Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Ventricular Remodeling D020257 28 associated lipids
Gliosis D005911 6 associated lipids
Neuralgia D009437 28 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Amnesia D000647 12 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Sneezing D012912 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Helicobacter Infections D016481 21 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Mucositis D052016 7 associated lipids
Ileitis D007079 2 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Ichinose M et al. Activation of K+ current in macrophages by platelet activating factor. 1992 Biochem. Biophys. Res. Commun. pmid:1370616
Rezaul K et al. Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. 1997 Biochem. Biophys. Res. Commun. pmid:9345263
Mutoh H et al. Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-kappa B. 1994 Biochem. Biophys. Res. Commun. pmid:7802642
Kuruvilla A et al. High-level expression of functional platelet-activating factor receptors on a human B lymphoblastoid cell line. 1991 Biochem. Biophys. Res. Commun. pmid:1659411
Asano K et al. Cellular source(s) of platelet-activating-factor acetylhydrolase activity in plasma. 1999 Biochem. Biophys. Res. Commun. pmid:10425216
Chesney CM et al. Triazolobenzodiazepines competitively inhibit the binding of platelet activating factor (PAF) to human platelets. 1987 Biochem. Biophys. Res. Commun. pmid:3579913
Asano K et al. Distribution of platelet activating factor receptor mRNA along the rat nephron segments. 1996 Biochem. Biophys. Res. Commun. pmid:8753768
el Azzouzi B et al. Immunoregulatory functions of paf-acether. IX. Modulation of apoptosis in an immature T cell line. 1993 Biochem. Biophys. Res. Commun. pmid:8427577
Shindo K et al. PAF-induced eosinophil chemotaxis increases during an asthmatic attack and is inhibited by prednisolone in vivo and in vitro. 1997 Biochem. Biophys. Res. Commun. pmid:9266847
Liu B et al. Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. 1995 Biochem. Biophys. Res. Commun. pmid:7677747
Rengan R and Omann GM Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. 1999 Biochem. Biophys. Res. Commun. pmid:10462500
Doebber TW et al. Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. 1985 Biochem. Biophys. Res. Commun. pmid:2985058
Pfeilschifter J et al. Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. 1985 Biochem. Biophys. Res. Commun. pmid:2985064
Lerner R et al. Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. 1988 Biochem. Biophys. Res. Commun. pmid:2838025
Crouch MF and Lapetina EG No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation. 1988 Biochem. Biophys. Res. Commun. pmid:3132162
Hwang SB et al. Specific binding sites for platelet activating factor in human lung tissues. 1985 Biochem. Biophys. Res. Commun. pmid:2986633
Steiner M et al. Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). 1985 Biochem. Biophys. Res. Commun. pmid:3936503
Naccache PH et al. Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. 1985 Biochem. Biophys. Res. Commun. pmid:2992480
Avdonin PV et al. Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). 1985 Biochem. Biophys. Res. Commun. pmid:2994653
Maridonneau-Parini I et al. Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. 1985 Biochem. Biophys. Res. Commun. pmid:2994661
López-Farré A et al. Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. 1988 Biochem. Biophys. Res. Commun. pmid:3358756
Kuiper J et al. The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. 1988 Biochem. Biophys. Res. Commun. pmid:3144970
O'Flaherty JT et al. Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation. 1981 Biochem. Biophys. Res. Commun. pmid:6277309
Blank ML et al. Generation of the precursor (lyso-PAF) of platelet-activating factor via a CoA-dependent transacylase. 1995 Biochem. Biophys. Res. Commun. pmid:7763233
Tokumura A et al. Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain. 1987 Biochem. Biophys. Res. Commun. pmid:3593346
Touvay C et al. Effect of cyclosporin A and the platelet-activating factor (PAF) antagonist, BN 52021, on PAF- and antigen- induced bronchoconstriction in the guinea-pig. 1989 Biochem. Biophys. Res. Commun. pmid:2775253
Kojima S et al. Cooperativity between platelet-activating factor and collagen in platelet aggregation. 1987 Biochem. Biophys. Res. Commun. pmid:3593379
Bastien Y and Mazer BD Detection of the human platelet-activating factor receptor mRNA in human B lymphocytes by polymerase chain reaction on reverse transcripts (RT-PCR) 1994 Biochem. Biophys. Res. Commun. pmid:8060316
Lad PM et al. Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. 1985 Biochem. Biophys. Res. Commun. pmid:2990462
Comminges C et al. Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. 1996 Biochem. Biophys. Res. Commun. pmid:8607782
