Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Francescangeli E et al. | Activation of PAF-synthesizing enzymes in rat brain stem slices after LTP induction in the medial vestibular nuclei. | 2002 | Neurochem. Res. | pmid:12512951 |
| Roy Baker R and Chang Hy | MgATP may depress de novo neuronal nuclear PAF generation by promoting the formation of alkylacylglycerophosphate, an inhibitor of alkylglycerophosphate acetyltransferase. | 2002 | Biochim. Biophys. Acta | pmid:12457714 |
| Pan YH et al. | Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. | 2002 | Biochemistry | pmid:12475227 |
| Smith JM et al. | Platelet-activating factor and Escherichia coliO157:H7 infections. | 2002 | Pediatr. Nephrol. | pmid:12478356 |
| Makhija R and Kingsnorth AN | Cytokine storm in acute pancreatitis. | 2002 | J Hepatobiliary Pancreat Surg | pmid:12483260 |
| Lee YM et al. | Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. | 2002 | J. Lab. Clin. Med. | pmid:12434132 |
| Abu-Zidan FM and Windsor JA | Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials. | 2002 | Eur J Surg | pmid:12440758 |
| Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
| Baker PR et al. | Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. | 2002 | Biochim. Biophys. Acta | pmid:12379481 |
| Leusch A et al. | Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. | 2002 | Eur J Pharm Sci | pmid:12128165 |
| Megens AA et al. | Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12130734 |
| Podolak-Dawidziak M | [Role of white cells and neoplastic cells in haemostasis]. | 2002 | Pol. Arch. Med. Wewn. | pmid:12189915 |
| Strømgaard K et al. | Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation. | 2002 | J. Med. Chem. | pmid:12190325 |
| Wong RK et al. | Augmentation of the neutrophil respiratory burst through the action of advanced glycation end products: a potential contributor to vascular oxidant stress. | 2002 | Diabetes | pmid:12196480 |
| Goldring WP and Pattenden G | A total synthesis of phomactin A. | 2002 | Chem. Commun. (Camb.) | pmid:12196974 |
| Fujiu T et al. | Cellular adhesion is required for effector functions of human eosinophils via G-protein coupled receptors. | 2002 | Ann. Allergy Asthma Immunol. | pmid:12141728 |
| Bazan NG et al. | What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis. | 2002 | Prog. Brain Res. | pmid:12143339 |
| McLennan SV et al. | Effects of mesangium glycation on matrix metalloproteinase activities: possible role in diabetic nephropathy. | 2002 | Diabetes | pmid:12145178 |
| Claud EC et al. | Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. | 2002 | Pediatr. Res. | pmid:12149490 |
| Hostettler ME et al. | Platelet-activating factor induces cell death in cultured astrocytes and oligodendrocytes: involvement of caspase-3. | 2002 | Glia | pmid:11968060 |
| Boisfer E et al. | Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II. | 2002 | J. Lipid Res. | pmid:11971944 |
| Steel HC and Anderson R | Dissociation of the PAF-receptor from NADPH oxidase and adenylate cyclase in human neutrophils results in accelerated influx and delayed clearance of cytosolic calcium. | 2002 | Br. J. Pharmacol. | pmid:11976271 |
| McKay CJ | Recent developments in the management of acute pancreatitis. | 2002 | Dig Surg | pmid:11979001 |
| Roudebush WE et al. | Embryonic platelet-activating factor: an indicator of embryo viability. | 2002 | Hum. Reprod. | pmid:11980756 |
| Hostettler ME and Carlson SL | PAF antagonist treatment reduces pro-inflammatory cytokine mRNA after spinal cord injury. | 2002 | Neuroreport | pmid:11924887 |
| Barletta E et al. | Platelet activating factor inhibits the expression of matrix metalloproteinases and affects invasiveness and differentiation in a system of human neuroblastoma clones. | 2002 | Biol. Chem. | pmid:11928813 |
| Larrucea S et al. | Agonist-induced aggregation of Chinese hamster ovary cells coexpressing the human receptors for fibrinogen (integrin alphaIIbbeta3) and the platelet-activating factor: dissociation between adhesion and aggregation. | 2002 | Blood | pmid:11929771 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Acuña AA et al. | Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma. | 2002 | Eur. Respir. J. | pmid:12030727 |
| Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
| Yoshikawa M et al. | Effect of extracellular matrix proteins on platelet-activating factor-induced eosinophil chemotaxis. | 2002 | Int. Arch. Allergy Immunol. | pmid:12065903 |
| Nakamura T et al. | Relationship between the platelet activating factor acetylhydrolase gene and intractability of ulcerative colitis. | 2002 | Dis. Colon Rectum | pmid:12068200 |
| Silva-Neto MA et al. | Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054663 |
