Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Ventricular Remodeling D020257 28 associated lipids
Gliosis D005911 6 associated lipids
Neuralgia D009437 28 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Amnesia D000647 12 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Sneezing D012912 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Helicobacter Infections D016481 21 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Mucositis D052016 7 associated lipids
Ileitis D007079 2 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Flamand N et al. Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils. 2006 Br. J. Pharmacol. pmid:16967052
Pirbhai M et al. The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells. 2006 J. Biol. Chem. pmid:16940052
Harputluoglu MM et al. The effects of Gingko biloba extract on acetic acid-induced colitis in rats. 2006 Turk J Gastroenterol pmid:16941250
Han JI et al. RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. 2006 J. Leukoc. Biol. pmid:16565322
Servillo L et al. Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages. 2006 FASEB J. pmid:16571775
Flamand N et al. Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF. 2006 J. Leukoc. Biol. pmid:16501051
He J and Bazan HE Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis. 2006 Invest. Ophthalmol. Vis. Sci. pmid:16505020
Barthomeuf C et al. Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. 2006 Free Radic. Biol. Med. pmid:16458188
Marchand C et al. Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells. 2006 J. Cell. Biochem. pmid:16479592
Buchanan MR Biological basis and clinical implications of acetylsalicylic acid resistance. 2006 Can J Cardiol pmid:16485051
Heinrich S et al. Evidence-based treatment of acute pancreatitis: a look at established paradigms. 2006 Ann. Surg. pmid:16432347
Ezoulin MJ et al. Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. 2006 Toxicol In Vitro pmid:16472967
Dianzani C et al. Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5-triazines. 2006 J. Pharm. Pharmacol. pmid:16451750
Gopichandran N and Leese HJ The effect of paracrine/autocrine interactions on the in vitro culture of bovine preimplantation embryos. 2006 Reproduction pmid:16452720
Baker KE et al. Nupafant, a PAF-antagonist prototype for suppression of ventricular fibrillation without liability for QT prolongation? 2006 Br. J. Pharmacol. pmid:16921398
Kim DH et al. Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion. 2006 Ann. Otol. Rhinol. Laryngol. pmid:16944661
Vahidy WH et al. Effects of intracerebroventricular injections of free fatty acids, lysophospholipids, or platelet activating factor in a mouse model of orofacial pain. 2006 Exp Brain Res pmid:16947060
Matsumura Y et al. A role for inflammatory mediators in the induction of immunoregulatory B cells. 2006 J. Immunol. pmid:16982922
Slomiany BL and Slomiany A Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation interferes with salivary mucin synthesis via platelet activating factor generation. 2006 Inflammopharmacology pmid:16983494
Zhang Q et al. Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. 2006 Exp. Dermatol. pmid:16984258
Hartvigsen K et al. 1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB. 2006 Lipids pmid:17069352
Sugimoto S et al. Purification and characterization of lysophospholipase D from rat brain. 2006 Biochim. Biophys. Acta pmid:17071136
Fallani A et al. Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line. 2006 Prostaglandins Other Lipid Mediat. pmid:17085325
Slomiany BL and Slomiany A Leptin modulates the detrimental effect of Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation on salivary mucin synthesis via ERK-signal transduction. 2006 Inflammopharmacology pmid:17093905
Jauchem JR The role of autacoids and the autonomic nervous system in cardiovascular responses to radio-frequency energy heating. 2006 Auton Autacoid Pharmacol pmid:16553641
Bi W et al. Dual-acting agents that possess free radical scavenging and antithrombotic activities: design, synthesis, and evaluation of phenolic tetrahydro-beta-carboline RGD peptide conjugates. 2006 Bioorg. Med. Chem. Lett. pmid:16797986
Purnell ET et al. Influence of the preimplantation embryo development (Ped) gene on embryonic platelet-activating factor (PAF) levels. 2006 J. Assist. Reprod. Genet. pmid:16799834
Slomiany BL and Slomiany A Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis. 2006 IUBMB Life pmid:16754300
Moreno SE et al. Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis. 2006 J. Immunol. pmid:16818786
Machado EM et al. WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph. 2006 J. Insect Physiol. pmid:16777137
