| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperalgesia | D006930 | 42 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Ventricular Fibrillation | D014693 | 16 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Pneumococcal Infections | D011008 | 7 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Shock, Septic | D012772 | 11 associated lipids |
| Immune Complex Diseases | D007105 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prunieras M | Melanocytes, melanogenesis, and inflammation. | 1986 | Int. J. Dermatol. | pmid:2433237 |
| Foegh ML et al. | Prolongation of cardiac allograft survival with BN 52021, a specific antagonist of platelet-activating factor. | 1986 | Transplantation | pmid:3523888 |
| Rampart M and Williams TJ | Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. | 1986 | Am. J. Pathol. | pmid:3524253 |
| Powling MJ and Hardisty RM | Differential effects of 12-O-tetradecanoylphorbol 13-acetate on platelet responses to various agonists in the presence and absence of extracellular Ca2+. | 1986 | Thromb. Res. | pmid:3787566 |
| Siffert W et al. | Inhibition of platelet aggregation by amiloride. | 1986 | Thromb. Res. | pmid:3787567 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Sage SO and Rink TJ | Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets. | 1986 | Eur. J. Pharmacol. | pmid:3758190 |
| Chignard M et al. | Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3759260 |
| Ramesha CS and Pickett WC | Measurement of sub-picogram quantities of platelet activating factor (AGEPC) by gas chromatography/negative ion chemical ionization mass spectrometry. | 1986 | Biomed. Environ. Mass Spectrom. | pmid:2938649 |
| Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
| Gay JC et al. | Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor. | 1986 | Blood | pmid:3006836 |
| Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
| Okayasu T et al. | Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. | 1986 | Biochim. Biophys. Acta | pmid:3947669 |
| Cirino M et al. | A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction. | 1986 | Prostaglandins | pmid:3763941 |
| Wallace JL and Whittle BJ | Profile of gastrointestinal damage induced by platelet-activating factor. | 1986 | Prostaglandins | pmid:3763942 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Herrmann DB et al. | Ether phospholipids as inhibitors of the arachidonoyl-CoA: 1-acyl-sn-glycero-3-phosphocholine acyltransferase in macrophages. | 1986 | Biochim. Biophys. Acta | pmid:3947667 |
| Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
| McIntosh TK and Faden AI | Thyrotropin-releasing hormone (TRH) and circulatory shock. | 1986 | Circ. Shock | pmid:3084122 |
| Bussolino F et al. | Interleukin 1 stimulates platelet activating factor production in cultured human endothelial cells. | 1986 | Pharmacol Res Commun | pmid:3490673 |
| Ghezzi E | Autacoids and some mediators in allergic and non allergic forms. | 1986 | Boll Ist Sieroter Milan | pmid:2877678 |
| Raphael GD and Metcalfe DD | Mediators of airway inflammation. | 1986 | Eur J Respir Dis Suppl | pmid:2429857 |
| Ramesha CS and Pickett WC | Metabolism of platelet-activating factor by arachidonic acid-depleted rat polymorphonuclear leukocytes. | 1986 | J. Biol. Chem. | pmid:3096991 |
| Page CP | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3466093 |
| Etienne A et al. | Antithrombotic activity of BN 50341, a structurally new compound with anticalcic and PAF-antagonistic properties. | 1986 | Agents Actions Suppl. | pmid:3468781 |
| Bessin P | PAF-acether and leukotriene participation in acute circulatory shock. | 1986 | Pharmacol Res Commun | pmid:3774841 |
| Goldstein RE et al. | Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774842 |
| Plante GE et al. | Hemodynamic effects of PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774843 |
