Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stroman PW et al. | Evaluation of effects of PAF on alveolar fluid clearance with use of NMR imaging. | 1993 | J. Appl. Physiol. | pmid:8307842 |
| Stoll LL et al. | Platelet-activating factor may stimulate both receptor-dependent and receptor-independent increases in [Ca2+] in human airway epithelial cells. | 1994 | J. Biol. Chem. | pmid:8307989 |
| Okawa T et al. | [Endothelin-1-induced contraction of pregnant rat myometrium: role of platelet-activating factor]. | 1994 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:8308402 |
| Katoh N et al. | [Evaluation of the mechanism of endothelin-induced rat gastric mucosal lesion formation]. | 1994 | Nihon Shokakibyo Gakkai Zasshi | pmid:8309086 |
| Ripps BA et al. | Platelet-activating factor production from in vitro and in vivo fertilized murine embryos is similar. | 1993 Sep-Oct | Am. J. Reprod. Immunol. | pmid:8311917 |
| Senoh M et al. | Early release of neutrophil chemotactic factor from isolated rat heart subjected to regional ischaemia followed by reperfusion. | 1993 | Cardiovasc. Res. | pmid:8313428 |
| Matsumoto K et al. | [Platelet activating factor and tumor necrosis factor-alpha in bronchoalveolar lavage fluid of patients with ARDS]. | 1993 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8315901 |
| Silliman CC et al. | Compounds biologically similar to platelet activating factor are present in stored blood components. | 1993 | Lipids | pmid:8316049 |
| Kantar A et al. | Effect of PAF on human lymphocyte membranes: a fluorescence study. | 1993 | Agents Actions | pmid:8317302 |
| Boonen GJ et al. | Activation of neutrophil migration by dioctanoyl-sn-glycerol and fMet-Leu-Phe is controlled by different pathways. | 1993 | Agents Actions | pmid:8317308 |
| Ohar JA et al. | Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. | 1993 | Am. Rev. Respir. Dis. | pmid:8317792 |
| Chiche D et al. | Pulmonary edema and shock after high-dose aracytine-C for lymphoma; possible role of TNF-alpha and PAF. | 1993 Mar-Apr | Eur. Cytokine Netw. | pmid:8318674 |
| Amorim CZ et al. | Interference of PCA 4248, a novel PAF receptor antagonist, with antigen-induced paw edema in mice. | 1993 | Eur. J. Pharmacol. | pmid:8319756 |
| Ohashi M et al. | Effect of ibudilast, a novel antiasthmatic agent, on anaphylactic bronchoconstriction: predominant involvement of endogenous slow reacting substance of anaphylaxis. | 1993 | Int. Arch. Allergy Immunol. | pmid:8324390 |
| Patterson WR et al. | Aggregation of killer whale platelets. | 1993 | Thromb. Res. | pmid:8327987 |
| Tanaka T et al. | Effect of a novel xanthine derivative on experimental ulcers in rats. | 1993 | Arzneimittelforschung | pmid:8329000 |
| Barr RM et al. | Platelet activating factor, lyso-platelet activating factor and arachidonic acid release in normal human skin and the influence of topical steroid treatment. | 1993 | Br J Clin Pharmacol | pmid:8329291 |
| Kohler C et al. | Effect of a series of 1-alkyl ether lipids on inhibition of phospholipase A2 activity and PAF responses. | 1993 | Inflammation | pmid:8330926 |
| Onuki Y et al. | [Experimental studies on the relation of platelet activating factor (PAF) to high mortality in sublethal endotoxemia after massive hepatectomy and effects of its antagonist]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:8332121 |
| Kawamura M et al. | Inhibitory effect of TCV-309, a novel platelet activating factor (PAF) antagonist, on endotoxin-induced disseminated intravascular coagulation in rats: possible role of PAF in tissue factor generation. | 1993 | Thromb. Res. | pmid:8332959 |
| Bozza PT et al. | Pharmacological modulation of lipopolysaccharide-induced pleural eosinophilia in the rat; a role for a newly generated protein. | 1993 | Eur. J. Pharmacol. | pmid:8339753 |
| Read RA et al. | Platelet-activating factor-induced polymorphonuclear neutrophil priming independent of CD11b adhesion. | 1993 | Surgery | pmid:8342134 |
| Gulbins E et al. | Effects of rC5a on the circulation of normal and split hydronephrotic rat kidneys. | 1993 | Am. J. Physiol. | pmid:8342619 |
