Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zang BX et al. | [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506296 |
| Bankers-Fulbright JL et al. | Platelet-activating factor stimulates cytoplasmic alkalinization and granule acidification in human eosinophils. | 2004 | J. Cell. Sci. | pmid:15507482 |
| Hertelendy F and Zakár T | Prostaglandins and the myometrium and cervix. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14683694 |
| Diez-Fraile A et al. | Effect of proinflammatory mediators and glucocorticoids on L-selectin expression in peripheral blood neutrophils from dairy cows in various stages of lactation. | 2004 | Am. J. Vet. Res. | pmid:15524330 |
| Mangan NE et al. | Helminth infection protects mice from anaphylaxis via IL-10-producing B cells. | 2004 | J. Immunol. | pmid:15528374 |
| Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
| Goldring WP and Pattenden G | Total synthesis of (+/-)-phomactin G, a platelet activating factor antagonist from the marine fungus Phoma sp. | 2004 | Org. Biomol. Chem. | pmid:14770224 |
| Rollin S et al. | VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis. | 2004 | Blood | pmid:14764537 |
| Hidalgo MA et al. | Platelet-activating factor increases pH(i) in bovine neutrophils through the PI3K-ERK1/2 pathway. | 2004 | Br. J. Pharmacol. | pmid:14691048 |
| Gabrijelcic J et al. | Formoterol protects against platelet-activating factor-induced effects in asthma. | 2004 | Eur. Respir. J. | pmid:14738234 |
| Geiser T | The role of neutrophils and neutrophil products in pulmonary hemodynamics of endotoxin in oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742354 |
| Hill LL et al. | Neutrophils and neutrophil products do not mediate pulmonary hemodynamic effects of endotoxin on oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742386 |
| Bouayad A et al. | Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14715488 |
| Chami O et al. | Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15271646 |
| Axelrad TW et al. | Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration. | 2004 | FASEB J. | pmid:14715700 |
| Chinybaeva LA | [Comparative characterization of hemostatic parameters in patients with cerebral stroke]. | 2004 | Klin Med (Mosk) | pmid:15449775 |
| Gambero A et al. | Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2. | 2004 | Toxicon | pmid:15450921 |
| Tokiwano T et al. | Biosynthesis of phomactins: common intermediate phomactatriene and taxadiene. | 2004 | Chem. Commun. (Camb.) | pmid:15154058 |
| Poli G et al. | Oxidative stress and cell signalling. | 2004 | Curr. Med. Chem. | pmid:15134513 |
| Zhelev DV et al. | Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants. | 2004 | Biophys. J. | pmid:15240502 |
| Gilroy DW et al. | A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. | 2004 | FASEB J. | pmid:15003994 |
| Hla T | Prostaglandins & other lipid mediators: a new phase, a new team. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165026 |
| Ruan Z et al. | Effects of platelet-activating factor and thromboxane A2 on isolated perfused guinea pig liver. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165033 |
| Nomikos TN et al. | Application of a TCA-precipitation method for the determination of 1-alkyl-sn-glycero-3-phosphate: Acetyl-CoA acetyltransferase in human renal tissue. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165037 |
| Kato M et al. | Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating factor. | 2004 | Int. Arch. Allergy Immunol. | pmid:15166482 |
| Lu J et al. | Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14512286 |
| Jantan I et al. | Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding. | 2004 | Phytother Res | pmid:15742349 |
| Kondratskaya EL et al. | Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. | 2004 | Neurochem. Int. | pmid:14568560 |
| Amer MD et al. | Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis. | 2004 | Biol. Neonate | pmid:14646336 |
| Cinamon G et al. | Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration. | 2004 | J. Immunol. | pmid:15585851 |
| Bender A et al. | Molecular surface point environments for virtual screening and the elucidation of binding patterns (MOLPRINT 3D). | 2004 | J. Med. Chem. | pmid:15588092 |
| Takeda K | [Role of increase in permeability and circulatory failure in the development of organ dysfunction in severe acute pancreatitis]. | 2004 | Nippon Rinsho | pmid:15552880 |
| Takase K et al. | [New aspects of pharmaco-therapy for acute pancreatitis]. | 2004 | Nippon Rinsho | pmid:15552891 |
