| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Emilsson A and Sundler R | Differential activation of phosphatidylinositol deacylation and a pathway via diphosphoinositide in macrophages responding to zymosan and ionophore A23187. | 1984 | J. Biol. Chem. | pmid:6321496 |
| Mueller HW et al. | 1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species. | 1984 | J. Lipid Res. | pmid:6427378 |
| Kramp W et al. | Observations on the critical micellar concentration of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine and a series of its homologs and analogs. | 1984 | Chem. Phys. Lipids | pmid:6744496 |
| Lefort J et al. | The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene. | 1984 | Br. J. Pharmacol. | pmid:6430375 |
| Hamasaki Y et al. | Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. | 1984 | Am. Rev. Respir. Dis. | pmid:6547031 |
| Dahlbäck M et al. | Bronchial anaphylaxis in actively sensitized Sprague Dawley rats: studies on mediators involved. | 1984 | Acta Pharmacol Toxicol (Copenh) | pmid:6431753 |
| Cervoni P et al. | Evidence for the lack of interaction between (+/-)-1-O-octadecyl-2-acetylglyceryl-3-phosphorylcholine and alpha-adrenoceptors in vivo and in vitro. | 1984 | Br. J. Pharmacol. | pmid:6091835 |
| Fink KL and Gross RW | Modulation of canine myocardial sarcolemmal membrane fluidity by amphiphilic compounds. | 1984 | Circ. Res. | pmid:6091941 |
| Wasserman SI | The human lung mast cell. | 1984 | Environ. Health Perspect. | pmid:6428878 |
| Handley DA et al. | Effect of platelet activating factor on endothelial permeability to plasma macromolecules. | 1984 | Immunopharmacology | pmid:6083990 |
| Camussi G et al. | Effect of platelet activating factor on guinea-pig papillary muscle. | 1984 | Experientia | pmid:6086382 |
| Riess H and Hiller E | Heparin and thrombocytopenia. | 1984 | Ann. Intern. Med. | pmid:6497200 |
| Blank ML et al. | Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6497876 |
| Lichey J et al. | Pressure effects and uptake of platelet-activating factor in isolated rat lung. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6501025 |
| Buxton DB et al. | Stimulation of glycogenolysis and platelet-activating factor production by heat-aggregated immunoglobulin G in the perfused rat liver. | 1984 | J. Biol. Chem. | pmid:6501277 |
| White GC | Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428395 |
| Mueller HW et al. | The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils. | 1984 | J. Biol. Chem. | pmid:6501307 |
| Goldenberg MM and Meurer RD | A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat. | 1984 | Prostaglandins | pmid:6505225 |
| Wissner A et al. | Analogues of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain. | 1984 | J. Med. Chem. | pmid:6471071 |
| Mallet AI et al. | Rapid isocratic high-performance liquid chromatographic purification of platelet activating factor (PAF) and lyso-PAF from human skin. | 1984 | J. Chromatogr. | pmid:6480761 |
| Kenzora JL et al. | Effects of acetyl glyceryl ether of phosphorylcholine (platelet activating factor) on ventricular preload, afterload, and contractility in dogs. | 1984 | J. Clin. Invest. | pmid:6480824 |
| Jackson EM et al. | High performance liquid chromatography of platelet-activating factors. | 1984 | J. Lipid Res. | pmid:6481248 |
| Smith RJ et al. | Stimulation of the human neutrophil superoxide anion-generating system with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3- phosphorylcholine. | 1984 | Biochem. Pharmacol. | pmid:6324816 |
| Dewar A et al. | Cutaneous and pulmonary histopathological responses to platelet activating factor (Paf-acether) in the guinea-pig. | 1984 | J. Pathol. | pmid:6481526 |
| Goldstein BM et al. | Effect of platelet activating factor (PAF) on blood flow distribution in the spontaneously hypertensive rat. | 1984 | Life Sci. | pmid:6482659 |