Blanchet MR et al. Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16782754
Gomes RN et al. Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. 2006 Shock pmid:16783197
Chen LW et al. Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. 2006 Shock pmid:16783201
Sneddon AA et al. Cytokine-induced monocyte adhesion to endothelial cells involves platelet-activating factor: suppression by conjugated linoleic acid. 2006 Biochim. Biophys. Acta pmid:16829183
Holder E et al. Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation. 2006 Gene Ther. pmid:16791284
Kaneko MK et al. Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor. 2006 Gene pmid:16766141
De Plaen IG et al. Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor. 2006 Immunology pmid:16771850
Karabina SA and Ninio E Plasma PAF-acetylhydrolase: an unfulfilled promise? 2006 Biochim. Biophys. Acta pmid:16807087
Cheng L et al. Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle. 2006 J. Pharmacol. Exp. Ther. pmid:16807360
Fragopoulou E et al. Platelet-activating factor (PAF) increase intracellular lipid accumulation by increasing both LDL and scavenger receptors in human mesangial cells. 2006 J. Lab. Clin. Med. pmid:16750665
McLaughlin NJ et al. Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. 2006 J. Immunol. pmid:16709866
Melnikova VO et al. Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. 2006 J. Biol. Chem. pmid:16306050
Thaete LG and Neerhof MG Endothelin and platelet-activating factor: significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat. 2006 Am. J. Obstet. Gynecol. pmid:16579936
Karagiorga G et al. Biochemical parameters of bronchoalveolar lavage fluid in fat embolism. 2006 Intensive Care Med pmid:16322975
Karantonis HC et al. In vivo antiatherogenic properties of olive oil and its constituent lipid classes in hyperlipidemic rabbits. 2006 Nutr Metab Cardiovasc Dis pmid:16580585
Balestrieri C et al. Relative effects of phenolic constituents from Yucca schidigera Roezl. bark on Kaposi's sarcoma cell proliferation, migration, and PAF synthesis. 2006 Biochem. Pharmacol. pmid:16580641
Poeckel D et al. 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells. 2006 J. Pharmacol. Exp. Ther. pmid:16174802
Waschke J et al. Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier. 2006 Histochem. Cell Biol. pmid:16195887
Kushikata T et al. Platelet activating factor and its metabolite promote sleep in rabbits. 2006 Neurosci. Lett. pmid:16263215
Antonopoulou S et al. Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus. 2006 J Med Food pmid:17004898
Gomes MT et al. Platelet-activating factor-like activity isolated from Trypanosoma cruzi. 2006 Int. J. Parasitol. pmid:16337632
Dohi T et al. [Role of platelet-activating factor on spinal pain transduction]. 2006 Nippon Yakurigaku Zasshi pmid:16508219
Karidis NP et al. Platelet-activating factor in liver injury: a relational scope. 2006 World J. Gastroenterol. pmid:16773686
Chu WF et al. Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. 2006 Basic Clin. Pharmacol. Toxicol. pmid:16433899
Ozturk H et al. PAF antagonist BN-52021 reduces intercellular adhesion molecule-1 expression and oxidative stress in rats with reperfusion damage due to unilateral testicular torsion. 2006 Pediatr. Surg. Int. pmid:16369775
Louis NA et al. Lipid mediator networks and leukocyte transmigration. 2005 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:15979294
Spitzer AL et al. Early nonenhanced abdominal computed tomography can predict mortality in severe acute pancreatitis. 2005 Sep-Oct J. Gastrointest. Surg. pmid:16137586
Akyürek N et al. The effect of platelet activating factor antagonist BN 52021 on bacterial translocation and ICAM-I expression in experimental obstructive jaundice. 2005 Sep-Oct J Invest Surg pmid:16249168
O'Neill C The role of paf in embryo physiology. 2005 May-Jun Hum. Reprod. Update pmid:15790601
Krasheninnikov ME and Pliashkevich IuG [Effects of the platelet activating factor on the proliferation and IgE secretion by U-266BL human myeloma cells]. 2005 Jul-Aug Eksp Klin Farmakol pmid:16193656
Marrache AM et al. Intracellular signaling of lipid mediators via cognate nuclear G protein-coupled receptors. 2005 Jan-Apr Endothelium pmid:16036317
Chang GT et al. Purification and characterization of a new anticoagulant protein, PP27, from placenta. 2005 Thromb. Res. pmid:16122555
Ezoulin MJ et al. Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells. 2005 Neurosci. Lett. pmid:16095823
Burgos RA et al. 14-deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils. 2005 Planta Med. pmid:16041644
Caplan MS et al. The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. 2005 Semin. Pediatr. Surg. pmid:16084401
