| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Filep JG et al. | Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor. | 1992 | Br. J. Pharmacol. | pmid:1324056 |
| de Lima WT et al. | Immune-complex alveolitis in the rat: evidence for platelet activating factor and leukotrienes as mediators of the vascular lesions. | 1992 | Eur. J. Pharmacol. | pmid:1323472 |
| Hanahan DJ | Platelet-activating factor: a novel lipid agonist. | 1992 | Curr. Top. Cell. Regul. | pmid:1323447 |
| Bito H et al. | Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. | 1992 | Neuron | pmid:1323312 |
| Jones MA et al. | Rabbit blastocysts accumulate platelet-activating factor (PAF) and lyso-PAF in vitro. | 1992 | Mol. Reprod. Dev. | pmid:1323306 |
| Snyder F et al. | 1-alkyl-2-lyso-sn-glycero-3-phosphate acetyltransferase. | 1992 | Meth. Enzymol. | pmid:1323050 |
| Lee TC and Snyder F | 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase. | 1992 | Meth. Enzymol. | pmid:1323043 |
| Chau LY et al. | Possible existence of two subsets of platelet-activating factor receptor to mediate polyphosphoinositide breakdown and calcium influx in neuroblastoma x glioma hybrid NG 108-15 cells. | 1992 | J. Neurochem. | pmid:1322966 |
| Cabellos C et al. | Differing roles for platelet-activating factor during inflammation of the lung and subarachnoid space. The special case of Streptococcus pneumoniae. | 1992 | J. Clin. Invest. | pmid:1322943 |
| Gandhi CR et al. | Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells. | 1992 | Biochim. Biophys. Acta | pmid:1322709 |
| Kowanko IC et al. | Platelet-activating factor inhibits proteoglycan synthesis and enhances neutrophil-mediated proteoglycan degradation in cartilage explants. | 1992 | Arthritis Rheum. | pmid:1322671 |
| Heller R et al. | Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells. | 1992 | Biochem. Pharmacol. | pmid:1322663 |
| Seyfried CE et al. | The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. | 1992 | Genomics | pmid:1322356 |
| Schwinger RH et al. | Existence of PAF receptors in human platelets and human lung tissue but not in the human myocardium. | 1992 | Am. Heart J. | pmid:1322030 |
| Hennet T et al. | A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. | 1992 | J. Immunol. | pmid:1321855 |
| Tufano MA et al. | Salmonella typhimurium porins stimulate platelet-activating factor synthesis by human polymorphonuclear neutrophils. | 1992 | J. Immunol. | pmid:1321849 |
| Patel KD et al. | Novel leukocyte agonists are released by endothelial cells exposed to peroxide. | 1992 | J. Biol. Chem. | pmid:1321830 |
| Mabuchi K et al. | Differential effects of platelet-activating factor on superoxide anion production in human eosinophils and neutrophils. | 1992 | Biochem. Int. | pmid:1321621 |
| Casale TB et al. | Degree of neutrophil chemotaxis is dependent upon the chemoattractant and barrier. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1320901 |
| Di Maria GU et al. | Nedocromil sodium inhibits the increase in airway reactivity induced by platelet activating factor in humans. | 1992 | Chest | pmid:1320563 |
| Travis SP and Jewell DP | Regional differences in the response to platelet-activating factor in rabbit colon. | 1992 | Clin. Sci. | pmid:1320548 |
| Sakamoto T et al. | Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig. | 1992 | Eur. J. Pharmacol. | pmid:1319919 |
| Zeng N | [Determination of plasma level of platelet activating factor in cirrhotic patients and its relation to endotoxemia]. | 1992 | Zhonghua Yi Xue Za Zhi | pmid:1319804 |
| Smither RL and Fan TP | Effects of platelet-activating factor on endothelial cells and fibroblasts in vitro. | 1992 | EXS | pmid:1319778 |
| Asako H et al. | Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. | 1992 | Gastroenterology | pmid:1319367 |
| Foster AP et al. | Effects of WEB 2086, an antagonist to the receptor for platelet-activating factor (PAF), on PAF-induced responses in the horse. | 1992 | Equine Vet. J. | pmid:1318830 |
