| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nishi O et al. | Effects of platelet activating factor on mouse embryo implantation in vitro. | 1995 | J. Assist. Reprod. Genet. | pmid:8520198 |
| Diserbo M et al. | Stimulation of platelet-activating factor (PAF) receptors increases inositol phosphate production and cytosolic free Ca2+ concentrations in N1E-115 neuroblastoma cells. | 1995 | Cell Calcium | pmid:8521458 |
| Nishida K et al. | Increased brain levels of platelet-activating factor in a murine acquired immune deficiency syndrome are NMDA receptor-mediated. | 1996 | J. Neurochem. | pmid:8522986 |
| Noel AA et al. | Inhibition of nitric oxide synthase attenuates primed microvascular permeability in the in vivo microcirculation. | 1995 | J. Vasc. Surg. | pmid:8523600 |
| Oshiro H et al. | L-type calcium channel blockers modulate the microvascular hyperpermeability induced by platelet-activating factor in vivo. | 1995 | J. Vasc. Surg. | pmid:8523608 |
| Ahmed A et al. | Oestradiol-17 beta modulates PAF-evoked phospholipase D activity but not inositide-lipid hydrolysis in human endometrial cell line, HEC-1B. | 1995 | Cell. Signal. | pmid:8527309 |
| Debek W et al. | Luminol-chemiluminescence in free peritoneal cells in hemorrhagic shock in rats treated with PAF-receptor-antagonist BN 52021. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528982 |
| Kirejczyk JK et al. | Ginkgolide BN 52021 protects against hemorrhagic shock-induced renal injury in rats. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528996 |
| Kirejczyk JK et al. | Oxygen-derived free radicals in kidney in experimental hemorrhagic shock treated by PAF-receptor antagonist BN 52021. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528997 |
| Giessler C et al. | Effects of PAF on cardiac function and eicosanoid release in the isolated perfused rat heart: comparison between normotensive and spontaneously hypertensive rats. | 1995 Jul-Aug | Basic Res. Cardiol. | pmid:8534259 |
| Schmid E et al. | Signaling by E-selectin and ICAM-1 induces endothelial tissue factor production via autocrine secretion of platelet-activating factor and tumor necrosis factor alpha. | 1995 | J. Interferon Cytokine Res. | pmid:8536111 |
| Bustos C et al. | Cyclosporin A (CsA) modulates the glomerular production of inflammatory mediators and proteoglycans in experimental nephrosis. | 1995 | Clin. Exp. Immunol. | pmid:8536380 |
| Guimbaud R et al. | Intraluminal excretion of PAF, lysoPAF, and acetylhydrolase in patients with ulcerative colitis. | 1995 | Dig. Dis. Sci. | pmid:8536524 |
| Schwappach JR et al. | Superoxide dismutase attenuates effects of platelet-activating factor on gastric microcirculation. | 1995 | J. Surg. Res. | pmid:8538173 |
| RamÃrez MM et al. | Platelet activating factor modulates microvascular permeability through nitric oxide synthesis. | 1995 | Microvasc. Res. | pmid:8538502 |
| Cluzel J et al. | Inhibition of platelet-activating factor-induced retinal impairments by cholera and pertussis toxins. | 1995 | Ophthalmic Res. | pmid:8538992 |
| Siminiak T et al. | Plasma mediated neutrophil stimulation during coronary angioplasty: autocrine effect of platelet activating factor. | 1995 | Br Heart J | pmid:8541167 |
| Izumi T and Shimizu T | Platelet-activating factor receptor: gene expression and signal transduction. | 1995 | Biochim. Biophys. Acta | pmid:8541341 |
| Abu-Zidan FM et al. | Role of platelet-activating factor antagonism in haemorrhagic shock in pigs. | 1995 | Eur Surg Res | pmid:8542923 |
| Naraba H et al. | Activation of phospholipase A2 and acylation of lysophospholipids: the major regulators for platelet activating factor production in rat neutrophils. | 1995 | J. Biochem. | pmid:8543583 |
| Furukawa M et al. | Biochemical evidence of platelet-activating factor (PAF) in human middle ear effusions. | 1995 | Laryngoscope | pmid:8544602 |
| Rubio de Krömer MT et al. | Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis. | 1995 | Acta Trop. | pmid:8546035 |
| Evangelou A et al. | Inhibition of PAF-acether effects on isolated guinea pig hearts by zinc ions (Zn2+). | 1995 | Biol Trace Elem Res | pmid:8546883 |
| Meijer F et al. | Nitric oxide induces vascular permeability changes in the guinea pig conjunctiva. | 1995 | Eur. J. Pharmacol. | pmid:8549637 |
