Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Corneal Neovascularization D016510 8 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Strongylida Infections D017206 5 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Venous Thrombosis D020246 11 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Thrombophilia D019851 6 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Colitis, Ischemic D017091 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Lagente V et al. Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. 1987 Prostaglandins pmid:2438723
Sakuma Y et al. Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice. 1991 Prostaglandins pmid:1801063
Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. 1987 Prostaglandins pmid:3671731
Billah MM et al. Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. 1985 Prostaglandins pmid:3936121
Kuzan FB et al. Role of spermatozoal platelet-activating factor in fertilization. 1990 Prostaglandins pmid:2155438
Takehara S et al. Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors. 1990 Prostaglandins pmid:1965554
Madden MC et al. Polarized release of lipid mediators derived from phospholipase A2 activity in a human bronchial cell line. 1994 Prostaglandins pmid:7809385
Bruijnzeel PL et al. Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. 1987 Prostaglandins pmid:3118415
Kikukawa Y et al. The effect of platelet activating factor on ovulation. 1991 Prostaglandins pmid:1775639
Pons L et al. Role of platelet-activating factor (PAF) and prostaglandins in colonic motor and secretory disturbances induced by Escherichia coli endotoxin in conscious rats. 1994 Prostaglandins pmid:8016383
Lee MJ et al. Endothelial cell 1-acyl-platelet-activating factor synthesis in response to anticardiolipin antibody-positive serum fractions. 1994 Prostaglandins pmid:8016391
Kaminski DL et al. The production of experimental cholecystitis by endotoxin. 1994 Prostaglandins pmid:8016392
Ibbotson GC and Wallace JL Beneficial effects of prostaglandin E2 in endotoxic shock are unrelated to effects on PAF-acether synthesis. 1989 Prostaglandins pmid:2727308
Yamanaka S et al. 11-Dehydro thromboxane B2: a reliable parameter of thromboxane A2 production in dogs. 1993 Prostaglandins pmid:8484010
Myers AK et al. Antagonism of PAF-induced death in mice. 1988 Prostaglandins pmid:3131837
Levine L Effects of the protein kinase inhibitors, staurosporine and K-252a, on PGI2 production by rat liver cells (the C-9 cell line). 1990 Prostaglandins pmid:2247616
Subissi A et al. Effects of anti-asthma drugs on PAF-induced death in mice. 1988 Prostaglandins pmid:2907663
Etienne A et al. Modulation of eosinophil recruitment in the rat by the platelet-activating factor (PAF) antagonist, BN 52021, the somatostatin analog, BIM 23014, and by cyclosporin A. 1989 Prostaglandins pmid:2748916
Morganroth ML et al. Decreased pulmonary vascular responsiveness in rats raised on an essential fatty acid deficient diet. 1987 Prostaglandins pmid:3108962
Terasawa M et al. Pharmacological actions of Y-24180: I. A potent and specific antagonist of platelet-activating factor. 1990 Prostaglandins pmid:2093935
Trochtenberg DS et al. Effects of thromboxane synthase and cyclooxygenase inhibition on PAF-induced changes in lung function and arachidonic acid metabolism. 1992 Prostaglandins pmid:1475377
Kim YD et al. Constriction of canine coronary arteries by platelet activating factor after brief ischemia. 1993 Prostaglandins pmid:8234834
Guinot P et al. Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergens in asthmatic patients. A preliminary study. 1987 Prostaglandins pmid:3432562
Ernst A et al. The effect of PAF in the cochlea of guinea pigs. 1989 Prostaglandins pmid:2602560
Chan WP and Levy JV Effects of antiplatelet agents on platelet aggregation induced by platelet--activating factor (PAF) in human whole blood. 1991 Prostaglandins pmid:1665568
Sakuma Y et al. Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs. 1991 Prostaglandins pmid:1763202
Camussi G et al. Inhibitory effect of prostacyclin (PGI2) on neutropenia induced by intravenous injection of platelet-activating-factor (PAF) in the rabbit. 1983 Prostaglandins pmid:6346397
Bureau M et al. Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. 1987 Prostaglandins pmid:3035615
Küster LJ and Frölich JC Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. 1986 Prostaglandins pmid:3097760
Moodley I and Stuttle A Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. 1987 Prostaglandins pmid:3035617
Cordeiro RS et al. Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. 1986 Prostaglandins pmid:3103172
Geissler FT et al. Lipid mediator production by post-implantation rat embryos in vitro. 1989 Prostaglandins pmid:2505333
Ezra D et al. Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig. 1987 Prostaglandins pmid:3685397
Hébert RL et al. Hemodynamic effects of PAF-acether on the dog kidney. 1987 Prostaglandins Leukot Med pmid:3033688
Otsuka A et al. Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. 1985 Prostaglandins Leukot Med pmid:3862138
Riedel A and Mest HJ The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. 1987 Prostaglandins Leukot Med pmid:3112804
Mehta J et al. Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. 1986 Prostaglandins Leukot Med pmid:3456620
Oh S et al. Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. 1986 Prostaglandins Leukot Med pmid:3459197
Acharya SB and MacIntyre DE Platelet products and vascular PGI2 production. 1983 Prostaglandins Leukot Med pmid:6338532
Hertelendy F and Zakár T Prostaglandins and the myometrium and cervix. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14683694
Herron D et al. Inhibition of PAF-induced human platelet aggregation by antithrombotic nipecotomides. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7630919
Gáti I et al. Effects of the PAF-analog and -antagonist CV-6209 on cultured human glioma cell lines. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1886907
Norman SJ and Poyser NL The effects of platelet-activating factor on the output of prostaglandins from the guinea-pig uterus. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1492106
Taylor KE et al. Could platelet activating factor play a role in developmental dyslexia? 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11334553
Mózes T et al. Protective effect of diclofenac sodium against endotoxic shock in anaesthetized pigs. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8446657
Shindo K et al. Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9431823
Akisu M et al. Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12878450
Landgraf RG et al. Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17923399
Sugatani J et al. The role of platelet activating factor (PAF) in the pathogenesis of gastric ulcers. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1808623
Cui S et al. L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17395449
Becker K et al. Influence of some prostaglandins and prostaglandin analogues on PAF-induced shock in mice. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:1696744
