Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Flamand N et al. | Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils. | 2006 | Br. J. Pharmacol. | pmid:16967052 |
| Zheng P et al. | Periodontal parameters and platelet-activating factor levels in serum and gingival crevicular fluid in a Chinese population. | 2006 | J. Clin. Periodontol. | pmid:16970624 |
| Tsoupras AB et al. | Isolation and identification of hydroxyl-platelet-activating factor from natural sources. | 2006 | Life Sci. | pmid:16860827 |
| Servillo L et al. | Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages. | 2006 | FASEB J. | pmid:16571775 |
| Flamand N et al. | Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF. | 2006 | J. Leukoc. Biol. | pmid:16501051 |
| He J and Bazan HE | Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16505020 |
| Barthomeuf C et al. | Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | 2006 | Free Radic. Biol. Med. | pmid:16458188 |
| Marchand C et al. | Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells. | 2006 | J. Cell. Biochem. | pmid:16479592 |
| Buchanan MR | Biological basis and clinical implications of acetylsalicylic acid resistance. | 2006 | Can J Cardiol | pmid:16485051 |
| Heinrich S et al. | Evidence-based treatment of acute pancreatitis: a look at established paradigms. | 2006 | Ann. Surg. | pmid:16432347 |
| Ezoulin MJ et al. | Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. | 2006 | Toxicol In Vitro | pmid:16472967 |
| Dianzani C et al. | Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5-triazines. | 2006 | J. Pharm. Pharmacol. | pmid:16451750 |
| Gopichandran N and Leese HJ | The effect of paracrine/autocrine interactions on the in vitro culture of bovine preimplantation embryos. | 2006 | Reproduction | pmid:16452720 |
| Fischer A et al. | The ether lipid inositol-C2-PAF is a potent inhibitor of cell proliferation in HaCaT cells. | 2006 | Chembiochem | pmid:16453359 |
| Liu LR and Xia SH | Role of platelet-activating factor in the pathogenesis of acute pancreatitis. | 2006 | World J. Gastroenterol. | pmid:16489665 |
| Spitzer AL et al. | Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model. | 2006 | Ann. Surg. | pmid:16495704 |
| Biancone L et al. | Platelet-activating factor synthesis and response on pancreatic islet endothelial cells: relevance for islet transplantation. | 2006 | Transplantation | pmid:16495796 |
| Slomiany BL and Slomiany A | Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation interferes with salivary mucin synthesis via platelet activating factor generation. | 2006 | Inflammopharmacology | pmid:16983494 |
| Zhang Q et al. | Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. | 2006 | Exp. Dermatol. | pmid:16984258 |
| Hartvigsen K et al. | 1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB. | 2006 | Lipids | pmid:17069352 |
| Sugimoto S et al. | Purification and characterization of lysophospholipase D from rat brain. | 2006 | Biochim. Biophys. Acta | pmid:17071136 |
| Fallani A et al. | Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085325 |
| Slomiany BL and Slomiany A | Leptin modulates the detrimental effect of Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation on salivary mucin synthesis via ERK-signal transduction. | 2006 | Inflammopharmacology | pmid:17093905 |
| Serradji N et al. | Structure-activity relationships in platelet-activating factor. Part 13: synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity. | 2006 | Bioorg. Med. Chem. | pmid:16893650 |
| Slomiany BL and Slomiany A | Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis. | 2006 | IUBMB Life | pmid:16754300 |
| Moreno SE et al. | Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis. | 2006 | J. Immunol. | pmid:16818786 |
| Machado EM et al. | WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph. | 2006 | J. Insect Physiol. | pmid:16777137 |
| Blanchet MR et al. | Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16782754 |
| Gomes RN et al. | Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. | 2006 | Shock | pmid:16783197 |
| Chen LW et al. | Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. | 2006 | Shock | pmid:16783201 |
| Sneddon AA et al. | Cytokine-induced monocyte adhesion to endothelial cells involves platelet-activating factor: suppression by conjugated linoleic acid. | 2006 | Biochim. Biophys. Acta | pmid:16829183 |
| Holder E et al. | Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation. | 2006 | Gene Ther. | pmid:16791284 |
| Kaneko MK et al. | Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor. | 2006 | Gene | pmid:16766141 |
