| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hattermann K et al. | The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis. | 2007 | FASEB J. | pmid:17264163 |
| De Vriese C et al. | Ghrelin interacts with human plasma lipoproteins. | 2007 | Endocrinology | pmid:17289852 |
| Liu WC et al. | Lipopolysaccharide-induced cerebral inflammatory damage and the therapeutic effect of platelet activating factor receptor antagonist. | 2007 | Neurosci Bull | pmid:17952135 |
| Wu B et al. | [Effects of bificobacterium longum on neonatal rat model of necrotizing enterocolitis and roles of platelet-activating factor and tumor necrosis factor-alpha]. | 2007 | Zhonghua Er Ke Za Zhi | pmid:17953818 |
| Owen JS et al. | Platelet-activating factor. | 2007 | Meth. Enzymol. | pmid:17954244 |
| Ying-fang S et al. | Effect of platelet-activating factor on cell proliferation & NF-kappaB activation in airway smooth muscle cells in rats. | 2007 | Indian J. Med. Res. | pmid:17932440 |
| Guerra CT et al. | Effect of chronic hepatitis C virus infection on inflammatory lipid mediators. | 2007 | Dig Liver Dis | pmid:17936229 |
| Kawano Y et al. | The effects of platelet-activating factor on the secretion of interleukin-8 and growth-regulated oncogene alpha in human immortalized granulosa cell line (GC1a). | 2007 | Am. J. Reprod. Immunol. | pmid:17922696 |
| Ebihara S et al. | A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. | 2007 | Inflamm. Res. | pmid:17406808 |
| Ullrich SE | Sunlight and skin cancer: lessons from the immune system. | 2007 | Mol. Carcinog. | pmid:17443748 |
| Richter M et al. | Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17448648 |
| Finnegan EM et al. | Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17483236 |
| Cattaneo M et al. | Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count. | 2007 | Haematologica | pmid:17488697 |
| Kälvegren H et al. | Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors. | 2007 | Eur. J. Pharmacol. | pmid:17459368 |
| Taheri F and Bazan HE | Platelet-activating factor overturns the transcriptional repressor disposition of Sp1 in the expression of MMP-9 in human corneal epithelial cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17460244 |
| Dinubile MJ | Plasma gelsolin: in search of its raison d'etre. Focus on "Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin". | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17428843 |
| Souza LJ et al. | Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor. | 2007 | Pancreatology | pmid:17449968 |
| Shin CR et al. | Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis. | 2007 | J. Periodont. Res. | pmid:17451539 |
| Bathgate R et al. | Effects of platelet-activating factor and platelet-activating factor: acetylhydrolase on in vitro post-thaw boar sperm parameters. | 2007 | Theriogenology | pmid:17157372 |
| Hammond A et al. | Platelets in equine recurrent airway obstruction. | 2007 | Res. Vet. Sci. | pmid:17107696 |
| Vinores SA et al. | TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. | 2007 | J. Neuroimmunol. | pmid:17107717 |
| Brkovic A and Sirois MG | Vascular permeability induced by VEGF family members in vivo: role of endogenous PAF and NO synthesis. | 2007 | J. Cell. Biochem. | pmid:17115409 |
| Choi JH et al. | Impairment of p38 MAPK-mediated cytosolic phospholipase A2 activation in the kidneys is associated with pathogenicity of Candida albicans. | 2007 | Immunology | pmid:17054728 |
| El Behi M et al. | Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs. | 2007 | J. Neuroimmunol. | pmid:17097744 |
| Blanchet MR et al. | Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. | 2007 | J. Leukoc. Biol. | pmid:17289799 |
| Shindou H et al. | A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. | 2007 | J. Biol. Chem. | pmid:17182612 |
| Ko HM et al. | Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. | 2007 | Int. J. Cancer | pmid:17187368 |
| Bate C et al. | Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | 2007 | J Neuroinflammation | pmid:17233902 |
| Park EJ et al. | Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. | 2007 | Shock | pmid:17510604 |
| Young RE et al. | Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. | 2007 | Br. J. Pharmacol. | pmid:17471175 |
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| Givehchi A et al. | Analysis of activity space by fragment fingerprints, 2D descriptors, and multitarget dependent transformation of 2D descriptors. | 2006 May-Jun | J Chem Inf Model | pmid:16711727 |
| Lang F et al. | Osmotic shock-induced suicidal death of erythrocytes. | 2006 May-Jun | Acta Physiol (Oxf) | pmid:16734755 |
