Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Leukemia, Experimental D007942 42 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Psoriasis D011565 47 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Thrombosis D013927 49 associated lipids
Osteosarcoma D012516 50 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Asthma D001249 52 associated lipids
Nerve Degeneration D009410 53 associated lipids
Parkinson Disease D010300 53 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Weight Loss D015431 56 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Reperfusion Injury D015427 65 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Neuroblastoma D009447 66 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Page CP et al. Platelets and asthma. 1985 Lancet pmid:2857401
Gresele P et al. Platelets and asthma. 1985 Lancet pmid:2857402
Lenihan DJ et al. Involvement of platelet activating factor in physiological stress in the lizard, Anolis carolinensis. 1985 Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. pmid:2861063
Michel L and Dubertret L A simple method for studying chemotaxis, vascular permeability and histological modifications induced by mediators of inflammation in vivo in man. 1985 Br. J. Dermatol. pmid:2990519
Barnes JL and Venkatachalam MA The role of platelets and polycationic mediators in glomerular vascular injury. 1985 Semin. Nephrol. pmid:2957770
Shukla SD Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. 1985 Arch. Biochem. Biophys. pmid:3875314
Wasserman SI Mast cell mediators in the blood of patients with asthma. 1985 Chest pmid:3880526
Halonen M et al. Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. 1985 Am. Rev. Respir. Dis. pmid:3881060
Moore TL and Weiss TD Mediators of inflammation. 1985 Semin. Arthritis Rheum. pmid:3936177
Malone B et al. Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product. 1985 J. Biol. Chem. pmid:3918041
Juhan-Vague I et al. Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro. 1985 Thromb. Res. pmid:3923649
Steiner M et al. Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). 1985 Biochem. Biophys. Res. Commun. pmid:3936503
Valone FH and Johnson B Modulation of cytoplasmic calcium in human platelets by the phospholipid platelet-activating factor 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine. 1985 J. Immunol. pmid:2578151
Shen TY et al. The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. 1985 Int J Tissue React pmid:2997065
Sánchez Crespo M et al. Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. 1985 Int J Tissue React pmid:2997066
Proll MA et al. Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. 1985 Mol. Pharmacol. pmid:2997592
MacIntyre DE et al. Endogenous and pharmacological mechanisms for the regulation of human platelet cytosolic free Ca2+. 1985 Nouv Rev Fr Hematol pmid:2997706
Lachachi H et al. Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. 1985 Biochem. Biophys. Res. Commun. pmid:2998370
Hemmendinger S et al. [Physiology of the interactions of blood and the blood vessel wall. Role of pharmacologically active lipids]. 1985 Arch Mal Coeur Vaiss pmid:3938941
Hwang SB et al. trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. 1985 J. Biol. Chem. pmid:2999126
Iñarrea P et al. Synthesis of PAF-acether and blood volume changes in gram-negative sepsis. 1985 Immunopharmacology pmid:3886598
Lellouch-Tubiana A et al. Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs. 1985 Br J Exp Pathol pmid:3890915
Camussi G et al. The role of platelet-activating factor in experimental immune complex pathology. 1985 Int J Tissue React pmid:2932406
Weber N and Mangold HK Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. 1985 J. Lipid Res. pmid:3891896
Hanahan DJ and Weintraub ST Platelet-activating factor isolation, identification, and assay. 1985 Methods Biochem Anal pmid:3894881
Murer EH The role of platelet calcium. 1985 Semin. Hematol. pmid:3901271
Davis JW et al. Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. 1985 Clin. Pharmacol. Ther. pmid:3987176
O'Neill C Examination of the causes of early pregnancy-associated thrombocytopenia in mice. 1985 J. Reprod. Fertil. pmid:3989801
Benveniste J Biosynthesis and function of PAF-acether (platelet-activating factor). 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936197
Kertscher HP and Ostermann G [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. 1985 Pharmazie pmid:3991788
Wal F et al. PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. 1985 Thromb. Haemost. pmid:3992525
Waku K et al. Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936199
Khan SN et al. Response to platelet-activating factor of platelets from patients with multiple sclerosis. 1985 Acta Neurol. Scand. pmid:3993327
Saito K et al. Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936200
Tamargo J et al. Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. 1985 Eur. J. Pharmacol. pmid:3996472
Hanahan DJ et al. Platelet-activating factor: a unique lipid chemical mediator. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936201
Terashita Z et al. Is platelet activating factor (PAF) a mediator of endotoxin shock? 1985 Eur. J. Pharmacol. pmid:3996473
Inoue K et al. Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936203
Lad PM et al. Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. 1985 Biochem. Biophys. Res. Commun. pmid:2990462
Billah MM et al. Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2. 1985 J. Biol. Chem. pmid:3922982
Ostermann G et al. Platelet-stimulating and membranolytic properties of racemic PAF-acether and analogues. 1985 Biomed. Biochim. Acta pmid:4004829
Satouchi K et al. Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:4004866
Detsouli A et al. Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether. 1985 Br. J. Pharmacol. pmid:4005486
Korth R et al. Unsaturated 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines (unsaturated platelet-activating factor): aggregation of human platelets after incubation with indomethacin, creatinephosphate/creatinephosphokinase, xylocain and hirudine, and serotonin release after incubation with indomethacin. 1985 Chem. Phys. Lipids pmid:4006034
Shigenobu K et al. Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. 1985 J. Pharmacobio-dyn. pmid:4009403
