| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Roth M et al. | Inhibition of receptor-mediated platelet activation by nedocromil sodium. | 1993 | J. Allergy Clin. Immunol. | pmid:8389778 |
| Venable ME et al. | Platelet-activating factor: a phospholipid autacoid with diverse actions. | 1993 | J. Lipid Res. | pmid:8389794 |
| Nishinaka Y et al. | A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390246 |
| Shiono S et al. | Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390248 |
| Laffi G et al. | Impaired superoxide anion, platelet-activating factor, and leukotriene B4 synthesis by neutrophils in cirrhosis. | 1993 | Gastroenterology | pmid:8390378 |
| Catalán RE et al. | PAF and thrombin actions in platelets are selectively affected by a new 1,4-dihydropyridine derivative. | 1993 | J. Biochem. | pmid:8390447 |
| Montero M et al. | Transient inhibition by chemotactic peptide of a store-operated Ca2+ entry pathway in human neutrophils. | 1993 | J. Biol. Chem. | pmid:8390453 |
| Müller E et al. | Identification and functional characterization of platelet-activating factor receptors in human leukocyte populations using polyclonal anti-peptide antibody. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8390683 |
| Rotllan E et al. | [Effect of PAF (platelet-activating factor) on hemostasis. Studies on endothelial cells and platelets]. | 1993 | Sangre (Barc) | pmid:8390724 |
| Zimmermann A and Keller H | Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022). | 1993 Mar-Apr | Anticancer Res. | pmid:8390801 |
| Gay JC | Mechanism and regulation of neutrophil priming by platelet-activating factor. | 1993 | J. Cell. Physiol. | pmid:8391006 |
| Tao W et al. | Recombinant bovine GM-CSF primes superoxide production but not degranulation induced by recombinant bovine interleukin-1 beta in bovine neutrophils. | 1993 | J. Leukoc. Biol. | pmid:8391055 |
| Zweiman B et al. | Comparison of cytosolic calcium shifts, superoxide generation, and lactoferrin secretion in the neutrophils of atopics and nonatopics. | 1993 | J. Leukoc. Biol. | pmid:8391056 |
| Tsukagoshi H and Kurosawa M | [Effect of Asthremedin on bronchial hyperresponsiveness (BHR) to histamine induced by intravenous administration of platelet activating factor (PAF) in guinea pigs]. | 1993 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8391092 |
| Chao W and Olson MS | Platelet-activating factor: receptors and signal transduction. | 1993 | Biochem. J. | pmid:8391253 |
| Tufano MA et al. | Outer-membrane porins from gram-negative bacteria stimulate platelet-activating-factor biosynthesis by cultured human endothelial cells. | 1993 | Eur. J. Biochem. | pmid:8391435 |
| O'Flaherty JT and Rossi AG | 5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism. | 1993 | J. Biol. Chem. | pmid:8392058 |
| Fonteh AN et al. | Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil. | 1993 | J. Immunol. | pmid:8392098 |
| Götz E et al. | Meningocortical lesion increases expression of the cholecystokinin gene in rat cerebral cortex: evidence for the involvement of platelet-activating factor (PAF). | 1993 | Brain Res. Mol. Brain Res. | pmid:8392132 |
| Bennett SA et al. | Platelet activating factor, an endogenous mediator of inflammation, induces phenotypic transformation of rat embryo cells. | 1993 | Carcinogenesis | pmid:8392443 |
| Abraham WM | Effect of nedocromil sodium on specific mediator- and antigen-induced airway responses in allergic sheep. | 1993 | J. Allergy Clin. Immunol. | pmid:8393023 |
| Barnes PJ | Effect of nedocromil sodium on platelet-activating factor-induced airway responses. | 1993 | J. Allergy Clin. Immunol. | pmid:8393026 |
| Kuruvilla A et al. | Tyrosine phosphorylation of phospholipase C concomitant with its activation by platelet-activating factor in a human B cell line. | 1993 | J. Immunol. | pmid:8393037 |
| Lerner R et al. | Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils. | 1993 | Blood | pmid:8393356 |
| Kester M | Platelet-activating factor stimulates phosphatidic acid formation in cultured rat mesangial cells: roles of phospholipase D, diglyceride kinase, and de novo phospholipid synthesis. | 1993 | J. Cell. Physiol. | pmid:8393878 |
