Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lohman IC and Halonen M | The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit. | 1993 | Am. Rev. Respir. Dis. | pmid:8484635 |
Meade CJ and Heuer H | PAF antagonism as an approach to the treatment of airway hyperreactivity. | 1991 | Am. Rev. Respir. Dis. | pmid:2003696 |
Smith LJ | The role of platelet-activating factor in asthma. | 1991 | Am. Rev. Respir. Dis. | pmid:2018248 |
Kazimierczak W et al. | Deuterium-oxide-induced histamine release from basophils of allergic subjects. I. Responsiveness to deuterium oxide requires an activation step. | 1984 | Am. Rev. Respir. Dis. | pmid:6201094 |
Halonen M et al. | Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. | 1981 | Am. Rev. Respir. Dis. | pmid:7294504 |
Ohar JA et al. | A rabbit model of pulmonary hypertension induced by the synthetic platelet-activating factor acetylglyceryl ether phosphorylcholine. | 1990 | Am. Rev. Respir. Dis. | pmid:2297169 |
Oda M et al. | The presence of platelet-activating factor associated with eosinophil and/or neutrophil accumulations in the pleural fluids. | 1990 | Am. Rev. Respir. Dis. | pmid:2350088 |
Smith LJ et al. | Mechanism of platelet activating factor-induced bronchoconstriction in humans. | 1988 | Am. Rev. Respir. Dis. | pmid:3195800 |
Bienenstock J et al. | Mast cell involvement in various inflammatory processes. | 1987 | Am. Rev. Respir. Dis. | pmid:3109295 |
Henson PM et al. | NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities. | 1992 | Am. Rev. Respir. Dis. | pmid:1312316 |
Miadonna A et al. | Evidence of PAF-acether metabolic pathway activation in antigen challenge of upper respiratory airways. | 1989 | Am. Rev. Respir. Dis. | pmid:2546468 |
Morgan WK et al. | Byssinosis: some unanswered questions. | 1982 | Am. Rev. Respir. Dis. | pmid:6808880 |
Page CP | Mechanisms of hyperresponsiveness: platelet-activating factor. | 1992 | Am. Rev. Respir. Dis. | pmid:1734810 |
Ohar JA et al. | Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. | 1993 | Am. Rev. Respir. Dis. | pmid:8317792 |
Smith LJ et al. | Effect of leukotriene D4 and platelet-activating factor on human alveolar macrophage eicosanoid and PAF synthesis. | 1993 | Am. Rev. Respir. Dis. | pmid:8368641 |
Watson JW et al. | IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators. | 1990 | Am. Rev. Respir. Dis. | pmid:2240832 |
Tocker JE et al. | Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists. | 1990 | Am. Rev. Respir. Dis. | pmid:2240843 |
Wardlaw AJ et al. | Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophils. Relationship to bronchoconstriction and changes in airway responsiveness. | 1990 | Am. Rev. Respir. Dis. | pmid:2405759 |
Diez-Fraile A et al. | Effect of proinflammatory mediators and glucocorticoids on L-selectin expression in peripheral blood neutrophils from dairy cows in various stages of lactation. | 2004 | Am. J. Vet. Res. | pmid:15524330 |
McClenahan DJ et al. | Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. | 2000 | Am. J. Vet. Res. | pmid:10714514 |
Kingston JK et al. | Measurement of the activation of equine platelets by use of fluorescent-labeled annexin V, anti-human fibrinogen antibody, and anti-human thrombospondin antibody. | 2002 | Am. J. Vet. Res. | pmid:11939312 |
Menzies-Gow NJ et al. | Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. | 2008 | Am. J. Vet. Res. | pmid:18241016 |
Kingston JK et al. | Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. | 2002 | Am. J. Vet. Res. | pmid:12061530 |
Wilson DV et al. | Histologic and ultrastructural changes after large-colon torsion, with and without use of a specific platelet-activating factor antagonist (WEB 2086), in ponies. | 1994 | Am. J. Vet. Res. | pmid:8067617 |
Wilson DV et al. | Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086. | 1993 | Am. J. Vet. Res. | pmid:8430938 |
Dodam JR et al. | Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages. | 1996 | Am. J. Vet. Res. | pmid:8712527 |
Weiss DJ and Evanson OA | Detection of activated platelets and platelet-leukocyte aggregates in horses. | 1997 | Am. J. Vet. Res. | pmid:9256963 |
Tsuchiya R et al. | Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. | 1999 | Am. J. Vet. Res. | pmid:10048555 |
McClenahan DJ et al. | In vitro evaluation of the role of platelet-activating factor and interleukin-8 in Mannheimia haemolytica-induced bovine pulmonary endothelial cell injury. | 2002 | Am. J. Vet. Res. | pmid:11911574 |
Watanabe M et al. | Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. | 2016 | Am. J. Vet. Res. | pmid:27580108 |
Lee EK and Kehrli ME | Expression of adhesion molecules on neutrophils of periparturient cows and neonatal calves. | 1998 | Am. J. Vet. Res. | pmid:9442240 |
Wilson DV and Stick JA | Effect of a specific platelet-activating factor antagonist on cardiovascular and peripheral cellular responses to colonic ischemia and reperfusion in anesthetized ponies. | 1993 | Am. J. Vet. Res. | pmid:8498751 |
Burgos RA et al. | Determination of specific receptor sites for platelet activating factor in bovine neutrophils. | 2004 | Am. J. Vet. Res. | pmid:15141884 |
