| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prescott SM et al. | Inflammation as an early component of atherosclerosis and vascular damage--a role for P-selectin and platelet-activating factor. | 1996 | Jpn. Circ. J. | pmid:8741238 |
| Clark GD et al. | Lipids as axon guidance molecules? | 1995 | Neuroreport | pmid:8741737 |
| Clark GD et al. | Platelet-activating factor produces neuronal growth cone collapse. | 1995 | Neuroreport | pmid:8741765 |
| Tellis C et al. | Isolation, chemical characterization, and subcellular distribution of 1-O-alkyl-2-acetyl-sn-glycerol in Tetrahymena pyriformis cells. | 1996 | J. Biochem. | pmid:8743588 |
| Psychoyos A et al. | The role of prostaglandins in blastocyst implantation. | 1995 | Hum. Reprod. | pmid:8745299 |
| Liu Y and Kang GF | [Lipid mediators and liver injury]. | 1995 | Sheng Li Ke Xue Jin Zhan | pmid:8745570 |
| Arnould T et al. | Hypoxia induces PMN adherence to umbilical vein endothelium. | 1995 | Cardiovasc. Res. | pmid:8746218 |
| Muñoz HR et al. | Platelet-activating factor (PAF) does not affect diastolic function in isolated rat hearts. | 1995 | Cardiovasc. Res. | pmid:8746220 |
| Seeds EA et al. | Role of lipoxygenase metabolites in platelet-activating factor- and antigen-induced bronchial hyperresponsiveness and eosinophil infiltration. | 1995 | Eur. J. Pharmacol. | pmid:8748690 |
| Hirashima Y et al. | Platelet-activating factor (PAF) and the formation of chronic subdural haematoma. Measurement of plasma PAF levels and anti-PAF immunoglobulin titers. | 1995 | Acta Neurochir (Wien) | pmid:8748861 |
| Serhan CN et al. | Lipid mediator networks in cell signaling: update and impact of cytokines. | 1996 | FASEB J. | pmid:8751717 |
| Kawata E et al. | Effect of benzodiazepine on antigen-induced eosinophil infiltration into guinea pig conjunctiva. | 1996 | Arerugi | pmid:8752723 |
| Travers JB et al. | Platelet-activating factor biosynthesis induced by various stimuli in human HaCaT keratinocytes. | 1996 | J. Invest. Dermatol. | pmid:8752845 |
| Asano K et al. | Distribution of platelet activating factor receptor mRNA along the rat nephron segments. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8753768 |
| Radhika V et al. | Granulocytes from chronic myeloid leukemia (CML) patients show differential response to different chemoattractants. | 1996 | Am. J. Hematol. | pmid:8756080 |
| Masclans JR et al. | Salbutamol reduces pulmonary neutrophil sequestration of platelet-activating factor in humans. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8756833 |
| Xiao J et al. | [Effect of platelet activating factor receptor at spinal cord neurocyte membrane on secondary damage after spinal cord injury]. | 1996 | Zhonghua Yi Xue Za Zhi | pmid:8758444 |
| Zhu Z et al. | Platelet activating factor inhibits fluid transport by corneal endothelium. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8759360 |
| Macari DM et al. | Priming of eosinophil recruitment in vivo by LPS pretreatment. | 1996 | J. Immunol. | pmid:8759756 |
| Soldi R et al. | Platelet-activating factor (PAF) induces the early tyrosine phosphorylation of focal adhesion kinase (p125FAK) in human endothelial cells. | 1996 | Oncogene | pmid:8760293 |
| Ding Z et al. | Inhibitory effects of isoproterenol on PAF-induced endothelial cell permeability and morphological changes. | 1996 | Sci. China, C, Life Sci. | pmid:8760474 |
| Woolley DS et al. | Platelet activating factor mediates cardiopulmonary dysfunction during graded bacteremic shock. | 1996 | J Trauma | pmid:8760539 |
| Trapali M et al. | PAF-acetylhydrolase activity and PAF levels in pancreas and plasma of well-fed, diabetic and fasted rat. | 1996 | Life Sci. | pmid:8761318 |
| Nahas N et al. | Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists. | 1996 | Biochem. J. | pmid:8761479 |
| Xiao J et al. | [Effects of platelet activating factor and platelet activating factor receptor antagonist on spinal cord blood flow after spinal cord injury]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8762548 |
| Izaki S et al. | Platelet-activating factor and arachidonic acid metabolites in psoriatic inflammation. | 1996 | Br. J. Dermatol. | pmid:8763425 |
