| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Hyperuricemia | D033461 | 4 associated lipids |
| Jaundice, Obstructive | D041781 | 2 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kawasaki T and Snyder F | Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. | 1988 | J. Biol. Chem. | pmid:3422635 |
| Heptinstall S and Bevan J | How can we inhibit 5-HT-induced platelet aggregation and why should we bother? | 1988 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2465956 |
| Bodzenta-Lukaszyk A et al. | Blood platelet function in patients with obliterative arteriosclerosis of the lower limbs. | 1988 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2465957 |
| Terashita Z et al. | Protective effects of a platelet activating factor (PAF) antagonist and its combined treatment with prostaglandin (PG) E1 in traumatic shock. | 1988 | J. Cardiovasc. Pharmacol. | pmid:2468048 |
| Bourdillat B et al. | Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. | 1988 | Eur. J. Pharmacol. | pmid:2836213 |
| Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
| Yamada K et al. | Parallel inhibition of platelet-activating factor-induced protein phosphorylation and serotonin release by K-252a, a new inhibitor of protein kinases, in rabbit platelets. | 1988 | Biochem. Pharmacol. | pmid:3128296 |
| Fernandez-Gallardo S et al. | Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids. | 1988 | Biochem. J. | pmid:2848496 |
| Rossi AG et al. | Stereospecific bioactions of 5-hydroxyeicosatetraenoate. | 1988 | FEBS Lett. | pmid:3191990 |
| Nakamura T et al. | Effect of azelastine on the intracellular Ca2+ mobilization in guinea pig peritoneal macrophages. | 1988 | Eur. J. Pharmacol. | pmid:2898372 |
| Del Monte M and Subissi A | Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3149718 |
| Hofmann B et al. | Effects of synthetic analogues of platelet-activating factor (PAF) on fibrinolytic activity in the rat. | 1988 | Biomed. Biochim. Acta | pmid:3150268 |
| Bahr T et al. | Influence of inhibitors of the eicosanoid metabolism, of antagonists of the eicosanoids and of PAF on mortality assayed in three biochemically characterized shock models. | 1988 | Biomed. Biochim. Acta | pmid:3150272 |
| Myers AK et al. | Antagonism of PAF-induced death in mice. | 1988 | Prostaglandins | pmid:3131837 |
| Archer CB et al. | Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man. | 1988 | J. Invest. Dermatol. | pmid:3385217 |
| Taylor RR et al. | Time dependence of whole blood aggregation in response to platelet activating factor (PAF). | 1988 | Thromb. Haemost. | pmid:3388292 |
| Powling MJ and Hardisty RM | Potentiation by adrenaline of Ca2+ influx and mobilization in stimulated human platelets: dissociation from thromboxane generation and aggregation. | 1988 | Thromb. Haemost. | pmid:3388294 |
| Pirotzky E et al. | Cyclosporine-induced nephrotoxicity: preventive effect of a PAF-acether antagonist, BN 52063. | 1988 | Transplant. Proc. | pmid:3388505 |
| Ward SG and Westwick J | Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells. | 1988 | Br. J. Pharmacol. | pmid:3390650 |
| Feuerstein G and Siren AL | Platelet-activating factor and shock. | 1988 | Prog Biochem Pharmacol | pmid:3043432 |
| Godfroid JJ and Heymans F | Chemistry of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043433 |
| Casals-Stenzel J and Heuer H | Pharmacology of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043436 |
| Rola-Pleszczynski M | PAF in cellular immunology. | 1988 | Prog Biochem Pharmacol | pmid:3043437 |
| Baggiolini M et al. | Effects of PAF on neutrophils and mononuclear phagocytes. | 1988 | Prog Biochem Pharmacol | pmid:3043438 |
| Camussi G et al. | Synthesis and release of platelet-activating factor is inhibited by plasma alpha 1-proteinase inhibitor or alpha 1-antichymotrypsin and is stimulated by proteinases. | 1988 | J. Exp. Med. | pmid:3049910 |
| Cahill M et al. | Effect of des arginine9-bradykinin and other bradykinin fragments on the synthesis of prostacyclin and the binding of bradykinin by vascular cells in culture. | 1988 | Agents Actions | pmid:3051930 |
| Page CP et al. | Drugs affecting pulmonary responses to platelet activating factor as novel anti-asthma drugs. | 1988 | Agents Actions Suppl. | pmid:3051932 |
| Makino S | [Platelet activating factor in allergic reaction]. | 1988 | Arerugi | pmid:3052368 |
| Wasserman SI | Platelet-activating factor as a mediator of bronchial asthma. | 1988 | Hosp. Pract. (Off. Ed.) | pmid:3053741 |
| Pai JK et al. | Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3422154 |
| Lee TC et al. | Formation of 1-alkyl-2-acetyl-sn-glycerols via the de novo biosynthetic pathway for platelet-activating factor. Characterization of 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase in rat spleens. | 1988 | J. Biol. Chem. | pmid:2828351 |