| Rediske JJ et al. | Platelet activating factor stimulates intracellular calcium transients in human neutrophils: involvement of endogenous 5-lipoxygenase products. | 1992 | J. Leukoc. Biol. | pmid:1318349 |
| Hidi R et al. | Formation of LTB4 by fMLP-stimulated alveolar macrophages accounts for eosinophil migration in vitro. | 1992 | J. Leukoc. Biol. | pmid:1318347 |
| Herbert JM | Characterization of specific binding sites of 3H-labelled platelet-activating factor ([3H]PAF) and a new antagonist, [3H]SR 27417, on guinea-pig tracheal epithelial cells. | 1992 | Biochem. J. | pmid:1318021 |
| Guinn DE et al. | Synthesis and structure-activity relationships of a series of novel benzopyran-containing platelet activating factor antagonists. | 1992 | J. Med. Chem. | pmid:1317924 |
| Graham RM et al. | Plasma platelet-activating factor degradation in patients with severe coronary artery disease. | 1992 | Clin. Sci. | pmid:1317763 |
| Smith LJ | Bioactive mediators in asthma. | 1992 | Chest | pmid:1317278 |
| Moreira-Ludewig R and Healy CT | A rapid microtiter plate method for the detection of lysozyme release from human neutrophils. | 1992 | J Pharmacol Toxicol Methods | pmid:1317227 |
| Joly F et al. | Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1317174 |
| Kimura K et al. | Different preparations of zymosan induce glycogenolysis independently in the perfused rat liver. Involvement of mannose receptors, peptide-leukotrienes and prostaglandins. | 1992 | Biochem. J. | pmid:1317164 |
| Pinckard RN et al. | Differential responsiveness of human neutrophils to the autocrine actions of 1-O-alkyl-homologs and 1-acyl analogs of platelet-activating factor. | 1992 | J. Immunol. | pmid:1316919 |
| Sehmi R et al. | Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects. | 1992 | Blood | pmid:1316789 |
| Fukuchi Y et al. | Low ligand binding activities of two distinct types of Fc gamma receptor on guinea-pig peripheral blood polymorphonuclear leukocytes are differentially improved by proteolysis or platelet activating factor. | 1992 | Mol. Immunol. | pmid:1316550 |
| Koltai M et al. | Role of PAF and cytokines in microvascular tissue injury. | 1992 | J. Lab. Clin. Med. | pmid:1316420 |
| Morland CM et al. | Selective eosinophil leukocyte recruitment by transendothelial migration and not by leukocyte-endothelial cell adhesion. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1316135 |
| Adler KB et al. | Platelet-activating factor provokes release of mucin-like glycoproteins from guinea pig respiratory epithelial cells via a lipoxygenase-dependent mechanism. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1316134 |
| Carveth HJ et al. | Regulation of platelet-activating factor (PAF) synthesis and PAF-mediated neutrophil adhesion to endothelial cells activated by thrombin. | 1992 | Semin. Thromb. Hemost. | pmid:1315452 |
| Kuijpers TW et al. | Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8. | 1992 | J. Cell Biol. | pmid:1315317 |
| Zarco P et al. | Involvement of platelet-activating factor and tumour necrosis factor in the pathogenesis of joint inflammation in rabbits. | 1992 | Clin. Exp. Immunol. | pmid:1315229 |
| Rabinovici R et al. | Platelet activating factor mediates interleukin-2-induced lung injury in the rat. | 1992 | J. Clin. Invest. | pmid:1314853 |
| Zhu YP et al. | The presence of platelet-activating factor binding sites in human myometrium and their role in uterine contraction. | 1992 | Am. J. Obstet. Gynecol. | pmid:1314480 |
| Schaberg T et al. | Superoxide anion release induced by platelet-activating factor is increased in human alveolar macrophages from smokers. | 1992 | Eur. Respir. J. | pmid:1314191 |
| e Silva PM et al. | Nedocromil sodium prevents in vivo generation of the eosinophilotactic substance induced by PAF but fails to antagonize its effects. | 1992 | Br. J. Pharmacol. | pmid:1313729 |
| Chatterjee SS et al. | Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. | 2003 | Pharmacopsychiatry | pmid:13130392 |
