Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Leukemia, Experimental D007942 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Psoriasis D011565 47 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Thrombosis D013927 49 associated lipids
Osteosarcoma D012516 50 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Asthma D001249 52 associated lipids
Nerve Degeneration D009410 53 associated lipids
Parkinson Disease D010300 53 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Reperfusion Injury D015427 65 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Neuroblastoma D009447 66 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Doebber TW et al. Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. 1985 Biochem. Biophys. Res. Commun. pmid:2985058
Pfeilschifter J et al. Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. 1985 Biochem. Biophys. Res. Commun. pmid:2985064
Moore TL and Weiss TD Mediators of inflammation. 1985 Semin. Arthritis Rheum. pmid:3936177
Hwang SB et al. Specific binding sites for platelet activating factor in human lung tissues. 1985 Biochem. Biophys. Res. Commun. pmid:2986633
Terashita Z et al. Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet. 1985 Biochem. Pharmacol. pmid:2986648
Vanderwel M and Haslam RJ Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate. 1985 J. Clin. Invest. pmid:2991338
Iñarrea P et al. Synthesis of PAF-acether and blood volume changes in gram-negative sepsis. 1985 Immunopharmacology pmid:3886598
Lellouch-Tubiana A et al. Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs. 1985 Br J Exp Pathol pmid:3890915
Weber N and Mangold HK Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. 1985 J. Lipid Res. pmid:3891896
Hanahan DJ and Weintraub ST Platelet-activating factor isolation, identification, and assay. 1985 Methods Biochem Anal pmid:3894881
Maes L et al. In vivo arterial platelet-vessel wall interaction and thrombosis: induction, on-line registration and ultrastructural control. 1985 Adv. Exp. Med. Biol. pmid:3832867
Tuffin DP et al. Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. 1985 Adv. Exp. Med. Biol. pmid:3834789
Parente L and Flower RJ Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes. 1985 Life Sci. pmid:3838566
Kumar R et al. Occurrence of glyceryl ethers in the phosphatidylcholine fraction of surfactant from dog lungs. 1985 Biochim. Biophys. Acta pmid:3839684
Lad PM et al. Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. 1985 Biochem. Biophys. Res. Commun. pmid:2990462
Hayashi H et al. Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. 1985 J. Biochem. pmid:3839790
Tokumura A et al. Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation. 1985 J. Biol. Chem. pmid:3840169
Sánchez-Crespo M et al. Inhibition of the vascular actions of IgG aggregates by BN 52021, a highly specific antagonist of paf-acether. 1985 Immunopharmacology pmid:3840779
Billah MM et al. Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2. 1985 J. Biol. Chem. pmid:3922982
Tokumura A and Tsukatani H [Antagonists of platelet activating factor]. 1985 Seikagaku pmid:3009656
MacIntyre DE et al. Agonist-induced inositol phospholipid metabolism and Ca++ flux in human platelet activation. 1985 Adv. Exp. Med. Biol. pmid:3010662
Hallam TJ et al. Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. 1985 Adv. Exp. Med. Biol. pmid:3010663
Gerrard JM et al. Platelet protein phosphorylation. 1985 Adv. Exp. Med. Biol. pmid:3010667
Haslam RJ et al. Receptor-effector coupling in platelets: roles of guanine nucleotides. 1985 Adv. Exp. Med. Biol. pmid:3010668
Satouchi K et al. Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:4004866
Detsouli A et al. Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether. 1985 Br. J. Pharmacol. pmid:4005486
Korth R et al. Unsaturated 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines (unsaturated platelet-activating factor): aggregation of human platelets after incubation with indomethacin, creatinephosphate/creatinephosphokinase, xylocain and hirudine, and serotonin release after incubation with indomethacin. 1985 Chem. Phys. Lipids pmid:4006034
Shigenobu K et al. Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. 1985 J. Pharmacobio-dyn. pmid:4009403
Saeki S et al. Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart. 1985 Life Sci. pmid:4010479
Nunn B et al. Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. 1985 Antimicrob. Agents Chemother. pmid:4015075
Weintraub ST et al. Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. 1985 Biochem. Biophys. Res. Commun. pmid:4015656
Yousufzai SY and Abdel-Latif AA Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists. 1985 Biochem. J. pmid:3927898