Walz PH et al. | Platelet function and association of bovine viral diarrhea virus with platelets of persistently infected cattle. | 2005 | Am. J. Vet. Res. | pmid:16273905 |
LeBlanc CJ et al. | Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs. | 2008 | Am. J. Vet. Res. | pmid:18380580 |
Yan ZY et al. | Platelet activating factor-induced changes in gastric motility and vascular resistance. | 1992 | Am. J. Surg. | pmid:1346361 |
Soybel DI et al. | Effects of platelet-activating factor on canine gastric mucosal blood flow and permeability to luminal acid. | 1988 | Am. J. Surg. | pmid:3341532 |
Ono S et al. | A clinical study on the significance of platelet-activating factor in the pathophysiology of septic disseminated intravascular coagulation in surgery. | 1996 | Am. J. Surg. | pmid:8604832 |
Nagase T et al. | Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9372685 |
Larkin EK et al. | New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:25408961 |
Samapati R et al. | Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22246702 |
Masclans JR et al. | Salbutamol reduces pulmonary neutrophil sequestration of platelet-activating factor in humans. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8756833 |
Maruoka S et al. | PAF-induced RANTES production by human airway smooth muscle cells requires both p38 MAP kinase and Erk. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10712344 |
Spence DP et al. | The effect of the orally active platelet-activating factor antagonist WEB 2086 in the treatment of asthma. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8173754 |
Fukuyama S et al. | Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10852755 |
Pretolani M et al. | Role of eosinophil activation in the bronchial reactivity of allergic guinea pigs. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8173756 |
Kafoury RM et al. | Induction of inflammatory mediators in human airway epithelial cells by lipid ozonation products. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10588609 |
McBride DE et al. | Inflammatory effects of ozone in the upper airways of subjects with asthma. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8173759 |
Göggel R et al. | Platelet-activating factor-induced pulmonary edema is partly mediated by prostaglandin E(2), E-prostanoid 3-receptors, and potassium channels. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12204861 |
Thorne JR and Broadley KJ | Adenosine-induced bronchoconstriction in conscious hyperresponsive and sensitized guinea pigs. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8306036 |
Lou YP et al. | Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620929 |
Falk S et al. | Quinolines attenuate PAF-induced pulmonary pressor responses and edema formation. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10556149 |
Nakos G et al. | Bronchoalveolar lavage alterations in pulmonary embolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9817700 |
Kuitert LM et al. | Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7735582 |
Mason GR et al. | The effect of inhalation of platelet-activating factor on the pulmonary clearance of 99mTc-DTPA aerosol. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7735622 |
Félez MA et al. | Inhaled platelet-activating factor worsens gas exchange in mild asthma. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8049817 |
Gómez FP et al. | The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603138 |
Berger A et al. | Dioleylphosphatidylglycerol inhibits the expression of type II phospholipase A2 in macrophages. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:9927381 |
Roca J et al. | Salbutamol inhibits pulmonary effects of platelet activating factor in man. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7767515 |
Ohar JA et al. | Chronic platelet-activating factor induces a decrease in pulmonary vascular compliance, hydroxyproline, and loss of vascular matrix. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8004322 |
Shin MH et al. | Nasal allergen challenge generates 1-0-hexadecyl-2-lyso-sn-glycero-3-phosphocholine. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8118633 |
Chen CR et al. | Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8111595 |
Lekka ME et al. | The impact of intravenous fat emulsion administration in acute lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14656749 |
Satoh N et al. | Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10051281 |
Henig NR et al. | Effect of recombinant human platelet-activating factor-acetylhydrolase on allergen-induced asthmatic responses. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10934081 |
Sulakvelidze I and McDonald DM | Anti-edema action of formoterol in rat trachea does not depend on capsaicin-sensitive sensory nerves. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:7509246 |
Nagase T et al. | Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11790655 |
O'Connor BJ et al. | Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8025768 |
Evans DJ et al. | Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230719 |
DÃaz O et al. | Inhibition of PAF-induced gas exchange defects by beta-adrenergic agonists in mild asthma is not due to bronchodilation. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230720 |
Triggiani M et al. | Characterization of platelet-activating factor acetylhydrolase in human bronchoalveolar lavage. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230731 |
Hozawa S et al. | Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7551370 |
Imai Y et al. | Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:7952613 |
Ishizuka S et al. | Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11306440 |
Samet JM et al. | Effect of ozone on platelet-activating factor production in phorbol-differentiated HL60 cells, a human bronchial epithelial cell line (BEAS S6), and primary human bronchial epithelial cells. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1419027 |
Okada S et al. | Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9376127 |
Guilbert M et al. | 5-Oxo-6,8,11,14-eicosatetraenoic acid induces important eosinophil transmigration through basement membrane components: comparison of normal and asthmatic eosinophils. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10385597 |
McNulty CA et al. | Characterization of the integrin and activation steps mediating human eosinophil and neutrophil adhesion to chronically inflamed airway endothelium. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10340944 |
Walker BA et al. | Adenosine A3 receptor expression and function in eosinophils. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9160835 |
Shirasaki H et al. | Expression of platelet-activating factor receptor mRNA in human and guinea pig lung. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8179916 |
Henson PM | PAF--a perspective. | 1989 | Am. J. Respir. Cell Mol. Biol. | pmid:2696514 |
Casale TB et al. | Platelet-activating factor-induced human eosinophil transendothelial migration: evidence for a dynamic role of the endothelium. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8380250 |
Liu L et al. | Transmigration of human neutrophils across airway epithelial cell monolayers is preferentially in the physiologic basolateral-to-apical direction. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8969272 |
Larivée P et al. | Platelet-activating factor induces airway mucin release via activation of protein kinase C: evidence for translocation of protein kinase C to membranes. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8049080 |
Nauck M et al. | Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is downregulated by corticosteroids. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9115750 |
Okada S et al. | Transmigration of eosinophils through basement membrane components in vitro: synergistic effects of platelet-activating factor and eosinophil-active cytokines. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9115757 |
Kroegel C et al. | Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet-activating factor in eosinophil activation. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:7946388 |
Chase PB et al. | Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8383507 |
Zoratti EM et al. | Platelet-activating factor primes human eosinophil generation of superoxide. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1309421 |
Kondo M et al. | Effect of platelet-activating factor on intracellular free calcium in cow tracheal epithelium. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8117446 |
Neeley SP et al. | Selective regulation of expression of surface adhesion molecules Mac-1, L-selectin, and VLA-4 on human eosinophils and neutrophils. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:7686761 |
Burke-Gaffney A and Hellewell PG | A CD18/ICAM-1-dependent pathway mediates eosinophil adhesion to human bronchial epithelial cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9730868 |
Adler KB et al. | Platelet-activating factor provokes release of mucin-like glycoproteins from guinea pig respiratory epithelial cells via a lipoxygenase-dependent mechanism. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1316134 |
Delong P et al. | Bacterial lipopolysaccharide induction of the prostaglandin G/H synthase 2 gene causes thromboxane-dependent pulmonary hypertension in rabbits. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10030848 |
Morland CM et al. | Selective eosinophil leukocyte recruitment by transendothelial migration and not by leukocyte-endothelial cell adhesion. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1316135 |
Kikuchi I et al. | Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16456187 |
Yukawa T et al. | The effects of activated eosinophils and neutrophils on guinea pig airway epithelium in vitro. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2322467 |
Adler KB et al. | Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase. | 1995 | Am. J. Respir. Cell Mol. Biol. | pmid:7576687 |
Casale TB et al. | Degree of neutrophil chemotaxis is dependent upon the chemoattractant and barrier. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1320901 |
Miotla JM et al. | Platelet-activating factor plays a pivotal role in the induction of experimental lung injury. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9476906 |