| Kingston JK et al. | Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. | 2002 | Am. J. Vet. Res. | pmid:12061530 |
| Zhou ZG and Chen YD | Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. | 2002 | World J. Gastroenterol. | pmid:12046059 |
| Kato T et al. | Mitochondrial calcium response in human transformed lymphoblastoid cells. | 2002 | Life Sci. | pmid:12052442 |
| Haynes J and Obiako B | Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11748055 |
| Christie PE and Henderson WR | Lipid inflammatory mediators: leukotrienes, prostaglandins, platelet-activating factor. | 2002 | Clin Allergy Immunol | pmid:11577541 |
| Ibe BO et al. | Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. | 2002 | Mol. Genet. Metab. | pmid:12409272 |
| Childs EW et al. | In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. | 2002 | Shock | pmid:12412620 |
| Eikelboom JW et al. | Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes. | 2002 | Eur. Heart J. | pmid:12419297 |
| Tanaka S and Koike T | Selective inflammatory stimulations enhance release of microglial response factor (MRF)-1 from cultured microglia. | 2002 | Glia | pmid:12420315 |
| Cuschieri J et al. | Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. | 2002 | Surgery | pmid:12219006 |
| Kato M et al. | Platelet-activating factor activates two distinct effector pathways in human eosinophils. | 2002 | J. Immunol. | pmid:12391244 |
| Ueno H et al. | Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure. | 2002 | Crit. Care Med. | pmid:12394951 |
| Tsuyuki K et al. | Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages. | 2002 | Biochim. Biophys. Acta | pmid:12069846 |
| Sakamoto H et al. | Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. | 2002 | J. Biol. Chem. | pmid:12397078 |
| Ichinowatari G et al. | Participation of prostaglandin E2 and platelet-activating factor in thapsigargin-induced production of interleukin-6. | 2002 | Eur. J. Pharmacol. | pmid:11779582 |
| Klein A et al. | Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice. | 2002 | Br. J. Pharmacol. | pmid:11877329 |
| Bulger EM et al. | The macrophage response to endotoxin requires platelet activating factor. | 2002 | Shock | pmid:11900334 |
| Mitsuoka H et al. | Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. | 2002 | Shock | pmid:11900339 |
| Kondratskaya EL et al. | BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel. | 2002 | Neurochem. Int. | pmid:11900860 |
| Hu G et al. | Isoflurane inhibits neutrophil-endothelium interactions in the coronary circulation: lack of a role for adenosine triphosphate-sensitive potassium channels. | 2002 | Anesth. Analg. | pmid:11916783 |
| Ozgün H et al. | Lexipafant inhibits postsurgical adhesion formation. | 2002 | J. Surg. Res. | pmid:11922727 |
| Cellai C et al. | Specific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cells. | 2002 | FASEB J. | pmid:11923217 |
| Rivera A et al. | Modulation of Gardos channel activity by cytokines in sickle erythrocytes. | 2002 | Blood | pmid:11756192 |
| Furukawa M et al. | Presence of platelet-activating factor in nasal polyps and eosinophils. | 2002 | Acta Otolaryngol. | pmid:12542208 |
| Farmer PJ et al. | Inhibition of prostaglandin G/H synthase unveils a potent effect of platelet activating factor on the permeability of bovine aortic endothelial cells to albumin. | 2002 | Inflammation | pmid:12546134 |
| Tselepis AD and John Chapman M | Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase. | 2002 | Atheroscler Suppl | pmid:12573364 |
| McKenna DJ et al. | Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. | 2001 Sep-Oct | Altern Ther Health Med | pmid:11565403 |
| de Souza LJ et al. | Effect of platelet-activating factor antagonists (BN-52021, WEB-2170, and BB-882) on bacterial translocation in acute pancreatitis. | 2001 Jul-Aug | J. Gastrointest. Surg. | pmid:11985976 |
| Coker A et al. | Is mannitol effective against platelet-activating factor (PAF)-induced liver damage in obstructive jaundice? | 2001 Jul-Aug | Hepatogastroenterology | pmid:11490817 |
| Dery RE et al. | Inhibition of allergic inflammation by C-terminal peptides of the prohormone submandibular rat 1 (SMR-1). | 2001 Jan-Mar | Int. Arch. Allergy Immunol. | pmid:11306968 |
| Iwazaki S et al. | FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs. | 2001 Jan-Feb | Hepatogastroenterology | pmid:11268964 |
| Magai RM and Shukla SD | Metabolic fate of [14C]-ethanol into endothelial cell phospholipids including platelet-activating factor, sphingomyelin and phosphatidylethanol. | 2001 Jan-Feb | J. Biomed. Sci. | pmid:11173988 |
| Denizot Y et al. | Is there a role of platelet-activating factor in human lung cancer? | 2001 Aug-Sep | Lung Cancer | pmid:11551414 |
