Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang GQ et al. | [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. | 2003 | Zhonghua Er Ke Za Zhi | pmid:14751060 |
| Saeed SA and Rasheed H | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. | 2003 | Acta Pharmacol. Sin. | pmid:12511226 |
| Russo S et al. | Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction. | 2003 | J. Immunol. | pmid:14607955 |
| Slomiany BL and Slomiany A | Biphasic role of platelet-activating factor in oral mucosal ulcer healing. | 2003 | IUBMB Life | pmid:14609204 |
| Shigematsu S et al. | Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. | 2003 | Free Radic. Biol. Med. | pmid:12654468 |
| Zhang Y et al. | Antioxidant superoxide dismutase attenuates increased endothelial permeability induced by platelet-activating factor. | 2003 | J. Soc. Gynecol. Investig. | pmid:12517587 |
| Collado MP et al. | Endothelin-1 decreases ethanolamine plasmalogen levels and evokes PAF production in brain microvessels. | 2003 | Microvasc. Res. | pmid:14609525 |
| Odeh AI et al. | Effect of platelet-activating factor (PAF) on stallion sperm motility, capacitation and the acrosome reaction. | 2003 | Reproduction | pmid:14611633 |
| Kuo RY et al. | Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12873516 |
| Sugimoto Y et al. | Inhibitory effects of glucocorticoids on rat eosinophil superoxide generation and chemotaxis. | 2003 | Int. Immunopharmacol. | pmid:12781701 |
| Yang Y et al. | Kupffer cells are a major source of increased platelet activating factor in the CCl4-induced cirrhotic rat liver. | 2003 | J. Hepatol. | pmid:12873816 |
| Zhu X et al. | Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. | 2003 | Life Sci. | pmid:14519449 |
| Gabrijelcic J et al. | Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. | 2003 | Eur. Respir. J. | pmid:12952263 |
| Handa RK et al. | Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo. | 2003 | Kidney Blood Press. Res. | pmid:12886044 |
| Taggart DP et al. | Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist. | 2003 | Heart | pmid:12860868 |
| Takafuji S et al. | Matrix metalloproteinase-9 release from human leukocytes. | 2003 | J Investig Allergol Clin Immunol | pmid:12861851 |
| Bar-Or D et al. | Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. | 2003 | Shock | pmid:12865660 |
| Kujiraoka T et al. | Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus. | 2003 | J. Lipid Res. | pmid:12867534 |
| D'Andrea D et al. | Induction of tissue factor in the arterial wall during recurrent thrombus formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12869352 |
| Lupia E et al. | The membrane attack complex of complement contributes to plasmin-induced synthesis of platelet-activating factor by endothelial cells and neutrophils. | 2003 | Immunology | pmid:12871223 |
| Fernandes ES et al. | Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw. | 2003 | Br. J. Pharmacol. | pmid:12839871 |
| Saruc M et al. | An experimental model of hemolysis-induced acute pancreatitis. | 2003 | Braz. J. Med. Biol. Res. | pmid:12845374 |
| Nomikos TN et al. | Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue. | 2003 | Eur. J. Biochem. | pmid:12846832 |
| Suzuki M et al. | Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils. | 2003 | J. Allergy Clin. Immunol. | pmid:12847489 |
| Casillan AJ et al. | Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. | 2003 | J. Appl. Physiol. | pmid:12598480 |
| Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
| Rios-Santos F et al. | A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. | 2003 | Shock | pmid:12558146 |
| Mano T et al. | Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase. | 2003 | Bioorg. Med. Chem. | pmid:12927848 |
| Talvani A et al. | Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. | 2003 | Microbes Infect. | pmid:12850205 |
| Triggiani M et al. | Secretory phospholipases A2 activate selective functions in human eosinophils. | 2003 | J. Immunol. | pmid:12626587 |
| Strait RT et al. | IL-4 exacerbates anaphylaxis. | 2003 | J. Immunol. | pmid:12646651 |
| Al-Darmaki S et al. | Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells. | 2003 | J. Immunol. | pmid:12496397 |
| Lukashova V et al. | Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. | 2003 | J. Immunol. | pmid:14500680 |
| Lie WJ et al. | Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12911788 |
| Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
