Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Jia XQ et al. | [Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention]. | 2012 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22464576 |
Chen S et al. | [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells]. | 2010 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:20367900 |
Ding DD et al. | [Changes of platelet α-particle membrane protein, platelet activating factor and platelet parameters in patients with hyperuricemia]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541106 |
Guo NJ et al. | [Activation of platelet-neutrophil mediated by platelet-activating factor]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15972139 |
Bao GQ and Ju AZ | [Signal pathways of eryptosis-review]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:19698269 |
Wang LJ et al. | [Role of platelet activating factor in the injury of intestinal immuno-barrier function in young rats]. | 2006 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:16522243 |
Li X and Luo H | [Advances in pharmacological study of Piper kadsura (Choisy) Ohwi]. | 2002 | Zhong Yao Cai | pmid:14748373 |
Xu CL et al. | [Inhibitory effect of TBN on platelet aggregation in rabbit]. | 2010 | Zhong Yao Cai | pmid:21243778 |
Zhang XT et al. | [Study on the pharmacokinetics of ginkgolide B for injection in rats]. | 2012 | Zhong Yao Cai | pmid:22876684 |
Zhang XT et al. | [Study on pharmacokinetics of ginkgolide B injection in Beagle dogs]. | 2012 | Zhong Yao Cai | pmid:23213741 |
Huang GD et al. | [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. | 2007 | Zhong Yao Cai | pmid:18422199 |
Xiao HS | [Relation of blood platelets and the cause of bronchial asthma]. | 1989 | Zhong Xi Yi Jie He Za Zhi | pmid:2532572 |
Zong RK and Liu J | [Effects of Chinese herbal medicine Xinfeng Capsule on expressions of platelet-activating factor and interleukins 6 and 17 in peripheral blood of rats with adjuvant arthritis]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22152774 |
Xie DS and Xie YT | [Role of platelet activating factor in hepatorenal syndrome]. | 2005 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:16045031 |
Zhao XY et al. | [Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release]. | 2003 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:12970925 |
Poveshchenko AF and Kozlov VA | [The effect of platelet-activating factor and its antagonist--BN 52021--on immune reactions in vivo in mice and in vitro]. | 1999 Jul-Aug | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:10852052 |
Shebzukhov IuV et al. | [The effect of platelet-activating factor and its synthetic analogs on Ia-antigen expression by mouse peritoneal macrophages]. | 1996 May-Jun | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:8771751 |
Van de Weerdt ML et al. | Role of the cholinergic pathway in mediating platelet-activating factor-induced pulmonary dysfunctions in unsedated calves. | 1999 | Zentralbl Veterinarmed A | pmid:10216447 |
Bastos da Silva M et al. | Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine. | 1997 | Zentralbl Veterinarmed A | pmid:9284631 |
da Silva MB et al. | Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine. | 1996 | Zentralbl Veterinarmed A | pmid:8921726 |