| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Blom M et al. | Priming of human eosinophils by platelet-activating factor enhances the number of cells able to bind and respond to opsonized particles. | 1992 | J. Immunol. | pmid:1431137 |
| Calderón E and Lockey RF | A possible role for adhesion molecules in asthma. | 1992 | J. Allergy Clin. Immunol. | pmid:1430710 |
| Holland MR et al. | Activation of the acetyl-coenzyme A:lysoplatelet-activating factor acetyltransferase regulates platelet-activating factor synthesis in human endothelial cells. | 1992 | J. Biol. Chem. | pmid:1429636 |
| Zhou W et al. | Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion. | 1992 | Hepatology | pmid:1427662 |
| Sobhani I et al. | Raised concentrations of platelet activating factor in colonic mucosa of Crohn's disease patients. | 1992 | Gut | pmid:1427375 |
| Remé C et al. | Light and lithium effects in the rat retina: modification by the PAF antagonist BN 52021. | 1992 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:1427144 |
| López Bernal A et al. | Platelet-activating factor levels in human follicular and amniotic fluids. | 1992 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:1426500 |
| Adamson LM et al. | Loss of PAF-like activity from human embryo conditioned media (ECM) following HPLC separation. | 1992 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:1426496 |
| Johnson PR et al. | Platelet-activating factor-induced contraction of human isolated bronchus. | 1992 | Eur. Respir. J. | pmid:1426205 |
| Kroegel C | Does airway smooth muscle care about platelet-activating factor? | 1992 | Eur. Respir. J. | pmid:1426197 |
| Harper MJ | The implantation window. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1424330 |
| Dreyer WJ et al. | Kinetics of C5a release in cardiac lymph of dogs experiencing coronary artery ischemia-reperfusion injury. | 1992 | Circ. Res. | pmid:1423944 |
| Takada Y et al. | Protective effect of platelet-activating factor antagonist on hepatic energy metabolism following transient hepatic inflow occlusion in rabbits. | 1992 | Circ. Shock | pmid:1423921 |
| e Silva PM et al. | Pharmacological modulation of the late eosinophilia induced by antigen in actively sensitized rats. | 1992 | Int. Arch. Allergy Immunol. | pmid:1422263 |
| Kulikov VI and Muzia GI | [Acyl and plasmalogen analogs of platelet activating factor--new lipid cellular bioregulators]. | 1992 | Biokhimiia | pmid:1420585 |
| Caplan MS et al. | Hypoxia increases stimulus-induced PAF production and release from human umbilical vein endothelial cells. | 1992 | Biochim. Biophys. Acta | pmid:1420292 |
| Tsuruta S et al. | Adenosine inhibits divalent cation influx across human neutrophil plasma membrane via surface adenosine A2 receptors. | 1992 | Cell. Signal. | pmid:1419490 |
| Samet JM et al. | Effect of ozone on platelet-activating factor production in phorbol-differentiated HL60 cells, a human bronchial epithelial cell line (BEAS S6), and primary human bronchial epithelial cells. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1419027 |
| Blank M et al. | Induction of experimental anti-phospholipid syndrome associated with SLE following immunization with human monoclonal pathogenic anti-DNA idiotype. | 1992 | J. Autoimmun. | pmid:1418290 |
| Mügge A et al. | Activation of leukocytes with complement C5a is associated with prostanoid-dependent constriction of large arteries in atherosclerotic monkeys in vivo. | 1992 | Atherosclerosis | pmid:1418094 |
| Muacevic G and Heuer HO | Platelet-activating factor antagonists in experimental shock. | 1992 | Arzneimittelforschung | pmid:1418068 |
| Chuvilin AN et al. | [Synthesis of phosphono analogs of a phospholipid platelet activating factor]. | 1992 | Bioorg. Khim. | pmid:1418000 |
| Joseph S and MacDermot J | Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells. Analysis of the signalling mechanisms mediating actin polymerization. | 1992 | Biochem. J. | pmid:1417754 |