| Kusunoki H et al. | Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. | 2003 | Diabetes Care | pmid:12766129 |
| Strümper D et al. | Effects of antidepressants on function and viability of human neutrophils. | 2003 | Anesthesiology | pmid:12766643 |
| Pizurki L et al. | Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production. | 2003 | Br. J. Pharmacol. | pmid:12770938 |
| Akisu M et al. | Supplementation with Saccharomyces boulardii ameliorates hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. | 2003 | Eur J Pediatr Surg | pmid:14618522 |
| Takizawa T et al. | Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. | 2003 | Int. Arch. Allergy Immunol. | pmid:12771544 |
| Zhang X et al. | Age-related increase of plasma platelet-activating factor concentrations in Chinese. | 2003 | Clin. Chim. Acta | pmid:14568193 |
| De Vriese AS and Bourgeois M | Pharmacologic treatment of acute renal failure in sepsis. | 2003 | Curr Opin Crit Care | pmid:14639066 |
| Alviano DS et al. | Differentiation of Fonsecaea pedrosoi mycelial forms into sclerotic cells is induced by platelet-activating factor. | 2003 | Res. Microbiol. | pmid:14643407 |
| Chlopicki S et al. | Obligatory role of lipid mediators in platelet-neutrophil adhesion. | 2003 | Thromb. Res. | pmid:14592550 |
| Montrucchio G et al. | Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood. | 2003 | Thromb. Haemost. | pmid:14597983 |
| Shabanov VV | [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. | 2003 | Vestn. Akad. Med. Nauk SSSR | pmid:14598737 |
| Estellés R et al. | Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo. | 2003 | Br. J. Pharmacol. | pmid:14559857 |
| Kell PJ et al. | Inhibition of platelet-activating factor (PAF) acetylhydrolase by methyl arachidonyl fluorophosphonate potentiates PAF synthesis in thrombin-stimulated human coronary artery endothelial cells. | 2003 | J. Pharmacol. Exp. Ther. | pmid:14560038 |
| Denizot Y et al. | Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients. | 2003 | Oncogene | pmid:14562051 |
| Ivanov AI et al. | Platelet-activating factor: a previously unrecognized mediator of fever. | 2003 | J. Physiol. (Lond.) | pmid:14565987 |
| Cole KP and Hsung RP | Intramolecular formal oxa-[3 + 3] cycloaddition approach to the ABD system of phomactin A. | 2003 | Org. Lett. | pmid:14653688 |
| Hao J et al. | [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. | 2003 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:14552687 |
| Elovitz MA et al. | A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. | 2003 | Am. J. Pathol. | pmid:14578208 |
| Kogure K et al. | Temporary membrane distortion of vascular smooth muscle cells is responsible for their apoptosis induced by platelet-activating factor-like oxidized phospholipids and their degradation product, lysophosphatidylcholine. | 2003 | Chem. Phys. Lipids | pmid:14580708 |
| Schuster DP et al. | Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. | 2003 | Crit. Care Med. | pmid:12794395 |
| Rabinovici R | Platelet activating factor inhibition in sepsis: the end? | 2003 | Crit. Care Med. | pmid:12794432 |
| Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
| Denizot Y et al. | Platelet-activating factor and normal or leukaemic haematopoiesis. | 2003 | Leuk. Lymphoma | pmid:12802913 |
| Olanders K et al. | Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. | 2003 | Scand. J. Gastroenterol. | pmid:12825870 |
| Adamson RH et al. | PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12649070 |
| Haraldsen P et al. | Multimodal management - of value in fulminant acute pancreatitis? | 2003 | Pancreatology | pmid:12649560 |
| Denizot Y et al. | No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis. | 2003 | Mediators Inflamm. | pmid:12775360 |
| Yan W et al. | Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12775763 |
| Nie ZG and Wang WJ | [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. | 2003 | Yao Xue Xue Bao | pmid:12778742 |
| Fragopoulou E et al. | Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties. | 2003 | Biochim. Biophys. Acta | pmid:12782155 |
| Marshall JC | Such stuff as dreams are made on: mediator-directed therapy in sepsis. | 2003 | Nat Rev Drug Discov | pmid:12750742 |
| Bayar MA et al. | The effect of EGb-761 on morphologic vasospasm in canine basilar artery after subarachnoid hemorrhage. | 2003 | J. Cardiovasc. Pharmacol. | pmid:12960685 |
| Kato M et al. | The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis. | 2003 | J Ocul Pharmacol Ther | pmid:12964956 |