| Hofer RE et al. | The effect of a platelet activating factor antagonist (BN 52021) on neurologic outcome and histopathology in a canine model of complete cerebral ischemia. | 1993 | Anesthesiology | pmid:8342844 |
| Villa L et al. | Chiral PAF agonists: synthesis, theoretical analysis of their stereoelectronic properties and structure activity relationships. | 1993 | Farmaco | pmid:8343209 |
| Freitag A et al. | Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses. | 1993 | Thorax | pmid:8346486 |
| Ihara Y et al. | Hormonal regulation of platelet-activating factor-acetyltransferase activity in rat tissues. | 1993 | Arch. Biochem. Biophys. | pmid:8346925 |
| Sugatani J et al. | Modulation by drugs acting on the autonomic nervous system of platelet-activating factor in the stomach of rats. | 1993 | Biochem. Pharmacol. | pmid:8347135 |
| Kooistra T et al. | Triazolobenzodiazepines: a new class of stimulators of tissue-type plasminogen activator synthesis in human endothelial cells. | 1993 | Biochem. Pharmacol. | pmid:8347138 |
| Torras J et al. | Protective effect of the PAF antagonist BN 52021 in an experimental renal warm ischemia model. | 1993 | Transpl. Int. | pmid:8347271 |
| Thibodeaux JK et al. | Stimulation of development of in vitro-matured and in vitro-fertilized bovine embryos by platelets. | 1993 | J. Anim. Sci. | pmid:8349520 |
| Hall AV et al. | Abrogation of MRL/lpr lupus nephritis by dietary flaxseed. | 1993 | Am. J. Kidney Dis. | pmid:8352261 |
| Rhee CK et al. | Experimental otitis media with effusion induced by platelet activating factor. | 1993 | Ann. Otol. Rhinol. Laryngol. | pmid:8352483 |
| Golino P et al. | Short-term and long-term role of platelet activating factor as a mediator of in vivo platelet aggregation. | 1993 | Circulation | pmid:8353882 |
| Borobia FG et al. | Platelet-activating factor antagonist BN52021 improves survival in normothermic liver ischemia in rats. | 1993 | Transplant. Proc. | pmid:8356661 |
| Koltai M et al. | PAF-induced amplification of mediator release in septic shock: prevention or downregulation by PAF antagonists. | 1993 Mar-Apr | J Lipid Mediat | pmid:8357981 |
| Yee GM et al. | Lipid mediators of implantation and decidualization. | 1993 Mar-Apr | J Lipid Mediat | pmid:8358012 |
| Castro-Faria-Neto HC et al. | Pharmacological profile of epiyangambin: a furofuran lignan with PAF antagonist activity. | 1993 | J Lipid Mediat | pmid:8358020 |
| Defaux JP et al. | Involvement of platelet-activating factor (PAF) in endotoxin- or ischaemia-induced intestinal hyperpermeability in the rat. | 1993 | J Lipid Mediat | pmid:8358021 |
| Hirafuji M and Shinoda H | Roles of prostacyclin, EDRF and active oxygens in leukocyte-dependent platelet adhesion to endothelial cells induced by platelet-activating factor in vitro. | 1993 | Br. J. Pharmacol. | pmid:8358552 |
| Kitajima T et al. | Role of endothelin and platelet-activating factor in indomethacin-induced gastric mucosal injury in rats. | 1993 | Digestion | pmid:8359557 |
| Kawatake H and Kawakami Y | [Pulmonary thromboembolism and IgE]. | 1993 | Nippon Naika Gakkai Zasshi | pmid:8360566 |
| Maki N et al. | [Analysis of platelet-activating factor and its effect on the lung]. | 1993 | Rinsho Byori | pmid:8361018 |
| Kald B et al. | Release of platelet-activating factor in acute experimental pancreatitis. | 1993 | Pancreas | pmid:8361963 |
| Nakamura T et al. | Effects of saiboku-to (TJ-96) on the production of platelet-activating factor in human neutrophils. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8363265 |
| Wierenga EA et al. | Relative contributions of human types 1 and 2 T-helper cell-derived eosinophilotrophic cytokines to development of eosinophilia. | 1993 | Blood | pmid:8364199 |
| Louis R et al. | No increase in plasma histamine during PAF-induced airway obstruction in allergic asthmatics. | 1993 | Chest | pmid:8365293 |
| Rayner TE et al. | Prostaglandin F2 alpha mediates platelet-activating factor-stimulated atrial natriuretic factor release from the isolated rat heart. | 1993 | Endocrinology | pmid:8365356 |