| Zhu T et al. | Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. | 2006 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:16902584 |
| Gu Y et al. | PAF levels and PAF-AH activities in placentas from normal and preeclamptic pregnancies. | 2006 Jun-Jul | Placenta | pmid:16122793 |
| Lang F et al. | Mechanisms and significance of eryptosis. | 2006 Jul-Aug | Antioxid. Redox Signal. | pmid:16910766 |
| Vasques E et al. | Impairment of endothelium-dependent aorta relaxation by phospholipid components of oxidized low-density lipoprotein. | 2006 Jan-Feb | Endothelium | pmid:16885061 |
| Davoine F et al. | Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis. | 2006 | Int. Arch. Allergy Immunol. | pmid:16735797 |
| Lima RG et al. | Interaction of macrophages with apoptotic cells enhances HIV Type 1 replication through PGE2, PAF, and vitronectin receptor. | 2006 | AIDS Res. Hum. Retroviruses | pmid:16910832 |
| Gora S et al. | The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2. | 2006 | Biochim. Biophys. Acta | pmid:16962371 |
| Kassuya CA et al. | Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor. | 2006 | Eur. J. Pharmacol. | pmid:16925995 |
| Cauwels A et al. | Anaphylactic shock depends on PI3K and eNOS-derived NO. | 2006 | J. Clin. Invest. | pmid:16886062 |
| Wolf P et al. | Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. | 2006 | Am. J. Pathol. | pmid:16936256 |
| Pirbhai M et al. | The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells. | 2006 | J. Biol. Chem. | pmid:16940052 |
| Harputluoglu MM et al. | The effects of Gingko biloba extract on acetic acid-induced colitis in rats. | 2006 | Turk J Gastroenterol | pmid:16941250 |
| Han JI et al. | RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. | 2006 | J. Leukoc. Biol. | pmid:16565322 |
| Servillo L et al. | Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages. | 2006 | FASEB J. | pmid:16571775 |
| Flamand N et al. | Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF. | 2006 | J. Leukoc. Biol. | pmid:16501051 |
| He J and Bazan HE | Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16505020 |
| Barthomeuf C et al. | Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | 2006 | Free Radic. Biol. Med. | pmid:16458188 |
| Marchand C et al. | Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells. | 2006 | J. Cell. Biochem. | pmid:16479592 |
| Keles GC et al. | Levels of platelet activating factor in gingival crevice fluid following periodontal surgical therapy. | 2006 | J. Periodont. Res. | pmid:17076775 |
| Denizot Y et al. | Platelet-activating factor and human meningiomas. | 2006 | Neuropathol. Appl. Neurobiol. | pmid:17083481 |
| Wang GD et al. | Platelet-activating factor in the enteric nervous system of the guinea pig small intestine. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17030900 |
| Herman AG and Stockwell BR | Enzyme annotation with chemical tools. | 2006 | Chem. Biol. | pmid:17052604 |
| Chiang KP et al. | An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. | 2006 | Chem. Biol. | pmid:17052608 |
| Brown SL et al. | Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals. | 2006 | J. Immunol. | pmid:16920964 |
| Baker KE et al. | Nupafant, a PAF-antagonist prototype for suppression of ventricular fibrillation without liability for QT prolongation? | 2006 | Br. J. Pharmacol. | pmid:16921398 |
| Kim DH et al. | Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion. | 2006 | Ann. Otol. Rhinol. Laryngol. | pmid:16944661 |
| Vahidy WH et al. | Effects of intracerebroventricular injections of free fatty acids, lysophospholipids, or platelet activating factor in a mouse model of orofacial pain. | 2006 | Exp Brain Res | pmid:16947060 |
| Matsumura Y et al. | A role for inflammatory mediators in the induction of immunoregulatory B cells. | 2006 | J. Immunol. | pmid:16982922 |
| Slomiany BL and Slomiany A | Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation interferes with salivary mucin synthesis via platelet activating factor generation. | 2006 | Inflammopharmacology | pmid:16983494 |
| Zhang Q et al. | Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. | 2006 | Exp. Dermatol. | pmid:16984258 |
| Hartvigsen K et al. | 1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB. | 2006 | Lipids | pmid:17069352 |
| Sugimoto S et al. | Purification and characterization of lysophospholipase D from rat brain. | 2006 | Biochim. Biophys. Acta | pmid:17071136 |
| Tabarés-Seisdedos R et al. | Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: a preliminary study. | 2006 | Neuroscience | pmid:16549273 |
