| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Watanabe M et al. | Enhancement by cyclo-oxygenase inhibitors of platelet-activating factor production in thapsigargin-stimulated macrophages. | 1995 | Br. J. Pharmacol. | pmid:8640357 |
| Giannini S et al. | Platelet-activating factor enhances production of insulin-like growth factor binding proteins in a human adenocarcinoma cell line (HEC-1A) | 1996 | Gynecol. Oncol. | pmid:8641611 |
| Isogai E et al. | Platelet-activating-factor-mediated pathogenesis in Lyme disease. | 1996 | Infect. Immun. | pmid:8641753 |
| Mori M et al. | Predominant expression of platelet-activating factor receptor in the rat brain microglia. | 1996 | J. Neurosci. | pmid:8642404 |
| Reddy DS and Singh M | Antiperoxidative effects of platelet activating factor antagonists against iron-dependent lipid peroxidation in murine ventricular membranes. | 1995 Jul-Aug | Methods Find Exp Clin Pharmacol | pmid:8642899 |
| Parent JL et al. | Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8645288 |
| Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
| Ikemura T et al. | KW-4679, an antiallergic drug, inhibits the production of inflammatory lipids in human polymorphonuclear leukocytes and guinea pig eosinophils. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645979 |
| Korth RM | Specific high affinity binding of platelet activating factor to intact human blood neutrophils and eosinophils. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645989 |
| Aïssa J et al. | Tissue levels of histamine, PAF-acether and lysopaf-acether in carrageenan-induced granuloma in rats. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645997 |
| Nikolelis DP and Siontorou CG | Ammonium ion minisensors form self-assembled bilayer lipid membranes using gramicidin as an ionophore. Modulation of ammonium selectivity by platelet-activating factor. | 1996 | Anal. Chem. | pmid:8651482 |
| Resink T et al. | Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8651917 |
| Im SY et al. | Augmentation of tumor metastasis by platelet-activating factor. | 1996 | Cancer Res. | pmid:8653713 |
| Iatrou C et al. | The production of platelet-activating factor (PAF) during hemodialysis with cuprophane membrane. Does the calcium concentration in the dialysate play any role on it? | 1995 | Int J Artif Organs | pmid:8655220 |
| Miadonna A et al. | Nasal neutrophilia and release of myeloperoxidase induced by nasal challenge with platelet activating factor: different degrees of responsiveness in atopic and nonatopic subjects. | 1996 | J. Allergy Clin. Immunol. | pmid:8655890 |
| Das AK and Hajra AK | A simple chemical synthesis of the ether analog of lysophosphatidylcholine and platelet-activating factor. | 1995 | J. Lipid Res. | pmid:8656084 |
| Zimmerman GA et al. | Platelet-activating factor: antagonists, terminators, molecular mimics, and microbial opportunism. | 1996 | J. Intern. Med. | pmid:8656138 |
| Franciose RJ et al. | Hypoxia/reoxygenation of human endothelium activates PMNs to detach endothelial cells via a PAF mechanism. | 1996 | J. Surg. Res. | pmid:8656625 |
| Sheen WS et al. | Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. | 1996 | Planta Med. | pmid:8657756 |
| Leont'ev VK and Kankanian AP | [The local activation of leukocytes and thrombocytes in periodontal diseases: the role of thrombocyte-activating factor]. | 1996 | Stomatologiia (Mosk) | pmid:8658569 |
| Ganbo T et al. | Effects of platelet activating factor on mucociliary clearance of the eustachian tube. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8659935 |
| Ferby IM et al. | Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase. | 1996 | J. Biol. Chem. | pmid:8662643 |
| Ettinger SL et al. | Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation. | 1996 | J. Biol. Chem. | pmid:8663229 |
| Nathan N et al. | Effects of a paf-receptor antagonist on hemodynamics during and after cardiopulmonary bypass. | 1995 | J. Cardiothorac. Vasc. Anesth. | pmid:8664454 |
