| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lagente V et al. | Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. | 1987 | Prostaglandins | pmid:2438723 |
| Wallace JL and Whittle BJ | Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. | 1986 | Prostaglandins | pmid:3726156 |
| McCulloch RK and Vandongen R | Mechanisms of platelet activating factor-induced aggregation and secretion in human platelets. | 1990 | Prostaglandins | pmid:2106712 |
| Billah MM et al. | Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. | 1985 | Prostaglandins | pmid:3936121 |
| Toyofuku T et al. | Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. | 1986 | Prostaglandins | pmid:3754344 |
| Cucala M et al. | Central regulation of gastric acid secretion by platelet-activating factor in anesthesized rats. | 1989 | Prostaglandins | pmid:2499013 |
| Bourgain RH et al. | The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. | 1985 | Prostaglandins | pmid:3931178 |
| Kuzan FB et al. | Role of spermatozoal platelet-activating factor in fertilization. | 1990 | Prostaglandins | pmid:2155438 |
| Kaminski DL et al. | Studies on the etiology of acute acalculous cholecystitis: the effect of lipopolysaccharide on human gallbladder mucosal cells. | 1994 | Prostaglandins | pmid:8041874 |
| Jancar S et al. | Comparative effects of platelet activating factor, leukotriene D4 and histamine on guinea pig trachea, bronchus and lung parenchyma. | 1987 | Prostaglandins | pmid:3588970 |
| Malo PE et al. | Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor. | 1987 | Prostaglandins | pmid:3588971 |
| Madden MC et al. | Polarized release of lipid mediators derived from phospholipase A2 activity in a human bronchial cell line. | 1994 | Prostaglandins | pmid:7809385 |
| Bruijnzeel PL et al. | Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | 1987 | Prostaglandins | pmid:3118415 |
| Pons L et al. | Role of platelet-activating factor (PAF) and prostaglandins in colonic motor and secretory disturbances induced by Escherichia coli endotoxin in conscious rats. | 1994 | Prostaglandins | pmid:8016383 |
| Lee MJ et al. | Endothelial cell 1-acyl-platelet-activating factor synthesis in response to anticardiolipin antibody-positive serum fractions. | 1994 | Prostaglandins | pmid:8016391 |
| Kaminski DL et al. | The production of experimental cholecystitis by endotoxin. | 1994 | Prostaglandins | pmid:8016392 |
| Ibbotson GC and Wallace JL | Beneficial effects of prostaglandin E2 in endotoxic shock are unrelated to effects on PAF-acether synthesis. | 1989 | Prostaglandins | pmid:2727308 |
| Yamanaka S et al. | 11-Dehydro thromboxane B2: a reliable parameter of thromboxane A2 production in dogs. | 1993 | Prostaglandins | pmid:8484010 |
| Levine L | Effects of the protein kinase inhibitors, staurosporine and K-252a, on PGI2 production by rat liver cells (the C-9 cell line). | 1990 | Prostaglandins | pmid:2247616 |
| Whatley RE et al. | Relative amounts of 1-O-alkyl- and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in stimulated endothelial cells. | 1992 | Prostaglandins | pmid:1546171 |
| Subissi A et al. | Effects of anti-asthma drugs on PAF-induced death in mice. | 1988 | Prostaglandins | pmid:2907663 |
| Radeau T et al. | Enhanced esterification process of 5-hydroxyeicosatetraenoic acid (5-HETE) in PMN from asthmatic patients. | 1992 | Prostaglandins | pmid:1410523 |
| Qu X et al. | Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. | 1996 | Prostaglandins | pmid:8935185 |
| Etienne A et al. | Modulation of eosinophil recruitment in the rat by the platelet-activating factor (PAF) antagonist, BN 52021, the somatostatin analog, BIM 23014, and by cyclosporin A. | 1989 | Prostaglandins | pmid:2748916 |
| Kim YD et al. | Constriction of canine coronary arteries by platelet activating factor after brief ischemia. | 1993 | Prostaglandins | pmid:8234834 |
| Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
| Ernst A et al. | The effect of PAF in the cochlea of guinea pigs. | 1989 | Prostaglandins | pmid:2602560 |
| Chan WP and Levy JV | Effects of antiplatelet agents on platelet aggregation induced by platelet--activating factor (PAF) in human whole blood. | 1991 | Prostaglandins | pmid:1665568 |
| Bureau M et al. | Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. | 1987 | Prostaglandins | pmid:3035615 |
| Moodley I and Stuttle A | Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. | 1987 | Prostaglandins | pmid:3035617 |
| Bonnet J et al. | Dependency of the Paf-acether induced bronchospasm on the lipoxygenase pathway in the guinea-pig. | 1983 | Prostaglandins | pmid:6419289 |
| Geissler FT et al. | Lipid mediator production by post-implantation rat embryos in vitro. | 1989 | Prostaglandins | pmid:2505333 |