Saeki S et al. Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart. 1985 Life Sci. pmid:4010479
Nunn B et al. Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. 1985 Antimicrob. Agents Chemother. pmid:4015075
Weintraub ST et al. Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. 1985 Biochem. Biophys. Res. Commun. pmid:4015656
Archer CB et al. Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation? 1985 Br. J. Dermatol. pmid:4015978
Morley J et al. The role of circulating cells in skin reactions. 1985 Br. J. Dermatol. pmid:4015983
Pirotzky E et al. A role for Paf-acether (platelet-activating factor) in acute skin inflammation? 1985 Br. J. Dermatol. pmid:4015984
Ohno M et al. An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. 1985 Chem. Pharm. Bull. pmid:4017109
O'Neill C et al. Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. 1985 J In Vitro Fert Embryo Transf pmid:4020241
Heymans F et al. Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . 1985 J. Med. Chem. pmid:4020830
Brain SD and Williams TJ Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. 1985 Br. J. Pharmacol. pmid:2416378
Touqui L et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. 1985 Biochim. Biophys. Acta pmid:3967037
Yousufzai SY and Abdel-Latif AA Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists. 1985 Biochem. J. pmid:3927898
Ardaillou N et al. Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. 1985 Am. J. Physiol. pmid:3918460
Suemune H et al. Synthetic studies on platelet-activating factor (PAF). 1985 Chem. Pharm. Bull. pmid:4028291
Parente L et al. The release of lyso-PAF from guinea-pig lungs. 1985 Eur. J. Pharmacol. pmid:4029263
Lee TC Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. 1985 J. Biol. Chem. pmid:4030776
Pritchard PH et al. The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease). 1985 Blood pmid:4063532
MacIntyre DE et al. Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. 1985 FEBS Lett. pmid:2981715
Imbs AB et al. [Synthesis of a fluorescently-labeled platelet activating factor]. 1985 Bioorg. Khim. pmid:4062993
Sugiura T et al. Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). 1985 Biochem. Biophys. Res. Commun. pmid:2935146
Tokumura A et al. Gas chromatographic-mass spectrometric analysis of biologically active phospholipids having an sn-2-acetyl group. 1985 J. Chromatogr. pmid:4066848
Meloni Bruneri LH and Barbieri D [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. 1985 Sangre (Barc) pmid:4071355
Söling HD et al. Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. 1985 Adv. Enzyme Regul. pmid:4072796
Mushayakarara EC and Mantsch HH Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. 1985 Can. J. Biochem. Cell Biol. pmid:4075223
Zimmerman GA et al. Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. 1985 J. Clin. Invest. pmid:4077977
Young JM et al. Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. 1985 Prostaglandins pmid:4081060
Is there a case for PAF-acether antagonists? Institut Pasteur, Paris, 21 June 1985. Abstracts. 1985 Prostaglandins pmid:4081064
Valone FH and Johnson B Decay of the activating signal after platelet stimulation with 1-0-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine: changes in calcium permeability. 1985 Thromb. Res. pmid:4082115
Scherer GF 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. 1985 Biochem. Biophys. Res. Commun. pmid:4084306
Handley DA et al. Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. 1985 Thromb. Haemost. pmid:4089809
Hemker HC and Béguin S The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. 1985 Verh. K. Acad. Geneeskd. Belg. pmid:4090648
Hallam TJ et al. Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. 1985 Biochem. J. pmid:4091795
Fouque F and Vargaftig BB Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. 1985 J Pharmacol pmid:4094442
Vigo C Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. 1985 J. Biol. Chem. pmid:3919022
Morley J et al. PAF and airway hyperreactivity. 1985 Lancet pmid:2863479
Morley J et al. Platelets in asthma. 1985 Lancet pmid:2863708
Armstrong RA et al. Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha. 1985 Prostaglandins pmid:2988022
Cox CP Activation of washed chicken thrombocytes by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (platelet-activating factor). 1985 Comp Biochem Physiol A Comp Physiol pmid:2864195
Sugiura T and Waku K CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. 1985 Biochem. Biophys. Res. Commun. pmid:3919727
Dewald B and Baggiolini M Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. 1985 Biochem. Biophys. Res. Commun. pmid:2985075
Peach MJ et al. Mechanisms of endothelium-dependent vascular smooth muscle relaxation. 1985 Biochem. Pharmacol. pmid:2988558
Wasserman SI The mast cell and theophylline in asthma. 1985 Am. J. Med. pmid:3002176
Braquet M et al. Leukocytic functions in burn-injured patients. 1985 Prostaglandins pmid:2989978
Hallam TJ and Rink TJ Agonists stimulate divalent cation channels in the plasma membrane of human platelets. 1985 FEBS Lett. pmid:2408921
O'Neill C et al. Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. 1985 Ann. N. Y. Acad. Sci. pmid:2409860
Sage SO and Rink TJ Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. 1985 FEBS Lett. pmid:2410292
Grandel KE et al. Association of platelet-activating factor with primary acquired cold urticaria. 1985 N. Engl. J. Med. pmid:2410790
Bussolino F et al. Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells. 1985 J. Immunol. pmid:2411812
Johnson HM and Torres BA Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2412225
Tou J Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:3921017
Fjellner B and Hägermark O Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. 1985 Acta Derm. Venereol. pmid:2416164
Avdonin PV and Altukhova IP [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. 1985 Biokhimiia pmid:2416359
Lee TD et al. Heterogeneity in mast cell populations. 1985 Clin Immunol Rev pmid:2417770
Leclercq M et al. [Effects of Hymenoptera stings: physiopathology and immunology according to recent literature findings]. 1985 Rev Med Liege pmid:2418479
Pipili E Platelet membrane potential: simultaneous measurement of diSC3(5) fluorescence and optical density. 1985 Thromb. Haemost. pmid:2418525