| Rosam AC et al. | Potent ulcerogenic actions of platelet-activating factor on the stomach. | 1986 Jan 2-8 | Nature | pmid:3510396 |
| Kako KJ | Membrane phospholipids and plasmalogens in the ischemic myocardium. | 1986 May-Jun | Can J Cardiol | pmid:2424580 |
| von Tscharner V et al. | Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. | 1986 Nov 27-Dec 3 | Nature | pmid:2431318 |
| Benhamou M and Mencia-Huerta JM | Effect of glucocorticosteroids on the expression of Fc epsilon R1 and on mediator release from mast cells. | 1986 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:2948525 |
| Morley J | Theophylline in asthma. | 1986 Sep-Oct | Bull Eur Physiopathol Respir | pmid:3801711 |
| Smallbone BW et al. | Effects of L-652,731, a platelet-activating factor (PAF) receptor antagonist, on PAF- and complement-induced pulmonary hypertension in sheep. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2821222 |
| Bussolino F et al. | Chick retina generates platelet-activating factor. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890284 |
| Mikashima H et al. | An antagonistic activity of etizolam on platelet-activating factor (PAF). In vitro effects on platelet aggregation and PAF receptor binding. | 1987 | Jpn. J. Pharmacol. | pmid:2890779 |
| Gautheron PD et al. | A study of PAF-induced ocular inflammation in the rat and its inhibition by the PAF antagonist, L-652,731. | 1987 | J. Pharm. Pharmacol. | pmid:2891830 |
| Kornecki E et al. | Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. | 1987 | Adv. Exp. Med. Biol. | pmid:2893525 |
| Stahl GL and Lefer AM | Heterogeneity of vascular smooth muscle responsiveness to lipid vasoactive mediators. | 1987 | Blood Vessels | pmid:3567363 |
| Kumar R et al. | Metabolism of platelet-activating factor (alkylacetylphosphocholine) by type-II epithelial cells and fibroblasts from rat lungs. | 1987 | Biochim. Biophys. Acta | pmid:3790610 |
| Sigal CE et al. | Preferential human eosinophil chemotactic activity of the platelet-activating factor (PAF) 1-0-hexadecyl-2-acetyl-sn-glyceryl-3-phosphocholine (AGEPC). | 1987 | J. Clin. Immunol. | pmid:3571436 |
| Godfroid JJ et al. | Structure-activity relationship in PAF-acether. 3. Hydrophobic contribution to agonistic activity. | 1987 | J. Med. Chem. | pmid:3572968 |
| Simon MF et al. | Effect of BN 52021, a specific antagonist of platelet activating factor (PAF-acether), on calcium movements and phosphatidic acid production induced by PAF-acether in human platelets. | 1987 | Thromb. Res. | pmid:3576518 |
| Alam I and Silver MJ | Metabolism of 1-alkyl-2-acyl-GPC in human platelets in response to stimulation by thrombin. | 1987 | Thromb. Res. | pmid:3576519 |
| Hannun YA et al. | Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. | 1987 | J. Biol. Chem. | pmid:3115982 |
| Sipka S et al. | Atropine is an inhibitor of the chemiluminescence induced by platelet-activating factor in human neutrophils. | 1987 | Acta Biochim. Biophys. Hung. | pmid:3132002 |
| Chang SW et al. | Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. | 1987 | J. Clin. Invest. | pmid:3553241 |
| Saunders RN and Handley DA | Platelet-activating factor antagonists. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3555317 |
| Stafforini DM et al. | Human plasma platelet-activating factor acetylhydrolase. Purification and properties. | 1987 | J. Biol. Chem. | pmid:3558407 |
| Adamson LM et al. | Mechanistic studies of early pregnancy associated thrombocytopenia (EPAT) in the mouse. | 1987 | Am J Reprod Immunol Microbiol | pmid:3605486 |
| Miwa M et al. | Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver. | 1987 | J. Biol. Chem. | pmid:3804997 |
| Sugiura T et al. | Transacylation of lyso platelet-activating factor and other lysophospholipids by macrophage microsomes. Distinct donor and acceptor selectivities. | 1987 | J. Biol. Chem. | pmid:3805017 |