| Nieto ML et al. | Biosynthesis of platelet-activating factor in human polymorphonuclear leukocytes. Involvement of the cholinephosphotransferase pathway in response to the phorbol esters. | 1988 | J. Biol. Chem. | pmid:2828363 |
| Ponpipom MM et al. | (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2829894 |
| Braquet P et al. | Platelet activating factor as a mediator in cerebral ischemia and related disorders. | 1988 | Biomed. Biochim. Acta | pmid:3073761 |
| Wainwright CL et al. | The effects of PAF antagonists on ischaemia and reperfusion arrhythmias and ischaemia-induced platelet aggregation. | 1988 | Biomed. Biochim. Acta | pmid:3248108 |
| Dembińska-Kieć A et al. | Release of cysteinyl-leukotrienes is of minor importance in PAF induced reduction of perfusion rate in the gastric vascular bed. | 1988 | Biomed. Biochim. Acta | pmid:3248109 |
| Ostermann G et al. | Structure-activity relationships of synthetic analogues of platelet-activating factor. | 1988 | Biomed. Biochim. Acta | pmid:3248110 |
| Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
| Stahl GL et al. | Role of platelet activating factor in propagation of cardiac damage during myocardial ischemia. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3252036 |
| Williams WR et al. | Plates and anti-asthma drugs. | 1988 | Pneumonol Pol | pmid:3254508 |
| Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
| Sirois MG et al. | PAF increases vascular permeability in selected tissues: effect of BN-52021 and L-655,240. | 1988 | Prostaglandins | pmid:3238010 |
| Schindler PW et al. | Fluorophore-labeled ether lipids: substrates for enzymes of the platelet-activating factor cycle in peritoneal polymorphonuclear leukocytes. | 1988 | Anal. Biochem. | pmid:3239750 |
| Silva PM et al. | Adrenalectomy exacerbates paw edema without interfering with desensitization induced by PAF-acether in rats. | 1988 | Braz. J. Med. Biol. Res. | pmid:3240383 |
| Fradin A et al. | Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin 's'. | 1988 | Biochim. Biophys. Acta | pmid:2848583 |
| Fichelle J et al. | Bronchospasmolytic effects of RU 42173. | 1988 | Fundam Clin Pharmacol | pmid:3240917 |
| Misawa M and Takata T | [Effects of platelet activating factor on the bronchial musculature and vasculature in dogs]. | 1988 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3241511 |
| Perico N et al. | Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney. | 1988 | Lab. Invest. | pmid:3123798 |
| Lakin KM et al. | [Action of calcium antagonists on thrombocyte aggregation]. | 1987 Sep-Oct | Farmakol Toksikol | pmid:2826225 |
| Berdel WE et al. | Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. | 1987 Nov-Dec | Anticancer Res. | pmid:3442414 |
| Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
| Arnoux B et al. | Antigenic release of paf-acether and beta-glucuronidase from alveolar macrophages of asthmatics. | 1987 Mar-Apr | Bull Eur Physiopathol Respir | pmid:3607326 |
| Lurie A et al. | Exercise- and allergen-induced asthma do not change the production of Paf-acether by neutrophils and platelets. | 1987 Jul-Aug | Bull Eur Physiopathol Respir | pmid:3690021 |
| Auriault C et al. | The effector function of platelets is induced and regulated by T lymphocytes. | 1987 Jul-Aug | Ann. Inst. Pasteur Immunol. | pmid:3118905 |
| Liu BN | [Neoplastic membrane-toxic activity as one of the pathogenetic factors in blood cell and tumor growth changes]. | 1987 Jan-Feb | Patol Fiziol Eksp Ter | pmid:3550649 |
| Lagente V et al. | Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. | 1987 | Prostaglandins | pmid:2438723 |
| Tselepis AD et al. | Electrocardiographic alterations induced by AGEPC in Wistar rats in relation to its hypotensive and hematologic effects. | 1987 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2885139 |
| Hayashi M et al. | Characterization of the activity of a platelet activating factor antagonist, CV-3988. | 1987 | Jpn. J. Pharmacol. | pmid:2888915 |
| Bussolino F et al. | Chick retina generates platelet-activating factor. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890284 |
| Mikashima H et al. | An antagonistic activity of etizolam on platelet-activating factor (PAF). In vitro effects on platelet aggregation and PAF receptor binding. | 1987 | Jpn. J. Pharmacol. | pmid:2890779 |
| Patterson R et al. | Evaluation of the effect of a platelet activating factor antagonist on platelet activating factor and Ascaris antigen-induced airway responses in rhesus monkeys. | 1987 | J. Lab. Clin. Med. | pmid:3668360 |
| Stewart AG and Piper PJ | Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro. | 1987 | Prog. Clin. Biol. Res. | pmid:3671383 |
| Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
| Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
| Homma H et al. | Binding and internalization of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in washed rabbit platelets. | 1987 | J. Biol. Chem. | pmid:3038889 |
| Myers A et al. | Pharmacological manipulation of platelet-activating factor toxicity in rodents. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960198 |
| Mangold HK et al. | Biologically active lipids. Semi-synthesis of 3H-labeled ether glycerophospholipids and ether glyceroglycolipids from ratfish liver oil. | 1987 | FEBS Lett. | pmid:3609315 |
| Caffrey E et al. | Aggregation responses to platelet-activating factor in normal subjects. | 1987 | Haemostasis | pmid:3609916 |
| Bittman R et al. | Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone. | 1987 | J. Lipid Res. | pmid:3611974 |
| Terashita Z et al. | CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3612533 |
| Bruijnzeel PL et al. | Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | 1987 | Prostaglandins | pmid:3118415 |
| Taylor RR et al. | Whole blood platelet aggregation is not affected by cigarette smoking but is sex-related. | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:3440324 |
| Shimazaki N et al. | Diketopiperazines as a new class of platelet-activating factor inhibitors. | 1987 | J. Med. Chem. | pmid:3656347 |
| Ruan CG et al. | Studies on monoclonal antibodies against human platelets--a monoclonal antibody to human platelet glycoprotein I--SZ-2. | 1987 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:3659897 |
| Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
| Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
| Haroldsen PE et al. | Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. | 1987 | J. Lipid Res. | pmid:3104521 |
| Bloom JW et al. | Intravenous platelet activating factor does not affect lung epithelial permeability. | 1987 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3326081 |
| de Almeida PJ et al. | [Biochemical bases of platelet activity in homeostasis and thrombogenesis. III]. | 1987 | Arq. Bras. Cardiol. | pmid:3328601 |
| O'Neill C | Embryo-derived platelet activating factor: a preimplantation embryo mediator of maternal recognition of pregnancy. | 1987 | Domest. Anim. Endocrinol. | pmid:3333935 |
| Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
| Mathur RS et al. | Current concepts in asthma. | 1987 | J Assoc Physicians India | pmid:3320019 |
| Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
| Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
| Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
| Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
| Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
| Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
| Chung KF et al. | Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. | 1987 | Lancet | pmid:2880069 |
| Casals-Stenzel J and Weber KH | Triazolodiazepines: dissociation of their Paf (platelet activating factor) antagonistic and CNS activity. | 1987 | Br. J. Pharmacol. | pmid:2880622 |
| Leff AR et al. | Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo. | 1987 | J. Appl. Physiol. | pmid:2881917 |
| Spinks NR and O'Neill C | Embryo-deprived platelet-activating factor is essential for establishment of pregnancy in the mouse. | 1987 | Lancet | pmid:2432367 |
| Khandwala A et al. | REV 2871 (CHBZ): a potent antiallergic agent with a novel mechanism of action. I. Activity profile as an inhibitor of mediator release. | 1987 | Biochem. Pharmacol. | pmid:2435293 |
| Altin JG et al. | Evidence that Ca2+ fluxes and respiratory, glycogenolytic and vasoconstrictive effects induced by the action of platelet-activating factor and L-alpha-lysophosphatidylcholine in the perfused rat liver are mediated by products of the cyclo-oxygenase pathway. | 1987 | Biochem. J. | pmid:3117040 |
| Terashita Z et al. | A lethal role of platelet activating factor in anaphylactic shock in mice. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3118009 |
| de Arriba G et al. | Changes in glomerular cross-sectional area induced by platelet activating factor. | 1987 | Nephrol. Dial. Transplant. | pmid:3118261 |
| Darius H and Lefer AM | Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. | 1987 | Prog. Clin. Biol. Res. | pmid:3118384 |
| Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
| Moodley I and Stuttle A | Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. | 1987 | Prostaglandins | pmid:3035617 |
| Codde JP et al. | Effects of altered prostanoid and lyso-PAF synthesis by marine oil diets on blood pressure of salt loaded spontaneously hypertensive rats. | 1987 | Agents Actions Suppl. | pmid:3481207 |