| Sibelius U et al. | Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells. | 1996 | Infect. Immun. | pmid:8550226 |
| Lee TC et al. | Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels. | 1996 | J. Biol. Chem. | pmid:8550561 |
| Patke CL et al. | Differential effects of interleukin-2 and interleukin-4 on immunomodulatory role of platelet-activating factor in human B cells. | 1994 | Clin. Diagn. Lab. Immunol. | pmid:8556480 |
| Kita H et al. | Extracellular matrix proteins attenuate activation and degranulation of stimulated eosinophils. | 1996 | J. Immunol. | pmid:8557995 |
| Endemann G et al. | Novel anti-inflammatory compounds prevent CD11b/CD18, alpha M beta 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8558456 |
| Carceller E et al. | Design, synthesis, and structure-activity relationship studies of novel 1-[(1-acyl-4-piperidyl)methyl]-1H-2- methylimidazo[4,5-c]pyridine derivatives as potent, orally active platelet-activating factor antagonists. | 1996 | J. Med. Chem. | pmid:8558517 |
| Tetta C et al. | Adherence of human monocytes to haemodialysis membranes: LFA 1 (CD11a/CD18) CR1 (CD35) and CR3 (CD11b/CD18) triggering promotes the biosynthesis of platelet-activating factor and adherence. | 1995 | Nephrol. Dial. Transplant. | pmid:8559489 |
| van der Poll T et al. | Interleukin 10 release during endotoxaemia in chimpanzees: role of platelet-activating factor and interleukin 6. | 1996 | Scand. J. Immunol. | pmid:8560191 |
| Kaneko T et al. | Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. | 1995 | Cell. Signal. | pmid:8562314 |
| Lorant DE et al. | Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion. | 1995 | Semin. Cell Biol. | pmid:8562922 |
| Wang C et al. | [Inhalation of platelet-activating factor induced guinea pig airway hyperresponsiveness: role of eosinophils activation]. | 1995 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:8565083 |
| Yu P et al. | [The roles of platelet activating factor in intestinal mucosal barrier injury after burn]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8565724 |
| Dillon AM and Heath MF | Protein tyrosine phosphorylation in equine platelets: the effect of stimulation by thrombin and platelet-activating factor (PAF) | 1995 | Equine Vet. J. | pmid:8565942 |
| Costuleanu M et al. | Effects of liposome-entrapped platelet-activating factor in the isolated rat trachea. | 1995 | Eur. J. Pharmacol. | pmid:8566122 |
| Sasaki Y et al. | [Effect of KW-4679, a novel antiallergic drug, on platelet-activating factor (PAF)-induced bronchoconstriction, airway hyperresponsiveness and pulmonary cell accumulation in guinea pigs]. | 1995 | Nippon Yakurigaku Zasshi | pmid:8566911 |
| Kyriacopoulos F et al. | Role of PAF in the late airway microvascular leakage induced by antigen in IgE-sensitized rat. | 1995 | Fundam Clin Pharmacol | pmid:8566934 |
| Lin CN et al. | Synthesis and antiplatelet effects of omega-aminoalkoxylxanthones. | 1995 | J. Pharm. Pharmacol. | pmid:8568627 |
| Kudolo GB et al. | Differential metabolism of exogenous platelet-activating factor by glandular epithelial and stromal cells of rabbit endometrium. | 1995 | J. Reprod. Fertil. | pmid:8568777 |
| Muzia GI et al. | [Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist]. | 1995 Jul-Aug | Vopr. Med. Khim. | pmid:8571587 |
| Samuelsson J | Impaired activation of phospholipase D in polycythaemia vera-implications for the pathogenesis of the disease? | 1995 | Leuk. Lymphoma | pmid:8574168 |
| Fukumura D et al. | Oxidative stress in gastric mucosal injury: role of platelet-activating factor-activated granulocytes. | 1995 | J. Gastroenterol. | pmid:8574326 |
| Naz RK and Minhas BS | Enhancement of sperm function for treatment of male infertility. | 1995 Sep-Oct | J. Androl. | pmid:8575977 |
| Manning R et al. | Lipid changes in HL-60 cells on differentiation into macrophages by treatment with a phorbol ester. | 1995 | Lipids | pmid:8577224 |
| Monthly prostaglandin bibliography prepared by the University of Sheffield Biomedical Information Service. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577776 | |
| Diserbo M et al. | Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579584 |
