| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Desai S and Barton R | Role of platelet activating factor in the pathogenesis of active and passive models of experimental allergic encephalomyelitis in the rat. | 1990 | Agents Actions | pmid:2285021 |
| Swingle KF and Reiter MJ | Inhibition of Paf-acether-induced edema of the rat's paw. | 1986 | Agents Actions | pmid:2875631 |
| Flower RJ | Background and discovery of lipocortins. | 1986 | Agents Actions | pmid:2938452 |
| Cunha FQ et al. | Failure of PAF-acether to induce in vivo neutrophil migration. | 1988 | Agents Actions | pmid:3055873 |
| Touvay C et al. | Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. | 1986 | Agents Actions | pmid:3754380 |
| Etienne A et al. | In vivo inhibition of plasma protein leakage and Salmonella enteritidis-induced mortality in the rat by a specific paf-acether antagonist: BN 52021. | 1986 | Agents Actions | pmid:3515870 |
| Mastacchi R et al. | Interaction of a new low molecular weight heparin (OP/LMWH) with human platelets. | 1986 | Agents Actions | pmid:3518359 |
| Pettipher ER et al. | PAF-acether in chronic arthritis. | 1987 | Agents Actions | pmid:3630862 |
| Parente L et al. | The effect of glucocorticoids on lyso-PAF formation in vitro and in vivo. | 1986 | Agents Actions | pmid:3962774 |
| Tarayre JP et al. | Inflammatory action of PAF-acether in the rat pleural cavity. | 1986 | Agents Actions | pmid:3962789 |
| Okamoto H et al. | Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. | 1992 | Agents Actions | pmid:1388318 |
| Ogunbiyi PO and Eyre P | Pharmacological studies of pulmonary anaphylaxis in vitro: a review. | 1985 | Agents Actions | pmid:2420161 |
| Kantar A et al. | Effect of PAF on human lymphocyte membranes: a fluorescence study. | 1993 | Agents Actions | pmid:8317302 |
| Boonen GJ et al. | Activation of neutrophil migration by dioctanoyl-sn-glycerol and fMet-Leu-Phe is controlled by different pathways. | 1993 | Agents Actions | pmid:8317308 |
| Murphy G | Report of the 14th meeting of the British Inflammation Research Association. Topic: cellular and molecular aspects of inflammatory bowel disease. | 1993 | Agents Actions | pmid:8480529 |
| Sakamoto T et al. | Effect of beta 2-adrenoceptor agonists against platelet-activating factor-induced airway microvascular leakage and bronchoconstriction in the guinea pig. | 1993 | Agents Actions | pmid:7908496 |
| Jouvin-Marche E et al. | Platelet-activating factor (PAF-acether), an activator of neutrophil functions. | 1982 | Agents Actions | pmid:6299078 |
| Lefort J et al. | Pharmacological properties of PAF-acether in the guinea-pig: platelet-dependent and independent reactions. | 1982 | Agents Actions | pmid:7164948 |
| Izzo AA et al. | Platelet activating factor potentiates rat paw oedema induced by different phlogogen agents. | 1994 | Agents Actions | pmid:7524288 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |