Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Denizot Y et al. | PAF and hematopoiesis. VIII. Biosynthesis and metabolism of PAF by human bone marrow stromal cells. | 1996 | Exp. Hematol. | pmid:8862444 |
Wang X et al. | Potentiation of acetylcholine-induced responses in freshly isolated rabbit aortic endothelial cells. | 1996 Sep-Oct | J. Vasc. Res. | pmid:8862147 |
Saito H et al. | Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8859220 |
Jouët P and Sarna SK | Platelet-activating factor (PAF) stimulates giant migrating contractions during ileal inflammation. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8858995 |
Shi LC et al. | Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells. | 1996 | J. Neurochem. | pmid:8858930 |
Lopes-Martins R et al. | Pharmacological evidence of a role for platelet activating factor as a modulator of vasomotor tone and blood pressure. | 1996 | Eur. J. Pharmacol. | pmid:8858301 |
Abu-Zidan FM et al. | Role of platelet-activating factor antagonism in posthemorrhage septic shock in pigs. | 1996 | J Trauma | pmid:8858021 |
Mastroroberto P et al. | Elevated circulating levels of von Willebrand factor and D-dimer in patients with heart failure and mechanical prosthesis. | 1996 | Scand J Thorac Cardiovasc Surg | pmid:8857679 |
Albert DH et al. | ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. | 1996 | Shock | pmid:8856845 |
Chen CC et al. | Tumor necrosis factor-alpha, platelet-activating factor, and hydrogen peroxide activate protein kinase C subtypes alpha and epsilon in human saphenous vein endothelial cells. | 1996 | J. Cardiovasc. Pharmacol. | pmid:8856479 |
Ebara T et al. | Role of platelet-activating factor and prostanoids in hemodynamic changes in rat experimental endotoxic shock. | 1996 | Jpn. J. Pharmacol. | pmid:8854207 |
Gaylord MS et al. | Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. | 1996 | Am. J. Med. Sci. | pmid:8853062 |
Hoffman BF et al. | Arrhythmias caused by platelet activating factor. | 1996 | J. Cardiovasc. Electrophysiol. | pmid:8853022 |
Renesto P et al. | Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils. | 1996 | Br. J. Pharmacol. | pmid:8851508 |
Hahn M et al. | Blockade of receptor-operated calcium channels by mibefradil (Ro 40-5967): effects on intracellular calcium and platelet aggregation. | 1995 | Cardiovasc Drugs Ther | pmid:8850387 |
Yokota K et al. | Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro. | 1996 | Jpn. J. Pharmacol. | pmid:8847836 |
Libert C et al. | Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality. | 1995-1996 | J. Inflamm. | pmid:8844494 |
Kemény L et al. | Effect of locally applied WEB 2086, a platelet-activating factor antagonist, on inflammatory skin conditions in mice. | 1996 | Arch. Dermatol. Res. | pmid:8844132 |
Paulino N et al. | Mechanisms involved in the contractile responses induced by the hydroalcoholic extract of Phyllanthus urinaria on the guinea pig isolated trachea: evidence for participation of tachykinins and influx of extracellular Ca2+ sensitive to ruthenium red. | 1996 | Gen. Pharmacol. | pmid:8842681 |
Tenor H et al. | Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. | 1996 | Br. J. Pharmacol. | pmid:8842438 |
Isogai E et al. | [Platelet activating factor (PAF) and Lyme disease]. | 1996 | Nippon Saikingaku Zasshi | pmid:8840817 |
Imagawa M et al. | Modulation of platelet-activating factor synthesis by recombinant interferon-alpha in human renal cell carcinoma. | 1996 | Urol. Int. | pmid:8840484 |
Kurata M et al. | A comparative study of whole-blood platelet aggregation in laboratory animals: its species differences and comparison with turbidimetric method. | 1995 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:8838690 |
Louis RE and Radermecker MF | Acute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine. | 1996 | Eur. Respir. J. | pmid:8836652 |
Barkai U and Kraicer PF | Intrauterine signaling and embryonic implantation. | 1996 Mar-Apr | Biol. Signals | pmid:8836494 |
Taylor ML et al. | Differential expression of platelet activation markers in aspirin-sensitive asthmatics and normal subjects. | 1996 | Clin. Exp. Allergy | pmid:8835129 |