Wang HG et al. Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9384519
Hardy P et al. New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850712
Mentz P et al. Interactions of prostanoids with the platelet activating factors. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1279731
Richter M et al. Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17448648
Louis NA et al. Lipid mediator networks and leukocyte transmigration. 2005 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:15979294
Akisu M et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic-ischemic brain in young mice. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12468264
de Lima WT et al. Studies on the mechanism of PAF-induced vasopermeability in rat lungs. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7784472
Hughes H et al. PAF formation by H2O2-stimulated perfused canine carotid arteries. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846103
Albertini M and Clement MG In pigs, inhaled nitric oxide (NO) counterbalances PAF-induced pulmonary hypertension. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846107
Hirata Y et al. Enhancement of thrombotic arterial occlusion following cholesterol feeding in the guinea-pig: a role for thromboxane A2. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7972270
Sakurai T et al. Pharmacological studies of platelet-activating factor (PAF)-induced augmentation of response to histamine in guinea-pigs. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7972272
Galli C et al. Modulation of lipid derived mediators by polyunsaturated fatty acids. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8424123
Tsunoda H et al. Involvement of leukotriene C4 in PAF-induced death in mice. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2353029
Ichimaru T and Tai HH Alteration of platelet activating factor (PAF) metabolism in rat pulmonary alveolar macrophages and plasma by cigarette smoking. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1461922
Becker K et al. PAF effects on eicosanoid release in neonatal rat cardiomyocytes. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7480082
Evans RD et al. Platelet-activating factor and its metabolic effects. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1946557
Salamonsen LA Effect of platelet activating factor on prostaglandin release from ovine endometrial cells in culture. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1946564
Travis SP and Jewell DP The role of platelet-activating factor in the pathogenesis of gastrointestinal disease. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:8208748
Albertini M and Clement MG Inhaled nitric oxide reverses PAF-dependent bronchoconstriction in the pig. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7644558
Evangelou AM Platelet-activating factor (PAF): implications for coronary heart and vascular diseases. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:8146205
Viossat I et al. Effects of platelet activating factor (PAF) and its receptor antagonist BN 52021 on isolated perfused guinea-pig heart. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2622972
Shindo K and Fukumura M Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8951989
González E et al. A novel enhancing effect of platelet activating factor (PAF) on glucose oxidation in uteri from pregnant rats. Participation of prostaglandins and leukotrienes. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2399270
Peplow PV and Mikhailidis DP Platelet-activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2274568
Jeremy JY et al. Eicosanoids and septicaemia. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7938078
Monthly prostaglandin bibliography prepared by the University of Sheffield Biomedical Information Service. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:8577776
Berdeli A et al. Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15301793
Shindo K et al. Effect of azelastine hydrochloride on release and production of platelet activating factor in human neutrophils. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9175174
Clement MG et al. PAF and the role of the vagus nerve in the breathing pattern of the pig. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1561234
Saito M et al. Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8415807
Arribas I et al. Direct interactions between platelets and cultured rat mesangial cells. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8415809
Plante GE et al. Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3231663
Pédrono F et al. Natural 1-O-alkylglycerols reduce platelet-activating factor-induced release of [3H]-serotonin in rabbit platelets. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15172680
Becker K et al. PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8385779
Wise H Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9482170
Peplow PV Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10509861
Kikuchi M et al. Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. 2008 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:18502110
Shindo K and Fukumura M Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9578146
Tiemann U et al. Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. 2001 Prostaglandins Other Lipid Mediat. pmid:11403499
Tiemann U et al. Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating factor receptor in endometrial explant perfusion cultures from ovariectomized bovine. 2005 Prostaglandins Other Lipid Mediat. pmid:15967160
Tsutsumi T et al. Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. 2007 Prostaglandins Other Lipid Mediat. pmid:17259070
Chen C and Bazan NG Lipid signaling: sleep, synaptic plasticity, and neuroprotection. 2005 Prostaglandins Other Lipid Mediat. pmid:16099392
Hla T Prostaglandins & other lipid mediators: a new phase, a new team. 2004 Prostaglandins Other Lipid Mediat. pmid:15165026
Ruan Z et al. Effects of platelet-activating factor and thromboxane A2 on isolated perfused guinea pig liver. 2004 Prostaglandins Other Lipid Mediat. pmid:15165033
Nomikos TN et al. Application of a TCA-precipitation method for the determination of 1-alkyl-sn-glycero-3-phosphate: Acetyl-CoA acetyltransferase in human renal tissue. 2004 Prostaglandins Other Lipid Mediat. pmid:15165037
Watanabe S et al. Suppression of platelet-activating factor generation and modulation of arachidonate metabolism by dietary enrichment with (n-9) eicosatrienoic acid or docosahexaenoic acid in mouse peritoneal cells. 2001 Prostaglandins Other Lipid Mediat. pmid:11534547
Argyrou C et al. Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes. 2017 Prostaglandins Other Lipid Mediat. pmid:28323197
Hiran T et al. Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. 2001 Prostaglandins Other Lipid Mediat. pmid:11785782
Besana A et al. Lipids and two-pore domain K+ channels in excitable cells. 2005 Prostaglandins Other Lipid Mediat. pmid:16099395