| Baldo BA and Tovey ER | Allergy, allergens and allergen standardization. | 1984 | Med. J. Aust. | pmid:6482786 |
| Saeki S et al. | Effect of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine on blood pressure by intra-lateral ventricular injection in the rat. | 1984 | Med J Osaka Univ | pmid:6482814 |
| Buxton DB et al. | Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine. | 1984 | J. Biol. Chem. | pmid:6693418 |
| Ostermann G et al. | Cooperative effects of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF-acether) and exogenous arachidonic acid in stimulation of human blood platelets. | 1984 | Thromb. Res. | pmid:6710440 |
| Lalau Keraly C et al. | Inhibition by ticlopidine of Paf-acether-induced in vitro aggregation of rabbit and human platelets. | 1984 | Thromb. Res. | pmid:6740569 |
| Ostermann G et al. | Halo lipids. VI. Stimulation of human and rabbit blood platelets by racemic halo analogues of O-alkyl-glycerophosphocholine. | 1984 | Biomed. Biochim. Acta | pmid:6743307 |
| Pinckard RN et al. | Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743335 |
| Levi R et al. | Acetyl glyceryl ether phosphorylcholine (AGEPC). A putative mediator of cardiac anaphylaxis in the guinea pig. | 1984 | Circ. Res. | pmid:6692502 |
| Humphrey DM et al. | Morphologic basis of increased vascular permeability induced by acetyl glyceryl ether phosphorylcholine. | 1984 | Lab. Invest. | pmid:6694349 |
| Masugi F et al. | Effect of 1-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine inhibitor on the reduction of one-kidney, one clip hypertension after unclipping in the rat. | 1984 | Life Sci. | pmid:6694519 |
| Bottecchia D et al. | Influence of the pure synthetic PAF (platelet aggregating factor) on clot retraction and platelet aggregation. | 1984 | Scand J Haematol | pmid:6695148 |
| Blank ML et al. | A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6696762 |
| McGivern DV and Basran GS | Synergism between platelet-activating factor (PAF-acether) and prostaglandin E2 in man. | 1984 | Eur. J. Pharmacol. | pmid:6592097 |
| Beaubien BB et al. | Platelet-activating factor stimulation of peptidoleukotriene release: inhibition by vasoactive polypeptide. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6594998 |
| Roubin R et al. | The role of immunomodulators in the production of lipid mediators by macrophages (M phi). | 1984 | Int J Tissue React | pmid:6596298 |
| Archer CB et al. | Synergistic interaction between prostaglandins and PAF-acether in experimental animals and man. | 1984 | Prostaglandins | pmid:6203139 |
| Infante JP | Biosynthesis of acyl-specific glycerophospholipids in mammalian tissues. Postulation of new pathways. | 1984 | FEBS Lett. | pmid:6373368 |
| Camussi G et al. | Platelet-activating factor-induced loss of glomerular anionic charges. | 1984 | Kidney Int. | pmid:6374251 |
| Schlondorff D et al. | Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells. | 1984 | J. Clin. Invest. | pmid:6423667 |
| Vargaftig BB et al. | [Platelet aggregation and PAF-acether. Pharmacologic interference]. | 1984 | J Pharmacol | pmid:6374298 |
| Ito S et al. | Hyperacute renal allograft rejection in the rabbit. The role of platelet-activating factor and of cationic proteins derived from polymorphonuclear leukocytes and from platelets. | 1984 | Lab. Invest. | pmid:6379289 |
| Bult H et al. | Complement derived factors and prostacyclin formation by rabbit isolated peritoneum and cultured mesothelial cells. | 1984 | Agents Actions Suppl. | pmid:6382974 |
| Hechtman HB et al. | Role of humoral mediators in adult respiratory distress syndrome. | 1984 | Chest | pmid:6383742 |
| Kelton JG et al. | The detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. | 1984 | Ann. Intern. Med. | pmid:6333196 |
| Bussolino F et al. | Release of platelet-activating factor (PAF)-like material from human lymphoid cell lines. | 1984 | Exp. Hematol. | pmid:6333353 |