| White HL and Faison LD | Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. | 1988 | Prostaglandins | pmid:2903520 |
| Hébert RL et al. | Hemodynamic effects of PAF-acether on the dog kidney. | 1987 | Prostaglandins Leukot Med | pmid:3033688 |
| Otsuka A et al. | Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. | 1985 | Prostaglandins Leukot Med | pmid:3862138 |
| Riedel A and Mest HJ | The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. | 1987 | Prostaglandins Leukot Med | pmid:3112804 |
| Mehta J et al. | Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. | 1986 | Prostaglandins Leukot Med | pmid:3456620 |
| Oh S et al. | Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. | 1986 | Prostaglandins Leukot Med | pmid:3459197 |
| Acharya SB and MacIntyre DE | Platelet products and vascular PGI2 production. | 1983 | Prostaglandins Leukot Med | pmid:6338532 |
| Hertelendy F and Zakár T | Prostaglandins and the myometrium and cervix. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14683694 |
| Herron D et al. | Inhibition of PAF-induced human platelet aggregation by antithrombotic nipecotomides. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7630919 |
| Gáti I et al. | Effects of the PAF-analog and -antagonist CV-6209 on cultured human glioma cell lines. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1886907 |
| Norman SJ and Poyser NL | The effects of platelet-activating factor on the output of prostaglandins from the guinea-pig uterus. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1492106 |
| Taylor KE et al. | Could platelet activating factor play a role in developmental dyslexia? | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334553 |
| Mózes T et al. | Protective effect of diclofenac sodium against endotoxic shock in anaesthetized pigs. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8446657 |
| Shindo K et al. | Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431823 |
| Akisu M et al. | Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878450 |
| Landgraf RG et al. | Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17923399 |
| Sugatani J et al. | The role of platelet activating factor (PAF) in the pathogenesis of gastric ulcers. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1808623 |
| Cui S et al. | L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17395449 |
| Becker K et al. | Influence of some prostaglandins and prostaglandin analogues on PAF-induced shock in mice. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1696744 |
| Wang HG et al. | Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384519 |
| Hardy P et al. | New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850712 |
| Mentz P et al. | Interactions of prostanoids with the platelet activating factors. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1279731 |
| Richter M et al. | Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17448648 |
| Louis NA et al. | Lipid mediator networks and leukocyte transmigration. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979294 |
| Akisu M et al. | The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic-ischemic brain in young mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468264 |
| de Lima WT et al. | Studies on the mechanism of PAF-induced vasopermeability in rat lungs. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784472 |
| Hughes H et al. | PAF formation by H2O2-stimulated perfused canine carotid arteries. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846103 |
| Albertini M and Clement MG | In pigs, inhaled nitric oxide (NO) counterbalances PAF-induced pulmonary hypertension. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846107 |
| Hirata Y et al. | Enhancement of thrombotic arterial occlusion following cholesterol feeding in the guinea-pig: a role for thromboxane A2. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972270 |
| Sakurai T et al. | Pharmacological studies of platelet-activating factor (PAF)-induced augmentation of response to histamine in guinea-pigs. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972272 |
| Galli C et al. | Modulation of lipid derived mediators by polyunsaturated fatty acids. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8424123 |
| Tsunoda H et al. | Involvement of leukotriene C4 in PAF-induced death in mice. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2353029 |
| Ichimaru T and Tai HH | Alteration of platelet activating factor (PAF) metabolism in rat pulmonary alveolar macrophages and plasma by cigarette smoking. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1461922 |
| Becker K et al. | PAF effects on eicosanoid release in neonatal rat cardiomyocytes. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480082 |
| Evans RD et al. | Platelet-activating factor and its metabolic effects. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946557 |
| Salamonsen LA | Effect of platelet activating factor on prostaglandin release from ovine endometrial cells in culture. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946564 |
| Travis SP and Jewell DP | The role of platelet-activating factor in the pathogenesis of gastrointestinal disease. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8208748 |
| Albertini M and Clement MG | Inhaled nitric oxide reverses PAF-dependent bronchoconstriction in the pig. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7644558 |
| Evangelou AM | Platelet-activating factor (PAF): implications for coronary heart and vascular diseases. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8146205 |
| Viossat I et al. | Effects of platelet activating factor (PAF) and its receptor antagonist BN 52021 on isolated perfused guinea-pig heart. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2622972 |
| Shindo K and Fukumura M | Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951989 |
| González E et al. | A novel enhancing effect of platelet activating factor (PAF) on glucose oxidation in uteri from pregnant rats. Participation of prostaglandins and leukotrienes. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2399270 |
| Peplow PV and Mikhailidis DP | Platelet-activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274568 |
| Jeremy JY et al. | Eicosanoids and septicaemia. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7938078 |
| Monthly prostaglandin bibliography prepared by the University of Sheffield Biomedical Information Service. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577776 | |
| Berdeli A et al. | Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15301793 |
| Shindo K et al. | Effect of azelastine hydrochloride on release and production of platelet activating factor in human neutrophils. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9175174 |
| Clement MG et al. | PAF and the role of the vagus nerve in the breathing pattern of the pig. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1561234 |
| Saito M et al. | Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415807 |
| Arribas I et al. | Direct interactions between platelets and cultured rat mesangial cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415809 |
| Plante GE et al. | Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3231663 |
| Pédrono F et al. | Natural 1-O-alkylglycerols reduce platelet-activating factor-induced release of [3H]-serotonin in rabbit platelets. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15172680 |
| Becker K et al. | PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8385779 |
| Wise H | Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482170 |
| Peplow PV | Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10509861 |
| Kikuchi M et al. | Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. | 2008 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18502110 |
| Shindo K and Fukumura M | Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578146 |
| Steil AA et al. | Platelet-activating factor and eicosanoids are mediators of local and systemic changes induced by immune-complexes in mice. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367295 |
| Fujimura M et al. | No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10680775 |
| Li L et al. | Estrogen effects on platelet-activating factor and platelet-activating factor acetylhydrolase activity in rat uterus during the late stages of pregnancy. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10402216 |
| Tiemann U et al. | Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating factor receptor in endometrial explant perfusion cultures from ovariectomized bovine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967160 |
| Tsutsumi T et al. | Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259070 |
| Fallani A et al. | Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085325 |
| Fallani A et al. | Synthesis of platelet-activating factor (PAF) in transformed cell lines of a different origin. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428690 |
| Tiano L et al. | Oxidative response and membrane modification of diabetic platelets challenged with PAF. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060899 |
| Argyrou C et al. | Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes. | 2017 | Prostaglandins Other Lipid Mediat. | pmid:28323197 |
| Calcerrada MC et al. | Modulation of protein kinase C isoforms by PAF in cerebral cortex. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482284 |
| Nakasaki T et al. | Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482285 |