| Sturk A et al. | Platelet-activating factor: mediator of the third pathway of platelet aggregation? A study in three patients with deficient platelet-activating factor synthesis. | 1987 | J. Clin. Invest. | pmid:3805272 |
| Brunelleschi S et al. | Platelet-activating factor-acether-induced relaxation of guinea pig airway muscle: role of prostaglandin E2 and the epithelium. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3478474 |
| O'Neill C et al. | Use of a bioassay for embryo-derived platelet-activating factor as a means of assessing quality and pregnancy potential of human embryos. | 1987 | Fertil. Steril. | pmid:3595903 |
| Etienne A et al. | Inhibition of rat endotoxin-induced lethality by BN 52021 and BN 52063, compounds with PAF-acether antagonistic effect and protease-inhibitory activity. | 1987 | Int J Tissue React | pmid:3596954 |
| Doly M et al. | Effects of PAF-acether on electrophysiological response of isolated retina. | 1987 | Int J Tissue React | pmid:3596955 |
| Casals-Stenzel J | Effects of WEB 2086, a novel antagonist of platelet activating factor, in active and passive anaphylaxis. | 1987 | Immunopharmacology | pmid:3597059 |
| Handley DA et al. | Biological properties of the antagonist SRI 63-441 in the PAF and endotoxin models of hypotension in the rat and dog. | 1987 | Immunopharmacology | pmid:3597060 |
| Ramesha CS and Pickett WC | Fatty acid composition of diacyl, alkylacyl, and alkenylacyl phospholipids of control and arachidonate-depleted rat polymorphonuclear leukocytes. | 1987 | J. Lipid Res. | pmid:3106551 |
| Dallob A et al. | Pharmacological evidence for a role of lipoxygenase products in platelet-activating factor (PAF)-induced hyperalgesia. | 1987 | Biochem. Pharmacol. | pmid:2822047 |
| Wilcox RW et al. | The degradation of platelet-activating factor and related lipids: susceptibility to phospholipases C and D. | 1987 | Lipids | pmid:3444369 |
| Coëffier E et al. | Platelet-leukocyte interaction: activation of rabbit platelets by FMLP-stimulated neutrophils. | 1987 | Br. J. Pharmacol. | pmid:3118996 |
| Kudo I et al. | Antitumor activity of synthetic alkylphospholipids with or without PAF activity. | 1987 | Lipids | pmid:3444379 |
| Söling U et al. | Effect of synthetic phospholipids on platelet aggregation and serotonin release. | 1987 | Lipids | pmid:3444380 |
| Schick HD et al. | Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro. | 1987 | Lipids | pmid:3444383 |
| Hirafuji M et al. | Regulation of PAF-acether (platelet-activating factor) biosynthesis in cultured human vascular endothelial cells stimulated with thrombin. | 1987 | Biochim. Biophys. Acta | pmid:2888488 |
| Hanahan DJ and Kumar R | Platelet activating factor; chemical and biochemical characteristics. | 1987 | Prog. Lipid Res. | pmid:3313430 |
| Pignol B et al. | Effect of platelet-activating factor (PAF-acether) and its specific receptor antagonist, BN 52021, on interleukin 1 (IL1) release and synthesis by rat spleen adherent monocytes. | 1987 | Prostaglandins | pmid:3313526 |
| Braquet P and Rola-Pleszczynski M | The role of PAF in immunological responses: a review. | 1987 | Prostaglandins | pmid:3313527 |
| Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
| Barnes PJ | New concepts in the pathogenesis of bronchial hyperresponsiveness. | 1987 | Agents Actions Suppl. | pmid:3314413 |
| O'Flaherty JT and Nishihira J | Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils. | 1987 | J. Immunol. | pmid:3029224 |
| Henderson WR | Lipid-derived and other chemical mediators of inflammation in the lung. | 1987 | J. Allergy Clin. Immunol. | pmid:3031147 |
| Chen DC | [Phosphoinositide metabolism and platelet activation]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2838899 |