Denizot Y et al. Platelet-activating factor and liver metastasis of colorectal cancer. 2005 Int. J. Cancer pmid:15455343
Shindou H et al. Priming effect of lipopolysaccharide on acetyl-coenzyme A:lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent. 2005 J. Immunol. pmid:16002720
Black S et al. An intact phosphocholine binding site is necessary for transgenic rabbit C-reactive protein to protect mice against challenge with platelet-activating factor. 2005 J. Immunol. pmid:16002722
Koch E Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. 2005 Phytomedicine pmid:15693702
Jantan I et al. Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. 2005 Phytomedicine pmid:15693713
El-Medany A et al. Attenuation of bleomycin-induced lung fibrosis in rats by mesna. 2005 Eur. J. Pharmacol. pmid:15713430
Yeh JH et al. 2-O-methyl PAF as a Ca2+ mobilizer in Madin Darby canine kidney cells. 2005 Life Sci. pmid:15878360
Medvedev IN and GromnatsiÄ­ NI [The influence of nebivolol on thrombocyte aggregation in patients with arterial hypertension with metabolic sydrome]. 2005 Klin Med (Mosk) pmid:15881638
Rastelli VM et al. Influence of insulin on the microvascular response to inflammatory mediators in neonatal streptozotocin diabetic rats. 2005 Inflamm. Res. pmid:15883740
Ko HM et al. Involvement of matrix metalloproteinase-9 in platelet-activating factor-induced angiogenesis. 2005 FEBS Lett. pmid:15848174
Hardy P et al. New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850712
Chen LW et al. Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils. 2005 J. Biomed. Sci. pmid:15917990
Goldring WP et al. Novel phomactin analogues as PAF receptor ligands. 2005 Bioorg. Med. Chem. Lett. pmid:15922596
Tombul T et al. Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction. 2005 J Clin Neurosci pmid:15925775
Boccellino M et al. Platelet-activating factor regulates cadherin-catenin adhesion system expression and beta-catenin phosphorylation during Kaposi's sarcoma cell motility. 2005 Am. J. Pathol. pmid:15855650
Schram MT et al. Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study. 2005 Hypertension pmid:15851628
Denizot Y et al. Platelet-activating factor and human thyroid cancer. 2005 Eur. J. Endocrinol. pmid:15994743
Uhlig S et al. Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung. 2005 Pharmacol Rep pmid:16415501
Kumar S and Sharma A Platelet activating factor improves the in vitro penetration of zona free hamster eggs by buffalo (Bubalus bubalis) spermatozoa. 2005 Theriogenology pmid:15763101
Asai Y Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880. 2005 Pharmazie pmid:15801673
Nacken W et al. S100A9 deficiency alters adenosine-5'-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils. 2005 Int. J. Biochem. Cell Biol. pmid:15778088
Minnear FL et al. Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15778280
Perry SW et al. HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. 2005 J. Immunol. pmid:15778398
Ishiura Y et al. In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine. 2005 Prostaglandins Other Lipid Mediat. pmid:15789611
Gaudreault E et al. Involvement of leukotriene B4 receptor 1 signaling in platelet-activating factor-mediated neutrophil degranulation and chemotaxis. 2005 Prostaglandins Other Lipid Mediat. pmid:15789613
Calcerrada MC et al. Selective translocation of protein kinase c isozymes by PAF in rabbit platelets. 2005 Prostaglandins Other Lipid Mediat. pmid:15789614
Hudry-Clergeon H et al. Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase. 2005 FASEB J. pmid:15791001
Ueda Y et al. Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ. 2005 Biol. Pharm. Bull. pmid:16141562
Chang GT et al. Inhibitory effect of the Korean herbal medicine, Dae-Jo-Whan, on platelet-activating factor-induced platelet aggregation. 2005 J Ethnopharmacol pmid:16125889
Iversen VV et al. Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. 2005 Acta Physiol. Scand. pmid:16128692
Fragopoulou E et al. Characterization of acetyl-CoA: lyso-PAF acetyltransferase of human mesangial cells. 2005 Mediators Inflamm. pmid:16258193
Shibamoto T et al. Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig livers. 2005 Prostaglandins Other Lipid Mediat. pmid:16303618
Vieira-de-Abreu A et al. Anti-allergic properties of the bromeliaceae Nidularium procerum: inhibition of eosinophil activation and influx. 2005 Int. Immunopharmacol. pmid:16275631
Bellizzi MJ et al. Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor. 2005 J. Clin. Invest. pmid:16276420
Yu P et al. Mitogen-activated protein kinases regulate platelet-activating factor-induced hyperpermeability. 2005 Microcirculation pmid:16284005