| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Page CP et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857401 |
| Gresele P et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857402 |
| Lenihan DJ et al. | Involvement of platelet activating factor in physiological stress in the lizard, Anolis carolinensis. | 1985 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2861063 |
| Braquet P et al. | Involvement of platelet activating factor in respiratory anaphylaxis, demonstrated by PAF-acether inhibitor BN 52021. | 1985 | Lancet | pmid:2861423 |
| McIntyre TM et al. | Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. | 1985 | J. Clin. Invest. | pmid:2862164 |
| Terashita Z et al. | Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004156 |
| Archer CB et al. | Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man. | 1985 | Br. J. Pharmacol. | pmid:2862936 |
| Billah MM et al. | Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. | 1985 | Prostaglandins | pmid:3936121 |
| McKean ML and Silver MJ | Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor. | 1985 | Biochem. J. | pmid:3919710 |
| Bruynzeel PL et al. | Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan. | 1985 | FEBS Lett. | pmid:2995125 |
| Archer CB et al. | Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. | 1985 | Agents Actions | pmid:3923788 |
| Sturk A et al. | Synergistic effects of platelet-activating factor and other platelet agonists in human platelet aggregation and release: the role of ADP and products of the cyclooxygenase pathway. | 1985 | Thromb. Res. | pmid:2934863 |
| Morley J et al. | Pharmacology of the late response to allergen and its relevance to asthma prophylaxis. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:3924841 |
| Hwang SB et al. | Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist. | 1985 | Lab. Invest. | pmid:3925239 |
| Valone FH and Johnson B | Modulation of cytoplasmic calcium in human platelets by the phospholipid platelet-activating factor 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine. | 1985 | J. Immunol. | pmid:2578151 |
| Bourgain RH et al. | The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. | 1985 | Prostaglandins | pmid:3931178 |
| Ribbes G et al. | Evidence that biosynthesis of platelet-activating factor (paf-acether) by human neutrophils occurs in an intracellular membrane. | 1985 | FEBS Lett. | pmid:3932094 |
| GarcÃa-Sáinz JA and Hernández-Sotomayor SM | Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933497 |
| Barnes PJ | Mediators and asthma. | 1985 | Br J Hosp Med | pmid:3936563 |
| Hemmendinger S et al. | [Physiology of the interactions of blood and the blood vessel wall. Role of pharmacologically active lipids]. | 1985 | Arch Mal Coeur Vaiss | pmid:3938941 |
| Benveniste J | Biosynthesis and function of PAF-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936197 |
| Waku K et al. | Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936199 |
| Saito K et al. | Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936200 |
| Hanahan DJ et al. | Platelet-activating factor: a unique lipid chemical mediator. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936201 |
| Inoue K et al. | Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936203 |
| Touqui L et al. | Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. | 1985 | Biochem. J. | pmid:4052028 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159192 |
| Verstraete M et al. | An overview of antiplatelet and antithrombotic drugs. | 1985 | Haemostasis | pmid:3159632 |
| Zimmerman GA et al. | Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin. | 1985 | Circulation | pmid:3928193 |
| Darius H et al. | Beneficial effects of a new potent and specific thromboxane receptor antagonist (SQ-29,548) in vitro and in vivo. | 1985 | J. Pharmacol. Exp. Ther. | pmid:2997428 |
| Emeis JJ and Kluft C | PAF-acether-induced release of tissue-type plasminogen activator from vessel walls. | 1985 | Blood | pmid:3924144 |
| Benveniste J and Chignard M | A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? | 1985 | Circulation | pmid:3928192 |
| Cordón-Cardó C | [The barley cell or mastocyte: cellular and molecular biology]. | 1985 | Med Clin (Barc) | pmid:2580196 |
| McManus LM and Pinckard RN | Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit. | 1985 | Am. J. Pathol. | pmid:4050977 |
| Disselnkötter H et al. | [Synthesis of phosphono analogs of 2-O-acetyl-1-O-hexadecyl(octadecyl)-sn-3-glycerylphosphorylcholine (platelet-activating factor)]. | 1985 | Arch. Pharm. (Weinheim) | pmid:4051690 |
| Ogunbiyi PO and Eyre P | Pharmacological studies of pulmonary anaphylaxis in vitro: a review. | 1985 | Agents Actions | pmid:2420161 |
| Robinson M and Snyder F | Metabolism of platelet-activating factor by rat alveolar macrophages: lyso-PAF as an obligatory intermediate in the formation of alkylarachidonoyl glycerophosphocholine species. | 1985 | Biochim. Biophys. Acta | pmid:4052436 |
| Kozlov VK et al. | [Characteristics of the activation of rabbit platelets induced by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet activation factor)]. | 1985 | Biull Eksp Biol Med | pmid:4052603 |
| Page CP et al. | Properties of PAF-acether appropriate to a mediator of the inflammatory aspects of asthma. | 1985 | Int J Tissue React | pmid:4055261 |
| Wardlow ML | Rapid isocratic procedure for the separation of platelet-activating factor from phospholipids in human saliva by high-performance liquid chromatography. | 1985 | J. Chromatogr. | pmid:4055961 |
| Hubbard JW et al. | Cardiac output and peripheral vascular resistance during intravenous infusion of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine in conscious normotensive and spontaneously hypertensive rats. | 1985 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:4059660 |
| Imbs AB et al. | [Synthesis of a fluorescently-labeled platelet activating factor]. | 1985 | Bioorg. Khim. | pmid:4062993 |
| Vanhoutte PM and Houston DS | Platelets, endothelium, and vasospasm. | 1985 | Circulation | pmid:3861273 |
| Sandler RM et al. | Heparin-induced thrombocytopenia and thrombosis: detection and specificity of a platelet-aggregating IgG. | 1985 | Am. J. Clin. Pathol. | pmid:4003343 |
| Tencé M et al. | Ether-phospholipid composition in neutrophils and platelets. | 1985 | Thromb. Res. | pmid:4024039 |
| Oda M et al. | Production of platelet-activating factor by washed rabbit platelets. | 1985 | J. Lipid Res. | pmid:3934305 |
| Tan EL and Snyder F | Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by capillary endothelial cells isolated from rat epididymal adipose tissue. | 1985 | Thromb. Res. | pmid:4024051 |
| Weisman SM et al. | Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3862805 |
| Leclercq M et al. | [Effects of Hymenoptera stings: physiopathology and immunology according to recent literature findings]. | 1985 | Rev Med Liege | pmid:2418479 |
| Pipili E | Platelet membrane potential: simultaneous measurement of diSC3(5) fluorescence and optical density. | 1985 | Thromb. Haemost. | pmid:2418525 |