Weber C et al. Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. 1993 Biochem. Biophys. Res. Commun. pmid:8373423
Wykle RL et al. Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils. 1981 Biochem. Biophys. Res. Commun. pmid:7295320
Franklin RA et al. Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes. 1995 Biochem. Biophys. Res. Commun. pmid:7733966
Rola-Pleszczynski M et al. Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether): reversal by a specific antagonist, BN 52021. 1987 Biochem. Biophys. Res. Commun. pmid:3493773
Svetlov S and Nigam S Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. 1993 Biochem. Biophys. Res. Commun. pmid:8380690
Gil MG et al. Inhibition of phospholipid methyltransferase during zymosan induced secretion of platelet-activating factor in human polymorphonuclear leukocytes. 1981 Biochem. Biophys. Res. Commun. pmid:7306113
Blank ML et al. Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets. 1984 Biochem. Biophys. Res. Commun. pmid:6497876
White GC Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6428395
Fukao M et al. Structural differences in the ability of lysophospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric arteries. 1996 Biochem. Biophys. Res. Commun. pmid:8878540
Schlondorff D et al. Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. 1986 Biochem. Biophys. Res. Commun. pmid:3099783
Resink T et al. Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells. 1996 Biochem. Biophys. Res. Commun. pmid:8651917
Murphy CT et al. Evidence for the presence and location of annexins in human platelets. 1992 Biochem. Biophys. Res. Commun. pmid:1482379
Xu N et al. Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. 2002 Biochem. Biophys. Res. Commun. pmid:11944906
Weintraub ST et al. Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. 1985 Biochem. Biophys. Res. Commun. pmid:4015656
Fernández B and Balsinde J Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx. 1991 Biochem. Biophys. Res. Commun. pmid:1659393
Kok PT et al. Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. 1988 Biochem. Biophys. Res. Commun. pmid:3132917
Nogami M et al. The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells. 1990 Biochem. Biophys. Res. Commun. pmid:2346478
Kojima S et al. Cooperativity between platelet-activating factor and collagen in aggregation of bovine platelets, II. 1990 Biochem. Biophys. Res. Commun. pmid:2346486
Watson F and Edwards SW Stimulation of primed neutrophils by soluble immune complexes: priming leads to enhanced intracellular Ca2+ elevations, activation of phospholipase D, and activation of the NADPH oxidase. 1998 Biochem. Biophys. Res. Commun. pmid:9647777
Joseph R and Han E Amyloid beta-protein fragment 25-35 causes activation of cytoplasmic calcium in neurons. 1992 Biochem. Biophys. Res. Commun. pmid:1590803
Filep J et al. Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog. 1989 Biochem. Biophys. Res. Commun. pmid:2916986
Pinckard RN et al. Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. 1984 Biochem. Biophys. Res. Commun. pmid:6743335
Rigat B et al. GM2 activator protein inhibits platelet activating factor signaling in rats. 2009 Biochem. Biophys. Res. Commun. pmid:19486886
Lee TC et al. 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) stimulates calcium influx in rabbit platelets. 1981 Biochem. Biophys. Res. Commun. pmid:6797422
Denizot Y et al. Paf-acether production by Escherichia coli. 1989 Biochem. Biophys. Res. Commun. pmid:2660796
Fisher GJ et al. Differential activation of human skin cells by platelet activating factor: stimulation of phosphoinositide turnover and arachidonic acid mobilization in keratinocytes but not in fibroblasts. 1989 Biochem. Biophys. Res. Commun. pmid:2476985
Di Marzo V et al. Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. 1987 Biochem. Biophys. Res. Commun. pmid:2822041
Sakakibara M et al. Induction of photoresponse by the hydrolysis of polyphosphoinositides in the Hermissenda type B photoreceptor. 1994 Biochem. Biophys. Res. Commun. pmid:7518677
Schulam PG et al. Evidence for a platelet-activating factor receptor on human lymphoblastoid B cells: activation of the phosphatidylinositol cycle and induction of calcium mobilization. 1990 Biochem. Biophys. Res. Commun. pmid:2154211
Crouch MF and Lapetina EG Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. 1988 Biochem. Biophys. Res. Commun. pmid:3178827
Joly F et al. Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. 1992 Biochem. Biophys. Res. Commun. pmid:1317174
Maruyama Y et al. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. 1994 Biochem. Biophys. Res. Commun. pmid:8147869
Sugiura T et al. Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). 1985 Biochem. Biophys. Res. Commun. pmid:2935146
