| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Shock | D012769 | 11 associated lipids |
| Polycythemia Vera | D011087 | 13 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamazaki H | [Recent medical topics on platelets in hemorrhagic and thrombotic diseases]. | 1986 | Nippon Naika Gakkai Zasshi | pmid:3027214 |
| Prunieras M | Melanocytes, melanogenesis, and inflammation. | 1986 | Int. J. Dermatol. | pmid:2433237 |
| Rink TJ | Stimulus-response coupling mechanisms in human platelets. | 1986 | Agents Actions Suppl. | pmid:3028101 |
| Baroggi N et al. | Changes in cytosolic free calcium induced by platelet-activating factor in rabbit platelets: specific inhibition by BN 52021 and structurally related compounds. | 1986 | Agents Actions Suppl. | pmid:3028108 |
| Ozaki Y et al. | A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway. | 1986 | Biochem. Pharmacol. | pmid:3021173 |
| Okamoto M et al. | FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. | 1986 | J. Antibiot. | pmid:3082838 |
| Vanhoutte PM et al. | Modulation of vascular smooth muscle contraction by the endothelium. | 1986 | Annu. Rev. Physiol. | pmid:2871807 |
| Camussi G | Potential role of platelet-activating factor in renal pathophysiology. | 1986 | Kidney Int. | pmid:3517457 |
| Mastacchi R et al. | Interaction of a new low molecular weight heparin (OP/LMWH) with human platelets. | 1986 | Agents Actions | pmid:3518359 |
| Simmet T and Peskar BA | Eicosanoids and the coronary circulation. | 1986 | Rev. Physiol. Biochem. Pharmacol. | pmid:3520775 |
| Moudgil GC | Anaesthesia and allergic drug reactions. | 1986 | Can Anaesth Soc J | pmid:3521800 |
| Foegh ML et al. | Prolongation of cardiac allograft survival with BN 52021, a specific antagonist of platelet-activating factor. | 1986 | Transplantation | pmid:3523888 |
| Rampart M and Williams TJ | Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. | 1986 | Am. J. Pathol. | pmid:3524253 |
| Zanetti A et al. | The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine. | 1986 | Eur. J. Pharmacol. | pmid:2944757 |
| Bush LR and Smith SG | Antagonism of U46619-induced aggregation of human and canine platelets by four TXA2 receptor antagonists. | 1986 | Thromb. Res. | pmid:2948294 |
| Braquet P | Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949548 |
| Kloprogge E et al. | PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine)-induced fibrinogen binding to platelets depends on metabolic energy. | 1986 | Biochem. J. | pmid:3800968 |
| Panchenko EP et al. | [Free cytoplasmic calcium and thrombocyte aggregation in patients with ischemic heart disease. The effect of ADP, thrombocyte activation factor and serotonin]. | 1986 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3801147 |
| Chamone DF et al. | Increased levels of eosinophil-derived PAF-acether activity in a patient with idiopathic hypereosinophilic syndrome. | 1986 | Braz. J. Med. Biol. Res. | pmid:3801724 |
| Toth PD and Mikulaschek AW | Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat. | 1986 | Circ. Shock | pmid:3802423 |
| O'Flaherty JT et al. | Metabolism of 5-hydroxyicosatetraenoate by human neutrophils: production of a novel omega-oxidized derivative. | 1986 | J. Immunol. | pmid:3095426 |
| Weber N | [A platelet-activating factor--a physiologically active ether lipid]. | 1986 | Pharm Unserer Zeit | pmid:3749211 |
| Berti F et al. | Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives. | 1986 | Pharmacol Res Commun | pmid:3749244 |
| Burhop KE et al. | Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites. | 1986 | Am. Rev. Respir. Dis. | pmid:3752711 |
| Hemmendinger S et al. | [Methods of studying platelet function. Biological markers of the activation of human platelets in vivo and in vitro]. | 1986 | Ann. Biol. Clin. (Paris) | pmid:3538949 |
| Roubin R et al. | Biosynthesis of paf-acether: VIII: Impairment of paf-acether production in activated macrophages does not depend upon acetyltransferase activity. | 1986 | J. Immunol. | pmid:3950403 |
| Adnot S et al. | Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig. | 1986 | Prostaglandins | pmid:3562865 |
| Malavasi F et al. | Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3085094 |
| Simpson AW et al. | Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. | 1986 | FEBS Lett. | pmid:3086128 |
| Nakaya H and Tohse N | Electrophysiological effects of acetyl glyceryl ether phosphorylcholine on cardiac tissues: comparison with lysophosphatidylcholine and long chain acyl carnitine. | 1986 | Br. J. Pharmacol. | pmid:3814909 |
| Schlondorff D et al. | Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. | 1986 | Am. J. Physiol. | pmid:3087218 |
| Coëffier E et al. | Effects of PAF-acether and structural analogues on platelet activation and bronchoconstriction in guinea-pigs. | 1986 | Eur. J. Pharmacol. | pmid:3816952 |