| Ishiura Y et al. | Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction. | 2003 | J Investig Allergol Clin Immunol | pmid:12968390 |
| Calabresi L et al. | Endothelial protection by high-density lipoproteins: from bench to bedside. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12969988 |
| Zhao XY et al. | [Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release]. | 2003 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:12970925 |
| Izquierdo I et al. | Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. A review of pharmacological profile and clinical management of allergic rhinitis. | 2003 | Drugs Today | pmid:12944997 |
| Zang BX et al. | [Antagonistic effect of myricetin on platelet activing factor]. | 2003 | Yao Xue Xue Bao | pmid:14991995 |
| Loucks EB et al. | Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. | 2003 | Can J Cardiol | pmid:12677282 |
| Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
| Wu B et al. | Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. | 2003 | FASEB J. | pmid:12709415 |
| Bussolati B et al. | The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. | 2003 | J. Immunol. | pmid:12538709 |
| Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
| Hirayama K et al. | Platelet-activating factor, a critical mediator in the pathogenesis of dextran sulfate sodium-induced colitis in rats. | 2003 | Dis. Colon Rectum | pmid:12544529 |
| Balestrieri ML et al. | Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. | 2003 | J. Lipid Res. | pmid:12576520 |
| Lee JM et al. | Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. | 2003 | J. Biol. Chem. | pmid:12556532 |
| Handa RK et al. | Platelet-activating factor and solute transport processes in the kidney. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:12529272 |
| Zhao H et al. | Influence of platelet activating factor on expression of adhesion molecules in experimental pancreatitis. | 2003 | World J. Gastroenterol. | pmid:12532462 |
| Kolko M et al. | Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. | 2003 | Neurosci. Lett. | pmid:12566178 |
| Chen L et al. | [Determination of platelet activating factor in middle ear effusion of patients with secretory oitits media]. | 2003 | Lin Chuang Er Bi Yan Hou Ke Za Zhi | pmid:14727433 |
| Dinarello CA | The IL-1 family and inflammatory diseases. | 2002 Sep-Oct | Clin. Exp. Rheumatol. | pmid:14989423 |
| Chłopicki S et al. | Hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lung; modulation by thromboxane A2, platelet-activating factor, cysteinyl leukotrienes and endothelin-1. | 2002 Sep-Oct | Pol J Pharmacol | pmid:12593530 |
| Klabunde RE and Anderson DE | Role of nitric oxide and reactive oxygen species in platelet-activating factor-induced microvascular leakage. | 2002 May-Jun | J. Vasc. Res. | pmid:12097822 |
| Huang JB et al. | Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470617 |
| Levine AS et al. | A review of the effect of platelet-activating factor on male reproduction and sperm function. | 2002 Jul-Aug | J. Androl. | pmid:12065449 |
| Farbiszewski R et al. | [The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system]. | 2002 Jul-Aug | Neurol. Neurochir. Pol. | pmid:12418143 |
| Göggel R et al. | Platelet-activating factor-induced pulmonary edema is partly mediated by prostaglandin E(2), E-prostanoid 3-receptors, and potassium channels. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12204861 |
| Silva AR et al. | Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein. | 2002 | J. Immunol. | pmid:11937571 |
| Tachibana A et al. | Respiratory syncytial virus enhances the expression of CD11b molecules and the generation of superoxide anion by human eosinophils primed with platelet-activating factor. | 2002 | Intervirology | pmid:11937770 |
| Marin V et al. | Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type. | 2002 | Eur. J. Immunol. | pmid:12355450 |
| Beauchamp MH et al. | Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356842 |
| Sakai H et al. | E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. | 2002 | Br. J. Pharmacol. | pmid:12023941 |
| Talvani A et al. | Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. | 2002 | Infect. Immun. | pmid:12117933 |
| Stangl V et al. | Negative inotropic mediators released from the heart after myocardial ischaemia-reperfusion. | 2002 | Cardiovasc. Res. | pmid:11744010 |
| Cheminade C et al. | 1-O-alkylglycerols improve boar sperm motility and fertility. | 2002 | Biol. Reprod. | pmid:11804958 |