Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li X and Luo H | [Advances in pharmacological study of Piper kadsura (Choisy) Ohwi]. | 2002 | Zhong Yao Cai | pmid:14748373 |
| Sibelius U et al. | Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10. | 2002 | Crit. Care Med. | pmid:12394960 |
| Francescangeli E et al. | Activation of PAF-synthesizing enzymes in rat brain stem slices after LTP induction in the medial vestibular nuclei. | 2002 | Neurochem. Res. | pmid:12512951 |
| Roy Baker R and Chang Hy | MgATP may depress de novo neuronal nuclear PAF generation by promoting the formation of alkylacylglycerophosphate, an inhibitor of alkylglycerophosphate acetyltransferase. | 2002 | Biochim. Biophys. Acta | pmid:12457714 |
| Pan YH et al. | Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. | 2002 | Biochemistry | pmid:12475227 |
| Smith JM et al. | Platelet-activating factor and Escherichia coliO157:H7 infections. | 2002 | Pediatr. Nephrol. | pmid:12478356 |
| Makhija R and Kingsnorth AN | Cytokine storm in acute pancreatitis. | 2002 | J Hepatobiliary Pancreat Surg | pmid:12483260 |
| Lee YM et al. | Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. | 2002 | J. Lab. Clin. Med. | pmid:12434132 |
| Abu-Zidan FM and Windsor JA | Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials. | 2002 | Eur J Surg | pmid:12440758 |
| Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
| Baker PR et al. | Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. | 2002 | Biochim. Biophys. Acta | pmid:12379481 |
| Barbuti A et al. | Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003807 |
| Kulikov VI and Muzya GI | Influence of platelet-activating factor, its cell analogs, and antagonist on the production of superoxide radicals by blood leukocytes of healthy and hypercholesterolemic individuals. | 2002 | Biochemistry Mosc. | pmid:12126473 |
| Leusch A et al. | Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. | 2002 | Eur J Pharm Sci | pmid:12128165 |
| Megens AA et al. | Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12130734 |
| Podolak-Dawidziak M | [Role of white cells and neoplastic cells in haemostasis]. | 2002 | Pol. Arch. Med. Wewn. | pmid:12189915 |
| Strømgaard K et al. | Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation. | 2002 | J. Med. Chem. | pmid:12190325 |
| Wong RK et al. | Augmentation of the neutrophil respiratory burst through the action of advanced glycation end products: a potential contributor to vascular oxidant stress. | 2002 | Diabetes | pmid:12196480 |
| Goldring WP and Pattenden G | A total synthesis of phomactin A. | 2002 | Chem. Commun. (Camb.) | pmid:12196974 |
| Fujiu T et al. | Cellular adhesion is required for effector functions of human eosinophils via G-protein coupled receptors. | 2002 | Ann. Allergy Asthma Immunol. | pmid:12141728 |
| Kolaczkowska E et al. | Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. | 2002 | Inflammation | pmid:11989789 |
| Bazan NG et al. | What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis. | 2002 | Prog. Brain Res. | pmid:12143339 |
| McLennan SV et al. | Effects of mesangium glycation on matrix metalloproteinase activities: possible role in diabetic nephropathy. | 2002 | Diabetes | pmid:12145178 |
| Claud EC et al. | Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. | 2002 | Pediatr. Res. | pmid:12149490 |
| Unno N et al. | Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass. | 2002 | Surgery | pmid:12110797 |
| Parker MA et al. | Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. | 2002 | J. Neurosci. Res. | pmid:12111814 |
| Chang HW et al. | Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness. | 2002 | Ann. Neurol. | pmid:12112082 |
| Ewer AK | Role of platelet-activating factor in the pathophysiology of necrotizing enterocolitis. | 2002 | Acta Paediatr Suppl | pmid:12200892 |
| Göggel R et al. | Platelet-activating factor-induced pulmonary edema is partly mediated by prostaglandin E(2), E-prostanoid 3-receptors, and potassium channels. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12204861 |
| Bazan H and Ottino P | The role of platelet-activating factor in the corneal response to injury. | 2002 | Prog Retin Eye Res | pmid:12207945 |
| Teather LA et al. | Platelet-activating factor increases prostaglandin E(2) release from astrocyte-enriched cortical cell cultures. | 2002 | Brain Res. | pmid:12133598 |
| De Plaen IG et al. | Endotoxin, but not platelet-activating factor, activates nuclear factor-kappaB and increases IkappaBalpha and IkappaBbeta turnover in enterocytes. | 2002 | Immunology | pmid:12153521 |
| Akisu M et al. | The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic-ischemic brain in young mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468264 |