| Ma Y et al. | [Studies on PAF antagonistic bicyclo(3,2,1) octanoid neolignans from Piper kadsura]. | 1993 | Yao Xue Xue Bao | pmid:8368081 |
| Smith LJ et al. | Effect of leukotriene D4 and platelet-activating factor on human alveolar macrophage eicosanoid and PAF synthesis. | 1993 | Am. Rev. Respir. Dis. | pmid:8368641 |
| Norris LA et al. | Whole blood platelet aggregation in moderate and severe pre-eclampsia. | 1993 | Br J Obstet Gynaecol | pmid:8369255 |
| Bannenberg G et al. | Hydrogen peroxide-induced broncho- and vasoconstriction in the isolated perfused and ventilated guinea pig lung. | 1993 Apr-May | Pharmacol. Toxicol. | pmid:8372054 |
| Narahara H and Johnston JM | Effects of endotoxins and cytokines on the secretion of platelet-activating factor-acetylhydrolase by human decidual macrophages. | 1993 | Am. J. Obstet. Gynecol. | pmid:8372856 |
| Weber C et al. | Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8373423 |
| Bazan HE et al. | Platelet-activating factor induces collagenase expression in corneal epithelial cells. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8378347 |
| Casale TB et al. | Platelet-activating factor-induced human eosinophil transendothelial migration: evidence for a dynamic role of the endothelium. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8380250 |
| Ko FN et al. | CIS-19, a novel platelet activating factor receptor antagonist: in vitro and in vivo studies. | 1993 | Biochim. Biophys. Acta | pmid:8380343 |
| Asako H et al. | Leukocyte adherence in rat mesenteric venules: effects of adenosine and methotrexate. | 1993 | Gastroenterology | pmid:8380395 |
| Svetlov S and Nigam S | Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8380690 |
| Chilton FH et al. | Dietary n-3 fatty acid effects on neutrophil lipid composition and mediator production. Influence of duration and dosage. | 1993 | J. Clin. Invest. | pmid:8380809 |
| Slama H et al. | Metabolism of arachidonic acid by caruncular and allantochorionic tissues in cows with retained fetal membranes (RFM). | 1993 | Prostaglandins | pmid:8380936 |
| Hatzelmann A et al. | Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds. | 1993 | Biochem. Pharmacol. | pmid:8381000 |
| Herbert JM et al. | Binding of [3H]SR 27417, a novel platelet-activating factor (PAF) receptor antagonist, to rabbit and human platelets and polymorphonuclear leukocytes. | 1993 | Biochem. Pharmacol. | pmid:8381007 |
| Martins MA et al. | Role of PAF in the allergic pleurisy caused by ovalbumin in actively sensitized rats. | 1993 | J. Leukoc. Biol. | pmid:8381149 |
| Weg VB et al. | A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. | 1993 | J. Exp. Med. | pmid:8381157 |
| Christy IJ et al. | Mediators of the hypotensive response to increased renal perfusion in rabbits. | 1993 | Hypertension | pmid:8381391 |
| Ring PC et al. | Pharmacological characterization of a receptor for platelet-activating factor on guinea pig peritoneal macrophages using [3H]apafant, a selective and competitive platelet-activating factor antagonist: evidence that the noncompetitive behavior of apafant in functional studies relates to slow kinetics of dissociation. | 1993 | Mol. Pharmacol. | pmid:8381515 |
| Montrucchio G et al. | Role of platelet-activating factor in hypotension and platelet activation induced by infusion of thrombolytic agents in rabbits. | 1993 | Circ. Res. | pmid:8381725 |
| Eliakim R et al. | Octreotide effectively decreases mucosal damage in experimental colitis. | 1993 | Gut | pmid:8381760 |
| Sperling RI et al. | Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. | 1993 | J. Clin. Invest. | pmid:8381824 |
| Bertrand C et al. | Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea. | 1993 | J. Immunol. | pmid:8381836 |
| Ito K | [Thrombotic thrombocytopenic purpura--recent development of TTP study]. | 1993 | Nippon Rinsho | pmid:8381882 |
| Alonso-Torre SR et al. | Control of Ca2+ entry into HL60 and U937 human leukaemia cells by the filling state of the intracellular Ca2+ stores. | 1993 | Biochem. J. | pmid:8382050 |
| Stewart AG and Harris T | Adenosine inhibits platelet-activating factor, but not tumour necrosis factor-alpha-induced priming of human neutrophils. | 1993 | Immunology | pmid:8382188 |
