| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim YD et al. | Constriction of canine coronary arteries by platelet activating factor after brief ischemia. | 1993 | Prostaglandins | pmid:8234834 |
| Kojima T et al. | Production and secretion of progesterone in vitro and presence of platelet activating factor (PAF) in early pregnancy of the marsupial, Macropus eugenii. | 1993 | Reprod. Fertil. Dev. | pmid:8234890 |
| Nobe K et al. | Effect of diacylglycerol kinase inhibitor, R59022 on cytosolic free calcium level and force development in guinea pig taenia coli. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8235067 |
| Krämer K et al. | Studies on the metabolism of metallothionein and alkaline phosphatase of adult rat primary hepatocyte cultures: role of fetal calf serum and agonists of the phosphoinositide cascade. | 1993 | Z Ernahrungswiss | pmid:8237077 |
| Ma Y et al. | [PAF antagonistic benzofuran neolignans from Piper kadsura]. | 1993 | Yao Xue Xue Bao | pmid:8237383 |
| Weintraub ST et al. | Synthesis of pentafluorobenzoic anhydride: a superior derivatizing agent for lipids. | 1993 | Anal. Chem. | pmid:8238933 |
| Fletcher JR | Eicosanoids. Critical agents in the physiological process and cellular injury. | 1993 | Arch Surg | pmid:8239981 |
| Laneuville O et al. | Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4. | 1993 | Biochem. J. | pmid:8240236 |
| Rochon YP and Frojmovic MM | Regulation of human neutrophil aggregation: comparable latent times, activator sensitivities, and exponential decay in aggregability for FMLP, platelet-activating factor, and leukotriene B4. | 1993 | Blood | pmid:8241512 |
| Perez SA et al. | Eosinophil granulocyte proliferation induced by an intermediate factor generated in the pleural cavity of rats injected with platelet-activating factor-acether. | 1993 | Int. Arch. Allergy Immunol. | pmid:8241799 |
| Saito H et al. | Platelet-activating-factor-induced augmentation of production of eosinophil-lineage cells in hematopoietic precursor cells obtained from human umbilical cord blood. | 1993 | Int. Arch. Allergy Immunol. | pmid:8241800 |
| Eda R et al. | Inhibitory effects of formoterol on platelet-activating factor induced eosinophil chemotaxis and degranulation. | 1993 | Int. Arch. Allergy Immunol. | pmid:8241801 |
| Bkaily G et al. | PAF activation of a voltage-gated R-type Ca2+ channel in human and canine aortic endothelial cells. | 1993 | Br. J. Pharmacol. | pmid:8242226 |
| Hu W et al. | Partial agonist effect of the platelet-activating factor receptor antagonists, WEB 2086 and WEB 2170, in the rat perfused heart. | 1993 | Br. J. Pharmacol. | pmid:8242237 |
| Emmendörffer A et al. | Production of oxygen radicals by fibroblasts and neutrophils from a patient with x-linked chronic granulomatous disease. | 1993 | Eur. J. Haematol. | pmid:8243611 |
| McDonald PP et al. | Induction by chemokines of lipid mediator synthesis in granulocyte-macrophage colony-stimulating factor-treated human neutrophils. | 1993 | J. Immunol. | pmid:8245474 |
| van der Bruggen T et al. | Transient exposure of human eosinophils to the protein kinase C inhibitors CGP39-360, CGP41-251, and CGP44-800 leads to priming of the respiratory burst induced by opsonized particles. | 1993 | J. Leukoc. Biol. | pmid:8245706 |
| Duque I et al. | Calcium channel blockers inhibit hydrogen peroxide-induced proliferation of cultured rat mesangial cells. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8246135 |
| Musemeche CA et al. | Intestinal ischemia in the newborn: the role of intestinal maturation. | 1993 | J. Surg. Res. | pmid:8246492 |
| Zeng GQ et al. | Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249627 |
| Zhang B and Long K | Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249632 |
| Imai T et al. | [Relation of platelet activating factor induced airway hyperresponsiveness to thromboxane A2 and neutrophil in dogs]. | 1993 | Arerugi | pmid:8250720 |
| Archer CB | Platelet activating factor--a mediator of inflammation in the skin--medical implications. | 1993 | Clin. Exp. Dermatol. | pmid:8252783 |