| Torley LW et al. | Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis. | 1992 | Antimicrob. Agents Chemother. | pmid:1416889 |
| Tan WC and Bethel RA | The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs. | 1992 | Am. Rev. Respir. Dis. | pmid:1416419 |
| Tam FW et al. | Inhaled platelet-activating factor causes pulmonary neutrophil sequestration in normal humans. | 1992 | Am. Rev. Respir. Dis. | pmid:1416388 |
| Faden AI and Tzendzalian PA | Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma. | 1992 | Am. J. Physiol. | pmid:1415805 |
| Dorn GW and Davis MG | Differential megakaryocytic desensitization to platelet agonists. | 1992 | Am. J. Physiol. | pmid:1415671 |
| Milhoan KA et al. | Hypoxia induces endothelial cells to increase their adherence for neutrophils: role of PAF. | 1992 | Am. J. Physiol. | pmid:1415623 |
| Kruse-Elliott KT et al. | Differential effects of WEB 2086 and SRI 63-441 on TNF-alpha-induced alterations in cardiopulmonary function. | 1992 | Am. J. Physiol. | pmid:1415600 |
| Duque I et al. | Effects of reactive oxygen species on cultured rat mesangial cells and isolated rat glomeruli. | 1992 | Am. J. Physiol. | pmid:1415575 |
| Prescott SM | What are the effects of dietary fatty acid modification on platelet eicosanoid metabolism, platelet-activating factor, and platelet function? How might these metabolic alterations influence thrombosis? | 1992 | Am. J. Clin. Nutr. | pmid:1414987 |
| Tran A et al. | Separate induction of human blood platelet aggregation or cytotoxicity by different concentrations of PAF-acether and thrombin. | 1992 | Agents Actions | pmid:1414687 |
| Wong CW et al. | Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor. | 1992 | Agents Actions | pmid:1414679 |
| Csáki C et al. | Role of platelet-activating factor in the development of endothelial dysfunction in hemorrhagic hypotension and retransfusion. | 1992 | Thromb. Res. | pmid:1412179 |
| Radeau T et al. | Enhanced esterification process of 5-hydroxyeicosatetraenoic acid (5-HETE) in PMN from asthmatic patients. | 1992 | Prostaglandins | pmid:1410523 |
| Kraut JA et al. | Platelet-activating factor attenuates the arginine vasopressin-induced fall of transepithelial resistance across inner medullary collecting duct monolayers. | 1992 | Miner Electrolyte Metab | pmid:1406507 |
| Mariano F et al. | Role of alpha 1-proteinase inhibitor in restraining peritoneal inflammation in CAPD patients. | 1992 | Kidney Int. | pmid:1405351 |
| Girotra NN et al. | Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester. | 1992 | J. Med. Chem. | pmid:1404229 |
| Lee TC et al. | A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor (PAF) with PAF as the acetate donor in HL-60 cells. | 1992 | J. Biol. Chem. | pmid:1400315 |
| Davidson D and Drafta D | Prolonged pulmonary hypertension caused by platelet-activating factor and leukotriene C4 in the rat lung. | 1992 | J. Appl. Physiol. | pmid:1400062 |
| Ono S et al. | PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats. | 1992 | J. Appl. Physiol. | pmid:1400021 |
| Hogaboam CM et al. | PF-5901 inhibits gastrointestinal platelet-activating factor synthesis in vivo. | 1992 | Eur. J. Pharmacol. | pmid:1397016 |
| Herbert JM et al. | Effect of SR 27417 on oedema formation induced in rabbit skin by platelet-activating factor or antigen. | 1992 | Eur. J. Pharmacol. | pmid:1397004 |
| Pretolani M et al. | Inhibition by azelastine of the effects of platelet-activating factor in lungs from actively sensitised guinea-pigs. | 1992 | Eur. J. Pharmacol. | pmid:1397002 |
| Friedman M et al. | Effects of ozone exposure on lipid metabolism in human alveolar macrophages. | 1992 | Environ. Health Perspect. | pmid:1396473 |
| Sobhani I et al. | Significance and regulation of gastric secretion of platelet-activating factor (PAF-acether) in man. | 1992 | Dig. Dis. Sci. | pmid:1396006 |
| Taniguchi H et al. | Role of platelet-activating factor in pulmonary edema after coronary ligation in dogs. | 1992 | Chest | pmid:1395776 |