| Goudevenos J et al. | Platelet aggregability to platelet activating factor at rest and after exercise in patients with coronary artery disease. | 1995 | Eur. Heart J. | pmid:8665964 |
| Fujii E et al. | Role of nitric oxide and prostaglandins in lipopolysaccharide-induced increase in vascular permeability in mouse skin. | 1996 | Eur. J. Pharmacol. | pmid:8666058 |
| Bozza PT et al. | Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids. | 1996 | J. Exp. Med. | pmid:8666909 |
| Handa RK and Strandhoy JW | Nitric oxide mediates the inhibitory action of platelet-activating factor on angiotensin II-induced renal vasoconstriction, in vivo. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8667214 |
| Albert DH et al. | Properties of ABT-299, a prodrug of A-85783, a highly potent platelet activating factor receptor antagonist. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8667228 |
| Yamada M et al. | Platelet-activating factor production in stimulated macrophages is down-regulated by concurrently produced prostaglandin E2. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8667229 |
| Bustos C et al. | Urinary excretion of platelet-activating factor in human and experimental nephrosis. | 1996 | Nephrol. Dial. Transplant. | pmid:8671780 |
| Bagnis C et al. | Prevention of cyclosporin nephrotoxicity with a platelet-activating factor (PAF) antagonist. | 1996 | Nephrol. Dial. Transplant. | pmid:8671822 |
| Wardle TD et al. | Platelet activating factor: release from colonic mucosa in patients with ulcerative colitis and its effect on colonic secretion. | 1996 | Gut | pmid:8675086 |
| Mustafa SB et al. | Platelet-activating factor augments lipopolysaccharide-induced nitric oxide formation by rat Kupffer cells. | 1996 | Hepatology | pmid:8675186 |
| Serizawa A et al. | Involvement of platelet-activating factor in cytokine production and neutrophil activation after hepatic ischemia-reperfusion. | 1996 | Hepatology | pmid:8675190 |
| Nadel JA | Genetics reveals importance of platelet activating factor in asthma and possibly other inflammatory states. | 1996 | J. Clin. Invest. | pmid:8675676 |
| Oda Y et al. | Quantitation of platelet-activating factor in biological samples using liquid chromatography/mass spectrometry with column-switching technique. | 1995 | Anal. Biochem. | pmid:8678293 |
| Shibata K et al. | Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils. | 1996 | Biochem. Pharmacol. | pmid:8678902 |
| Nixon AB et al. | Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. | 1996 | Biochim. Biophys. Acta | pmid:8679683 |
| Sobhani I et al. | Regulation of platelet-activating factor production in gastric epithelial cells. | 1996 | Eur. J. Clin. Invest. | pmid:8682156 |
| Nakatsuji T | Alpha 1 antitrypsin defective Lewis rats injected with heparin: comparison of the glomerular changes with those of Lewis rats produced anti BSA antibody. | 1996 | Keio J Med | pmid:8683900 |
| Kuenemann-Migeot C et al. | Urinary promutagens of smokers: comparison of concentration methods and relation to cigarette consumption. | 1996 | Mutat. Res. | pmid:8684404 |
| Abu-Zidan FM et al. | BB-882 is a potent antagonist of the haemodynamic changes induced by platelet-activating factor in pigs. | 1996 | Pharmacol. Toxicol. | pmid:8685082 |
| Rodrigues CO et al. | Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8687466 |
| Glaser KB et al. | Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. | 1995 | Skin Pharmacol. | pmid:8688196 |
| González-Fajardo JA et al. | Protective effect of a platelet-activating factor antagonist (WEB-2086) in postischemic renal failure. | 1996 | Ann Vasc Surg | pmid:8688291 |
| Sansom JE et al. | Effects of H1- and H2-antihistamines on platelet-activating factor and bradykinin-induced inflammatory responses in human skin. | 1996 | Clin. Exp. Dermatol. | pmid:8689766 |
| Noda S et al. | Population of hepatic macrophages and response of perfused liver to platelet-activating factor during production of thioacetamide-induced cirrhosis in rats. | 1996 | Hepatology | pmid:8690413 |