| Hotchkiss JA et al. | Platelet activating factor stimulates rapid mucin secretion in rat nasal airways in vivo. | 1993 Sep-Oct | Exp. Lung Res. | pmid:8253058 |
| Nathan N and Denziot Y | Platelet-activating factor and nonalcoholic cirrhotics. | 1993 | Gastroenterology | pmid:8253376 |
| Sengoku K et al. | Effects of platelet activating factor on human sperm function in vitro. | 1993 | Hum. Reprod. | pmid:8253933 |
| Palmblad J et al. | Signal transduction mechanisms for leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils. | 1994 | J. Immunol. | pmid:8254196 |
| Chopra K et al. | Involvement of oxygen free radicals in the action of BN 52021 (PAF antagonist) to limit myocardial infarct size. | 1993 | Methods Find Exp Clin Pharmacol | pmid:8255122 |
| Herbert JM et al. | Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist. | 1993 | J Lipid Mediat | pmid:8257776 |
| Squadrito F et al. | Platelet activating factor interaction with tumor necrosis factor in myocardial ischaemia-reperfusion injury. | 1993 | J Lipid Mediat | pmid:8257777 |
| Noris M et al. | Defective glomerular [3H]lysoPAF metabolism in the autologous phase of rabbit nephrotoxic nephritis. | 1993 | Kidney Int. | pmid:8258952 |
| Doly M et al. | Prevention of chloroquine-induced electroretinographic damage by a new platelet-activating factor antagonist, BN 50730. | 1993 | Ophthalmic Res. | pmid:8259265 |
| Steen VM et al. | The platelet-stimulating effect of adrenaline through alpha 2-adrenergic receptors requires simultaneous activation by a true stimulatory platelet agonist. Evidence that adrenaline per se does not induce human platelet activation in vitro. | 1993 | Thromb. Haemost. | pmid:8259557 |
| MacKendrick W et al. | Increase in plasma platelet-activating factor levels in enterally fed preterm infants. | 1993 | Biol. Neonate | pmid:8260551 |
| Elwood W et al. | Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet-activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the brown Norway rat. | 1994 | Int. Arch. Allergy Immunol. | pmid:8260852 |
| Hartnell A et al. | CD69 is expressed by human eosinophils activated in vivo in asthma and in vitro by cytokines. | 1993 | Immunology | pmid:8262555 |
| Raeburn D and Karlsson JA | Effects of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea pig airways in vivo. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8263775 |
| Rabinovici R et al. | Tumor necrosis factor-alpha mediates endotoxin-induced lung injury in platelet activating factor-primed rats. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8263817 |
| McManus LM et al. | PAF molecular heterogeneity: pathobiological implications. | 1993 | Lab. Invest. | pmid:8264227 |
| Freire-Maia L and de Matos IM | Heparin or a PAF antagonist (BN-52021) prevents the acute pulmonary edema induced by Tityus serrulatus scorpion venom in the rat. | 1993 | Toxicon | pmid:8266352 |
| Corcoran PC et al. | Reduction of conjugated dienes in lung transplantation: effect of BN 52021. | 1993 | Ann. Thorac. Surg. | pmid:8267425 |
| Waga I et al. | Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267581 |
| Manzini S et al. | Interactions between sensory neuropeptides and lipid mediators in the airways. | 1993 | J Lipid Mediat | pmid:8268456 |
| Tjebbes GW et al. | Production of lipid mediators in experimental keratitis of rabbit eye. | 1993 | J Lipid Mediat | pmid:8268458 |
| Vásquez-Bravo YL et al. | Differential sensitivity of mouse strains to platelet activating factor-induced vasopermeability and mortality: effect of antagonists. | 1993 | J Lipid Mediat | pmid:8268459 |
| Okamoto Y et al. | PAF-releasing factor in human serum and inflammatory exudate. | 1993 | J Lipid Mediat | pmid:8268461 |
| David S et al. | Production of platelet activating factor by human neutrophils after backfiltration of endotoxin contaminated dialysate. | 1993 Jul-Sep | ASAIO J. | pmid:8268642 |
| Stephens CJ et al. | Variation in plasma platelet-activating factor degradation and serum lipids after acute myocardial infarction. | 1993 | Coron. Artery Dis. | pmid:8269210 |
