Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Ventricular Remodeling D020257 28 associated lipids
Gliosis D005911 6 associated lipids
Neuralgia D009437 28 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Amnesia D000647 12 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Sneezing D012912 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Helicobacter Infections D016481 21 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Mucositis D052016 7 associated lipids
Ileitis D007079 2 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Hattermann K et al. The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis. 2007 FASEB J. pmid:17264163
Boetkjaer A et al. Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. 2007 Neurosci. Lett. pmid:17881124
De Vriese C et al. Ghrelin interacts with human plasma lipoproteins. 2007 Endocrinology pmid:17289852
Owen JS et al. Platelet-activating factor. 2007 Meth. Enzymol. pmid:17954244
Ying-fang S et al. Effect of platelet-activating factor on cell proliferation & NF-kappaB activation in airway smooth muscle cells in rats. 2007 Indian J. Med. Res. pmid:17932440
Guerra CT et al. Effect of chronic hepatitis C virus infection on inflammatory lipid mediators. 2007 Dig Liver Dis pmid:17936229
Kawano Y et al. The effects of platelet-activating factor on the secretion of interleukin-8 and growth-regulated oncogene alpha in human immortalized granulosa cell line (GC1a). 2007 Am. J. Reprod. Immunol. pmid:17922696
Keam SJ and Plosker GL Rupatadine: a review of its use in the management of allergic disorders. 2007 Drugs pmid:17335300
Van Overloop H et al. On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. 2007 Biol. Chem. pmid:17338639
Ebihara S et al. A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. 2007 Inflamm. Res. pmid:17406808
Finnegan EM et al. Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17483236
Cattaneo M et al. Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count. 2007 Haematologica pmid:17488697
Kälvegren H et al. Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors. 2007 Eur. J. Pharmacol. pmid:17459368
Taheri F and Bazan HE Platelet-activating factor overturns the transcriptional repressor disposition of Sp1 in the expression of MMP-9 in human corneal epithelial cells. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17460244
Dinubile MJ Plasma gelsolin: in search of its raison d'etre. Focus on "Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin". 2007 Am. J. Physiol., Cell Physiol. pmid:17428843
Souza LJ et al. Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor. 2007 Pancreatology pmid:17449968
Shin CR et al. Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis. 2007 J. Periodont. Res. pmid:17451539
Truffinet V et al. No effect of platelet-activating factor on the proliferation and apoptosis of immature forms of leukemic blasts. 2007 Leuk. Res. pmid:17350684
Paterson WG et al. Role of platelet-activating factor in acid-induced esophageal mucosal injury. 2007 Dig. Dis. Sci. pmid:17415649
Tsimikas S et al. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17626905
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Takahashi T et al. Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. 2007 Microvasc. Res. pmid:17027041
Brkovic A and Sirois MG Vascular permeability induced by VEGF family members in vivo: role of endogenous PAF and NO synthesis. 2007 J. Cell. Biochem. pmid:17115409
Choi JH et al. Impairment of p38 MAPK-mediated cytosolic phospholipase A2 activation in the kidneys is associated with pathogenicity of Candida albicans. 2007 Immunology pmid:17054728
El Behi M et al. Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs. 2007 J. Neuroimmunol. pmid:17097744
Blanchet MR et al. Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. 2007 J. Leukoc. Biol. pmid:17289799
Shindou H et al. A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. 2007 J. Biol. Chem. pmid:17182612
Ko HM et al. Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. 2007 Int. J. Cancer pmid:17187368
Bate C et al. Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. 2007 J Neuroinflammation pmid:17233902
Caini P et al. Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. 2007 J. Viral Hepat. pmid:17212640
Subbotina LA [Procedure of blood agregation system analysis]. 2006 Sep-Oct Aviakosm Ekolog Med pmid:17357632
Givehchi A et al. Analysis of activity space by fragment fingerprints, 2D descriptors, and multitarget dependent transformation of 2D descriptors. 2006 May-Jun J Chem Inf Model pmid:16711727