| Jolly S et al. | Effect of intravenous platelet-activating factor on bovine pulmonary mast cells. | 2001 Aug-Oct | J. Comp. Pathol. | pmid:11578122 |
| Marathe GK et al. | Oxidized LDL contains inflammatory PAF-like phospholipids. | 2001 Apr-May | Trends Cardiovasc. Med. | pmid:11686003 |
| Ulrich CD | Lexipafant in severe acute pancreatitis: the final word? | 2001 | Curr Gastroenterol Rep | pmid:11276374 |
| Ishizuka S et al. | Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11306440 |
| Hirashima Y et al. | Effect of a platelet-activating factor receptor antagonist, E5880, on cerebral vasospasm after aneurysmal subarachnoid hemorrhage--open clinical trial to investigate efficacy and safety. | 2001 | Neurol. Med. Chir. (Tokyo) | pmid:11381675 |
| Liu XH et al. | Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. | 2001 | Pediatr. Res. | pmid:11385142 |
| Mi B and Maleczka RE | A Nozaki-Hiyama-Kishi Ni(II)/Cr(II) coupling approach to the phomactins. | 2001 | Org. Lett. | pmid:11388849 |
| Elzi DJ et al. | Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11401859 |
| Tiemann U et al. | Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11403499 |
| Tong N et al. | Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. | 2001 | Eur. J. Neurosci. | pmid:11403684 |
| Roudebush WE | Role of platelet-activating factor in reproduction: sperm function. | 2001 | Asian J. Androl. | pmid:11404790 |
| Tavakoli S et al. | Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133502 |
| Rodrigo L et al. | Hydrolysis of platelet-activating factor by human serum paraoxonase. | 2001 | Biochem. J. | pmid:11171072 |
| Del Sorbo L et al. | Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. | 2001 | Eur. J. Immunol. | pmid:11180101 |
| Gandhi CR et al. | A23187 causes release of inositol phosphates from cultured rat Kupffer cells. | 2001 | Eur. J. Pharmacol. | pmid:11245846 |
| Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
| Storey RF et al. | Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole blood. | 2001 | Platelets | pmid:11674863 |
| Camici M and Sagripanti A | Plasma platelet activating factor in nephrotic syndrome. | 2001 | Minerva Med. | pmid:11675576 |
| Kohno S and Nabe T | [Inflammatory mediators (leukotrienes, thromboxane A2, tachykinins and others)]. | 2001 | Nippon Rinsho | pmid:11676130 |
| Pettorossi VE and Grassi S | Different contributions of platelet-activating factor and nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2001 | Acta Otolaryngol Suppl | pmid:11677732 |
| Wielockx B et al. | Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor. | 2001 | J. Hepatol. | pmid:11682033 |
| Bhatia M et al. | Inflammatory mediators as therapeutic targets in acute pancreatitis. | 2001 | Curr Opin Investig Drugs | pmid:11566005 |
| Emingil G et al. | Levels of platelet-activating factor in gingival crevicular fluid and gingival tissue in specific periodontal diseases. | 2001 | J. Periodontol. | pmid:11525434 |
| Thomet OA et al. | Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils. | 2001 | Clin. Exp. Allergy | pmid:11529903 |
| Watanabe S et al. | Suppression of platelet-activating factor generation and modulation of arachidonate metabolism by dietary enrichment with (n-9) eicosatrienoic acid or docosahexaenoic acid in mouse peritoneal cells. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11534547 |
| Stafforini DM | PAF acetylhydrolase gene polymorphisms and asthma severity. | 2001 | Pharmacogenomics | pmid:11535107 |
| Hourton D et al. | Oxidized low density lipoproteins downregulate LPS-induced platelet-activating factor receptor expression in human monocyte-derived macrophages: implications for LPS-induced nuclear factor-kappaB binding activity. | 2001 | Eur. J. Biochem. | pmid:11502209 |
| Velasquez LA et al. | PAF receptor and PAF acetylhydrolase expression in the endosalpinx of the human Fallopian tube: possible role of embryo-derived PAF in the control of embryo transport to the uterus. | 2001 | Hum. Reprod. | pmid:11473946 |
| Akisu M et al. | The role of recombinant human erythropoietin in lipid peroxidation and platelet-activating factor generation in a rat model of necrotizing enterocolitis. | 2001 | Eur J Pediatr Surg | pmid:11475112 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
| Hiran T et al. | Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785782 |
| Binisti C et al. | Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A(2) inhibition: syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines. | 2001 | Eur J Med Chem | pmid:11738488 |
| Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
| Alam N et al. | Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata. | 2001 | J. Nat. Prod. | pmid:11325244 |