| Barnum D et al. | Identification of common functional configurations among molecules. | 1996 May-Jun | J Chem Inf Comput Sci | pmid:8690757 |
| Roth M et al. | Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor. | 1996 | J. Exp. Med. | pmid:8691134 |
| Smith PF et al. | The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). | 1996 | J Ethnopharmacol | pmid:8691847 |
| Mimura K et al. | Changes in glycerophospholipid profile in experimental nephrotic syndrome. | 1996 | Metab. Clin. Exp. | pmid:8692015 |
| Goldsmith JA et al. | Plasma potentiates the priming effects of endotoxin on platelet activating factor-induced pulmonary hypertension in the rabbit lung. | 1996 | Anesth. Analg. | pmid:8694300 |
| Anderson R et al. | Membrane stabilizing, anti-oxidative interactions of propranolol and dexpropranolol with neutrophils. | 1996 | Biochem. Pharmacol. | pmid:8694859 |
| Cypcar D et al. | Rat eosinophils: isolation and characterization of superoxide production. | 1996 | J. Leukoc. Biol. | pmid:8699113 |
| Camici M | [Progression of renal insufficiency and platelet activating factor (PAF)]. | 1996 | Minerva Med. | pmid:8700358 |
| Tsai JJ et al. | The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs. | 1995 | Asian Pac. J. Allergy Immunol. | pmid:8703249 |
| Shen K et al. | Properties of circulating leukocytes in spontaneously hypertensive rats. | 1995 Jul-Aug | Biochem. Cell Biol. | pmid:8703419 |
| Biffl WL and Moore EE | Splanchnic ischaemia/reperfusion and multiple organ failure. | 1996 | Br J Anaesth | pmid:8703631 |
| Denizot Y et al. | Platelet-activating factor and haematopoiesis. XI. Platelet-activating factor has no effect on the production of interleukin-6 and tumor necrosis factor-alpha by human bone marrow stromal cells. | 1996 Jan-Mar | Eur. Cytokine Netw. | pmid:8704099 |
| Dong JC et al. | [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. | 1995 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8704427 |
| Agrawal DK et al. | Increased hypodense eosinophils after activation with PAF-acether and calcium ionophore in asthmatic subjects. | 1996 | J Asthma | pmid:8707776 |
| Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
| Gallego MJ et al. | Cyclosporine enhances leukocyte adhesion to vascular endothelium under physiologic flow conditions. | 1996 | Am. J. Kidney Dis. | pmid:8712218 |
| Dodam JR et al. | Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages. | 1996 | Am. J. Vet. Res. | pmid:8712527 |
| Emil S et al. | Inhaled nitric oxide prevents experimental platelet activating factor-induced shock. | 1996 | Arch Surg | pmid:8712910 |
| Grigg ME et al. | Characterization of a platelet-activating factor acetylhydrolase secreted by the nematode parasite Nippostrongylus brasiliensis. | 1996 | Biochem. J. | pmid:8713083 |
| Segerer H et al. | Rapid tracheal infusion of surfactant versus bolus instillation in rabbits: effects on oxygenation, blood pressure and surfactant distribution. | 1996 | Biol. Neonate | pmid:8713657 |
| Miao FJ et al. | Role of sympathetic postganglionic neurons in synovial plasma extravasation induced by bradykinin. | 1996 | J. Neurophysiol. | pmid:8714647 |
| Ortiz JL et al. | Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8717161 |
| Thorlacius H et al. | Microvascular mechanisms of histamine-induced potentiation of leukocyte adhesion evoked by chemoattractants. | 1995 | Br. J. Pharmacol. | pmid:8719793 |
| De Kimpe SJ et al. | Role for intracellular platelet-activating factor in the circulatory failure in a model of gram-positive shock. | 1995 | Br. J. Pharmacol. | pmid:8719795 |
| Nunoya K et al. | S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast. | 1995 | Xenobiotica | pmid:8719904 |
| Keicher U et al. | Omega-3 fatty acids suppress the enhanced production of 5-lipoxygenase products from polymorph neutrophil granulocytes in cystic fibrosis. | 1995 | Eur. J. Clin. Invest. | pmid:8719931 |
| Suzuki H et al. | Enhanced levels of chemiluminescence and platelet activating factor in urease-positive gastric ulcers. | 1996 | Free Radic. Biol. Med. | pmid:8720917 |