| Wanten G et al. | Lipid effects on neutrophil calcium signaling induced by opsonized particles: platelet activating factor is only part of the story. | 2004 | Clin Nutr | pmid:15297099 |
| Han XB et al. | Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15319184 |
| Berdeli A et al. | Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15301793 |
| Ma X et al. | [Corneal epithelial wound healing is delayed by platelet activating factor treatment]. | 2004 | Zhonghua Yan Ke Za Zhi | pmid:15307983 |
| Bossi F et al. | Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex. | 2004 | J. Immunol. | pmid:15557188 |
| Venkatesha RT et al. | Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. | 2004 | J. Biol. Chem. | pmid:15308653 |
| Crawford SE et al. | Captopril suppresses post-transplantation angiogenic activity in rat allograft coronary vessels. | 2004 | J. Heart Lung Transplant. | pmid:15366425 |
| Seo KH et al. | Estrogen enhances angiogenesis through a pathway involving platelet-activating factor-mediated nuclear factor-kappaB activation. | 2004 | Cancer Res. | pmid:15374958 |
| Ma X et al. | Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. | 2004 | Invest. Ophthalmol. Vis. Sci. | pmid:15326102 |
| Wright CS et al. | Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor. | 2004 | J. Mol. Biol. | pmid:15327957 |
| Thanou PG and Tsoukatos DC | Non-enzymatic platelet-activating factor formation by acetylated proteins. | 2004 | FEBS Lett. | pmid:15327967 |
| Chou KJ et al. | Platelet hyperreactivity in hemodialysis patients with frequently occluded vascular access. | 2004 | Thromb. Haemost. | pmid:15351860 |
| Llodrá J et al. | Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15280540 |
| Zhu L et al. | Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12946927 |
| Kato M et al. | Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. | 2004 | J. Pharmacol. Sci. | pmid:15286429 |
| Slomiany BL and Slomiany A | Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis. | 2004 | IUBMB Life | pmid:14992379 |
| Jung TT et al. | Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells. | 2004 | Ann. Otol. Rhinol. Laryngol. | pmid:14994775 |
| Fourcade O et al. | Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. | 2004 | Anesth. Analg. | pmid:15271713 |
| Getting SJ et al. | Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14996949 |
| Rasheed H and Saeed SA | Involvement of thromboxane A2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation. | 2004 | Exp. Mol. Med. | pmid:15272233 |
| Bate C et al. | Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication. | 2004 | J. Biol. Chem. | pmid:15210691 |
| Yamano S et al. | Human spermatozoa capacitated with progesterone or a long incubation show accelerated internalization by an alkyl ether lysophospholipid. | 2004 | Fertil. Steril. | pmid:15037409 |
| Jakubowski A et al. | Involvement of platelet activating factor in immediate heart response to lipopolysaccharide. | 2004 | J. Physiol. Pharmacol. | pmid:15213362 |
| Taylor KE | Familial cancer and developmental dyslexia: an observational pilot study. | 2004 | Dev Med Child Neurol | pmid:14974637 |
| Seo KH et al. | Essential role for platelet-activating factor-induced NF-kappaB activation in macrophage-derived angiogenesis. | 2004 | Eur. J. Immunol. | pmid:15259010 |
| Zhu P et al. | Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival. | 2004 | J. Neurosci. Res. | pmid:15264222 |
| Lu DP et al. | Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. | 2004 | J. Cell. Sci. | pmid:15020683 |
| Sarchielli P et al. | Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. | 2004 | Cephalalgia | pmid:15265050 |
| Ziche M | Absence of PAF actions increases angiogenesis. | 2004 | Br. J. Pharmacol. | pmid:15023858 |
| Roudebush WE et al. | Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility. | 2004 | Fertil. Steril. | pmid:15236989 |
| Ferreira MA et al. | Sponge-induced angiogenesis and inflammation in PAF receptor-deficient mice (PAFR-KO). | 2004 | Br. J. Pharmacol. | pmid:15023865 |
| Alloatti G et al. | Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. | 2004 | Biochem. Soc. Trans. | pmid:15046613 |
| Shio MT et al. | PAF is involved in the Mycoplasma arthritidis superantigen-triggering pathway for iNOS and COX-2 expression in murine peritoneal cells. | 2004 | Exp. Cell Res. | pmid:15242784 |
| Naoki K et al. | PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047169 |
| Smalling WE et al. | Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. | 2004 | Biol. Neonate | pmid:14981352 |