| Chang SW | Endotoxin-induced lung vascular injury: role of platelet activating factor, tumor necrosis factor and neutrophils. | 1992 | Clin Res | pmid:1395440 |
| Yoshikawa D and Goto F | Effect of platelet-activating factor antagonist and leukotriene antagonist on endotoxin shock in the rat: role of the leukocyte. | 1992 | Circ. Shock | pmid:1394861 |
| Iwakami S et al. | Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. | 1992 | Chem. Pharm. Bull. | pmid:1394633 |
| Shibuya H et al. | Syntheses of a glycerophospholipid, C16-platelet activating factor and a palmitoyl analogue of M-5, an anti-inflammatory glyceroglycolipid. | 1992 | Chem. Pharm. Bull. | pmid:1394629 |
| Mathison R et al. | Platelet activating factor and systemic anaphylaxis in Nippostrongylus brasiliensis-sensitized rats: differential effects of PAF antagonists. | 1992 | Br. J. Pharmacol. | pmid:1393261 |
| Yang YQ et al. | Binding of platelet-activating factor to oviductal membranes during early pregnancy in the rabbit. | 1992 | J Lipid Mediat | pmid:1391740 |
| Macpherson JL et al. | Production and characterization of antibodies to platelet-activating factor. | 1992 | J Lipid Mediat | pmid:1391739 |
| Bernat A et al. | Protective effect of SR 27417, a novel PAF antagonist, on PAF- or endotoxin-induced hypotension in the rat and the guinea-pig. | 1992 | J Lipid Mediat | pmid:1391738 |
| Kitagawa S et al. | Role of endogenous platelet-activating factor (PAF) in endotoxin-induced portal hypertension in rats. | 1992 Sep-Oct | J. Gastroenterol. Hepatol. | pmid:1391729 |
| Okamoto H et al. | Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. | 1992 | Agents Actions | pmid:1388318 |
| Hood JS et al. | Daltroban blocks thromboxane responses in the pulmonary vascular bed of the cat. | 1992 | J. Appl. Physiol. | pmid:1385804 |
| Numao T and Agrawal DK | Neuropeptides modulate human eosinophil chemotaxis. | 1992 | J. Immunol. | pmid:1385521 |
| Konturek SJ et al. | Role of platelet activating factor in pathogenesis of acute pancreatitis in rats. | 1992 | Gut | pmid:1385272 |
| Barrett KE | Complex cellular recognition events in acute inflammation. | 1992 | Gastroenterology | pmid:1385256 |
| Fumarola D and Pece S | More on pathogenesis and treatment of septic shock. | 1992 | Eur. J. Epidemiol. | pmid:1385209 |
| Martinez-Cuesta MA et al. | The role of nitric oxide and platelet-activating factor in the inhibition by endotoxin of pentagastrin-stimulated gastric acid secretion. | 1992 | Eur. J. Pharmacol. | pmid:1385169 |
| Andrade SP et al. | Effects of tumour cells on angiogenesis and vasoconstrictor responses in sponge implants in mice. | 1992 | Br. J. Cancer | pmid:1384642 |
| Kimoto M et al. | Dual effects of oleic acid on Ca2+ mobilization and protein phosphorylation in human platelets in presence or absence of platelet activating factor. | 1992 | Arch. Biochem. Biophys. | pmid:1384432 |
| Asako H et al. | Reduction of leukocyte adherence and emigration by cyclosporine and L683,590 (FK506) in postcapillary venules. | 1992 | Transplantation | pmid:1384191 |
| Massion PB and Frans A | [Role of platelet activating factor and its antagonists in bronchial asthma]. | 1992 | Rev Pneumol Clin | pmid:1384101 |
| Yano S | [Drug therapy of asthma by antiallergic agents]. | 1992 | Nippon Naika Gakkai Zasshi | pmid:1383362 |
| Hayes JP et al. | Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea-pigs. | 1992 | Br. J. Pharmacol. | pmid:1382788 |
| Andrade SP et al. | Effects of platelet activating factor (PAF) and other vasoconstrictors on a model of angiogenesis in the mouse. | 1992 | Int J Exp Pathol | pmid:1382541 |
| Tripathi YB et al. | Involvement of tyrosine kinase and protein kinase C in platelet-activating-factor-induced c-fos gene expression in A-431 cells. | 1992 | Biochem. J. | pmid:1382409 |
| Eliakim R and Rachmilewitz D | Inflammatory mediators and the pathogenesis of inflammatory bowel disease. | 1992 Jul-Aug | Ital J Gastroenterol | pmid:1381246 |
| Pretolani M et al. | Effect of human recombinant interleukin-5 on in vitro responsiveness to PAF of lung from actively sensitized guinea-pigs. | 1992 | Br. J. Pharmacol. | pmid:1380388 |
