| MeSH term | MeSH ID | Detail |
|---|---|---|
| Heart Arrest | D006323 | 13 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| HIV Infections | D015658 | 20 associated lipids |
| Subacute Sclerosing Panencephalitis | D013344 | 3 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| AIDS Dementia Complex | D015526 | 4 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kawasaki T and Snyder F | Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. | 1988 | J. Biol. Chem. | pmid:3422635 |
| Borin ML et al. | [Relation between the changes in Na+/H+-exchange and cytoplasmic Ca levels in platelet activation]. | 1988 | Biull Eksp Biol Med | pmid:2844320 |
| Smith SK and Kelly RW | Effect of platelet-activating factor on the release of PGF-2 alpha and PGE-2 by separated cells of human endometrium. | 1988 | J. Reprod. Fertil. | pmid:3422322 |
| Criscuoli M and Subissi A | Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice. | 1988 | Br. J. Pharmacol. | pmid:2894872 |
| Bourdillat B et al. | Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. | 1988 | Eur. J. Pharmacol. | pmid:2836213 |
| Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
| Elstad MR et al. | Synthesis and release of platelet-activating factor by stimulated human mononuclear phagocytes. | 1988 | J. Immunol. | pmid:3126231 |
| Hanss M and Dechavanne M | 48740 RP, an antagonist of PAF, does not affect human plasma fibrinolysis before and after venous occlusion. | 1988 | Thromb. Res. | pmid:3126559 |
| Nasmith PE and Grinstein S | Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils. | 1988 | Biosci. Rep. | pmid:2840131 |
| Dulioust A et al. | Immunoregulatory functions of paf-acether. I. Effect of paf-acether on CD4+ cell proliferation. | 1988 | J. Immunol. | pmid:2961808 |
| Acker G et al. | Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. | 1988 | Prostaglandins | pmid:3129758 |
| Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
| Bochner BS et al. | Adherence of human basophils to cultured umbilical vein endothelial cells. | 1988 | J. Clin. Invest. | pmid:3130394 |
| Yamada K et al. | Parallel inhibition of platelet-activating factor-induced protein phosphorylation and serotonin release by K-252a, a new inhibitor of protein kinases, in rabbit platelets. | 1988 | Biochem. Pharmacol. | pmid:3128296 |
| Crouch MF and Lapetina EG | No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132162 |
| Fernandez-Gallardo S et al. | Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids. | 1988 | Biochem. J. | pmid:2848496 |
| Neuwirth R et al. | Evidence for immunoglobulin Fc receptor-mediated prostaglandin2 and platelet-activating factor formation by cultured rat mesangial cells. | 1988 | J. Clin. Invest. | pmid:3166467 |
| Rossi AG et al. | Stereospecific bioactions of 5-hydroxyeicosatetraenoate. | 1988 | FEBS Lett. | pmid:3191990 |
| Nakamura T et al. | Effect of azelastine on the intracellular Ca2+ mobilization in guinea pig peritoneal macrophages. | 1988 | Eur. J. Pharmacol. | pmid:2898372 |
| Myers AK et al. | Antagonism of PAF-induced death in mice. | 1988 | Prostaglandins | pmid:3131837 |
| Shalit M et al. | Platelet activating factor increases expression of complement receptors on human neutrophils. | 1988 | J. Leukoc. Biol. | pmid:2842423 |
| Pirotzky E et al. | Cyclosporine-induced nephrotoxicity: preventive effect of a PAF-acether antagonist, BN 52063. | 1988 | Transplant. Proc. | pmid:3388505 |
| Ward SG and Westwick J | Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells. | 1988 | Br. J. Pharmacol. | pmid:3390650 |
| Demopoulos CA et al. | Abnormal platelet response to PAF and ADP in beta-thalassaemia. | 1988 | Int. J. Biochem. | pmid:3391336 |
| Lichterfeld A et al. | [Platelet activating factor and its possible role in bronchial asthma]. | 1988 | Prax Klin Pneumol | pmid:3041401 |
| Christman BW et al. | Role of circulating platelets and granulocytes in PAF-induced pulmonary dysfunction in awake sheep. | 1988 | J. Appl. Physiol. | pmid:3391901 |
| Greenberg S et al. | Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms. | 1988 | J. Biol. Chem. | pmid:3392016 |
| Etienne A et al. | Possible involvement of platelet-activating factor in endotoxin-induced abortion. | 1988 | Prog. Clin. Biol. Res. | pmid:3393560 |