| Christman BW et al. | Prostaglandin E2 limits arachidonic acid availability and inhibits leukotriene B4 synthesis in rat alveolar macrophages by a nonphospholipase A2 mechanism. | 1993 | J. Immunol. | pmid:8393898 |
| Stephens L et al. | Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins. | 1993 | J. Biol. Chem. | pmid:8394332 |
| Thivierge M et al. | Transcriptional modulation of platelet-activating factor receptor gene expression by cyclic AMP. | 1993 | J. Biol. Chem. | pmid:8394344 |
| Moreno P et al. | Changes in peripheral blood levels of platelet-activating factor after orthotopic liver transplantation. | 1993 | Transplant. Proc. | pmid:8395105 |
| Nakamura M et al. | Isolation and properties of platelet-activating factor receptor cDNAs. | 1993 Mar-Apr | J Lipid Mediat | pmid:8395240 |
| Bito H et al. | Characterization of platelet-activating factor (PAF) receptor in the rat brain. | 1993 Mar-Apr | J Lipid Mediat | pmid:8395241 |
| Herbert JM et al. | Effect of SR 27417 on the binding of [3H]PAF to rabbit and human platelets and human polymorphonuclear leukocytes. | 1993 | J Lipid Mediat | pmid:8395255 |
| Martins MA et al. | Interference of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen. | 1993 | Eur. J. Pharmacol. | pmid:8395390 |
| Arndt H et al. | Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. | 1993 | Gastroenterology | pmid:8395443 |
| Pothoulakis C et al. | Ketotifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum. | 1993 | Gastroenterology | pmid:8395445 |
| Pendino KJ et al. | Induction of functionally active platelet-activating factor receptors in rat alveolar macrophages. | 1993 | J. Biol. Chem. | pmid:8396125 |
| Hogaboam CM et al. | Modulation of rat mast cell reactivity by IL-1 beta. Divergent effects on nitric oxide and platelet-activating factor release. | 1993 | J. Immunol. | pmid:8397260 |
| Baker RR and Chang HY | The potential for platelet-activating factor synthesis in brain: properties of cholinephosphotransferase and 1-alkyl-sn-glycero-3-phosphate acetyltransferase in microsomal fractions of immature rabbit cerebral cortex. | 1993 | Biochim. Biophys. Acta | pmid:8399340 |
| Mezzano S et al. | Detection of platelet-activating factor in plasma of patients with streptococcal nephritis. | 1993 | J. Am. Soc. Nephrol. | pmid:8400088 |
| Hwang SB et al. | MK 287: a potent, specific, and orally active receptor antagonist of platelet-activating factor. | 1993 | J Lipid Mediat | pmid:8400114 |
| Burgers JA et al. | Occupancy of platelet receptors for platelet-activating factor in asthmatic patients during an allergen-induced bronchoconstrictive reaction. | 1993 | J Lipid Mediat | pmid:8400115 |
| Aglietta M et al. | Interleukin-3 in vivo: kinetic of response of target cells. | 1993 | Blood | pmid:8400256 |
| Woodman RC et al. | Effects of human neutrophil elastase (HNE) on neutrophil function in vitro and in inflamed microvessels. | 1993 | Blood | pmid:8400269 |
| Northover AM | An in vitro method for assessing the effects of pro-inflammatory and anti-inflammatory compounds on microvascular permeability in the rat small intestine. | 1993 | J Pharmacol Toxicol Methods | pmid:8400419 |
| Cheng DY and Chen WB | [The current status of the research on platelet activating factor and pulmonary hypertension]. | 1993 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:8403064 |
| Noda N et al. | Isolation and characterization of seven lyso platelet-activating factors and two lyso phosphatidylcholines from the crude drug "suitetsu" (the leech, Hirudo nipponica). | 1993 | Chem. Pharm. Bull. | pmid:8403084 |
| Lu Z and Wolf MB | Platelet activating factor-induced microvascular permeability increases in the cat hindlimb. | 1993 | Circ. Shock | pmid:8403248 |
| Montrucchio G et al. | Streptokinase induces intravascular release of platelet-activating factor in patients with acute myocardial infarction and stimulates its synthesis by cultured human endothelial cells. | 1993 | Circulation | pmid:8403295 |
| Kuo RC et al. | A metabolic view of receptor activation in cultured cells following cryopreservation. | 1993 | Cryobiology | pmid:8403989 |