Gabryelewicz A | Etiology and pathogenesis of acute pancreatitis--current view. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8834603 |
Matsuo Y et al. | Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain. | 1996 | Brain Res. | pmid:8833766 |
Tsukioka K et al. | Increased plasma level of platelet-activating factor (PAF) and decreased serum PAF acetylhydrolase (PAFAH) activity in adults with bronchial asthma. | 1996 Jan-Feb | J Investig Allergol Clin Immunol | pmid:8833165 |
Savu SR et al. | Determination of 1-O-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, platelet-activating factor and related phospholipids in biological samples by high-performance liquid chromatography--tandem mass spectrometry. | 1996 | J. Chromatogr. B, Biomed. Appl. | pmid:8832423 |
Ribaldi E et al. | Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation. | 1996 | Br. J. Pharmacol. | pmid:8832056 |
Sandoval D et al. | The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. | 1996 | Gastroenterology | pmid:8831604 |
Galloway SW and Kingsnorth AN | Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist. | 1996 | Pancreas | pmid:8829181 |
Spangelo BL and Jarvis WD | Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. | 1996 | Endocrinology | pmid:8828503 |
López-Novoa JM et al. | The role of platelet-activating factor and the effect of PAF blocking receptors on the outcome of ARF. | 1996 | Ren Fail | pmid:8827995 |
Grinyó JM et al. | The role of platelet-activating factor antagonists in the prophylaxis of posttransplant acute tubular necrosis. | 1996 | Ren Fail | pmid:8827990 |
Burt RP et al. | The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens. | 1996 | Br. J. Pharmacol. | pmid:8825367 |
Predescu D et al. | The vascular distribution of the platelet-activating factor receptor. | 1996 | Eur. J. Cell Biol. | pmid:8825027 |
Yang HO et al. | Biological and pharmacological effects of pinusolide, a novel platelet activating factor antagonist. | 1995 | Planta Med. | pmid:8824945 |
Murakami K et al. | A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats. | 1996 | Thromb. Haemost. | pmid:8822594 |
Miguélez R et al. | Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis. | 1996 | J Lipid Mediat Cell Signal | pmid:8821809 |
Kuitert L and Barnes NC | PAF and asthma--time for an appraisal? | 1995 | Clin. Exp. Allergy | pmid:8821294 |
Lin J et al. | Effects of platelet-activating factor (PAF) receptor blockage on mucous glycoprotein secretion in cultured chinchilla middle ear epithelium. | 1996 | Acta Otolaryngol. | pmid:8820353 |
Abu-Zidan FM and Walther S | Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs. | 1996 | Eur J Surg | pmid:8817228 |
Le Solleu H et al. | A pharmacophore for high affinity PAF antagonists. I. Electronic model using molecular electrostatic potential. | 1996 | J Lipid Mediat Cell Signal | pmid:8816988 |
Le Texier L et al. | Structure-activity relationships in platelet-activating factor (PAF). 8. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors: anti-acetylcholinesterase activity and comparative SAR. | 1996 | J Lipid Mediat Cell Signal | pmid:8816985 |
Le Texier L et al. | Structure-activity relationships in platelet-activating factor (PAF). 7. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors. Synthesis and PAF-antagonistic activity. | 1996 | J Lipid Mediat Cell Signal | pmid:8816984 |
Bauldry SA and Wooten RE | Leukotriene B4 and platelet activating factor production in permeabilized human neutrophils: role of cytosolic PLA2 in LTB4 and PAF generation. | 1996 | Biochim. Biophys. Acta | pmid:8816854 |
Sato E et al. | Bradykinin stimulates alveolar macrophages to release neutrophil, monocyte, and eosinophil chemotactic activity. | 1996 | J. Immunol. | pmid:8816423 |
Erger RA and Casale TB | Eosinophil migration in response to three molecular species of platelet activating factor. | 1996 | Inflamm. Res. | pmid:8814455 |
Tao Y et al. | Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8814143 |
