| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Gliosis | D005911 | 6 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Tachycardia, Ventricular | D017180 | 9 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Malaria, Falciparum | D016778 | 22 associated lipids |
| Liver Failure | D017093 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Gastroesophageal Reflux | D005764 | 10 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Ileitis | D007079 | 2 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Postoperative Hemorrhage | D019106 | 7 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
| Böhm R and Giessler AJ | [Thrombocyte aggregation inhibitors. A new class of active substances]. | 1986 | Pharmazie | pmid:3515372 |
| Viero P et al. | Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: deficiency of an aspirin-independent mechanism? | 1986 | Haemostasis | pmid:3699584 |
| Etienne A et al. | In vivo inhibition of plasma protein leakage and Salmonella enteritidis-induced mortality in the rat by a specific paf-acether antagonist: BN 52021. | 1986 | Agents Actions | pmid:3515870 |
| Nunez D et al. | Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988. | 1986 | Eur. J. Pharmacol. | pmid:3086108 |
| Oxholm P and Winther K | Thrombocyte involvement in immune inflammatory reactions. | 1986 | Allergy | pmid:3515999 |
| Wallace JL and Whittle BJ | Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. | 1986 | Prostaglandins | pmid:3726156 |
| DeFeudis FV | Possible relationship between the syntheses of endothelium-derived relaxing factor (EDRF) and PAF-acether. | 1986 | Gen. Pharmacol. | pmid:3516791 |
| Eche N et al. | Platelet aggregating and procoagulant activities of cultured human breast cancer cells (FAM). | 1986 | Thromb. Res. | pmid:3726808 |
| Hoffman DR et al. | The role of platelet-activating factor in human fetal lung maturation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3728606 |
| Wardlaw AJ et al. | Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils. | 1986 | J. Clin. Invest. | pmid:3023451 |
| Toyofuku T et al. | Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. | 1986 | Prostaglandins | pmid:3754344 |
| O'Flaherty JT | Age dependency of the inflammatory response. | 1986 | Lab. Invest. | pmid:3537520 |
| Touvay C et al. | Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. | 1986 | Agents Actions | pmid:3754380 |
| Sybertz EJ et al. | AGEPC, a vasodilator phospholipid with profound circulatory actions. | 1986 | Prog. Clin. Biol. Res. | pmid:3538024 |
| Sugatani J and Hanahan DJ | Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. | 1986 | Arch. Biochem. Biophys. | pmid:3754710 |
| McGowan HM et al. | Increased aortic PGI2 and plasma lyso-PAF in the unclipped one-kidney hypertensive rat. | 1986 | Am. J. Physiol. | pmid:3538908 |
| Hsueh W et al. | Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. | 1986 | Eur. J. Pharmacol. | pmid:3754817 |
| Hemmendinger S et al. | [Methods of studying platelet function. Biological markers of the activation of human platelets in vivo and in vitro]. | 1986 | Ann. Biol. Clin. (Paris) | pmid:3538949 |
| Porcellini G | [Platelet-activating factor: a new biochemical and pharmacologic frontier]. | 1986 | Clin Ter | pmid:3720244 |
| Wallace JL and Whittle BJ | Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. | 1986 | Eur. J. Pharmacol. | pmid:3720841 |
| Oh-ishi S et al. | Suppression of phorbol myristate acetate-induced pleurisy by CV-3988, an antagonist of platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3829203 |
| Flower RJ | Background and discovery of lipocortins. | 1986 | Agents Actions | pmid:2938452 |
| Ramesha CS and Pickett WC | Measurement of sub-picogram quantities of platelet activating factor (AGEPC) by gas chromatography/negative ion chemical ionization mass spectrometry. | 1986 | Biomed. Environ. Mass Spectrom. | pmid:2938649 |
| Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
| Stimler-Gerard NP | Parasympathetic stimulation as a mechanism for platelet-activating factor-induced contractile responses in the lung. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3958964 |
| Wade PJ et al. | Effect of calcium and calcium antagonists on [3H]-Paf-acether binding to washed human platelets. | 1986 | Thromb. Res. | pmid:3961730 |
| Tarayre JP et al. | Inflammatory action of PAF-acether in the rat pleural cavity. | 1986 | Agents Actions | pmid:3962789 |
| Burhop KE et al. | Platelet-activating factor increases lung vascular permeability to protein. | 1986 | J. Appl. Physiol. | pmid:3804927 |
| Cox CP | Effects of CV-3988, an antagonist of platelet-activating factor (PAF), on washed rabbit platelets. | 1986 | Thromb. Res. | pmid:2421432 |
| Robertson DN and Smith GM | CV3988 inhibits in vivo platelet aggregation induced by PAF-acether and collagen. | 1986 | Eur. J. Pharmacol. | pmid:3709663 |
| Darius H et al. | Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. | 1986 | Science | pmid:3082008 |
| Kohayakawa M and Inoue K | Augmentation of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF)-induced human platelet activation by C-reactive protein. | 1986 | Thromb. Res. | pmid:3083530 |
| Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
| McIntosh TK and Faden AI | Thyrotropin-releasing hormone (TRH) and circulatory shock. | 1986 | Circ. Shock | pmid:3084122 |
| Hackenthal E and Taugner R | Hormonal signals and intracellular messengers for renin secretion. | 1986 | Mol. Cell. Endocrinol. | pmid:2875004 |
| Swingle KF and Reiter MJ | Inhibition of Paf-acether-induced edema of the rat's paw. | 1986 | Agents Actions | pmid:2875631 |
| Ghezzi E | Autacoids and some mediators in allergic and non allergic forms. | 1986 | Boll Ist Sieroter Milan | pmid:2877678 |
| Pécoud A and Frei PC | [Developmental trends in allergologic-immunologic research]. | 1986 | Internist (Berl) | pmid:2427469 |
| Raphael GD and Metcalfe DD | Mediators of airway inflammation. | 1986 | Eur J Respir Dis Suppl | pmid:2429857 |
| Mehta J et al. | Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. | 1986 | Prostaglandins Leukot Med | pmid:3456620 |
| McIntyre TM et al. | Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3457383 |
| Oh S et al. | Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. | 1986 | Prostaglandins Leukot Med | pmid:3459197 |
| Newhouse MT and Sears MR | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3462569 |
| Kloprogge E and Akkerman JW | Platelet-activating factor (PAF-acether) induces high- and low-affinity binding of fibrinogen to human platelets via independent mechanisms. | 1986 | Biochem. J. | pmid:3101672 |
| PAF and leukotrienes '85. Proceedings of the meeting. Paris, September 27th 1985. | 1986 | Pharmacol Res Commun | pmid:3774839 | |
| Vilain B et al. | Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021. | 1986 | Pharmacol Res Commun | pmid:3774840 |
| Bessin P | PAF-acether and leukotriene participation in acute circulatory shock. | 1986 | Pharmacol Res Commun | pmid:3774841 |
| Goldstein RE et al. | Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774842 |
| Lee TC et al. | A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen. | 1986 | J. Biol. Chem. | pmid:3007498 |