| Iwamoto S et al. | Platelet microparticles: a carrier of platelet-activating factor? | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579618 |
| Man RY and Kinnaird AA | Similar coronary vascular effects in the rat perfused heart of platelet-activating factor structural analogues with agonist and antagonist properties. | 1995 | Br. J. Pharmacol. | pmid:8581269 |
| Hilliquin P et al. | Production of PAF-acether by synovial fluid neutrophils in rheumatoid arthritis. | 1995 | Inflamm. Res. | pmid:8581516 |
| Kuwahara M et al. | Synthetic studies on condensed-azole derivatives. IV. Synthesis and anti-asthmatic activities of omega-sulfamoylalkyloxyimidazo[1,2-b]pyridazines. | 1996 | Chem. Pharm. Bull. | pmid:8582031 |
| Morris J et al. | Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study. | 1995 Jun-Jul | Clin. Exp. Pharmacol. Physiol. | pmid:8582091 |
| Arthur JF et al. | Paf antagonists block induction of nitric oxide synthase in cultured macrophages and vascular smooth muscle cells. | 1995 Jun-Jul | Clin. Exp. Pharmacol. Physiol. | pmid:8582100 |
| Komatsu H et al. | Platelet-activating factor induces cell growth through tyrosine phosphorylation pathway in cultured rat mesangial cells. | 1995 | Nihon Jinzo Gakkai Shi | pmid:8583698 |
| Tunón H et al. | Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. | 1995 | J Ethnopharmacol | pmid:8583796 |
| Cheng D and Chen W | [Distribution of platelet activating factor in the pulmonary tissues of normal rats]. | 1995 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:8586397 |
| Davis TM et al. | The metabolism of platelet-activating factor in severe and cerebral malaria. | 1995 | J. Infect. | pmid:8586836 |
| Myers SI et al. | Platelet activating factor (PAF) stimulates release of PGI2 from inflamed rabbit gallbladder cell cultures. | 1995 | Prostaglandins | pmid:8588069 |
| Calligerou M et al. | Platelet activating factor and lyso-phosphatidylcholines from strawberry. | 1996 | Phytochemistry | pmid:8588879 |
| Suzuki H et al. | Evidence for the production of platelet-activating factor by murine embryos and its putative role in the maternal physiology. | 1995 | Biochem. Mol. Biol. Int. | pmid:8589634 |
| Pettigrew LC et al. | Delayed elevation of platelet activating factor in ischemic hippocampus. | 1995 | Brain Res. | pmid:8590061 |
| Hurst JS and Bazan HE | Activation of the phospholipase/cyclooxygenase cascade in the rabbit cornea by platelet-activating factor is challenged by PAF receptor antagonists. | 1995 | J Ocul Pharmacol Ther | pmid:8590265 |
| Zhou W et al. | Evidence for altered cellular calcium in the pathogenetic mechanism of acute pancreatitis in rats. | 1996 | J. Surg. Res. | pmid:8592406 |
| Bazan NG et al. | Mediators of injury in neurotrauma: intracellular signal transduction and gene expression. | 1995 | J. Neurotrauma | pmid:8594208 |
| Klabunde RE and Calvello C | Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor. | 1995 | Shock | pmid:8595525 |
| Dentan C et al. | Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase. | 1996 | Biochim. Biophys. Acta | pmid:8597590 |
| Carter MB et al. | Platelet-activating factor mediates pulmonary macromolecular leak following intestinal ischemia-reperfusion. | 1996 | J. Surg. Res. | pmid:8598677 |
| Dupuis F et al. | PAF and haematopoiesis. X. Macrophage colony-stimulating factor and granulocyte macrophage colony-stimulating factor enhance platelet-activating factor acetylhydrolase production by human blood-derived macrophages. | 1996 | Biochim. Biophys. Acta | pmid:8603099 |
| Lombard MN et al. | Liver and plasma concentrations in paf-acether and its precursors after partial hepatectomy. | 1996 | Cell Prolif. | pmid:8603108 |
| Pinckard RN and Prihoda TJ | Alkyl-PAF and acyl-PAF human neutrophil priming for enhanced fMLP- and rC5a-induced superoxide anion production. | 1996 | J. Leukoc. Biol. | pmid:8603994 |
| Schweizer RC et al. | Mechanisms involved in eosinophil migration. Platelet-activating factor-induced chemotaxis and interleukin-5-induced chemokinesis are mediated by different signals. | 1996 | J. Leukoc. Biol. | pmid:8604012 |
| Ono S et al. | A clinical study on the significance of platelet-activating factor in the pathophysiology of septic disseminated intravascular coagulation in surgery. | 1996 | Am. J. Surg. | pmid:8604832 |