| Nossaman BD et al. | Blockade of thromboxane/endoperoxide receptor-mediated responses in the pulmonary vascular bed of the cat by sulotroban. | 1992 | Eur. J. Pharmacol. | pmid:1379928 |
| Bellan JA et al. | Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat. | 1992 | Am. J. Physiol. | pmid:1379004 |
| Zimmerman GA et al. | Endothelial cell interactions with granulocytes: tethering and signaling molecules. | 1992 | Immunol. Today | pmid:1377920 |
| Vieira LB et al. | Angiogenic activity of PAF and inhibition of blood flow by Bothrops Jararaca venom in a mouse sponge model. | 1992 | EXS | pmid:1377548 |
| Block LH and Bühler FR | Atherosclerosis, cell motility, calcium, and calcium-channel blockers. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1377297 |
| Hines KL and Fisher RA | Regulation of hepatic glycogenolysis and vasoconstriction during antigen-induced anaphylaxis. | 1992 | Am. J. Physiol. | pmid:1375439 |
| Lohde C et al. | Influence of platelet activating factor antagonists on the protamine sulphate stimulated release of histamine from peritoneal mast cells of rats in vitro. | 1992 | Arzneimittelforschung | pmid:1375025 |
| Kunz D et al. | The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. | 1992 | J. Biol. Chem. | pmid:1374385 |
| Chanez P et al. | [Mediators and neuromediators in asthma]. | 1992 | Presse Med | pmid:1372975 |
| McCormack DG et al. | Bleomycin-induced lung injury in rats selectively abolishes hypoxic pulmonary vasoconstriction: evidence against a role for platelet-activating factor. | 1992 | Clin. Sci. | pmid:1372199 |
| Ziegler-Heitbrock HW et al. | Gangliosides suppress tumor necrosis factor production in human monocytes. | 1992 | J. Immunol. | pmid:1371788 |
| Ichinose M et al. | Activation of K+ current in macrophages by platelet activating factor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1370616 |
| Khanna A et al. | Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats. | 2003 | J. Surg. Res. | pmid:13678693 |
| May GR et al. | The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit. | 1991 | Br. J. Pharmacol. | pmid:1364849 |
| Chang TW et al. | Blood levels of platelet-activating factor in endotoxin-sensitive and endotoxin-resistant mice during endotoxemia. | 1992 | J. Formos. Med. Assoc. | pmid:1363632 |
| Nakajima H et al. | CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. | 1992 | Am. Rev. Respir. Dis. | pmid:1362635 |
| Asako H et al. | Phalloidin prevents leukocyte emigration induced by proinflammatory stimuli in rat mesentery. | 1992 | Am. J. Physiol. | pmid:1362329 |
| Pasquale CP et al. | Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized rats. | 1992 | Eur. J. Pharmacol. | pmid:1362160 |
| Ramassamy C et al. | The Ginkgo biloba extract, EGb761, increases synaptosomal uptake of 5-hydroxytryptamine: in-vitro and ex-vivo studies. | 1992 | J. Pharm. Pharmacol. | pmid:1361545 |
| Spring J et al. | Failure of salmeterol to inhibit circulating white cell responses and bronchoconstriction induced by platelet activating factor. | 1992 | Thorax | pmid:1361250 |
| Capasso F et al. | PAF formation by human gastrointestinal mucosa/submucosa in-vitro: release by ricinoleic acid, and inhibition by 5-aminosalicylic acid. | 1992 | J. Pharm. Pharmacol. | pmid:1360533 |
| Tsangaris GT et al. | Study of the glycogenolytic action of platelet activating factor in Tetrahymena pyriformis. | 1992 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:1360357 |
| Morley J | Asthma mortality and inhaled beta agonist therapy. | 1992 | Aust N Z J Med | pmid:1359864 |
| Rachmilewitz D et al. | Cytokines and platelet-activating factor in human inflamed colonic mucosa. | 1992 | Agents Actions | pmid:1359744 |
| Kleijnen J and Knipschild P | Ginkgo biloba. | 1992 | Lancet | pmid:1359218 |
| Mascolo N et al. | Effects of senna and its active compounds rhein and rhein-anthrone on PAF formation by rat colon. | 1992 | J. Pharm. Pharmacol. | pmid:1359100 |