| Colard O et al. | Biosynthesis of platelet-activating factor in cultured mast cells. Involvement of the CoA-independent transacylase demonstrated by analysis of the molecular species of platelet-activating factor. | 1993 | Eur. J. Biochem. | pmid:8404903 |
| Ito Y et al. | Corneal PAF acetylhydrolase increases in anterior segment ischemia in rabbits. | 1993 | Exp. Eye Res. | pmid:8405166 |
| Mabuchi-Itoh K et al. | Aspirin induces non-enzymatic formation of platelet-activating factor from lyso platelet-activating factor. | 1993 | FEBS Lett. | pmid:8405463 |
| Wang R et al. | Platelet activating factor and pentoxifylline as human sperm cryoprotectants. | 1993 | Fertil. Steril. | pmid:8405531 |
| Denizot Y and Nathan N | Platelet-activating factor antagonists and infected cirrhosis. | 1993 | Gastroenterology | pmid:8405881 |
| Boichot E et al. | Bronchopulmonary responses to endothelin-1 in sensitized and challenged guinea-pigs: role of cyclooxygenase metabolites and platelet-activating factor. | 1993 | Fundam Clin Pharmacol | pmid:8406292 |
| Wozniak A et al. | Interleukin-8 primes human neutrophils for enhanced superoxide anion production. | 1993 | Immunology | pmid:8406585 |
| Tripathi YB et al. | Anti-platelet activating factor property of Rubia cordifolia Linn. | 1993 | Indian J. Exp. Biol. | pmid:8406601 |
| Tremblay GM et al. | Murine hypersensitivity pneumonitis: evidences for the role of eicosanoids and platelet activating factor. | 1993 | Immunol. Invest. | pmid:8406624 |
| Pellon MI et al. | Effect of immunological stimulation on the production of platelet-activating factor by rat peritoneal cells: its relevance to anaphylactic reactions. | 1993 Jul-Aug | Immunopharmacology | pmid:8407286 |
| Pires JG et al. | ICI 169,369, A 5-HT2/5-HT1C antagonist, that can evoke endothelium-dependent relaxation in rabbit aorta. | 1993 | J Auton Pharmacol | pmid:8408095 |
| Tomioka K et al. | GM-CSF regulates human eosinophil responses to F-Met peptide and platelet activating factor. | 1993 | J. Immunol. | pmid:8409452 |
| Ninio E et al. | Autocrine amplification of PAF-acether formation in immunologically activated murine macrophages. | 1993 | J. Leukoc. Biol. | pmid:8409751 |
| Lepage N et al. | Distribution of lysophospholipids and metabolism of platelet-activating factor in human follicular and peritoneal fluids. | 1993 | J. Reprod. Fertil. | pmid:8410799 |
| Angle MJ et al. | Effect of platelet-activating factor (PAF) on human spermatozoa-oocyte interactions. | 1993 | J. Reprod. Fertil. | pmid:8410823 |
| Carceller E et al. | Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists. | 1993 | J. Med. Chem. | pmid:8411016 |
| Katnik C and Nelson DJ | Platelet activating factor-induced increase in cytosolic calcium and transmembrane current in human macrophages. | 1993 | J. Membr. Biol. | pmid:8411123 |
| Saito H and Tamura Y | [Antiatherogenic action of omega-3 polyunsaturated fatty acids]. | 1993 | Nippon Rinsho | pmid:8411664 |
| Saito M et al. | Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415807 |
| Arribas I et al. | Direct interactions between platelets and cultured rat mesangial cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415809 |
| Wang KS et al. | Protective effect of platelet-activating factor antagonist on ischemia-induced liver injury in rats. | 1993 | Surgery | pmid:8417492 |
| Burgers JA et al. | Human platelets secrete chemotactic activity for eosinophils. | 1993 | Blood | pmid:8417801 |
| Mangin EL et al. | Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. | 1993 | Circ. Res. | pmid:8417838 |
| Yoshida H et al. | Platelet-activating factor acetylhydrolase in red cell membranes. Does decreased activity impair erythrocyte deformability in ischemic stroke patients? | 1993 | Stroke | pmid:8418541 |
| Amirkhanian JD and Taeusch HW | Reversible and irreversible inactivation of preformed pulmonary surfactant surface films by changes in subphase constituents. | 1993 | Biochim. Biophys. Acta | pmid:8418890 |
| Morteau O et al. | Platelet-activating factor and interleukin 1 are involved in colonic dysmotility in experimental colitis in rats. | 1993 | Gastroenterology | pmid:8419261 |