| Bazan NG | Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. | 2003 | J. Lipid Res. | pmid:13130128 |
| Alonso MT et al. | Effects of the antithrombitic agent PCA 4230 on agonist-induced Ca2+ entry and Ca2+ release in human platelets. | 1992 | Biochim. Biophys. Acta | pmid:1312357 |
| Henson PM et al. | NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities. | 1992 | Am. Rev. Respir. Dis. | pmid:1312316 |
| Aepfelbacher M et al. | Bacterial lipopolysaccharide up-regulates platelet-activating factor-stimulated Ca2+ mobilization and eicosanoid release in human Mono Mac 6 cells. | 1992 | J. Immunol. | pmid:1312103 |
| Shukla SD | Platelet-activating factor receptor and signal transduction mechanisms. | 1992 | FASEB J. | pmid:1312046 |
| Catalán RE et al. | PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1311925 |
| Wu T et al. | Endothelin-1 stimulates eicosanoid production in cultured human nasal mucosa. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1311593 |
| Grandoni KM et al. | Trichothecene mycotoxins inhibit phosphoinositide hydrolysis in bovine platelets stimulated with platelet activating factor. | 1992 | Toxicology | pmid:1311467 |
| Yue TL et al. | Platelet-activating factor stimulates phosphoinositide turnover in neurohybrid NCB-20 cells: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins and inhibition by protein kinase C. | 1992 | Mol. Pharmacol. | pmid:1311408 |
| Földes-Filep E et al. | C-reactive protein inhibits intracellular calcium mobilization and superoxide production by guinea pig alveolar macrophages. | 1992 | J. Leukoc. Biol. | pmid:1311010 |
| Jagels MA and Hugli TE | Neutrophil chemotactic factors promote leukocytosis. A common mechanism for cellular recruitment from bone marrow. | 1992 | J. Immunol. | pmid:1310708 |
| Gandhi CR et al. | A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells. | 1992 | Biochem. J. | pmid:1310601 |
| Schwaner I et al. | Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. | 1992 | Biochem. J. | pmid:1310589 |
| Ono S and Voelkel NF | PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model. | 1992 | Lung | pmid:1310128 |
| Bratton DL et al. | The mechanism of internalization of platelet-activating factor in activated human neutrophils. Enhanced transbilayer movement across the plasma membrane. | 1992 | J. Immunol. | pmid:1309560 |
| van Willigen G and Akkerman JW | Regulation of glycoprotein IIB/IIIA exposure on platelets stimulated with alpha-thrombin. | 1992 | Blood | pmid:1309427 |
| Zoratti EM et al. | Platelet-activating factor primes human eosinophil generation of superoxide. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1309421 |
| Klöcking HP | Inhibition of PAF-induced tPA release by KO-286011. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1309038 |
| Li Q | [Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects]. | 1992 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:1307517 |
| Hirano T and Manabe T | "Cocktail" therapy for acute pancreatitis: combined therapy of protease inhibitor, xanthine oxidase inhibitor and platelet activating factor antagonist in rat caerulein-induced pancreatis. | 1992 | Nihon Geka Hokan | pmid:1306981 |
| Nijkamp FP et al. | Reversal of the endotoxin-induced bronchial hyperreactivity to histamine by the platelet activating factor antagonist BN 52021. | 1992 | Pneumonol Alergol Pol | pmid:1305483 |
| Doly M et al. | Inhibition of vincristine-induced retinal impairments by a specific PAF antagonist. | 1992 | Lens Eye Toxic Res | pmid:1301801 |
| Wu QX | [Amplification and desensitization in platelet activation]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1299958 |
| Wong B et al. | Identification of a membrane-associated 1-0-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine hydrolyzing phospholipase A2 in guinea pig 1 epidermis. Implications in the cutaneous biosynthesis of platelet-activating factor. | 1992 | FEBS Lett. | pmid:1299618 |
| Cheng NN et al. | [The composition of phospholipid and biosynthesis of platelet-activating factor in earthworm (Eisenia foetida)]. | 1992 | Yao Xue Xue Bao | pmid:1299136 |