| Hirashima Y et al. | Platelet-activating factor (PAF) concentration and PAF acetylhydrolase activity in cerebrospinal fluid of patients with subarachnoid hemorrhage. | 1994 | J. Neurosurg. | pmid:8271019 |
| Roberts C et al. | Platelet activating factor (PAF) enhances mitosis in preimplantation mouse embryos. | 1993 | Reprod. Fertil. Dev. | pmid:8272531 |
| Jørgensen L et al. | Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy. | 1993 | Scand. J. Clin. Lab. Invest. | pmid:8272758 |
| Raff GW et al. | Procoagulant property of platelet activating factor (PAF). | 1993 | Agents Actions | pmid:8273543 |
| Meats JE et al. | Identification of phospholipase D (PLD) activity in mouse peritoneal macrophages. | 1993 | Agents Actions | pmid:8273553 |
| Thomas TK et al. | Differential antagonism of platelet activating factor-induced neutrophilia and gastric hemorrhage in the rat. | 1993 | Agents Actions | pmid:8273566 |
| Glaser KB et al. | Pharmacological characterization of WAY-121,520: a potent anti-inflammatory indomethacin-based inhibitor of 5-lipoxygenase (5-LO)/phospholipase A2 (PLA2). | 1993 | Agents Actions | pmid:8273577 |
| Chen ZN | [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8274205 |
| Chau LY and Hu CY | Platelet-activating factor receptor-mediated calcium influx in NG 108-15 cells. | 1993 | Chin J Physiol | pmid:8275798 |
| Montero A et al. | A role for platelet-activating factor in endothelin-1-induced rat mesangial cell proliferation. | 1993 | Eur. J. Pharmacol. | pmid:8276075 |
| DeJoy SQ et al. | Effect of CL 184,005, a platelet-activating factor antagonist in a murine model of Staphylococcus aureus-induced gram-positive sepsis. | 1994 | J. Infect. Dis. | pmid:8277176 |
| Zhou W et al. | Lipid mediator production in acute and chronic pancreatitis in the rat. | 1994 | J. Surg. Res. | pmid:8277767 |
| Denizot Y et al. | [Fecal platelet-activating factor (PAF). A marker of digestive inflammatory disorders]. | 1993 | Presse Med | pmid:8278326 |
| Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
| Thompson WA et al. | The metabolic effects of platelet-activating factor antagonism in endotoxemic man. | 1994 | Arch Surg | pmid:8279943 |
| Turner JS et al. | Plasmin modulates the thrombin-evoked calcium response in C6 glioma cells. | 1994 | Biochem. J. | pmid:8280096 |
| Parent JL and Stankova J | Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8280163 |
| Tanaka T et al. | Platelet-aggregating effects of platelet-activating factor-like phospholipids formed by oxidation of phosphatidylcholines containing an sn-2-polyunsaturated fatty acyl group. | 1994 | Biochim. Biophys. Acta | pmid:8280771 |
| O'Flaherty JT et al. | Comparison of 1-O-alkyl-, 1-O-alk-1'-enyl-, and 1-O-acyl-2-acetyl-sn-glycero-3-phosphoethanolamines and -3-phosphocholines as agonists of the platelet-activating factor family. | 1994 | Biochim. Biophys. Acta | pmid:8280772 |
| Maziere C et al. | 1 Acyl-2 acetyl-sn-glycero-3 phosphocholine decreases the susceptibility of low-density lipoprotein to oxidative modification by copper ions, monocytes or endothelial cells. | 1994 | Biochim. Biophys. Acta | pmid:8280775 |
| Rodriguez-Roisin R et al. | Platelet-activating factor causes ventilation-perfusion mismatch in humans. | 1994 | J. Clin. Invest. | pmid:8282786 |
| Tordai A et al. | Autocrine stimulation of B lymphocytes by a platelet-activating factor receptor agonist, 1-palmitoyl-2-acetyl-sn-glycero-3-phosphocholine. | 1994 | J. Immunol. | pmid:8283038 |
| Gerard NP and Gerard C | Receptor-dependent internalization of platelet-activating factor. | 1994 | J. Immunol. | pmid:8283052 |
| Zeng GQ et al. | Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro. | 1993 | Yao Xue Xue Bao | pmid:8285049 |
| Gupta JB et al. | Platelet-activating-factor-induced changes in cardiovascular function and oxyradical status of myocardium in presence of the PAF antagonist CV-6209. | 1994 | Angiology | pmid:8285381 |
| Chupin VV et al. | [Formation of a structural isomer of platelet activating factor during acetylation of 1-alkyl-sn-glycero-3-phosphocholine]. | 1993 | Bioorg. Khim. | pmid:8285924 |