Tokumura A et al. Gas chromatographic-mass spectrometric analysis of biologically active phospholipids having an sn-2-acetyl group. 1985 J. Chromatogr. pmid:4066848
Meloni Bruneri LH and Barbieri D [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. 1985 Sangre (Barc) pmid:4071355
Söling HD et al. Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. 1985 Adv. Enzyme Regul. pmid:4072796
Mushayakarara EC and Mantsch HH Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. 1985 Can. J. Biochem. Cell Biol. pmid:4075223
Zimmerman GA et al. Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. 1985 J. Clin. Invest. pmid:4077977
Young JM et al. Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. 1985 Prostaglandins pmid:4081060
Is there a case for PAF-acether antagonists? Institut Pasteur, Paris, 21 June 1985. Abstracts. 1985 Prostaglandins pmid:4081064
Morley J et al. Platelets in asthma. 1985 Lancet pmid:2863708
Cox CP Activation of washed chicken thrombocytes by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (platelet-activating factor). 1985 Comp Biochem Physiol A Comp Physiol pmid:2864195
Dewald B and Baggiolini M Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. 1985 Biochem. Biophys. Res. Commun. pmid:2985075
Peach MJ et al. Mechanisms of endothelium-dependent vascular smooth muscle relaxation. 1985 Biochem. Pharmacol. pmid:2988558
Braquet M et al. Leukocytic functions in burn-injured patients. 1985 Prostaglandins pmid:2989978
Snyder F Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline-phospholipids. 1985 Jan-Mar Med Res Rev pmid:2984489
Kozubski W and Stańczyk L [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. 1985 Jul-Aug Neurol. Neurochir. Pol. pmid:4094642
Bette-Bobillo P et al. Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor. 1985 Jun-Jul Chem. Phys. Lipids pmid:4042252
Leprán I and Lefer AM Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. 1985 Mar-Apr Basic Res. Cardiol. pmid:4039929
Feuerstein G et al. Thyrotropin-releasing hormone blocks the hypotensive effects of platelet-activating factor in the unanesthetized guinea pig. 1985 Mar-Apr J. Cardiovasc. Pharmacol. pmid:2581089
Mencia-Huerta JM Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. 1985 Sep-Oct Ann. Inst. Pasteur Immunol. pmid:3878684
Masugi F et al. Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. 1985 Sep-Oct Hypertension pmid:4030044
Ozaki Y et al. A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway. 1986 Biochem. Pharmacol. pmid:3021173
Okamoto M et al. FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. 1986 J. Antibiot. pmid:3082838
Vanhoutte PM et al. Modulation of vascular smooth muscle contraction by the endothelium. 1986 Annu. Rev. Physiol. pmid:2871807
Suemune H et al. Enzymatic synthesis of 2,3-O-isopropylidene-sn-glycerol, a chiral building block for platelet-activating factor. 1986 Chem. Pharm. Bull. pmid:3791517
Silva PM et al. Platelet involvement in rat paw edema induced by 2-methoxy-PAF. 1986 Inflammation pmid:3793206
Wu MS et al. Inhibition of the platelet activating factor (PAF)-induced in vivo responses in rats by trans-2,5-(3,4,5-trimethoxyphenyl) tetrahydrofuran (L-652,731), a PAF receptor antagonist. 1986 J. Pharmacol. Exp. Ther. pmid:3795043
Tetta C et al. Platelet-activating factor contracts human myometrium in vitro. 1986 Proc. Soc. Exp. Biol. Med. pmid:3797421
Montrucchio G et al. In vitro contractile effect of platelet-activating factor on guinea-pig myometrium. 1986 Prostaglandins pmid:3797692
Bourgain RH et al. Vivo effects of PAF-acether and arterial thrombosis. 1986 Adv. Exp. Med. Biol. pmid:3799334
Kloprogge E et al. PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine)-induced fibrinogen binding to platelets depends on metabolic energy. 1986 Biochem. J. pmid:3800968
Desquand S et al. Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. 1986 Eur. J. Pharmacol. pmid:3019727
Daniel LW et al. A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. 1986 J. Biol. Chem. pmid:3087989
Ohno M et al. Molecular design toward biologically significant compounds based on platelet activating factor: a highly selective agonist as a potential antihypertensive agent. 1986 J. Med. Chem. pmid:3761300
Parnham MJ and Bittner C Pharmacological analysis of guinea-pig macrophage chemiluminescence responses to platelet activating factor and opsonized zymosan. 1986 Int. J. Immunopharmacol. pmid:3804536
Adnot S et al. Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig. 1986 Prostaglandins pmid:3562865
Malavasi F et al. Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3085094