| DeFily DV et al. | PAF attenuates endothelium-dependent coronary arteriolar vasodilation. | 1996 | Am. J. Physiol. | pmid:8764261 |
| Lupia E et al. | Role of tumor necrosis factor-alpha and platelet-activating factor in neoangiogenesis induced by synovial fluids of patients with rheumatoid arthritis. | 1996 | Eur. J. Immunol. | pmid:8765007 |
| Xie X et al. | Interdigitation of bilayers from ether lipid analogs: (R)-PAF, (R)-Lyso-PAF and the antineoplastic (R)-ET-18-OMe. | 1996 | Biochim. Biophys. Acta | pmid:8765102 |
| Baker RR and Chang HY | Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex. | 1996 | Biochim. Biophys. Acta | pmid:8765148 |
| de Paulis A et al. | Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. | 1996 | J. Allergy Clin. Immunol. | pmid:8765829 |
| Harris NR and Granger DN | Mechanisms underlying enhanced capillary filtration induced by platelet-activating factor. | 1996 | Am. J. Physiol. | pmid:8769743 |
| Walcher F et al. | Platelet-activating factor is involved in the regulation of pathological leukocyte adhesion after liver transplantation. | 1996 | J. Surg. Res. | pmid:8769973 |
| Shebzukhov IuV et al. | [The effect of platelet-activating factor and its synthetic analogs on Ia-antigen expression by mouse peritoneal macrophages]. | 1996 May-Jun | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:8771751 |
| Reinhardt PH et al. | Monosodium urate crystals promote neutrophil adhesion via a CD18-independent and selectin-independent mechanism. | 1996 | Am. J. Physiol. | pmid:8772427 |
| Sun XM et al. | Role of leukocyte beta 2-integrin in PAF-induced shock and intestinal injury. | 1996 | Am. J. Physiol. | pmid:8772517 |
| Kamata K et al. | Mechanisms of desensitization of vasodilatation induced by platelet-activating factor in hypertensive rats. | 1996 | Eur. J. Pharmacol. | pmid:8773455 |
| Moriguchi T et al. | Diamide primes neutrophils for enhanced release of superoxide anion: relationship to S-thiolation of cellular proteins. | 1996 | J. Leukoc. Biol. | pmid:8773580 |
| Ueno A et al. | The mediators involved in endotoxin-induced vascular permeability increase in the rat skin and their interactions. | 1996 | Jpn. J. Pharmacol. | pmid:8774757 |
| Nabe T et al. | Sephadex G-200-induced eosinophil infiltration into airways in non-sensitized and sensitized guinea pigs, and responsiveness of the cells to stimuli in vitro. | 1996 | Jpn. J. Pharmacol. | pmid:8774762 |
| Ayala A and Chaudry IH | Platelet activating factor and its role in trauma, shock, and sepsis. | 1996 | New Horiz | pmid:8774801 |
| Sobhani I et al. | Helicobacter pylori stimulates gastric acid secretion via platelet activating factor. | 1996 | J. Physiol. Pharmacol. | pmid:8777297 |
| Izumi T et al. | Platelet-activating factor receptor. | 1995 | J Lipid Mediat Cell Signal | pmid:8777584 |
| Sterner-Kock A et al. | Recombinant tumour necrosis factor-alpha and platelet-activating factor synergistically increase intercellular adhesion molecule-1 and E-selectin-dependent neutrophil adherence to endothelium in vitro. | 1996 | Immunology | pmid:8778033 |
| Kurose I et al. | Microvascular dysfunction induced by nonsteroidal anti-inflammatory drugs: role of leukocytes. | 1996 | Am. J. Physiol. | pmid:8779980 |
| Khoury J and Langleben D | Platelet-activating factor stimulates lung pericyte growth in vitro. | 1996 | Am. J. Physiol. | pmid:8780000 |
| Yang X et al. | Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective phospholipase C activation. | 1996 | Blood | pmid:8781423 |
| Almer S et al. | Concentrations of platelet activating factor in rectal mucosa in patients with ulcerative colitis. | 1996 | Eur J Surg | pmid:8781921 |
| Sasaki T et al. | A distribution study of 11C platelet-activating factor (PAF) analogs in normal and tumor-bearing mice. | 1996 | Nucl. Med. Biol. | pmid:8782242 |
| Uhlig S et al. | Cyclooxygenase-2-dependent bronchoconstriction in perfused rat lungs exposed to endotoxin. | 1996 | Mol. Med. | pmid:8784790 |
| Ogundaini A et al. | Isolation of two new antiinflammatory biflavanoids from Sarcophyte piriei. | 1996 | J. Nat. Prod. | pmid:8786365 |