| Lamparter E and Lunkenheimer CH | The automation of dissolution testing of solid oral dosage forms. | 1992 Oct-Dec | J Pharm Biomed Anal | pmid:1298375 |
| Zhao XY et al. | [Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release]. | 2003 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:12970925 |
| Calabresi L et al. | Endothelial protection by high-density lipoproteins: from bench to bedside. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12969988 |
| Ishiura Y et al. | Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction. | 2003 | J Investig Allergol Clin Immunol | pmid:12968390 |
| Kato M et al. | The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis. | 2003 | J Ocul Pharmacol Ther | pmid:12964956 |
| Bayar MA et al. | The effect of EGb-761 on morphologic vasospasm in canine basilar artery after subarachnoid hemorrhage. | 2003 | J. Cardiovasc. Pharmacol. | pmid:12960685 |
| Krause S et al. | Defective function of blood granulocytes in patients with diabetes mellitus-associated marginal periodontitis. | 1992 | Folia Biol. (Praha) | pmid:1295773 |
| Armenaka M and Rosenstreich DL | The pathophysiology of chronic urticaria. | 1992 | Clin Rev Allergy | pmid:1295690 |
| McDonagh PF et al. | Chronic expression of platelet adhesion proteins is associated with severe ischemic heart disease in type 2 diabetic patients: Chronic platelet activation in diabetic heart patients. | 2003 Sep-Oct | J. Diabetes Complicat. | pmid:12954156 |
| Perales J et al. | Neutralization of the oedematogenic activity of Bothrops jararaca venom on the mouse paw by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum. | 1992 | Agents Actions | pmid:1295374 |
| Gabrijelcic J et al. | Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. | 2003 | Eur. Respir. J. | pmid:12952263 |
| Wierzbicki T et al. | IL-4 primes human endothelial cells for secondary responses to histamine. | 2003 | J. Leukoc. Biol. | pmid:12949246 |
| Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
| Shinozaki K et al. | Species differences in platelet aggregation induced by platelet-activating factor (PAF). | 1992 | Methods Find Exp Clin Pharmacol | pmid:1294855 |
| Benelli R et al. | Neutrophils and angiogenesis: potential initiators of the angiogenic cascade. | 2003 | Chem Immunol Allergy | pmid:12947984 |
| Zhu L et al. | Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12946927 |
| Izquierdo I et al. | Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. A review of pharmacological profile and clinical management of allergic rhinitis. | 2003 | Drugs Today | pmid:12944997 |
| Tomaszewska R et al. | Platelet activating factor (PAF) inhibitor (TCV-309) reduces caerulein- and PAF-induced pancreatitis. A morphologic and functional study in the rat. | 1992 | J. Physiol. Pharmacol. | pmid:1294265 |
| Guarino MP et al. | PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12936911 |
| Abete P et al. | Age-related effects of platelet activating factor (PAF) in the isolated perfused rat heart. | 1992 | J. Mol. Cell. Cardiol. | pmid:1293314 |
| Kald B et al. | Platelet-activating factor (PAF-acether) formation in neonatal intestinal mucosa and in cultured intestinal epithelial cells. | 1992 | Eur Surg Res | pmid:1292936 |
| Mano T et al. | Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase. | 2003 | Bioorg. Med. Chem. | pmid:12927848 |
| Nakatsuka M et al. | Platelet activating factor in culture media as an indicator of human embryonic development after in-vitro fertilization. | 1992 | Hum. Reprod. | pmid:1291573 |
| Lie WJ et al. | Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12911788 |
| Tokuoka SM et al. | Involvement of platelet-activating factor and LIS1 in neuronal migration. | 2003 | Eur. J. Neurosci. | pmid:12911752 |
| Kalia N and Bardhan KD | Of blood and guts: association between Helicobacter pylori and the gastric microcirculation. | 2003 | J. Gastroenterol. Hepatol. | pmid:12911655 |