| Oda M et al. | Polymorphonuclear leukocyte-platelet interactions: acetylglyceryl ether phosphocholine-induced platelet activation under stimulation with chemotactic peptide. | 1986 | J. Biochem. | pmid:3818574 |
| Nishihira J and Ishibashi T | A phospholipase C with a high specificity for platelet-activating factor in rabbit liver light mitochondria. | 1986 | Lipids | pmid:3821393 |
| Lauri D et al. | Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. | 1986 | Agents Actions | pmid:3706054 |
| Nijssen JG et al. | Identification of a calcium-independent phospholipase A2 in rat lung cytosol and differentiation from acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF-acether). | 1986 | Biochim. Biophys. Acta | pmid:3707986 |
| Fitzgerald MF et al. | The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs. | 1986 | Br. J. Pharmacol. | pmid:3708213 |
| Alloatti G et al. | Effect of platelet-activating factor (PAF) on human cardiac muscle. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3941007 |
| Chand N et al. | The amplifier role of platelet activating factor (PAF), other chemical mediators and antigen in the induction of airway hyperreactivity to cold. | 1986 | Eur. J. Pharmacol. | pmid:3709669 |
| Lynch JM and Henson PM | The intracellular retention of newly synthesized platelet-activating factor. | 1986 | J. Immunol. | pmid:3093579 |
| Osborne JA et al. | In vivo anti-platelet properties of anipamil, a calcium channel blocker, in the rabbit. | 1986 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3715198 |
| McMurtry IF and Morris KG | Platelet-activating factor causes pulmonary vasodilation in the rat. | 1986 | Am. Rev. Respir. Dis. | pmid:3094417 |
| Issekutz AC and Ripley M | The effect of intravascular neutrophil chemotactic factors on blood neutrophil and platelet kinetics. | 1986 | Am. J. Hematol. | pmid:2934975 |
| Alexandre A et al. | Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3094518 |
| Alam I and Silver MJ | Acetyltransferase activity in human platelet microsomes and washed platelets. | 1986 | Biochim. Biophys. Acta | pmid:3094588 |
| Benhamou M et al. | Decrease in IgE Fc receptor expression on mouse bone marrow-derived mast cells and inhibition of paf-acether formation and of beta-hexosaminidase release by dexamethasone. | 1986 | J. Immunol. | pmid:2935578 |
| D'Humières S et al. | PAF-acether-induced synthesis of prostacyclin by human endothelial cells. | 1986 | Eur. J. Pharmacol. | pmid:3102256 |
| Chung KF et al. | Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3005546 |
| Morley J | Platelet activating factor and asthma. | 1986 | Agents Actions | pmid:3099555 |
| Orchard MA et al. | Basophil histamine release induced by a substance from stimulated human platelets. | 1986 | J. Immunol. | pmid:2419428 |
| Tselepis A et al. | Effects of AGEPC on the intracellular levels of ions in Tetrahymena pyriformis. | 1986 | Biochem. Int. | pmid:3099798 |
| Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
| Okayasu T et al. | Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. | 1986 | Biochim. Biophys. Acta | pmid:3947669 |
| Kloprogge E et al. | Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. | 1986 | J. Biol. Chem. | pmid:3015954 |
| O'Flaherty JT et al. | Binding and metabolism of platelet-activating factor by human neutrophils. | 1986 | J. Clin. Invest. | pmid:3016027 |
| Hanahan DJ | Platelet activating factor: a biologically active phosphoglyceride. | 1986 | Annu. Rev. Biochem. | pmid:3017194 |
| Bette-Bobillo P et al. | Interaction between blood components and a spin-labeled analogue of PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3017416 |
| Levesque JP et al. | Fibrinogen mitogenic effect on hemopoietic cell lines: control via receptor modulation. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3018735 |
| Bachelet M et al. | Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages. | 1986 | Biochim. Biophys. Acta | pmid:3092866 |
| Alonso F et al. | A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine. | 1986 | Biochim. Biophys. Acta | pmid:3092867 |
| Baranes J et al. | The effects of PAF-acether on the cardiovascular system and their inhibition by a new highly specific PAF-acether receptor antagonist BN 52021. | 1986 | Pharmacol Res Commun | pmid:3763677 |
| Cirino M et al. | A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction. | 1986 | Prostaglandins | pmid:3763941 |
| Wallace JL and Whittle BJ | Profile of gastrointestinal damage induced by platelet-activating factor. | 1986 | Prostaglandins | pmid:3763942 |
| Bourgain RH et al. | Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig. | 1986 | Prostaglandins | pmid:3763943 |
| Guinot P et al. | Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist. | 1986 | Prostaglandins | pmid:3763944 |
| Scherf H et al. | Hemodynamic effects of platelet activating factor in the dog kidney in vivo. | 1986 | Hypertension | pmid:3744467 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives. | 1986 | Chem. Pharm. Bull. | pmid:2421923 |
| Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models. | 1986 | Chem. Pharm. Bull. | pmid:2421924 |
| Touvay C et al. | Proof of the involvement of platelet activating factor (paf-acether) in pulmonary complex immune systems using a specific paf-acether receptor antagonist: BN 52021. | 1986 | Prog. Lipid Res. | pmid:2827186 |
| Herrmann DB et al. | Ether phospholipids as inhibitors of the arachidonoyl-CoA: 1-acyl-sn-glycero-3-phosphocholine acyltransferase in macrophages. | 1986 | Biochim. Biophys. Acta | pmid:3947667 |
| Söling HD and Fest W | Synthesis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in exocrine glands and its control by secretagogues. | 1986 | J. Biol. Chem. | pmid:3095313 |
| Ostermann G et al. | The role of lipoproteins in the degradation of platelet-activating factor. | 1986 | Thromb. Res. | pmid:3798402 |
| Bussolino F et al. | Platelet-activating factor--a powerful lipid autacoid possibly involved in microangiopathy. | 1986 | Acta Haematol. | pmid:3019063 |
| Bussolino F et al. | Interleukin 1 stimulates platelet activating factor production in cultured human endothelial cells. | 1986 | Pharmacol Res Commun | pmid:3490673 |
| Jackson CV et al. | Platelet-activating factor and the release of a platelet-derived coronary artery vasodilator substance in the canine. | 1986 | Circ. Res. | pmid:2868810 |
| Bussolino F et al. | Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells. | 1986 | J. Clin. Invest. | pmid:2872233 |
| Henocq E and Vargaftig BB | Accumulation of eosinophils in response to intracutaneous PAF-acether and allergens in man. | 1986 | Lancet | pmid:2872485 |
| Wallace JL and Whittle BJ | Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration. | 1986 | Br. J. Pharmacol. | pmid:3096408 |
| Ostermann G et al. | Stimulation and desensitization of human and rabbit platelets by 1-O-hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine and analogues. | 1986 | Thromb. Res. | pmid:3764811 |
| First International Alexis Carrel Conference on Lipid Mediators in Organ Transplantation. April 8-10, 1986, Washington, DC. | 1986 | Transplant. Proc. | pmid:3765055 | |
| Satoh K and Takamatsu S | [Inactivation by plasma of platelet-activating factor]. | 1986 | Nippon Ketsueki Gakkai Zasshi | pmid:3766067 |
| Kawaguchi H and Yasuda H | Effect of platelet-activating factor on arachidonic acid metabolism in renal epithelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3081036 |
| Gordeev KIu et al. | [Synthesis of thioanalogs of platelet activating factor (PAF)]. | 1986 | Bioorg. Khim. | pmid:3768051 |
| Hoffman DR et al. | Metabolism and function of platelet-activating factor in fetal rabbit lung development. | 1986 | Biochim. Biophys. Acta | pmid:3768390 |
| Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. III. Pharmacological studies of FR-900452 in animal models. | 1986 | Chem. Pharm. Bull. | pmid:3769104 |
| Ohga Y and Nakanishi M | Stopped-flow spectrophotometry monitoring the initial processes of platelet activation by platelet-activating factor. | 1986 | FEBS Lett. | pmid:3770190 |
| Ramesha CS and Pickett WC | Metabolism of platelet-activating factor by arachidonic acid-depleted rat polymorphonuclear leukocytes. | 1986 | J. Biol. Chem. | pmid:3096991 |
| Patterson R et al. | Inhibition of rhesus monkey airway and cutaneous responses to platelet-activating factor (PAF) (AGEPC) with the anti-PAF agent SRI 63-072. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3770978 |
| Newhouse MT and Sears MR | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3462569 |
| Smith PF et al. | The responsiveness of rabbit bronchial rings to antigen, AGEPC and histamine. | 1986 | Immunopharmacology | pmid:3771195 |
| Chignard M et al. | Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin). | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3464972 |
| Kawaguchi H and Yasuda H | Platelet-activating factor stimulates prostaglandin synthesis in cultured cells. | 1986 | Hypertension | pmid:3081442 |
| Andrikopoulos NK et al. | High-performance liquid chromatographic analysis of platelet activating factor on a cation-exchange column by direct ultraviolet detection. | 1986 | J. Chromatogr. | pmid:3771693 |
| Hahn HL et al. | Effects of platelet activating factor on tracheal mucus secretion, on airway mechanics and on circulating blood cells in live ferrets. | 1986 | Eur J Respir Dis Suppl | pmid:3465554 |
| Morley J and Sanjar S | Ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3466080 |
| Page CP | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3466093 |
| Etienne A et al. | Antithrombotic activity of BN 50341, a structurally new compound with anticalcic and PAF-antagonistic properties. | 1986 | Agents Actions Suppl. | pmid:3468781 |
| Zimmerman GA et al. | Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3471149 |
| Küster LJ and Frölich JC | Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. | 1986 | Prostaglandins | pmid:3097760 |