| Baker RR | Enzymes of platelet activating factor synthesis in brain. | 1995 | Neurochem. Res. | pmid:8786821 |
| Yoshii H et al. | Neurotropin inhibits accumulation of eosinophils induced by allergen through the suppression of sensitized T-cells. | 1995 | Int. J. Immunopharmacol. | pmid:8788117 |
| Battye KM et al. | Ovine endometrium synthesizes and releases platelet-activating factor, which can cause the release of prostaglandin F2 alpha by the uterus in situ. | 1996 | Biol. Reprod. | pmid:8788186 |
| Hirafuji M et al. | Involvement of platelet cyclic GMP but not cyclic AMP suppression in leukocyte-dependent platelet adhesion to endothelial cells induced by platelet-activating factor in vitro. | 1996 | Br. J. Pharmacol. | pmid:8789382 |
| Bazan NG and Allan G | Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. | 1996 | Adv Neurol | pmid:8790822 |
| Naraba H et al. | Inhibitory effect of arachidonic acid on platelet-activating factor production in rat neutrophils. | 1996 | Eur. J. Pharmacol. | pmid:8790999 |
| Aïssa J et al. | Biochemical and cellular effects of heparin-protamine injection in rabbits are partially inhibited by a PAF-acether receptor antagonist. | 1996 | Eur. J. Pharmacol. | pmid:8791000 |
| Weikert LF and Bernard GR | Pharmacotherapy of sepsis. | 1996 | Clin. Chest Med. | pmid:8792067 |
| Takeda H et al. | Release of fructose and hexose phosphates from perivascular cells induced by low density lipoprotein and acceleration of protein glycation in vitro. | 1996 | Diabetes Res. Clin. Pract. | pmid:8792096 |
| Abebe W et al. | Platelet-activating factor-induced inositol 1,4,5-trisphosphate generation in undifferentiated and differentiated U937 cells: role of tyrosine kinase. | 1996 | Int. J. Immunopharmacol. | pmid:8796445 |
| Parent JL et al. | Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis. | 1996 | J. Biol. Chem. | pmid:8798529 |
| Marcheselli VL and Bazan NG | Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. | 1996 | J. Biol. Chem. | pmid:8798751 |
| van Rossem K et al. | The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. | 1996 | Adv. Exp. Med. Biol. | pmid:8798843 |
| Westmoreland SV et al. | Toxicity of TNF alpha and platelet activating factor for human NT2N neurons: a tissue culture model for human immunodeficiency virus dementia. | 1996 | J. Neurovirol. | pmid:8799203 |
| Civelli M et al. | The involvement of the release of nitric oxide in the pharmacological activity of the new furoxan derivative CHF 2363. | 1996 | Br. J. Pharmacol. | pmid:8799563 |
| Noguchi K et al. | Involvement of nitric oxide and eicosanoids in platelet-activating factor-induced haemodynamic and haematological effects in dogs. | 1996 | Br. J. Pharmacol. | pmid:8799566 |
| Marrakchi N et al. | [Biochemical and pharmacologic properties of platelet aggregants and platelet antiaggregants of viper venoms in Tunisia]. | 1994 Jul-Oct | Arch Inst Pasteur Tunis | pmid:8801850 |
| Catalán RE et al. | Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806587 |
| Baskin SI et al. | The effects of EDRF/NO releasers or calcium ionophore A23187 on cyanide toxicity in mice. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8806852 |
| Dunlop ME et al. | Production of hyaluronan by glomerular mesangial cells in response to fibronectin and platelet-derived growth factor. | 1996 | Kidney Int. | pmid:8807570 |
| Arima S et al. | Platelet-activating factor dilates efferent arterioles through glomerulus-derived nitric oxide. | 1996 | J. Am. Soc. Nephrol. | pmid:8808114 |
| Tachibana F et al. | Platelet-activating factor and leukotrienes in acute otitis media, secretory otitis media, and chronic otitis media on the acute excerbation. | 1996 | Auris Nasus Larynx | pmid:8809319 |
| Yasugahira H et al. | [The changes of blood gas analysis values and platelet aggregability on acute phase in the experimental model of pulmonary embolism prepared by sephadex G-75 (SG-75) injection]. | 1996 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8810754 |