| Siafaka-Kapadai A and Hanahan D | An endogenous inhibitor of PAF-induced platelet aggregation, isolated from rat liver, has been identified as free fatty acid. | 1993 | Biochim. Biophys. Acta | pmid:8382959 |
| Ramos-Franco J et al. | Platelet-activating factor receptor-dependent activation of the muscarinic K+ current in bullfrog atrial myocytes. | 1993 | Circ. Res. | pmid:8383014 |
| Rossi AG et al. | Stimulation of human polymorphonuclear leukocytes by leukotriene B4 and platelet-activating factor: an ultrastructural and pharmacological study. | 1993 | J. Leukoc. Biol. | pmid:8383164 |
| Gardner CR et al. | Platelet-activating factor-induced calcium mobilization and oxidative metabolism in hepatic macrophages and endothelial cells. | 1993 | J. Leukoc. Biol. | pmid:8383168 |
| Chase PB et al. | Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8383507 |
| Sordano C et al. | Platelet activating factor modulates signal transduction in Dictyostelium. | 1993 | J. Cell. Sci. | pmid:8383695 |
| Mulder K and Colditz IG | Migratory responses of ovine neutrophils to inflammatory mediators in vitro and in vivo. | 1993 | J. Leukoc. Biol. | pmid:8384237 |
| Kato M et al. | Platelet-activating factor-induced enhancement of superoxide anion generation in guinea-pigs. | 1993 | Eur. J. Pharmacol. | pmid:8384564 |
| Hashimoto K et al. | Comparison of the effects of intra-third ventricular administration of interleukin-1 or platelet activating factor on ACTH secretion and the sympathetic-adrenomedullary system in conscious rats. | 1993 | Acta Med. Okayama | pmid:8384777 |
| Tsutsui H and Morisawa S | [Trend of molecular biological studies on the liver sinusoidal cells--Kupffer cells]. | 1993 | Nippon Rinsho | pmid:8385242 |
| Carrick JB et al. | Administration of a receptor antagonist for platelet-activating factor during equine endotoxaemia. | 1993 | Equine Vet. J. | pmid:8385601 |
| Becker K et al. | PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8385779 |
| Croft KD and Beilin LJ | Platelet and neutrophil function and eicosanoid release in a subject with abetalipoproteinaemia. | 1993 | Thromb. Res. | pmid:8385810 |
| Burgers JA and Akkerman JW | Regulation of the receptor for platelet-activating factor on human platelets. | 1993 | Biochem. J. | pmid:8385926 |
| Samiei M et al. | Activation of myelin basic protein and S6 peptide kinases in phorbol ester- and PAF-treated sheep platelets. | 1993 | Biochim. Biophys. Acta | pmid:8385998 |
| Levistre R et al. | Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins. | 1993 | Eur. J. Biochem. | pmid:8386624 |
| Dent G and Barnes PJ | Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils. | 1993 | Life Sci. | pmid:8387140 |
| Daniels RH et al. | Differential regulation of early phase and late phase responses in human neutrophils by cAMP. | 1993 | Biochem. Pharmacol. | pmid:8387301 |
| Rosenthal MD et al. | 1,3-Dioctanoylglycerol modulates arachidonate mobilization in human neutrophils and its inhibition by PGBx: evidence of a protein-kinase-C-independent role for diacylglycerols in signal transduction. | 1993 | Biochim. Biophys. Acta | pmid:8387343 |
| Winkler JD et al. | Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil. | 1993 | Biochem. J. | pmid:8387780 |
| Arndt H et al. | Leukocyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats. | 1993 | Hypertension | pmid:8387961 |
| Takizawa H | [Eosinophils in immediate allergic reactions]. | 1993 | Nippon Rinsho | pmid:8388063 |
| Tomioka H and Kagami M | [Clinical relevance on the inhibition of eosinophil functions--a review with special reference to eosinophilopietic cytokines]. | 1993 | Nippon Rinsho | pmid:8388064 |
| Brunton VG and Workman P | In vitro antitumour activity of the novel imidazoisoquinoline SDZ 62-434. | 1993 | Br. J. Cancer | pmid:8388233 |
| Nieuwland R et al. | Effect of epinephrine on the regulation of Na+/H+ exchange in human platelets. | 1993 | Biochim. Biophys. Acta | pmid:8389195 |
| Mori M et al. | Energy-dependent export of leukotriene B4 in Xenopus oocytes. | 1993 | Biochim. Biophys. Acta | pmid:8389202 |