| Heon Seo K et al. | Platelet-activating factor induces up-regulation of antiapoptotic factors in a melanoma cell line through nuclear factor-kappaB activation. | 2006 | Cancer Res. | pmid:16651419 |
| Doi K et al. | Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. | 2006 | Am. J. Pathol. | pmid:16651609 |
| Coleus forskohlii. Monograph. | 2006 | Altern Med Rev | pmid:16597194 | |
| Fernandes CJ and O'Donovan DJ | Platelet transfusions in infants with necrotizing enterocolitis. | 2006 | Curr. Hematol. Rep. | pmid:16537050 |
| Maliba R et al. | Angiopoietins-1 and -2 are both capable of mediating endothelial PAF synthesis: intracellular signalling pathways. | 2006 | Cell. Signal. | pmid:16617006 |
| Jauchem JR | The role of autacoids and the autonomic nervous system in cardiovascular responses to radio-frequency energy heating. | 2006 | Auton Autacoid Pharmacol | pmid:16553641 |
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| Purnell ET et al. | Influence of the preimplantation embryo development (Ped) gene on embryonic platelet-activating factor (PAF) levels. | 2006 | J. Assist. Reprod. Genet. | pmid:16799834 |
| Slomiany BL and Slomiany A | Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis. | 2006 | IUBMB Life | pmid:16754300 |
| Moreno SE et al. | Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis. | 2006 | J. Immunol. | pmid:16818786 |
| Machado EM et al. | WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph. | 2006 | J. Insect Physiol. | pmid:16777137 |
| Blanchet MR et al. | Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16782754 |
| Gomes RN et al. | Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. | 2006 | Shock | pmid:16783197 |
| Chen LW et al. | Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. | 2006 | Shock | pmid:16783201 |
| Mao YJ et al. | [Effect of ginkgolide B on the function of rat aorta smooth cells and U937 cells stimulated by oxLDL]. | 2006 | Yao Xue Xue Bao | pmid:16683525 |
| Ko HM et al. | Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity. | 2006 | FEBS Lett. | pmid:16684540 |
| Hermle T et al. | Decreased cation channel activity and blunted channel-dependent eryptosis in neonatal erythrocytes. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16723509 |
| Fonseca FV et al. | Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom. | 2006 | Protein J. | pmid:16729248 |
| Wang C et al. | Total synthesis of (+/-)-paeonilide. | 2006 | Org. Lett. | pmid:16737293 |
| Kaul DK et al. | Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16738001 |
| Thaete LG and Neerhof MG | Endothelin and platelet-activating factor: significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat. | 2006 | Am. J. Obstet. Gynecol. | pmid:16579936 |
| Karantonis HC et al. | In vivo antiatherogenic properties of olive oil and its constituent lipid classes in hyperlipidemic rabbits. | 2006 | Nutr Metab Cardiovasc Dis | pmid:16580585 |
| Balestrieri C et al. | Relative effects of phenolic constituents from Yucca schidigera Roezl. bark on Kaposi's sarcoma cell proliferation, migration, and PAF synthesis. | 2006 | Biochem. Pharmacol. | pmid:16580641 |
| Kikuchi I et al. | Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16456187 |
| Poeckel D et al. | 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16174802 |
| Mauri P et al. | LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts Correlation with pharmacological activity. | 2006 | J Pharm Biomed Anal | pmid:16343838 |
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| Eckford PD and Sharom FJ | P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors. | 2006 | Biochem. Cell Biol. | pmid:17215888 |
| Subbanna PK and Tyagi MG | PAF antagonism modifies neuroprotective action of histone deacetylase and calcineurin phosphatase inhibitors in mice. | 2006 | Indian J. Exp. Biol. | pmid:17205708 |
| Fang H et al. | Anaphylactic reaction induced by Toxoplasma gondii-derived heat shock protein 70. | 2006 | Int. Immunol. | pmid:16943259 |
| Antonopoulou S et al. | Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus. | 2006 | J Med Food | pmid:17004898 |
| Gomes MT et al. | Platelet-activating factor-like activity isolated from Trypanosoma cruzi. | 2006 | Int. J. Parasitol. | pmid:16337632 |
| Dohi T et al. | [Role of platelet-activating factor on spinal pain transduction]. | 2006 | Nippon Yakurigaku Zasshi | pmid:16508219 |
| Desaulniers P et al. | Characterization of an activation factor released from human neutrophils after stimulation by triclinic monosodium urate crystals. | 2006 | J. Rheumatol. | pmid:16652423 |