| Li L et al. | Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica. | 2002 | Eur. J. Pharmacol. | pmid:12163102 |
| Hostettler ME et al. | Platelet-activating factor induces cell death in cultured astrocytes and oligodendrocytes: involvement of caspase-3. | 2002 | Glia | pmid:11968060 |
| Boisfer E et al. | Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II. | 2002 | J. Lipid Res. | pmid:11971944 |
| Steel HC and Anderson R | Dissociation of the PAF-receptor from NADPH oxidase and adenylate cyclase in human neutrophils results in accelerated influx and delayed clearance of cytosolic calcium. | 2002 | Br. J. Pharmacol. | pmid:11976271 |
| McKay CJ | Recent developments in the management of acute pancreatitis. | 2002 | Dig Surg | pmid:11979001 |
| Roudebush WE et al. | Embryonic platelet-activating factor: an indicator of embryo viability. | 2002 | Hum. Reprod. | pmid:11980756 |
| Hostettler ME and Carlson SL | PAF antagonist treatment reduces pro-inflammatory cytokine mRNA after spinal cord injury. | 2002 | Neuroreport | pmid:11924887 |
| Barletta E et al. | Platelet activating factor inhibits the expression of matrix metalloproteinases and affects invasiveness and differentiation in a system of human neuroblastoma clones. | 2002 | Biol. Chem. | pmid:11928813 |
| Larrucea S et al. | Agonist-induced aggregation of Chinese hamster ovary cells coexpressing the human receptors for fibrinogen (integrin alphaIIbbeta3) and the platelet-activating factor: dissociation between adhesion and aggregation. | 2002 | Blood | pmid:11929771 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Ottino P et al. | Platelet-activating factor induces the gene expression of TIMP-1, -2, and PAI-1: imbalance between the gene expression of MMP-9 and TIMP-1 and -2. | 2002 | Exp. Eye Res. | pmid:12014920 |
| Michalis LK et al. | Platelet hyperaggregability to platelet activating factor (PAF) in non-ST elevation acute coronary syndromes. | 2002 | Curr Med Res Opin | pmid:12017208 |
| Zimmerman GA et al. | The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. | 2002 | Crit. Care Med. | pmid:12004251 |
| Silva AR et al. | Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein. | 2002 | J. Immunol. | pmid:11937571 |
| Tachibana A et al. | Respiratory syncytial virus enhances the expression of CD11b molecules and the generation of superoxide anion by human eosinophils primed with platelet-activating factor. | 2002 | Intervirology | pmid:11937770 |
| Kingston JK et al. | Measurement of the activation of equine platelets by use of fluorescent-labeled annexin V, anti-human fibrinogen antibody, and anti-human thrombospondin antibody. | 2002 | Am. J. Vet. Res. | pmid:11939312 |
| Deo DD et al. | Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism. | 2002 | J. Biol. Chem. | pmid:11940567 |
| Acuña AA et al. | Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma. | 2002 | Eur. Respir. J. | pmid:12030727 |
| Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
| Yoshikawa M et al. | Effect of extracellular matrix proteins on platelet-activating factor-induced eosinophil chemotaxis. | 2002 | Int. Arch. Allergy Immunol. | pmid:12065903 |
| Nakamura T et al. | Relationship between the platelet activating factor acetylhydrolase gene and intractability of ulcerative colitis. | 2002 | Dis. Colon Rectum | pmid:12068200 |
| Silva-Neto MA et al. | Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054663 |
| Kingston JK et al. | Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. | 2002 | Am. J. Vet. Res. | pmid:12061530 |
| Zhou ZG and Chen YD | Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. | 2002 | World J. Gastroenterol. | pmid:12046059 |
| Kato T et al. | Mitochondrial calcium response in human transformed lymphoblastoid cells. | 2002 | Life Sci. | pmid:12052442 |
| Downing SJ et al. | Effect of platelet-activating factor on the electrophysiology of the human Fallopian tube: early mediation of embryo-maternal dialogue? | 2002 | Reproduction | pmid:12361471 |
| Donnard M et al. | Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. | 2002 | Stem Cells | pmid:12351810 |
| Leung SW et al. | Platelet-activating factor enhanced the pressor response of endothelin-1. | 2002 | J. Cardiovasc. Pharmacol. | pmid:12352314 |
| Brewer C et al. | Platelet activating factor-induced apoptosis is inhibited by ectopic expression of the platelet activating factor G-protein coupled receptor. | 2002 | J. Neurochem. | pmid:12354298 |
| Marin V et al. | Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type. | 2002 | Eur. J. Immunol. | pmid:12355450 |
| Beauchamp MH et al. | Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356842 |
| Michibayashi T | Platelet aggregating response to platelet activating factor participates in activation of the 12-lipoxygenase pathway in platelets from rabbits. | 2002 | Int Angiol | pmid:12384648 |