| De Plaen IG et al. | Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor. | 2006 | Immunology | pmid:16771850 |
| Karabina SA and Ninio E | Plasma PAF-acetylhydrolase: an unfulfilled promise? | 2006 | Biochim. Biophys. Acta | pmid:16807087 |
| Cheng L et al. | Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16807360 |
| Fragopoulou E et al. | Platelet-activating factor (PAF) increase intracellular lipid accumulation by increasing both LDL and scavenger receptors in human mesangial cells. | 2006 | J. Lab. Clin. Med. | pmid:16750665 |
| McLaughlin NJ et al. | Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. | 2006 | J. Immunol. | pmid:16709866 |
| Hsu HC et al. | Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16712790 |
| Mathonnet M et al. | Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma. | 2006 | World J. Gastroenterol. | pmid:16718768 |
| Cellai C et al. | Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. | 2006 | Br. J. Cancer | pmid:16721373 |
| Melnikova VO et al. | Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. | 2006 | J. Biol. Chem. | pmid:16306050 |
| Karagiorga G et al. | Biochemical parameters of bronchoalveolar lavage fluid in fat embolism. | 2006 | Intensive Care Med | pmid:16322975 |
| Faghiri Z and Bazan NG | Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16384990 |
| Pégorier S et al. | Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis. | 2006 | Atherosclerosis | pmid:16386258 |
| Poeckel D et al. | 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16174802 |
| Waschke J et al. | Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier. | 2006 | Histochem. Cell Biol. | pmid:16195887 |
| Kushikata T et al. | Platelet activating factor and its metabolite promote sleep in rabbits. | 2006 | Neurosci. Lett. | pmid:16263215 |
| Gomes MT et al. | Platelet-activating factor-like activity isolated from Trypanosoma cruzi. | 2006 | Int. J. Parasitol. | pmid:16337632 |
| Karantonis HC et al. | Effect of fast-food Mediterranean-type diet on type 2 diabetics and healthy human subjects' platelet aggregation. | 2006 | Diabetes Res. Clin. Pract. | pmid:16236380 |
| Dohi T et al. | [Role of platelet-activating factor on spinal pain transduction]. | 2006 | Nippon Yakurigaku Zasshi | pmid:16508219 |
| Wu J et al. | Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. | 2006 | Biochem. J. | pmid:16255717 |
| Karidis NP et al. | Platelet-activating factor in liver injury: a relational scope. | 2006 | World J. Gastroenterol. | pmid:16773686 |
| Chu WF et al. | Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16433899 |
| Ozturk H et al. | PAF antagonist BN-52021 reduces intercellular adhesion molecule-1 expression and oxidative stress in rats with reperfusion damage due to unilateral testicular torsion. | 2006 | Pediatr. Surg. Int. | pmid:16369775 |
| Louis NA et al. | Lipid mediator networks and leukocyte transmigration. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979294 |
| Spitzer AL et al. | Early nonenhanced abdominal computed tomography can predict mortality in severe acute pancreatitis. | 2005 Sep-Oct | J. Gastrointest. Surg. | pmid:16137586 |
| Akyürek N et al. | The effect of platelet activating factor antagonist BN 52021 on bacterial translocation and ICAM-I expression in experimental obstructive jaundice. | 2005 Sep-Oct | J Invest Surg | pmid:16249168 |
| O'Neill C | The role of paf in embryo physiology. | 2005 May-Jun | Hum. Reprod. Update | pmid:15790601 |
| Krasheninnikov ME and Pliashkevich IuG | [Effects of the platelet activating factor on the proliferation and IgE secretion by U-266BL human myeloma cells]. | 2005 Jul-Aug | Eksp Klin Farmakol | pmid:16193656 |
| Marrache AM et al. | Intracellular signaling of lipid mediators via cognate nuclear G protein-coupled receptors. | 2005 Jan-Apr | Endothelium | pmid:16036317 |
| Choi IW et al. | TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation. | 2005 | J. Allergy Clin. Immunol. | pmid:16159621 |
| Caplan MS et al. | The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. | 2005 | Semin. Pediatr. Surg. | pmid:16084401 |
| Denizot Y et al. | Platelet-activating factor and liver metastasis of colorectal cancer. | 2005 | Int. J. Cancer | pmid:15455343 |
| Shindou H et al. | Priming effect of lipopolysaccharide on acetyl-coenzyme A:lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent. | 2005 | J. Immunol. | pmid:16002720 |
| Black S et al. | An intact phosphocholine binding site is necessary for transgenic rabbit C-reactive protein to protect mice against challenge with platelet-activating factor. | 2005 | J. Immunol. | pmid:16002722 |