Durán WN et al. | Platelet-activating factor modulates leukocyte adhesion to endothelium in ischemia-reperfusion. | 1996 | Microvasc. Res. | pmid:8812764 |
Yasugahira H et al. | [The changes of blood gas analysis values and platelet aggregability on acute phase in the experimental model of pulmonary embolism prepared by sephadex G-75 (SG-75) injection]. | 1996 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8810754 |
Tachibana F et al. | Platelet-activating factor and leukotrienes in acute otitis media, secretory otitis media, and chronic otitis media on the acute excerbation. | 1996 | Auris Nasus Larynx | pmid:8809319 |
Arima S et al. | Platelet-activating factor dilates efferent arterioles through glomerulus-derived nitric oxide. | 1996 | J. Am. Soc. Nephrol. | pmid:8808114 |
Dunlop ME et al. | Production of hyaluronan by glomerular mesangial cells in response to fibronectin and platelet-derived growth factor. | 1996 | Kidney Int. | pmid:8807570 |
Baskin SI et al. | The effects of EDRF/NO releasers or calcium ionophore A23187 on cyanide toxicity in mice. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8806852 |
Catalán RE et al. | Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806587 |
Marrakchi N et al. | [Biochemical and pharmacologic properties of platelet aggregants and platelet antiaggregants of viper venoms in Tunisia]. | 1994 Jul-Oct | Arch Inst Pasteur Tunis | pmid:8801850 |
Noguchi K et al. | Involvement of nitric oxide and eicosanoids in platelet-activating factor-induced haemodynamic and haematological effects in dogs. | 1996 | Br. J. Pharmacol. | pmid:8799566 |
Civelli M et al. | The involvement of the release of nitric oxide in the pharmacological activity of the new furoxan derivative CHF 2363. | 1996 | Br. J. Pharmacol. | pmid:8799563 |
Westmoreland SV et al. | Toxicity of TNF alpha and platelet activating factor for human NT2N neurons: a tissue culture model for human immunodeficiency virus dementia. | 1996 | J. Neurovirol. | pmid:8799203 |
van Rossem K et al. | The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. | 1996 | Adv. Exp. Med. Biol. | pmid:8798843 |
Marcheselli VL and Bazan NG | Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. | 1996 | J. Biol. Chem. | pmid:8798751 |
Parent JL et al. | Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis. | 1996 | J. Biol. Chem. | pmid:8798529 |
Abebe W et al. | Platelet-activating factor-induced inositol 1,4,5-trisphosphate generation in undifferentiated and differentiated U937 cells: role of tyrosine kinase. | 1996 | Int. J. Immunopharmacol. | pmid:8796445 |
Takeda H et al. | Release of fructose and hexose phosphates from perivascular cells induced by low density lipoprotein and acceleration of protein glycation in vitro. | 1996 | Diabetes Res. Clin. Pract. | pmid:8792096 |
Weikert LF and Bernard GR | Pharmacotherapy of sepsis. | 1996 | Clin. Chest Med. | pmid:8792067 |
Aïssa J et al. | Biochemical and cellular effects of heparin-protamine injection in rabbits are partially inhibited by a PAF-acether receptor antagonist. | 1996 | Eur. J. Pharmacol. | pmid:8791000 |
Naraba H et al. | Inhibitory effect of arachidonic acid on platelet-activating factor production in rat neutrophils. | 1996 | Eur. J. Pharmacol. | pmid:8790999 |
Bazan NG and Allan G | Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. | 1996 | Adv Neurol | pmid:8790822 |
Hirafuji M et al. | Involvement of platelet cyclic GMP but not cyclic AMP suppression in leukocyte-dependent platelet adhesion to endothelial cells induced by platelet-activating factor in vitro. | 1996 | Br. J. Pharmacol. | pmid:8789382 |
Battye KM et al. | Ovine endometrium synthesizes and releases platelet-activating factor, which can cause the release of prostaglandin F2 alpha by the uterus in situ. | 1996 | Biol. Reprod. | pmid:8788186 |
Yoshii H et al. | Neurotropin inhibits accumulation of eosinophils induced by allergen through the suppression of sensitized T-cells. | 1995 | Int. J. Immunopharmacol. | pmid:8788117 |
Baker RR | Enzymes of platelet activating factor synthesis in brain. | 1995 | Neurochem. Res. | pmid:8786821 |