| Shigematsu S et al. | Bradykinin-induced proinflammatory signaling mechanisms. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388246 |
| Christie PE and Henderson WR | Lipid inflammatory mediators: leukotrienes, prostaglandins, platelet-activating factor. | 2002 | Clin Allergy Immunol | pmid:11577541 |
| Arai H | Platelet-activating factor acetylhydrolase. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432911 |
| Ishii S et al. | Platelet-activating factor receptor. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432946 |
| Akai T et al. | Modulation of tissue-type plasminogen activator expression by platelet activating factor in human glioma cells. | 2002 | J. Neurooncol. | pmid:12241114 |
| Ibe BO et al. | Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. | 2002 | Mol. Genet. Metab. | pmid:12409272 |
| Childs EW et al. | In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. | 2002 | Shock | pmid:12412620 |
| Eikelboom JW et al. | Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes. | 2002 | Eur. Heart J. | pmid:12419297 |
| Tanaka S and Koike T | Selective inflammatory stimulations enhance release of microglial response factor (MRF)-1 from cultured microglia. | 2002 | Glia | pmid:12420315 |
| Cuschieri J et al. | Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. | 2002 | Surgery | pmid:12219006 |
| Kato M et al. | Platelet-activating factor activates two distinct effector pathways in human eosinophils. | 2002 | J. Immunol. | pmid:12391244 |
| Ueno H et al. | Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure. | 2002 | Crit. Care Med. | pmid:12394951 |
| Sakamoto H et al. | Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. | 2002 | J. Biol. Chem. | pmid:12397078 |
| Ueyama Y et al. | Effects of bile acids on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced aberrant crypt foci and DNA adduct formation in the rat colon. | 2002 | J. Exp. Clin. Cancer Res. | pmid:12636105 |
| Sakai H et al. | E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. | 2002 | Br. J. Pharmacol. | pmid:12023941 |
| Klein A et al. | Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice. | 2002 | Br. J. Pharmacol. | pmid:11877329 |
| Bulger EM et al. | The macrophage response to endotoxin requires platelet activating factor. | 2002 | Shock | pmid:11900334 |
| Mitsuoka H et al. | Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. | 2002 | Shock | pmid:11900339 |
| Kondratskaya EL et al. | BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel. | 2002 | Neurochem. Int. | pmid:11900860 |
| Hu G et al. | Isoflurane inhibits neutrophil-endothelium interactions in the coronary circulation: lack of a role for adenosine triphosphate-sensitive potassium channels. | 2002 | Anesth. Analg. | pmid:11916783 |
| Ozgün H et al. | Lexipafant inhibits postsurgical adhesion formation. | 2002 | J. Surg. Res. | pmid:11922727 |
| Cellai C et al. | Specific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cells. | 2002 | FASEB J. | pmid:11923217 |
| Talvani A et al. | Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. | 2002 | Infect. Immun. | pmid:12117933 |
| Rivera A et al. | Modulation of Gardos channel activity by cytokines in sickle erythrocytes. | 2002 | Blood | pmid:11756192 |
| Hanada K et al. | Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy. | 2002 | J. Exp. Med. | pmid:11781362 |
| Fonteh AN | Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils. Evidence for different arachidonate pools. | 2002 | Eur. J. Biochem. | pmid:12153573 |
| Ohshima N et al. | Receptor-dependent metabolism of platelet-activating factor in murine macrophages. | 2002 | J. Biol. Chem. | pmid:11786559 |
| Stangl V et al. | Negative inotropic mediators released from the heart after myocardial ischaemia-reperfusion. | 2002 | Cardiovasc. Res. | pmid:11744010 |
| Cheminade C et al. | 1-O-alkylglycerols improve boar sperm motility and fertility. | 2002 | Biol. Reprod. | pmid:11804958 |
| Walterscheid JP et al. | Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. | 2002 | J. Exp. Med. | pmid:11805144 |
| Chmiel B | [The influence of select pathophysiologic factors of acute pancreatitis on erythrocytes' deformability examined in vitro]. | 2002 | Wiad. Lek. | pmid:12715347 |
| Furukawa M et al. | Presence of platelet-activating factor in nasal polyps and eosinophils. | 2002 | Acta Otolaryngol. | pmid:12542208 |
| Farmer PJ et al. | Inhibition of prostaglandin G/H synthase unveils a potent effect of platelet activating factor on the permeability of bovine aortic endothelial cells to albumin. | 2002 | Inflammation | pmid:12546134 |
| Tselepis AD and John Chapman M | Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase. | 2002 | Atheroscler Suppl | pmid:12573364 |
| Chen WM et al. | [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12584792 |