Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tsunoda H et al. | Activity of a novel thienodiazepine derivative as a platelet-activating factor antagonist in guinea pig lungs. Effects on platelet-activating factor and allergen induced eosinophil accumulation. | 1991 | Arzneimittelforschung | pmid:1867658 |
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| Chu WF et al. | Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16433899 |
| Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
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| Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
| Napoli C et al. | Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein. | 1997 | Basic Res. Cardiol. | pmid:9166989 |
| Auchampach JA et al. | Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. | 1998 | Basic Res. Cardiol. | pmid:9833148 |
| Felix SB et al. | Cardiovascular reactions and respiratory events during platelet activating factor-induced shock. | 1990 May-Jun | Basic Res. Cardiol. | pmid:2383216 |
| Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
| Giessler C et al. | Effects of PAF on cardiac function and eicosanoid release in the isolated perfused rat heart: comparison between normotensive and spontaneously hypertensive rats. | 1995 Jul-Aug | Basic Res. Cardiol. | pmid:8534259 |
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| Jerusalinsky D et al. | Effect of antagonists of platelet-activating factor receptors on memory of inhibitory avoidance in rats. | 1994 | Behav. Neural Biol. | pmid:7945139 |
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| Shindo K et al. | PAF-induced eosinophil chemotaxis increases during an asthmatic attack and is inhibited by prednisolone in vivo and in vitro. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9266847 |
| O'Flaherty JT et al. | 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820395 |
| Doebber TW et al. | Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985058 |
| Pfeilschifter J et al. | Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985064 |
| Jamil KM et al. | Expression of platelet activating factor receptor in renal tubular cell line (LLC-PK1). | 1992 | Biochem. Biophys. Res. Commun. | pmid:1326956 |
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| Blank ML et al. | Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6497876 |
| Müller S and Nigam S | Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1335246 |
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| Harris JG et al. | Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630023 |
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| Parent JL et al. | Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8645288 |
| Randell E et al. | Interaction between rat serum phosphorylcholine binding protein and platelet activating factor. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2322233 |
| Chau LY et al. | Photoaffinity labeling of platelet activating factor binding sites in rabbit platelet membranes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2545193 |
| Ye RD et al. | Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1656963 |
| Parent JL and Stankova J | Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8280163 |
| Combadière C et al. | Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2158320 |