| Al-Darmaki S et al. | Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response. | 2004 | Clin. Diagn. Lab. Immunol. | pmid:15242947 |
| Sugatani J et al. | Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation. | 2004 | Int. Arch. Allergy Immunol. | pmid:15051936 |
| Tsironis LD et al. | Effect of lipoprotein (a) on platelet activation induced by platelet-activating factor: role of apolipoprotein (a) and endogenous PAF-acetylhydrolase. | 2004 | Cardiovasc. Res. | pmid:15194469 |
| Aguiari G et al. | Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells. | 2004 | FASEB J. | pmid:15001556 |
| Sumita C et al. | Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. | 2004 | Biochim. Biophys. Acta | pmid:15279882 |
| Xu Y and Tao YX | Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. | 2004 | Neuroreport | pmid:15076749 |
| Slomiany BL and Slomiany A | Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation. | 2004 | J. Physiol. Pharmacol. | pmid:15082869 |
| Yang YM et al. | Creation of reversed phase high-performance liquid chromatographic technique to assay platelet-activating factor. | 2004 | J. Zhejiang Univ. Sci. | pmid:15101112 |
| Brown GE et al. | Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. | 2004 | J. Biol. Chem. | pmid:15102856 |
| Balestrieri ML et al. | Lycopene in association with alpha-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress. | 2004 | Free Radic. Biol. Med. | pmid:15059646 |
| Burgos RA et al. | Determination of specific receptor sites for platelet activating factor in bovine neutrophils. | 2004 | Am. J. Vet. Res. | pmid:15141884 |
| Wang J et al. | [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. | 2004 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15143716 |
| Fu H et al. | The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. | 2004 | Immunology | pmid:15147563 |
| Beaudeux JL et al. | Activation of PAF receptor by oxidised LDL in human monocytes stimulates chemokine releases but not urokinase-type plasminogen activator expression. | 2004 | Clin. Chim. Acta | pmid:15149885 |
| Yang Y et al. | Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis. | 2004 | Gut | pmid:15138217 |
| Steel HC and Anderson R | Itraconazole antagonizes store-operated influx of calcium into chemoattractant-activated human neutrophils. | 2004 | Clin. Exp. Immunol. | pmid:15086388 |
| Reeves SR and Gozal D | Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15087283 |
| Hollmann MW et al. | Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics. | 2004 | Anesthesiology | pmid:15087620 |
| Ramos G et al. | Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. | 2004 | Toxicol. Appl. Pharmacol. | pmid:15020195 |
| Bate C et al. | The role of platelet activating factor in prion and amyloid-beta neurotoxicity. | 2004 | Neuroreport | pmid:15094513 |
| Khreiss T et al. | Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils. | 2004 | Cell. Signal. | pmid:15115659 |
| Ninio E et al. | Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. | 2004 | Hum. Mol. Genet. | pmid:15115767 |
| Bonin F et al. | Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. | 2004 | J. Biol. Chem. | pmid:15456758 |
| Martin C et al. | Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064228 |
| Alfaro V | Role of histamine and platelet-activating factor in allergic rhinitis. | 2004 | J. Physiol. Biochem. | pmid:15457928 |
| Baker KE and Curtis MJ | Left regional cardiac perfusion in vitro with platelet-activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous "mediators" facilitated by interactions, and moderated by paradoxical antagonism. | 2004 | Br. J. Pharmacol. | pmid:15066909 |
| Uemura K et al. | Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP). | 2004 | Glycoconj. J. | pmid:15467404 |
| Victorino GP et al. | Modulation of microvascular hydraulic permeability by platelet-activating factor. | 2004 | J Trauma | pmid:14960983 |
| Ko HH et al. | Structure-activity relationship studies on chalcone derivatives: potent inhibition of platelet aggregation. | 2004 | J. Pharm. Pharmacol. | pmid:15482650 |
| Ewer AK et al. | The role of platelet activating factor in a neonatal piglet model of necrotising enterocolitis. | 2004 | Gut | pmid:14724152 |
| Angeli V et al. | Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. | 2004 | Immunity | pmid:15485633 |
| Tai H et al. | TMVA, a snake C-type lectin-like protein from Trimeresurus mucrosquamatus venom, activates platelet via GPIb. | 2004 | Toxicon | pmid:15501291 |