| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Gliosis | D005911 | 6 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Tachycardia, Ventricular | D017180 | 9 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Malaria, Falciparum | D016778 | 22 associated lipids |
| Liver Failure | D017093 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Gastroesophageal Reflux | D005764 | 10 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Ileitis | D007079 | 2 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Postoperative Hemorrhage | D019106 | 7 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Smith RJ et al. | Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329191 |
| Kulikov VI and Bergel'son LD | [Binding of 1-0-alkyl-2-0-acetyl-sn-glycero-3-phosphocholine (thrombocyte activating factor) by plasma components. Exchange of the thrombocyte activating factor between lipoproteins and thrombocytes]. | 1984 | Biokhimiia | pmid:6093897 |
| Haye B et al. | Interactions between thyreostimulin and PAF-acether on thyroid cell metabolism. | 1984 | Eur. J. Pharmacol. | pmid:6094205 |
| Gordeev KIu et al. | [A bioregulator of lipid nature--a platelet activating factor (PAF)]. | 1984 | Bioorg. Khim. | pmid:6099122 |
| Wang ZY | [Advances in the physiopathology of platelets]. | 1984 | Zhonghua Nei Ke Za Zhi | pmid:6099795 |
| Clay KL et al. | Structure elucidation of platelet activating factor derived from human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6430285 |
| Nishihira J et al. | Production and characterization of specific antibodies against 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a potent hypotensive and platelet-activating ether-linked phospholipid). | 1984 | J. Biochem. | pmid:6430883 |
| Knauer KA et al. | Platelet augmentation of IgE-dependent histamine release from human basophils and mast cells. | 1984 | Int. Arch. Allergy Appl. Immunol. | pmid:6200443 |
| Kazimierczak W et al. | Deuterium-oxide-induced histamine release from basophils of allergic subjects. I. Responsiveness to deuterium oxide requires an activation step. | 1984 | Am. Rev. Respir. Dis. | pmid:6201094 |
| Feuerstein G et al. | Hypotension produced by platelet-activating factor is reversed by thyrotropin-releasing hormone. | 1984 | Circ. Shock | pmid:6432359 |
| Parnham MJ et al. | Regulation of the oxidative burst of macrophages by lipid mediators. | 1984 | Agents Actions Suppl. | pmid:6433680 |
| O'Flaherty JT et al. | Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6433920 |
| Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
| Fouque F and Vargaftig BB | Triggering by Paf-acether and adrenaline of cyclo-oxygenase-independent platelet aggregation. | 1984 | Br. J. Pharmacol. | pmid:6439269 |
| Karlsson G and Pipkorn U | Effect of disodium chromoglycate on changes in nasal airway resistance induced by platelet activating factor. | 1984 | Eur. J. Clin. Pharmacol. | pmid:6439565 |
| Sänze JU et al. | On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse. | 1984 | Biomed. Biochim. Acta | pmid:6440544 |
| Satouchi K et al. | Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor. | 1984 | Arch. Biochem. Biophys. | pmid:6486825 |
| Nakamura N et al. | Synthesis and biological activities of bioisosteric O-carba-analogues of platelet activating factor (PAF). | 1984 | Chem. Pharm. Bull. | pmid:6488414 |
| Sakamoto H et al. | Stimulation of leukocyte phagocytic activity by the platelet release reaction. | 1984 | Pathology | pmid:6462776 |
| Shukla SD and Hanahan DJ | Acetylglyceryl ether phosphorylcholine (AGEPC; platelet-activating factor)-induced stimulation of rabbit platelets: correlation between phosphatidic acid level, 45Ca2+ uptake, and [3H]serotonin secretion. | 1984 | Arch. Biochem. Biophys. | pmid:6465886 |
| Chilton FH et al. | 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes. | 1984 | J. Biol. Chem. | pmid:6434535 |
| Doebber TW et al. | Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6517949 |
| Heinrich J and Zimmermann RE | Compound 48/80 is a potent inhibitor of human platelet aggregation antagonizing the calmodulin-dependent platelet reaction in vitro. | 1984 | Thromb. Res. | pmid:6523451 |