| Durán WN et al. | Platelet-activating factor modulates leukocyte adhesion to endothelium in ischemia-reperfusion. | 1996 | Microvasc. Res. | pmid:8812764 |
| Tao Y et al. | Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8814143 |
| Erger RA and Casale TB | Eosinophil migration in response to three molecular species of platelet activating factor. | 1996 | Inflamm. Res. | pmid:8814455 |
| Sato E et al. | Bradykinin stimulates alveolar macrophages to release neutrophil, monocyte, and eosinophil chemotactic activity. | 1996 | J. Immunol. | pmid:8816423 |
| Bauldry SA and Wooten RE | Leukotriene B4 and platelet activating factor production in permeabilized human neutrophils: role of cytosolic PLA2 in LTB4 and PAF generation. | 1996 | Biochim. Biophys. Acta | pmid:8816854 |
| Le Texier L et al. | Structure-activity relationships in platelet-activating factor (PAF). 7. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors. Synthesis and PAF-antagonistic activity. | 1996 | J Lipid Mediat Cell Signal | pmid:8816984 |
| Le Texier L et al. | Structure-activity relationships in platelet-activating factor (PAF). 8. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors: anti-acetylcholinesterase activity and comparative SAR. | 1996 | J Lipid Mediat Cell Signal | pmid:8816985 |
| Le Solleu H et al. | A pharmacophore for high affinity PAF antagonists. I. Electronic model using molecular electrostatic potential. | 1996 | J Lipid Mediat Cell Signal | pmid:8816988 |
| Abu-Zidan FM and Walther S | Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs. | 1996 | Eur J Surg | pmid:8817228 |
| Lin J et al. | Effects of platelet-activating factor (PAF) receptor blockage on mucous glycoprotein secretion in cultured chinchilla middle ear epithelium. | 1996 | Acta Otolaryngol. | pmid:8820353 |
| Kuitert L and Barnes NC | PAF and asthma--time for an appraisal? | 1995 | Clin. Exp. Allergy | pmid:8821294 |
| Miguélez R et al. | Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis. | 1996 | J Lipid Mediat Cell Signal | pmid:8821809 |
| Murakami K et al. | A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats. | 1996 | Thromb. Haemost. | pmid:8822594 |
| Yang HO et al. | Biological and pharmacological effects of pinusolide, a novel platelet activating factor antagonist. | 1995 | Planta Med. | pmid:8824945 |
| Predescu D et al. | The vascular distribution of the platelet-activating factor receptor. | 1996 | Eur. J. Cell Biol. | pmid:8825027 |
| Burt RP et al. | The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens. | 1996 | Br. J. Pharmacol. | pmid:8825367 |
| Grinyó JM et al. | The role of platelet-activating factor antagonists in the prophylaxis of posttransplant acute tubular necrosis. | 1996 | Ren Fail | pmid:8827990 |
| López-Novoa JM et al. | The role of platelet-activating factor and the effect of PAF blocking receptors on the outcome of ARF. | 1996 | Ren Fail | pmid:8827995 |
| Spangelo BL and Jarvis WD | Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. | 1996 | Endocrinology | pmid:8828503 |
| Galloway SW and Kingsnorth AN | Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist. | 1996 | Pancreas | pmid:8829181 |
| Sandoval D et al. | The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. | 1996 | Gastroenterology | pmid:8831604 |
| Ribaldi E et al. | Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation. | 1996 | Br. J. Pharmacol. | pmid:8832056 |
| Savu SR et al. | Determination of 1-O-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, platelet-activating factor and related phospholipids in biological samples by high-performance liquid chromatography--tandem mass spectrometry. | 1996 | J. Chromatogr. B, Biomed. Appl. | pmid:8832423 |
| Tsukioka K et al. | Increased plasma level of platelet-activating factor (PAF) and decreased serum PAF acetylhydrolase (PAFAH) activity in adults with bronchial asthma. | 1996 Jan-Feb | J Investig Allergol Clin Immunol | pmid:8833165 |
| Matsuo Y et al. | Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain. | 1996 | Brain Res. | pmid:8833766 |
| Gabryelewicz A | Etiology and pathogenesis of acute pancreatitis--current view. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8834603 |