| Suemune H et al. | Asymmetric synthesis of (+)- and (-)-batyl alcohol, a key synthetic intermediate for platelet-activating factor, by using biocatalysts. | 1987 | Chem. Pharm. Bull. | pmid:3427701 |
| Shimazaki N et al. | Diketopiperazine derivatives, a new series of platelet-activating factor inhibitors. | 1987 | Chem. Pharm. Bull. | pmid:3427732 |
| Lang CH et al. | Attenuation of endotoxin-induced increase in glucose metabolism by platelet-activating factor antagonist. | 1987 | Circ. Shock | pmid:3427772 |
| Korth R and Benveniste J | BN 52021 displaces [3H]paf-acether from, and inhibits its binding to intact human platelets. | 1987 | Eur. J. Pharmacol. | pmid:3428349 |
| Matsumoto T et al. | G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3032170 |
| Steiger J et al. | Platelet activating factor (PAF) is a potent stimulator of porcine tracheal fluid secretion in vitro. | 1987 | Eur. J. Pharmacol. | pmid:3428351 |
| Leff AR et al. | Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo. | 1987 | J. Appl. Physiol. | pmid:2881917 |
| Khandwala A et al. | REV 2871 (CHBZ): a potent antiallergic agent with a novel mechanism of action. I. Activity profile as an inhibitor of mediator release. | 1987 | Biochem. Pharmacol. | pmid:2435293 |
| Stenzel H et al. | Effect of the PAF-antagonist SRI 63-441 on the allergic reaction in awake dogs with natural asthma. | 1987 | Agents Actions Suppl. | pmid:2823582 |
| Alloatti G et al. | Protective effect of verapamil on the cardiac and circulatory alterations induced by platelet-activating factor. | 1987 | J. Cardiovasc. Pharmacol. | pmid:2435996 |
| O'Flaherty JT and Wykle RL | Metabolic origin and fate of platelet-activating factor. | 1987 | Agents Actions Suppl. | pmid:2823583 |
| Kappa JR et al. | Carotid endarterectomy in patients with heparin-induced platelet activation: comparative efficacy of aspirin and iloprost (ZK36374). | 1987 | J. Vasc. Surg. | pmid:2437338 |
| Gomez-Cambronero J et al. | The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2823810 |
| Serafin WE and Austen KF | Mediators of immediate hypersensitivity reactions. | 1987 | N. Engl. J. Med. | pmid:2438554 |
| Bertani T et al. | Platelet activating factor (PAF) as a mediator of injury in nephrotoxic nephritis. | 1987 | Kidney Int. | pmid:3039232 |
| de Arriba G et al. | Changes in glomerular cross-sectional area induced by platelet activating factor. | 1987 | Nephrol. Dial. Transplant. | pmid:3118261 |
| Darius H and Lefer AM | Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. | 1987 | Prog. Clin. Biol. Res. | pmid:3118384 |
| Abramovici Y et al. | Control of the proliferation and differentiation of GEJ under platelet aggregating factor treatment. | 1987 | Acta Endocrinol Suppl (Copenh) | pmid:3475908 |
| Shalit M et al. | Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly. | 1987 | Blood | pmid:3118991 |
| Krishnamurthi S et al. | Effect of phorbol 12-myristate 13-acetate (PMA) on agonist-induced arachidonate release and 5-hydroxytryptamine secretion in human platelets. Dependence of effects on agonist type and time of incubation with PMA. | 1987 | Biochim. Biophys. Acta | pmid:3101746 |
| Sheth KJ et al. | Reversal of central nervous system involvement in hemolytic uremic syndrome by use of plasma exchanges. | 1987 | Clin Pediatr (Phila) | pmid:3119270 |
| Doebber TW and Wu MS | Platelet-activating factor (PAF) stimulates the PAF-synthesizing enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase and PAF synthesis in neutrophils. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3478712 |
| PAF, platelets and asthma. Proceedings of a meeting. September 7-9, 1986. | 1987 | Agents Actions Suppl. | pmid:3478993 | |
| Farr RS et al. | Platelet abnormalities in asthma--do they exist in humans? | 1987 | Agents Actions Suppl. | pmid:3478994 |
| Menz G et al. | Lack of PAF release in extrinsic asthma. | 1987 | Agents Actions Suppl. | pmid:3478995 |