| Oxholm P et al. | Lack of evidence for human lymphokines with thrombocyte aggregating activity. An in vitro study. | 1984 | Allergy | pmid:6528957 |
| Caramelo C et al. | Presence of platelet-activating factor in blood from humans and experimental animals. Its absence in anephric individuals. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732788 |
| Albert DH and Snyder F | Release of arachidonic acid from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine, a precursor of platelet-activating factor, in rat alveolar macrophages. | 1984 | Biochim. Biophys. Acta | pmid:6435681 |
| Basran GS et al. | Platelet-activating factor: a possible mediator of the dual response to allergen? | 1984 | Clin. Allergy | pmid:6697475 |
| Kelton JG et al. | Clinical usefulness of testing for a heparin-dependent platelet-aggregating factor in patients with suspected heparin-associated thrombocytopenia. | 1984 | J. Lab. Clin. Med. | pmid:6699475 |
| Feuerstein G et al. | Effect of platelet-activating factor on coronary circulation of the domestic pig. | 1984 | Am. J. Physiol. | pmid:6703081 |
| Pipkorn U et al. | Effect of platelet activating factor on the human nasal mucosa. | 1984 | Allergy | pmid:6703263 |
| Lüthje J and Ogilvie A | Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6704102 |
| Clare KA and Scrutton MC | The role of Ca2+ uptake in the response of human platelets to adrenaline and to 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor). | 1984 | Eur. J. Biochem. | pmid:6705791 |
| Kumar R et al. | A facile route to semi-synthesis of acetyl glycerylether phosphoethanolamine and its choline analogue. | 1984 | J. Lipid Res. | pmid:6707528 |
| Denburg JA et al. | Platelet activating factor: regulation by mast cells and aspirin. | 1984 | Agents Actions | pmid:6711391 |
| El Tamer A et al. | Studies on ether phospholipids. I. A new method of determination using phospholipase A1 from guinea pig pancreas: application to Krebs II ascites cells. | 1984 | Biochim. Biophys. Acta | pmid:6712966 |
| Touqui L et al. | Dissociation between inhibition of phospholipid methylation and production of PAF-acether by rabbit platelets. | 1984 | Experientia | pmid:6714369 |
| Masugi F et al. | [Etiological studies of hypertension. G. APRL (antihypertensive polar renomedullary lipid)]. | 1984 | Nippon Rinsho | pmid:6716685 |
| Kester M et al. | The potentiation of arterial contraction with platelet activating factor. | 1984 | Pflugers Arch. | pmid:6718228 |
| Pelczar-Wissner CJ et al. | Absence of platelet activating factor (PAF) mediated platelet aggregation: a new platelet defect. | 1984 | Am. J. Hematol. | pmid:6720685 |
| Guay DR and Richard A | Heparin-induced thrombocytopenia--association with a platelet aggregating factor and cross-sensitivity to bovine and porcine heparin. | 1984 | Drug Intell Clin Pharm | pmid:6723517 |
| Poitevin B et al. | Paf-acether generates chemiluminescence in human neutrophils in the absence of cytochalasin B. | 1984 | Immunopharmacology | pmid:6724877 |
| Kawaguchi H and Yasuda H | Platelet-activating factor stimulates phospholipase in quiescent Swiss mouse 3T3 fibroblast. | 1984 | FEBS Lett. | pmid:6436057 |
| Kramer RM et al. | Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. | 1984 | J. Biol. Chem. | pmid:6436245 |
| Andreesen R et al. | Tumor cytotoxicity of human macrophages after incubation with synthetic analogues of 2-lysophosphatidylcholine. | 1984 | J. Natl. Cancer Inst. | pmid:6582303 |
| Prescott SM et al. | Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6587368 |
| Iñarrea P et al. | Characteristics of the binding of platelet-activating factor to platelets of different animal species. | 1984 | Eur. J. Pharmacol. | pmid:6510472 |
| Kornecki E et al. | Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines. | 1984 | Science | pmid:6150550 |
| Chignard M et al. | Paf-acether formation and arachidonic acid freeing from platelet ether-linked glyceryl-phosphorylcholine. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6437404 |
| Schleimer RP et al. | Inflammatory mediators and mechanisms of release from purified human basophils and mast cells. | 1984 | J. Allergy Clin. Immunol. | pmid:6208229 |
| Gunby P | A new piece for the puzzle of inflammation. | 1984 | JAMA | pmid:6420583 |