| Chen BN et al. | Effect of ischaemia and role of eicosanoids in release of atrial natriuretic factor from rat heart. | 1993 | Cardiovasc. Res. | pmid:8287433 |
| Leoncini G et al. | S-D-lactoylglutathione accumulation in activated human platelets. | 1993 | Int. J. Biochem. | pmid:8288025 |
| Parks JE and Hough SR | Platelet-activating factor acetylhydrolase activity in bovine seminal plasma. | 1993 Sep-Oct | J. Androl. | pmid:8288488 |
| Sugatani J et al. | Quantitative analysis of platelet-activating factor in human plasma. Application to patients with liver cirrhosis and disseminated intravascular coagulation. | 1993 | J. Immunol. Methods | pmid:8288878 |
| Chang SW | Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor. | 1994 | J. Lab. Clin. Med. | pmid:8288963 |
| Pi F et al. | Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation. | 1994 | Transplantation | pmid:8291097 |
| Bell M et al. | Effect of cryoprotective additives and cryopreservation protocol on sperm membrane lipid peroxidation and recovery of motile human sperm. | 1993 Nov-Dec | J. Androl. | pmid:8294232 |
| Honda Z et al. | Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. | 1994 | J. Biol. Chem. | pmid:8294489 |
| Hodgkin EE et al. | A Monte Carlo pharmacophore generation procedure: application to the human PAF receptor. | 1993 | J. Comput. Aided Mol. Des. | pmid:8294944 |
| Shinozaki K et al. | A new method of purification and sensitive bioassay of platelet-activating factor (PAF) in human whole blood. | 1994 | Life Sci. | pmid:8295490 |
| Sjogren R et al. | Role of Shiga-like toxin I in bacterial enteritis: comparison between isogenic Escherichia coli strains induced in rabbits. | 1994 | Gastroenterology | pmid:8299898 |
| Caplan MS et al. | The role of endogenous nitric oxide and platelet-activating factor in hypoxia-induced intestinal injury in rats. | 1994 | Gastroenterology | pmid:8299901 |
| David S et al. | Adherence of human monocytes to haemodialysis membranes. | 1993 | Nephrol. Dial. Transplant. | pmid:8302460 |
| Saeed SA et al. | Rhazimine from Rhazya stricta: a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation. | 1993 | Planta Med. | pmid:8302958 |
| Kosar-Hashemi B et al. | Glyceryl ether monooxygenase [EC 1.14.16.5]: stoichiometry and inhibition. | 1993 | Adv. Exp. Med. Biol. | pmid:8304231 |
| Northover AM and Northover BJ | Involvement of protein kinase C in the control of microvascular permeability to colloidal carbon. | 1993 | Agents Actions | pmid:8304240 |
| Buerke M et al. | Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. | 1994 | Am. J. Physiol. | pmid:8304493 |
| Jambou D et al. | [Mediators of the vascular endothelium as markers of myocardial ischemia and reperfusion]. | 1993 | Arch Mal Coeur Vaiss | pmid:8304814 |
| Nishihira J et al. | A role for oxygen radicals in rat monocytic leukemia cell differentiation under stimulation with platelet-activating factor. | 1994 | Biochim. Biophys. Acta | pmid:8305501 |
| Thorne JR and Broadley KJ | Adenosine-induced bronchoconstriction in conscious hyperresponsive and sensitized guinea pigs. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8306036 |
| Filep JG and Földes-Filep E | Modulation by nitric oxide of platelet-activating factor-induced albumin extravasation in the conscious rat. | 1993 | Br. J. Pharmacol. | pmid:8306074 |
| Yamanaka S et al. | Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock. | 1993 | Br. J. Pharmacol. | pmid:8306093 |
| Graham RM et al. | Plasma degradation of platelet-activating factor in severely ill patients with clinical sepsis. | 1994 | Crit. Care Med. | pmid:8306677 |
| Denizot Y and Chaussade S | Platelet activating factor and Crohn's disease. | 1994 | Gut | pmid:8307440 |
| Sun X et al. | Tumour necrosis factor and endotoxin synergistically activate intestinal phospholipase A2 in mice. Role of endogenous platelet activating factor and effect of exogenous platelet activating factor. | 1994 | Gut | pmid:8307472 |
| Denizot Y and Chaussade S | Tumor necrosis factor and platelet activating factor in stool during salmonellosis. | 1994 | Gut | pmid:8307492 |