| Novo C et al. | Factors associated with hyperdynamic or hypodynamic circulation and role of platelet-activating factor in hemodynamic alterations in bacterial peritonitis in conscious rats. | 1995 | J. Cardiovasc. Pharmacol. | pmid:8606531 |
| Satoh K et al. | Production of platelet-activating factor by porcine brain microvascular endothelial cells in culture. | 1995 | Thromb. Haemost. | pmid:8607119 |
| Comminges C et al. | Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607782 |
| Gabbeta J et al. | Abnormal inside-out signal transduction-dependent activation of glycoprotein IIb-IIIa in a patient with impaired pleckstrin phosphorylation. | 1996 | Blood | pmid:8608226 |
| Tan XD et al. | Platelet activating factor and endotoxin increase the enzyme activity and gene expression of type II phospholipase A2 in the rat intestine. Role of polymorphonuclear leukocytes. | 1996 | J. Immunol. | pmid:8609420 |
| Nishida K and Markey SP | Platelet-activating factor in brain regions after transient ischemia in gerbils. | 1996 | Stroke | pmid:8610322 |
| Biffl WL et al. | Interleukin-6 stimulates neutrophil production of platelet-activating factor. | 1996 | J. Leukoc. Biol. | pmid:8613706 |
| Biffl WL et al. | Interleukin-6 delays neutrophil apoptosis via a mechanism involving platelet-activating factor. | 1996 | J Trauma | pmid:8614035 |
| Bailie MB et al. | Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity. | 1996 | Toxicol. Lett. | pmid:8614909 |
| Svetlov SI et al. | Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation. | 1996 | Arch. Biochem. Biophys. | pmid:8615681 |
| van Willigen G et al. | Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit. | 1996 | Biochem. J. | pmid:8615768 |
| Silva CL et al. | Formation of a highly stable complex between BN 50730 [tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4',3'-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4] and the platelet-activating factor receptor in rabbit platelet membranes. | 1996 | Biochem. Pharmacol. | pmid:8615889 |
| Dentan C et al. | Phagocytic activation induces formation of platelet-activating factor in human monocyte-derived macrophages and in macrophage-derived foam cells. Relevance to the inflammatory reaction in atherogenesis. | 1996 | Eur. J. Biochem. | pmid:8617285 |
| Burns AR et al. | Chemotactic factors stimulate CD18-dependent canine neutrophil adherence and motility on lung fibroblasts. | 1996 | J. Immunol. | pmid:8617965 |
| Nassif A et al. | Role of cytokines and platelet-activating factor in inflammatory bowel disease. Implications for therapy. | 1996 | Dis. Colon Rectum | pmid:8620791 |
| Longphre M et al. | PAF-induced airways hyperreactivity is modulated by mast cells in mice. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8624251 |
| Coceani F et al. | Response of newborn and adult sheep to pyrogens: relation between fever and brain eicosanoid changes. | 1995 | Brain Res. | pmid:8624710 |
| Antonopoulou S et al. | Blood cardiolipin in haemodialysis patients. Its implication in the biological action of platelet-activating factor. | 1996 | Int. J. Biochem. Cell Biol. | pmid:8624843 |
| Komatsu Y et al. | Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury. | 1996 | Dig. Dis. Sci. | pmid:8625746 |
| Parent JL et al. | Mutations of two adjacent amino acids generate inactive and constitutively active forms of the human platelet-activating factor receptor. | 1996 | J. Biol. Chem. | pmid:8626474 |
| Harris JG et al. | Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630023 |
| Alaei P et al. | Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630058 |
| Yin M et al. | The PAF antagonist TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. | 1996 | Transplantation | pmid:8633367 |
| Francischi JN et al. | Pharmacological characterization of Sephadex-induced oedema in rat paws: predominant role of serotonin and platelet-activating factor. | 1996 | Int. Arch. Allergy Immunol. | pmid:8634526 |
| Niwa Y et al. | Role of cytokines, tyrosine kinase, and protein kinase C on production of superoxide and induction of scavenging enzymes in human leukocytes. | 1996 | Clin. Immunol. Immunopathol. | pmid:8635290 |
| Saito M et al. | RANTES and platelet-activating factor open Ca2+-activated K+ channels in eosinophils. | 1996 | FASEB J. | pmid:8635697 |