Lang F et al. Osmotic shock-induced suicidal death of erythrocytes. 2006 May-Jun Acta Physiol (Oxf) pmid:16734755
Zhu T et al. Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. 2006 Mar-Apr Can. J. Physiol. Pharmacol. pmid:16902584
Gu Y et al. PAF levels and PAF-AH activities in placentas from normal and preeclamptic pregnancies. 2006 Jun-Jul Placenta pmid:16122793
Lang F et al. Mechanisms and significance of eryptosis. 2006 Jul-Aug Antioxid. Redox Signal. pmid:16910766
Vasques E et al. Impairment of endothelium-dependent aorta relaxation by phospholipid components of oxidized low-density lipoprotein. 2006 Jan-Feb Endothelium pmid:16885061
Flamand N et al. Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils. 2006 Br. J. Pharmacol. pmid:16967052
Cauwels A et al. Anaphylactic shock depends on PI3K and eNOS-derived NO. 2006 J. Clin. Invest. pmid:16886062
Wolf P et al. Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. 2006 Am. J. Pathol. pmid:16936256
Pirbhai M et al. The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells. 2006 J. Biol. Chem. pmid:16940052
Harputluoglu MM et al. The effects of Gingko biloba extract on acetic acid-induced colitis in rats. 2006 Turk J Gastroenterol pmid:16941250
Han JI et al. RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. 2006 J. Leukoc. Biol. pmid:16565322
Servillo L et al. Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages. 2006 FASEB J. pmid:16571775
Flamand N et al. Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF. 2006 J. Leukoc. Biol. pmid:16501051
He J and Bazan HE Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis. 2006 Invest. Ophthalmol. Vis. Sci. pmid:16505020
Barthomeuf C et al. Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. 2006 Free Radic. Biol. Med. pmid:16458188
Marchand C et al. Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells. 2006 J. Cell. Biochem. pmid:16479592
Buchanan MR Biological basis and clinical implications of acetylsalicylic acid resistance. 2006 Can J Cardiol pmid:16485051
Heinrich S et al. Evidence-based treatment of acute pancreatitis: a look at established paradigms. 2006 Ann. Surg. pmid:16432347
Ezoulin MJ et al. Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. 2006 Toxicol In Vitro pmid:16472967
Dianzani C et al. Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5-triazines. 2006 J. Pharm. Pharmacol. pmid:16451750
Herman AG and Stockwell BR Enzyme annotation with chemical tools. 2006 Chem. Biol. pmid:17052604
Chiang KP et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. 2006 Chem. Biol. pmid:17052608
Brown SL et al. Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals. 2006 J. Immunol. pmid:16920964
Baker KE et al. Nupafant, a PAF-antagonist prototype for suppression of ventricular fibrillation without liability for QT prolongation? 2006 Br. J. Pharmacol. pmid:16921398
Kim DH et al. Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion. 2006 Ann. Otol. Rhinol. Laryngol. pmid:16944661
Vahidy WH et al. Effects of intracerebroventricular injections of free fatty acids, lysophospholipids, or platelet activating factor in a mouse model of orofacial pain. 2006 Exp Brain Res pmid:16947060
Matsumura Y et al. A role for inflammatory mediators in the induction of immunoregulatory B cells. 2006 J. Immunol. pmid:16982922
Slomiany BL and Slomiany A Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation interferes with salivary mucin synthesis via platelet activating factor generation. 2006 Inflammopharmacology pmid:16983494
Zhang Q et al. Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. 2006 Exp. Dermatol. pmid:16984258
Hartvigsen K et al. 1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB. 2006 Lipids pmid:17069352
Sugimoto S et al. Purification and characterization of lysophospholipase D from rat brain. 2006 Biochim. Biophys. Acta pmid:17071136
Fallani A et al. Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line. 2006 Prostaglandins Other Lipid Mediat. pmid:17085325
Slomiany BL and Slomiany A Leptin modulates the detrimental effect of Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation on salivary mucin synthesis via ERK-signal transduction. 2006 Inflammopharmacology pmid:17093905
Coleus forskohlii. Monograph. 2006 Altern Med Rev pmid:16597194
Fernandes CJ and O'Donovan DJ Platelet transfusions in infants with necrotizing enterocolitis. 2006 Curr. Hematol. Rep. pmid:16537050