Ogundaini A et al. | Isolation of two new antiinflammatory biflavanoids from Sarcophyte piriei. | 1996 | J. Nat. Prod. | pmid:8786365 |
Uhlig S et al. | Cyclooxygenase-2-dependent bronchoconstriction in perfused rat lungs exposed to endotoxin. | 1996 | Mol. Med. | pmid:8784790 |
Sasaki T et al. | A distribution study of 11C platelet-activating factor (PAF) analogs in normal and tumor-bearing mice. | 1996 | Nucl. Med. Biol. | pmid:8782242 |
Almer S et al. | Concentrations of platelet activating factor in rectal mucosa in patients with ulcerative colitis. | 1996 | Eur J Surg | pmid:8781921 |
Yang X et al. | Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective phospholipase C activation. | 1996 | Blood | pmid:8781423 |
Khoury J and Langleben D | Platelet-activating factor stimulates lung pericyte growth in vitro. | 1996 | Am. J. Physiol. | pmid:8780000 |
Kurose I et al. | Microvascular dysfunction induced by nonsteroidal anti-inflammatory drugs: role of leukocytes. | 1996 | Am. J. Physiol. | pmid:8779980 |
Sterner-Kock A et al. | Recombinant tumour necrosis factor-alpha and platelet-activating factor synergistically increase intercellular adhesion molecule-1 and E-selectin-dependent neutrophil adherence to endothelium in vitro. | 1996 | Immunology | pmid:8778033 |
Izumi T et al. | Platelet-activating factor receptor. | 1995 | J Lipid Mediat Cell Signal | pmid:8777584 |
Sobhani I et al. | Helicobacter pylori stimulates gastric acid secretion via platelet activating factor. | 1996 | J. Physiol. Pharmacol. | pmid:8777297 |
Ayala A and Chaudry IH | Platelet activating factor and its role in trauma, shock, and sepsis. | 1996 | New Horiz | pmid:8774801 |
Nabe T et al. | Sephadex G-200-induced eosinophil infiltration into airways in non-sensitized and sensitized guinea pigs, and responsiveness of the cells to stimuli in vitro. | 1996 | Jpn. J. Pharmacol. | pmid:8774762 |
Ueno A et al. | The mediators involved in endotoxin-induced vascular permeability increase in the rat skin and their interactions. | 1996 | Jpn. J. Pharmacol. | pmid:8774757 |
Moriguchi T et al. | Diamide primes neutrophils for enhanced release of superoxide anion: relationship to S-thiolation of cellular proteins. | 1996 | J. Leukoc. Biol. | pmid:8773580 |
Kamata K et al. | Mechanisms of desensitization of vasodilatation induced by platelet-activating factor in hypertensive rats. | 1996 | Eur. J. Pharmacol. | pmid:8773455 |
Sun XM et al. | Role of leukocyte beta 2-integrin in PAF-induced shock and intestinal injury. | 1996 | Am. J. Physiol. | pmid:8772517 |
Reinhardt PH et al. | Monosodium urate crystals promote neutrophil adhesion via a CD18-independent and selectin-independent mechanism. | 1996 | Am. J. Physiol. | pmid:8772427 |
Shebzukhov IuV et al. | [The effect of platelet-activating factor and its synthetic analogs on Ia-antigen expression by mouse peritoneal macrophages]. | 1996 May-Jun | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:8771751 |
Walcher F et al. | Platelet-activating factor is involved in the regulation of pathological leukocyte adhesion after liver transplantation. | 1996 | J. Surg. Res. | pmid:8769973 |
Harris NR and Granger DN | Mechanisms underlying enhanced capillary filtration induced by platelet-activating factor. | 1996 | Am. J. Physiol. | pmid:8769743 |
de Paulis A et al. | Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. | 1996 | J. Allergy Clin. Immunol. | pmid:8765829 |
Baker RR and Chang HY | Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex. | 1996 | Biochim. Biophys. Acta | pmid:8765148 |
Xie X et al. | Interdigitation of bilayers from ether lipid analogs: (R)-PAF, (R)-Lyso-PAF and the antineoplastic (R)-ET-18-OMe. | 1996 | Biochim. Biophys. Acta | pmid:8765102 |
Lupia E et al. | Role of tumor necrosis factor-alpha and platelet-activating factor in neoangiogenesis induced by synovial fluids of patients with rheumatoid arthritis. | 1996 | Eur. J. Immunol. | pmid:8765007 |
DeFily DV et al. | PAF attenuates endothelium-dependent coronary arteriolar vasodilation. | 1996 | Am. J. Physiol. | pmid:8764261 |