987 | Am. Rev. Respir. Dis. | pmid:3300444 |
| Henderson WR | Lipid-derived and other chemical mediators of inflammation in the lung. | 1987 | J. Allergy Clin. Immunol. | pmid:3031147 |
| Lecrubier C et al. | [Platelet aggregation tests in 26 cases of heparin-induced thrombopenia. Methodological, diagnostic problems and therapeutic aspects]. | 1987 | J Mal Vasc | pmid:2834484 |
| Caramelo C et al. | Increased levels of platelet-activating factor in blood from patients with cirrhosis of the liver. | 1987 | Eur. J. Clin. Invest. | pmid:3106053 |
| Matsumoto T et al. | G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3032170 |
| Piper PJ and Stewart AG | Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists. | 1987 | Br. J. Pharmacol. | pmid:3034369 |
| Hwang SB | Specific receptor sites for platelet activating factor on rat liver plasma membranes. | 1987 | Arch. Biochem. Biophys. | pmid:2821908 |
| Shimizu K et al. | [Actions of platelet activating factor in pulmonary circulation--experimental investigation using rabbit blood vessel smooth muscle preparations]. | 1987 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3444152 |
| Lagente V et al. | Platelet-activating factor (PAF-acether) and microcirculation: effect of Lyso-PAF and PAF-antagonists. | 1987 | Braz. J. Med. Biol. Res. | pmid:3452452 |
| Robaut C et al. | PAF binding sites. Characterization by [3H]52770 RP, a pyrrolo[1,2-c]thiazole derivative, in rabbit platelets. | 1987 | Biochem. Pharmacol. | pmid:2822048 |
| Gentry PA et al. | Inhibitory effect of trichothecene mycotoxins on bovine platelets stimulated by platelet activating factor. | 1987 | Can. J. Vet. Res. | pmid:3453270 |
| Dale MM and Penfield A | Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils. | 1987 | Br. J. Pharmacol. | pmid:2822195 |
| Livio M et al. | A platelet-activating factor receptor antagonist protects against renal function deterioration in nephrotoxic nephritis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823570 |
| Stenzel H et al. | Effect of the PAF-antagonist SRI 63-441 on the allergic reaction in awake dogs with natural asthma. | 1987 | Agents Actions Suppl. | pmid:2823582 |
| Hartiala KT et al. | Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034265 |
| O'Flaherty JT and Wykle RL | Metabolic origin and fate of platelet-activating factor. | 1987 | Agents Actions Suppl. | pmid:2823583 |
| Krishnamurthi S et al. | Effect of phorbol 12-myristate 13-acetate (PMA) on agonist-induced arachidonate release and 5-hydroxytryptamine secretion in human platelets. Dependence of effects on agonist type and time of incubation with PMA. | 1987 | Biochim. Biophys. Acta | pmid:3101746 |
| Carlson RP et al. | Pharmacologic modulation of PAF-induced mortality in mice. | 1987 | Agents Actions | pmid:3120513 |
| Bussolino F et al. | Studies on the mechanism of interleukin 1 stimulation of platelet activating factor synthesis in human endothelial cells in culture. | 1987 | Biochim. Biophys. Acta | pmid:3024738 |
| Sweatt JD et al. | Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF. | 1987 | Circ. Res. | pmid:2822286 |
| Kurgan J | [Blood platelets and asthma and other lung diseases]. | 1987 | Pol Tyg Lek | pmid:3684765 |
| Ezra D et al. | Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig. | 1987 | Prostaglandins | pmid:3685397 |
| Liu BN | [Neoplastic membrane-toxic activity as one of the pathogenetic factors in blood cell and tumor growth changes]. | 1987 Jan-Feb | Patol Fiziol Eksp Ter | pmid:3550649 |
| Lurie A et al. | Exercise- and allergen-induced asthma do not change the production of Paf-acether by neutrophils and platelets. | 1987 Jul-Aug | Bull Eur Physiopathol Respir | pmid:3690021 |
| Auriault C et al. | The effector function of platelets is induced and regulated by T lymphocytes. | 1987 Jul-Aug | Ann. Inst. Pasteur Immunol. | pmid:3118905 |
| Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