Maliba R et al. Angiopoietins-1 and -2 are both capable of mediating endothelial PAF synthesis: intracellular signalling pathways. 2006 Cell. Signal. pmid:16617006
Jauchem JR The role of autacoids and the autonomic nervous system in cardiovascular responses to radio-frequency energy heating. 2006 Auton Autacoid Pharmacol pmid:16553641
Bi W et al. Dual-acting agents that possess free radical scavenging and antithrombotic activities: design, synthesis, and evaluation of phenolic tetrahydro-beta-carboline RGD peptide conjugates. 2006 Bioorg. Med. Chem. Lett. pmid:16797986
Purnell ET et al. Influence of the preimplantation embryo development (Ped) gene on embryonic platelet-activating factor (PAF) levels. 2006 J. Assist. Reprod. Genet. pmid:16799834
Slomiany BL and Slomiany A Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis. 2006 IUBMB Life pmid:16754300
Moreno SE et al. Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis. 2006 J. Immunol. pmid:16818786
Machado EM et al. WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph. 2006 J. Insect Physiol. pmid:16777137
Blanchet MR et al. Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16782754
Gomes RN et al. Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. 2006 Shock pmid:16783197
Chen LW et al. Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. 2006 Shock pmid:16783201
Sneddon AA et al. Cytokine-induced monocyte adhesion to endothelial cells involves platelet-activating factor: suppression by conjugated linoleic acid. 2006 Biochim. Biophys. Acta pmid:16829183
Holder E et al. Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation. 2006 Gene Ther. pmid:16791284
Kaneko MK et al. Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor. 2006 Gene pmid:16766141
De Plaen IG et al. Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor. 2006 Immunology pmid:16771850
Karabina SA and Ninio E Plasma PAF-acetylhydrolase: an unfulfilled promise? 2006 Biochim. Biophys. Acta pmid:16807087
Cheng L et al. Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle. 2006 J. Pharmacol. Exp. Ther. pmid:16807360
Fragopoulou E et al. Platelet-activating factor (PAF) increase intracellular lipid accumulation by increasing both LDL and scavenger receptors in human mesangial cells. 2006 J. Lab. Clin. Med. pmid:16750665
Melnikova VO et al. Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. 2006 J. Biol. Chem. pmid:16306050
Wang C et al. Total synthesis of (+/-)-paeonilide. 2006 Org. Lett. pmid:16737293
Kaul DK et al. Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation. 2006 Am. J. Physiol., Cell Physiol. pmid:16738001
Thaete LG and Neerhof MG Endothelin and platelet-activating factor: significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat. 2006 Am. J. Obstet. Gynecol. pmid:16579936
Karantonis HC et al. In vivo antiatherogenic properties of olive oil and its constituent lipid classes in hyperlipidemic rabbits. 2006 Nutr Metab Cardiovasc Dis pmid:16580585
Balestrieri C et al. Relative effects of phenolic constituents from Yucca schidigera Roezl. bark on Kaposi's sarcoma cell proliferation, migration, and PAF synthesis. 2006 Biochem. Pharmacol. pmid:16580641
Poeckel D et al. 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells. 2006 J. Pharmacol. Exp. Ther. pmid:16174802
Waschke J et al. Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier. 2006 Histochem. Cell Biol. pmid:16195887
Fang H et al. Anaphylactic reaction induced by Toxoplasma gondii-derived heat shock protein 70. 2006 Int. Immunol. pmid:16943259
Kushikata T et al. Platelet activating factor and its metabolite promote sleep in rabbits. 2006 Neurosci. Lett. pmid:16263215
Antonopoulou S et al. Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus. 2006 J Med Food pmid:17004898
Gomes MT et al. Platelet-activating factor-like activity isolated from Trypanosoma cruzi. 2006 Int. J. Parasitol. pmid:16337632
Dohi T et al. [Role of platelet-activating factor on spinal pain transduction]. 2006 Nippon Yakurigaku Zasshi pmid:16508219
Karidis NP et al. Platelet-activating factor in liver injury: a relational scope. 2006 World J. Gastroenterol. pmid:16773686
Chu WF et al. Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. 2006 Basic Clin. Pharmacol. Toxicol. pmid:16433899
Ozturk H et al. PAF antagonist BN-52021 reduces intercellular adhesion molecule-1 expression and oxidative stress in rats with reperfusion damage due to unilateral testicular torsion. 2006 Pediatr. Surg. Int. pmid:16369775