Orozco C et al. Platelet-activating factor induces the expression of early pregnancy factor activity in female mice. 1986 J. Reprod. Fertil. pmid:3806515
Wissner A et al. Analogues of platelet activating factor. 5. Multiple oxygen substitution of the alkoxy chain. 1986 J. Med. Chem. pmid:3806583
Ozaki Y et al. Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis. Measurement of hydrogen peroxide may most accurately represent enhancement of oxygen radical production during infection. 1986 Inflammation pmid:3011666
Doebber TW et al. Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. 1986 J. Immunol. pmid:3011900
McManus LM Pathobiology of platelet-activating factors. 1986 Pathol Immunopathol Res pmid:3543915
Tokumura A et al. Alkylacetylglycerophosphocholine effects on the metabolism of phospholipids in rabbit platelets: effects of extracellular Ca2+ and prostacyclin. 1986 Arch. Biochem. Biophys. pmid:3013094
Houslay MD et al. Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni. 1986 Biochem. J. pmid:3013161
Fechter M et al. Experimental eosinophilia and inflammation--the effect of various inflammatory mediators and chemoattractants. 1986 Exp Pathol pmid:3013671
Fisher RA et al. Effects of beta-adrenergic stimulation on 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine-mediated vasoconstriction and glycogenolysis in the perfused rat liver. 1986 J. Biol. Chem. pmid:3013865
Darius H et al. Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists. 1986 Int. Arch. Allergy Appl. Immunol. pmid:3015804
Coëffier E et al. Transient activation of the acetyltransferase necessary for paf-acether biosynthesis in thrombin-activated platelets. 1986 Br. J. Haematol. pmid:3964558
Bachelet M et al. Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages. 1986 Biochim. Biophys. Acta pmid:3092866
Alonso F et al. A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine. 1986 Biochim. Biophys. Acta pmid:3092867
Bourgain RH et al. Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig. 1986 Prostaglandins pmid:3763943
Guinot P et al. Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist. 1986 Prostaglandins pmid:3763944
Scherf H et al. Hemodynamic effects of platelet activating factor in the dog kidney in vivo. 1986 Hypertension pmid:3744467
Bussolino F et al. Platelet-activating factor--a powerful lipid autacoid possibly involved in microangiopathy. 1986 Acta Haematol. pmid:3019063
Dewald B and Baggiolini M Platelet-activating factor as a stimulus of exocytosis in human neutrophils. 1986 Biochim. Biophys. Acta pmid:3017443
Wallace JL and Whittle BJ Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration. 1986 Br. J. Pharmacol. pmid:3096408
Kester M et al. Alkylacetylglycerophosphocholine stimulates Na+-Ca2+ exchange, protein phosphorylation and polyphosphoinositide turnover in rat ileal plasmalemmal vesicles. 1986 Biochim. Biophys. Acta pmid:3019423
Voelkel NF et al. PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung. 1986 Prostaglandins pmid:3024235
Zimmerman GA et al. Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. 1986 Ann. N. Y. Acad. Sci. pmid:3471149
Küster LJ and Frölich JC Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. 1986 Prostaglandins pmid:3097760
Bruynzeel PL et al. Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. 1986 Pharmacol Res Commun pmid:3774850
Etienne A et al. The relative role of PAF-acether and icosanoids in septic shock. 1986 Pharmacol Res Commun pmid:3774851
Maes L et al. Endogenic PAF-acether production by guinea pig endothelial cells in experimental arterial thrombosis. 1986 Pharmacol Res Commun pmid:3774852
Handley DA et al. Inhibition of PAF-induced systemic responses in the rat, guinea pig, dog and primate by the receptor antagonist SRI 63-441. 1986 Thromb. Haemost. pmid:3775689
Hwang SB and Lam MH Species difference in the specific receptors of platelet activating factor. 1986 Biochem. Pharmacol. pmid:3024653
Han GQ et al. [Neolignans from Piper hancei Maxim]. 1986 Yao Xue Xue Bao pmid:3776545
Koltai M et al. Effect of BN 52021, a specific PAF-acether antagonist, on cardiac anaphylaxis in Langendorff hearts isolated from passively sensitized guinea-pigs. 1986 Eur. J. Pharmacol. pmid:3780855
Montrucchio G et al. Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist. 1986 Int J Tissue React pmid:3025124
Salari H Solid-phase extraction and reversed-phase high-performance liquid chromatographic technique for isolation and estimation of platelet activating factor in plasma. 1986 J. Chromatogr. pmid:3782417
Ng DS and Wong K GTP regulation of platelet-activating factor binding to human neutrophil membranes. 1986 Biochem. Biophys. Res. Commun. pmid:3026378