| Arnoux B et al. | Antigenic release of paf-acether and beta-glucuronidase from alveolar macrophages of asthmatics. | 1987 Mar-Apr | Bull Eur Physiopathol Respir | pmid:3607326 |
| Berdel WE et al. | Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. | 1987 Nov-Dec | Anticancer Res. | pmid:3442414 |
| Lakin KM et al. | [Action of calcium antagonists on thrombocyte aggregation]. | 1987 Sep-Oct | Farmakol Toksikol | pmid:2826225 |
| Frick KK et al. | Platelet-derived growth factor-induced c-myc RNA expression. Analysis of an inducible pathway independent of protein kinase C. | 1988 | J. Biol. Chem. | pmid:2449430 |
| Dillon PK and Durán WN | Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation. | 1988 | Circ. Res. | pmid:2450695 |
| Ferrell JE et al. | Membrane bilayer balance and platelet shape: morphological and biochemical responses to amphipathic compounds. | 1988 | Biochim. Biophys. Acta | pmid:3355815 |
| Csatò M and Czarnetzki BM | Effect of BN 52021, a platelet activating factor antagonist, on experimental murine contact dermatitis. | 1988 | Br. J. Dermatol. | pmid:3377969 |
| Hoffman DR et al. | Platelet-activating factor induces glycogen degradation in fetal rabbit lung in utero. | 1988 | J. Biol. Chem. | pmid:3379072 |
| Kertscher HP et al. | [Synthesis and thrombocyte-aggregating action of a structural analog of platelet activating factor with a modified head group]. | 1988 | Pharmazie | pmid:3380866 |
| Hirafuji M et al. | Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408504 |
| Stahl GL et al. | Salutary consequences of blockade of platelet activating factor in hemorrhagic shock. | 1988 | Eur. J. Pharmacol. | pmid:3409951 |
| Pretolani M et al. | Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection. | 1988 | Am. Rev. Respir. Dis. | pmid:3202509 |
| Adamus WS et al. | Inhibitory effect of oral WEB 2086, a novel selective PAF-acether antagonist, on ex vivo platelet aggregation. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181277 |
| Yanoshita R et al. | Hydrolysis of platelet activating factor and its methylated analogs by acetylhydrolases. | 1988 | J. Biochem. | pmid:3182751 |
| Suzuki Y et al. | Release of acetylhydrolase from platelets on aggregation with platelet-activating factor. | 1988 | Eur. J. Biochem. | pmid:3345757 |
| Benveniste J and Leyravaud S | Retention of platelet activating factor by human neutrophils. | 1988 | J. Immunol. | pmid:3346547 |
| Kimani G et al. | Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor. | 1988 | J. Immunol. | pmid:3361129 |
| Robertson DA et al. | Negative inotropic effect of platelet-activating factor: association with a decrease in intracellular sodium activity. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361438 |
| Egger M et al. | Human platelet electrorotation change induced by activation: inducer specificity and correlation to serotonin release. | 1988 | Biochim. Biophys. Acta | pmid:3143424 |
| Pitcock JA | Morphometric studies of the renomedullary interstitial cells. | 1988 | Am. J. Med. Sci. | pmid:3284348 |
| Plante GE et al. | Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3231663 |
| Santos JC et al. | Effect of intrarenal infusion of synthetic PAF-acether in dogs. | 1988 | Rev. Esp. Fisiol. | pmid:3231880 |
| Croft KD et al. | The effect of dietary fish oil and long-term salt loading on blood pressure and eicosanoid metabolism in spontaneously hypertensive rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3271614 |
| Valone FH | Interrelationships among platelet-activating factor binding and metabolism and induction of platelet activation. | 1988 | Prog. Clin. Biol. Res. | pmid:2850575 |
| Shukla SD and Morrison WJ | Platelet activating factor receptor occupancy in relation to activation and desensitization of phosphoinositide specific phospholipase C. | 1988 | Prog. Clin. Biol. Res. | pmid:2850576 |