| Koch E | Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. | 2005 | Phytomedicine | pmid:15693702 |
| Jantan I et al. | Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. | 2005 | Phytomedicine | pmid:15693713 |
| El-Medany A et al. | Attenuation of bleomycin-induced lung fibrosis in rats by mesna. | 2005 | Eur. J. Pharmacol. | pmid:15713430 |
| Ninio E | Phospholipid mediators in the vessel wall: involvement in atherosclerosis. | 2005 | Curr Opin Clin Nutr Metab Care | pmid:15716789 |
| Evans L et al. | A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies. | 2005 | J. Pharm. Pharmacol. | pmid:15720781 |
| Yoshida H et al. | Platelet-activating factor enhances the expression of nerve growth factor in normal human astrocytes under hypoxia. | 2005 | Brain Res. Mol. Brain Res. | pmid:15661369 |
| Zhu L and He P | Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15665052 |
| Cuschieri J et al. | Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming. | 2005 | Shock | pmid:15665723 |
| Cheng L et al. | Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis. | 2005 | Gastroenterology | pmid:16285965 |
| Hardy P et al. | New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850712 |
| Chen LW et al. | Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils. | 2005 | J. Biomed. Sci. | pmid:15917990 |
| Goldring WP et al. | Novel phomactin analogues as PAF receptor ligands. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15922596 |
| Tombul T et al. | Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction. | 2005 | J Clin Neurosci | pmid:15925775 |
| Boccellino M et al. | Platelet-activating factor regulates cadherin-catenin adhesion system expression and beta-catenin phosphorylation during Kaposi's sarcoma cell motility. | 2005 | Am. J. Pathol. | pmid:15855650 |
| Schram MT et al. | Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study. | 2005 | Hypertension | pmid:15851628 |
| Denizot Y et al. | Platelet-activating factor and human thyroid cancer. | 2005 | Eur. J. Endocrinol. | pmid:15994743 |
| Androulakis N et al. | Molecular and mechanistic characterization of platelet-activating factor-like bioactivity produced upon LDL oxidation. | 2005 | J. Lipid Res. | pmid:15995176 |
| Grypioti AD et al. | Platelet-activating factor (PAF) involvement in acetaminophen-induced liver toxicity and regeneration. | 2005 | Arch. Toxicol. | pmid:15995853 |
| Chatterjee BE et al. | Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. | 2005 | J. Leukoc. Biol. | pmid:16000391 |
| Guo NJ et al. | [Activation of platelet-neutrophil mediated by platelet-activating factor]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15972139 |
| Uhlig S et al. | Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung. | 2005 | Pharmacol Rep | pmid:16415501 |
| Perry SW et al. | HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. | 2005 | J. Immunol. | pmid:15778398 |
| Ishiura Y et al. | In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789611 |
| Gaudreault E et al. | Involvement of leukotriene B4 receptor 1 signaling in platelet-activating factor-mediated neutrophil degranulation and chemotaxis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789613 |
| Calcerrada MC et al. | Selective translocation of protein kinase c isozymes by PAF in rabbit platelets. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789614 |
| Hudry-Clergeon H et al. | Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase. | 2005 | FASEB J. | pmid:15791001 |
| Ersoy B et al. | The role of platelet-activating factor in pathogenesis of type 1 diabetes. | 2005 | Diabetes Care | pmid:15793212 |
| Grigoriou O et al. | Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination. | 2005 | Fertil. Steril. | pmid:15749490 |
| Cheng HH et al. | Defect in regulation of Ca2+ movement in platelets from patients with systemic lupus erythematosus. | 2005 | Pharmacology | pmid:15591819 |
| Penna C et al. | Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15637120 |
| Besana A et al. | Lipids and two-pore domain K+ channels in excitable cells. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099395 |
| Vieira-de-Abreu A et al. | Anti-allergic properties of the bromeliaceae Nidularium procerum: inhibition of eosinophil activation and influx. | 2005 | Int. Immunopharmacol. | pmid:16275631 |
| Bellizzi MJ et al. | Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor. | 2005 | J. Clin. Invest. | pmid:16276420 |
| Yu P et al. | Mitogen-activated protein kinases regulate platelet-activating factor-induced hyperpermeability. | 2005 | Microcirculation | pmid:16284005 |