Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mencia-Huerta JM | Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. | 1985 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:3878684 |
| Leslie CC and Detty DM | Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. | 1986 | Biochem. J. | pmid:3098232 |
| Lewis RE and Granger HJ | Neutrophil-dependent mediation of microvascular permeability. | 1986 | Fed. Proc. | pmid:3510911 |
| DeFeudis FV | Studies on endothelium-dependent vasorelaxation. | 1986 | Gen. Pharmacol. | pmid:3512363 |
| Huang C et al. | Polymorphic phase behavior of platelet-activating factor. | 1986 | Biophys. J. | pmid:3697472 |
| Wardlow ML et al. | Substrate specificity and partial characterization of the PAF-acylhydrolase in human serum that rapidly inactivates platelet-activating factor. | 1986 | J. Immunol. | pmid:3514760 |
| Böhm R and Giessler AJ | [Thrombocyte aggregation inhibitors. A new class of active substances]. | 1986 | Pharmazie | pmid:3515372 |
| Touvay C et al. | Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists. | 1986 | Immunopharmacology | pmid:3021651 |
| Weber N | [A platelet-activating factor--a physiologically active ether lipid]. | 1986 | Pharm Unserer Zeit | pmid:3749211 |
| Page CP et al. | Inflammatory mediators of asthma. | 1986 | Eur J Respir Dis Suppl | pmid:3527737 |
| Berti F et al. | Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives. | 1986 | Pharmacol Res Commun | pmid:3749244 |
| Mlczoch J | [Disorders of thrombocyte function and/or endothelial cell damage as a cause of primary pulmonary hypertension?]. | 1986 | Herz | pmid:3530927 |
| Burhop KE et al. | Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites. | 1986 | Am. Rev. Respir. Dis. | pmid:3752711 |
| Lovett DH and Sterzel RB | Cell culture approaches to the analysis of glomerular inflammation. | 1986 | Kidney Int. | pmid:3531678 |
| Yasuda K et al. | Platelet-activating factor in normal rat uterus. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3753495 |
| Muirhead EE et al. | Renal medullary system of blood pressure control. | 1986 | J Hypertens Suppl | pmid:3534182 |
| Buxton DB et al. | Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | Biochem. Pharmacol. | pmid:3754140 |
| Zimmerman GA and Klein-Knoeckel D | Human endothelial cells inhibit granulocyte aggregation in vitro. | 1986 | J. Immunol. | pmid:3009611 |
| Chand N et al. | The amplifier role of platelet activating factor (PAF), other chemical mediators and antigen in the induction of airway hyperreactivity to cold. | 1986 | Eur. J. Pharmacol. | pmid:3709669 |
| Osborne JA et al. | In vivo anti-platelet properties of anipamil, a calcium channel blocker, in the rabbit. | 1986 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3715198 |
| Westwick J et al. | Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro. | 1986 | Thromb. Res. | pmid:3715810 |
| Brock TA and Gimbrone MA | Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells. | 1986 | Am. J. Physiol. | pmid:3717361 |
| Piéroni G and Hanahan DJ | Effect of acetylglyceryl ether phosphocholine (platelet-activating factor) and thrombin on acylation of exogenous lysophosphoglycerides in rabbit platelets. | 1986 | Biochim. Biophys. Acta | pmid:3719000 |
| Benhamou M et al. | Decrease in IgE Fc receptor expression on mouse bone marrow-derived mast cells and inhibition of paf-acether formation and of beta-hexosaminidase release by dexamethasone. | 1986 | J. Immunol. | pmid:2935578 |
| Porcellini G | [Platelet-activating factor: a new biochemical and pharmacologic frontier]. | 1986 | Clin Ter | pmid:3720244 |
| Handley DA et al. | Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. | 1986 | Immunopharmacology | pmid:3733419 |
| Issekutz AC and Szpejda M | Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988. | 1986 | Lab. Invest. | pmid:3951199 |
| Shukla SD | Action of phosphatidylinositol specific phospholipase C on platelets: nonlytic release of acetylcholinesterase, effect on thrombin and PAF induced aggregation. | 1986 | Life Sci. | pmid:3951330 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1986 | Bull Eur Physiopathol Respir | pmid:3955269 |
| Phillips ML and Bonjouklian R | Cyclic platelet-activating factor analogues derived from 2-deoxy-D-erythro-pentose. | 1986 | Carbohydr. Res. | pmid:3955572 |
| Schneider E et al. | Transbilayer reorientation of platelet-activating factor in the erythrocyte membrane. | 1986 | FEBS Lett. | pmid:3956740 |
| Ban C et al. | Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human fetal membranes and decidua vera. | 1986 | Arch. Biochem. Biophys. | pmid:3963833 |
| Cerletti C et al. | Platelet-aggregation response to single or paired aggregating stimuli after low-dose aspirin. | 1986 | N. Engl. J. Med. | pmid:3941724 |
| Parente L et al. | The effect of glucocorticoids on lyso-PAF formation in vitro and in vivo. | 1986 | Agents Actions | pmid:3962774 |
| Blank ML et al. | Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3707974 |
| Tarayre JP et al. | Exudative, cellular and humoral reactions to platelet-activating factor (PAF-acether) in the pleural cavity of rats. | 1986 | Eur. J. Pharmacol. | pmid:3755401 |
| Kikawa Y et al. | Leukotriene B4 biosynthesis in polymorphonuclear leukocytes from blood of umbilical cord, infants, children, and adults. | 1986 | Pediatr. Res. | pmid:3012451 |
| Touvay C et al. | Proof of the involvement of platelet activating factor (paf-acether) in pulmonary complex immune systems using a specific paf-acether receptor antagonist: BN 52021. | 1986 | Prog. Lipid Res. | pmid:2827186 |
| Jackson CV et al. | Platelet-activating factor and the release of a platelet-derived coronary artery vasodilator substance in the canine. | 1986 | Circ. Res. | pmid:2868810 |
| Bussolino F et al. | Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells. | 1986 | J. Clin. Invest. | pmid:2872233 |
| Henocq E and Vargaftig BB | Accumulation of eosinophils in response to intracutaneous PAF-acether and allergens in man. | 1986 | Lancet | pmid:2872485 |
| Cuss FM et al. | Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. | 1986 | Lancet | pmid:2873440 |
| Montrucchio G et al. | Intravascular release of platelet-activating factor during atrial pacing. | 1986 | Lancet | pmid:2874319 |
| Smith PF et al. | The responsiveness of rabbit bronchial rings to antigen, AGEPC and histamine. | 1986 | Immunopharmacology | pmid:3771195 |
| Andrikopoulos NK et al. | High-performance liquid chromatographic analysis of platelet activating factor on a cation-exchange column by direct ultraviolet detection. | 1986 | J. Chromatogr. | pmid:3771693 |
| Cordeiro RS et al. | Desensitization to PAF-induced rat paw oedema by repeated intraplantar injections. | 1986 | Life Sci. | pmid:3773645 |
| Cox CP et al. | An extract of rat submandibular glands activates platelets and enhances cutaneous vascular permeability in rats and guinea pigs. | 1986 | Life Sci. | pmid:3773648 |
| Godfroid JJ et al. | Synthesis of ether phospholipids. | 1986 | Pharmacol Res Commun | pmid:3774838 |
| PAF and leukotrienes '85. Proceedings of the meeting. Paris, September 27th 1985. | 1986 | Pharmacol Res Commun | pmid:3774839 | |
| Lee TC et al. | A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen. | 1986 | J. Biol. Chem. | pmid:3007498 |