| Kidney JC et al. | Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219. | 1993 | Am. Rev. Respir. Dis. | pmid:8420421 |
| Kuitert LM et al. | Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen. | 1993 | Am. Rev. Respir. Dis. | pmid:8420437 |
| Ogata M et al. | An antagonist of platelet-activating factor suppresses endotoxin-induced tumor necrosis factor and mortality in mice pretreated with carrageenan. | 1993 | Infect. Immun. | pmid:8423096 |
| Yamamoto H et al. | The evidence of platelet activation in bronchial asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8423274 |
| McManus LM et al. | Radiation-induced increased platelet-activating factor activity in mixed saliva. | 1993 | Lab. Invest. | pmid:8423671 |
| Hemmings R et al. | Platelet-activating factor acetylhydrolase activity in peritoneal fluids of women with endometriosis. | 1993 | Obstet Gynecol | pmid:8423963 |
| Galli C et al. | Modulation of lipid derived mediators by polyunsaturated fatty acids. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8424123 |
| Jager GV et al. | Antagonist of platelet-activating factor prevents prostaglandin E2 induced ocular hypertension in rabbits. | 1993 | Prostaglandins | pmid:8424134 |
| Deigner HP and Dresel HA | Effect of platelet activating factor on the kinetics of LDL oxidation in vitro. | 1993 | FEBS Lett. | pmid:8425606 |
| el Azzouzi B et al. | Immunoregulatory functions of paf-acether. IX. Modulation of apoptosis in an immature T cell line. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8427577 |
| Bruijnzeel PL et al. | Eosinophil migration in atopic dermatitis. I: Increased migratory responses to N-formyl-methionyl-leucyl-phenylalanine, neutrophil-activating factor, platelet-activating factor, and platelet factor 4. | 1993 | J. Invest. Dermatol. | pmid:8429236 |
| Silver RK et al. | Acetylsalicylic acid inhibits anticardiolipin antibody-induced platelet-activating factor (PAF) synthesis. | 1993 | Prostaglandins | pmid:8430224 |
| Zheng ZG et al. | Platelet-activating factor stimulates resorption by rabbit osteoclasts in vitro. | 1993 | Am. J. Physiol. | pmid:8430791 |
| Wilson DV et al. | Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086. | 1993 | Am. J. Vet. Res. | pmid:8430938 |
| Salgado J et al. | Effects of platelet-activating factor and related lipids on dielaidoylphosphatidylethanolamine by DSC, FTIR and NMR. | 1993 | Biochim. Biophys. Acta | pmid:8431461 |
| Hattori A et al. | [Platelets-morphology, shape changing factor, and platelet agglutinating factor. TTP Research Group]. | 1993 | Nippon Rinsho | pmid:8433504 |
| Naruse T | [Hemolytic uremic syndrome (HUS): pathophysiology--with reference to the differentiation between HUS and thrombotic thrombocytopenic purpura]. | 1993 | Nippon Rinsho | pmid:8433517 |
| ten Cate H et al. | [Current viewpoints and hypotheses concerning in vivo blood coagulation]. | 1993 | Ned Tijdschr Geneeskd | pmid:8433772 |
| Harris MC et al. | Diminished actin polymerization by neutrophils from newborn infants. | 1993 | Pediatr. Res. | pmid:8433856 |
| Montrucchio G et al. | Role of platelet-activating factor in polymorphonuclear neutrophil recruitment in reperfused ischemic rabbit heart. | 1993 | Am. J. Pathol. | pmid:8434642 |
| Lin CN et al. | Antiplatelet activity of some prenylflavonoids. | 1993 | Biochem. Pharmacol. | pmid:8435100 |
| Hashemi S et al. | Platelet-activating factor secreted by DDAVP-treated monocytes mediates von Willebrand factor release from endothelial cells. | 1993 | J. Cell. Physiol. | pmid:8436598 |
| Valone F | Quantifying platelet-activating factor in biologic systems. | 1993 | J. Allergy Clin. Immunol. | pmid:8436770 |
| Hsieh KH and Ng CK | Increased plasma platelet-activating factor in children with acute asthmatic attacks and decreased in vivo and in vitro production of platelet-activating factor after immunotherapy. | 1993 | J. Allergy Clin. Immunol. | pmid:8436778 |
| Cheng JB et al. | Antigen-mediated pulmonary eosinophilia in immunoglobulin G1-sensitized guinea pigs: eosinophil peroxidase as a simple specific marker for detecting eosinophils in bronchoalveolar lavage fluid. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8437132 |