| Kruse-Elliott KT et al. | Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. | 1996 | Shock | pmid:8721386 |
| Zuberbier T et al. | Histamine releasability of basophils and skin mast cells in chronic urticaria. | 1996 | Allergy | pmid:8721524 |
| Kulikov VI and Muzia GI | [Biological role of cellular metabolites--structural analogs of platelet activating factor]. | 1996 | Biokhimiia | pmid:8724598 |
| Muzia GI and Kulikov VI | [Effect of sn-2-acetylated analogs of phosphatidalic acid on release and aggregation of human platelets]. | 1996 | Biokhimiia | pmid:8724603 |
| Misra UK and Pizzo SV | Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. | 1996 | J. Cell. Biochem. | pmid:8726354 |
| Ogura M et al. | Role of endogenous platelet-activating factor in the regulation of pancreatic blood flow during caerulein stimulation. | 1996 | J. Gastroenterol. | pmid:8726834 |
| Evans DJ et al. | Priming of circulating human eosinophils following late response to allergen challenge. | 1996 | Eur. Respir. J. | pmid:8726934 |
| Pastores SM et al. | Posttraumatic multiple-organ dysfunction syndrome: role of mediators in systemic inflammation and subsequent organ failure. | 1996 | Acad Emerg Med | pmid:8727633 |
| Thyssen E et al. | Quantification of distinct molecular species of platelet activating factor in ulcerative colitis. | 1996 | Lipids | pmid:8729129 |
| Iatrou C et al. | Platelet-activating factor levels and PAF acetylhydrolase activities in patients with primary glomerulonephritis. | 1996 | Nephron | pmid:8730430 |
| Anderson R et al. | Anti-inflammatory, membrane-stabilizing interactions of salmeterol with human neutrophils in vitro. | 1996 | Br. J. Pharmacol. | pmid:8730730 |
| Shi H et al. | [Effects of a platelet-activating factor antagonist ONO-6240 on antigen induced eosinophil infiltration into the airways]. | 1995 | Zhonghua Nei Ke Za Zhi | pmid:8731847 |
| Cheng D and Chen W | [Effects of ginkgolide B on isobaric hypoxic pulmonary hypertension in rats]. | 1995 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:8732057 |
| Salva AM et al. | Hypoxia attenuates metabolism of platelet activating factor by fetal and newborn lamb lungs. | 1996 | J. Lipid Res. | pmid:8732778 |
| Doly M and Oustrin J | [Suppression of platelet activating factor effects (PAF) on the retina by G-proteins inhibitors]. | 1996 | Ann Pharm Fr | pmid:8734330 |
| Jarvis GE and Evans RJ | Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735817 |
| Nakonechnicov S et al. | Platelet aggregation in patients with primary pulmonary hypertension. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735825 |
| Sanderson HM et al. | Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735830 |
| Stücker O et al. | Effects of Ginkgo biloba extract (EGb 761) on arteriolar spasm in a rat cremaster muscle preparation. | 1996 Mar-Apr | Int J Microcirc Clin Exp | pmid:8737713 |
| Kahhak L et al. | Decrease of ciliary beat frequency by platelet activating factor: protective effect of ketotifen. | 1996 | Inflamm. Res. | pmid:8737746 |
| Mascolo N et al. | Relationship between nitric oxide and platelet-activating factor in castor-oil induced mucosal injury in the rat duodenum. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8738301 |
| Ackerman Z et al. | Renal vasoactive mediator generation in portal hypertensive and bile duct ligated rats. | 1996 | J. Hepatol. | pmid:8738735 |
| Cardile V et al. | Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero- 3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. | 1996 | Brain Res. | pmid:8739627 |
| Giudice A et al. | Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine. | 1996 | Arzneimittelforschung | pmid:8740089 |
| Whelan CJ | Inhibition of PAF-, LPS-, and cytokine-induced granulocyte accumulation in guinea pig lung by dexamethasone: evidence that inhibition of IL-5 release is responsible for the selective inhibition of eosinophilia by glucocorticoids in guinea-pigs. | 1996 | Inflamm. Res. | pmid:8741005 |