Chen JJ and Liew CC Phosphorylation of an acid-soluble nuclear protein in response to catecholamine in cultured rat cardiocytes. 1993 Biochem. Biophys. Res. Commun. pmid:8439325
Sugiura T et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. 1996 Biochem. Biophys. Res. Commun. pmid:8954083
Domingo MT et al. Presence of specific binding sites for platelet-activating factor (PAF) in brain. 1988 Biochem. Biophys. Res. Commun. pmid:2831903
Touqui L et al. Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite. 1983 Biochem. Biophys. Res. Commun. pmid:6838557
Beaubien BB et al. Platelet-activating factor stimulation of peptidoleukotriene release: inhibition by vasoactive polypeptide. 1984 Biochem. Biophys. Res. Commun. pmid:6594998
Scherer GF 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. 1985 Biochem. Biophys. Res. Commun. pmid:4084306
Levine L Regulation of arachidonic acid metabolism by phenylarsine oxide. 1991 Biochem. Biophys. Res. Commun. pmid:1859423
Slomiany BL and Slomiany A Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. 2003 Biochem. Biophys. Res. Commun. pmid:12788098
Hsu HC et al. Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. 2006 Biochem. Biophys. Res. Commun. pmid:16712790
Levi R et al. Alkyl chain homologs of platelet-activating factor and their effects on the mammalian heart. 1989 Biochem. Biophys. Res. Commun. pmid:2742592
Touvay C et al. Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. 1988 Biochem. Biophys. Res. Commun. pmid:2835036
Yamada T et al. Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat. 1991 Biochem. Biophys. Res. Commun. pmid:2025290
Matsumoto T et al. G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. 1987 Biochem. Biophys. Res. Commun. pmid:3032170
Errasfa M et al. Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung. 1988 Biochem. Biophys. Res. Commun. pmid:2968795
Masugi F et al. Potent hypotensive activity of 1-O-hexadecyl-2-O-acetyl-SN-glycero-3-phosphocholine in spontaneously hypertensive rat. 1982 Biochem. Biophys. Res. Commun. pmid:7041899
Hauser CJ et al. Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. 2005 Biochem. Biophys. Res. Commun. pmid:16168959
O'Flaherty JT and Jacobson D Protein kinase C blockers and neutrophil receptors for leukotriene B4. 1989 Biochem. Biophys. Res. Commun. pmid:2551291
Ng DS and Wong K Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. 1988 Biochem. Biophys. Res. Commun. pmid:2843182
Harris JG et al. Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). 1996 Biochem. Biophys. Res. Commun. pmid:8630023
Sugiura T and Waku K CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. 1985 Biochem. Biophys. Res. Commun. pmid:3919727
Dewald B and Baggiolini M Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. 1985 Biochem. Biophys. Res. Commun. pmid:2985075
Inui H et al. Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells. 1994 Biochem. Biophys. Res. Commun. pmid:7802667
Hartiala KT et al. Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. 1987 Biochem. Biophys. Res. Commun. pmid:3034265
Chau LY et al. Photoaffinity labeling of platelet activating factor binding sites in rabbit platelet membranes. 1989 Biochem. Biophys. Res. Commun. pmid:2545193
Gomez-Cambronero J et al. The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. 1987 Biochem. Biophys. Res. Commun. pmid:2823810
Rouis M et al. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. 1988 Biochem. Biophys. Res. Commun. pmid:2847729
Doni MG et al. Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. 1988 Biochem. Biophys. Res. Commun. pmid:2847730
Yoshizumi M et al. Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells. 1990 Biochem. Biophys. Res. Commun. pmid:2405848
Smith RJ and Bowman BJ Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6803804
Wirthmueller U et al. Receptor-operated activation of polymorphonuclear leukocytes: different effects of NAP-1/IL-8 and fMet-Leu-Phe or C5a. 1991 Biochem. Biophys. Res. Commun. pmid:1645549
Alonso MT et al. Monitoring of the activation of receptor-operated calcium channels in human platelets. 1989 Biochem. Biophys. Res. Commun. pmid:2546547
Kroegel C et al. Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils. 1989 Biochem. Biophys. Res. Commun. pmid:2546554
Tou J Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:3921017
Nishinaka Y et al. A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. 1993 Biochem. Biophys. Res. Commun. pmid:8390246
Shiono S et al. Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. 1993 Biochem. Biophys. Res. Commun. pmid:8390248
Ng DS and Wong K GTP regulation of platelet-activating factor binding to human neutrophil membranes. 1986 Biochem. Biophys. Res. Commun. pmid:3026378
Corl CM et al. Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. 2003 Biochem. Biophys. Res. Commun. pmid:12615078