| Lazanas M et al. | PAF of biological fluids in disease: IV. Levels in blood in allergic reactions induced by drugs. | 1988 | Arch. Dermatol. Res. | pmid:3395143 |
| Satoh K et al. | Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease. | 1988 | Prostaglandins | pmid:3399678 |
| Mazière JC et al. | PAF-acether decreases low density lipoprotein degradation and alters lipid metabolism in cultured human fibroblasts. | 1988 | FEBS Lett. | pmid:3402608 |
| There is a case for PAF-acether antagonists. Abstracts of the conference. Paris, France, May 25-27, 1988. | 1988 | Prostaglandins | pmid:3399682 | |
| Valone FH | Platelet-activating factor binding and metabolism during human platelet aggregation. | 1988 | Thromb. Res. | pmid:3400077 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on antigen-induced, acute, and late-onset cutaneous responses in atopic subjects. | 1988 | J. Allergy Clin. Immunol. | pmid:3403863 |
| Koenderman L et al. | An improved method for the isolation of eosinophilic granulocytes from peripheral blood of normal individuals. | 1988 | J. Leukoc. Biol. | pmid:3404069 |
| Anderson GP and Fennessy MR | Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig. | 1988 | Agents Actions Suppl. | pmid:3140616 |
| Coyle AJ et al. | The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation. | 1988 | Eur. J. Pharmacol. | pmid:3383997 |
| Tokumura A et al. | Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis. | 1988 | Eur. J. Pharmacol. | pmid:3384001 |
| Lewis MS et al. | Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. | 1988 | J. Clin. Invest. | pmid:3198764 |
| Makino S | [Platelet activating factor in allergic reaction]. | 1988 | Arerugi | pmid:3052368 |
| Misawa M and Takata T | Effects of platelet-activating factor on rat airways. | 1988 | Jpn. J. Pharmacol. | pmid:3199608 |
| Wasserman SI | Platelet-activating factor as a mediator of bronchial asthma. | 1988 | Hosp. Pract. (Off. Ed.) | pmid:3053741 |
| Cunha FQ et al. | Failure of PAF-acether to induce in vivo neutrophil migration. | 1988 | Agents Actions | pmid:3055873 |
| Kato T et al. | Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). | 1988 | Biochem. Biophys. Res. Commun. | pmid:3202869 |
| Foegh ML | Eicosanoids and platelet activating factor mechanisms in organ rejection. | 1988 | Transplant. Proc. | pmid:3059615 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on PAF-induced bronchoconstriction in normal subjects. | 1988 | Br J Clin Pharmacol | pmid:3203062 |
| Lagarde M | Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. | 1988 | Prog. Lipid Res. | pmid:3060881 |
| Freitas JC et al. | Inhibition of platelet aggregation by manoalide: preliminary results. | 1988 | Braz. J. Med. Biol. Res. | pmid:3203166 |
| Pai JK et al. | Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes. | 1988 | J. Biol. Chem. | pmid:3165977 |
| Collier M et al. | Biochemical and pharmacological characterization of human embryo-derived platelet activating factor. | 1988 | Hum. Reprod. | pmid:3204154 |
| Rosario-Jansen T et al. | Phospholipids chiral at phosphorus. Synthesis and stereospecificity of phosphorothioate analogues of platelet-activating factor. | 1988 | Biochemistry | pmid:3167004 |
| Prévost MC et al. | Possible origins of PAF-acether and lyso-PAF-acether in rat lung alveoli secondary to hypoxia. | 1988 | Biochim. Biophys. Acta | pmid:3167085 |
| Nagpurkar A et al. | Effect of rat phosphorylcholine-binding protein on platelet aggregation. | 1988 | Biochim. Biophys. Acta | pmid:3167098 |
| Armstead WM et al. | Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs. | 1988 | Circ. Res. | pmid:3335052 |
| Bonventre JV et al. | PAF and PDGF increase cytosolic [Ca2+] and phospholipase activity in mesangial cells. | 1988 | Am. J. Physiol. | pmid:3337246 |
| Wallace JL and Whittle BJ | Gastrointestinal damage induced by platelet-activating factor. Inhibition by the corticoid, dexamethasone. | 1988 | Dig. Dis. Sci. | pmid:3338370 |
| Benveniste J et al. | Preformed PAF-acether and lyso PAF-acether are bound to blood lipoproteins. | 1988 | FEBS Lett. | pmid:3338565 |
| Michel L et al. | Biosynthesis of paf-acether factor-acether by human skin fibroblasts in vitro. | 1988 | J. Immunol. | pmid:3397536 |
| Ponpipom MM et al. | (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2829894 |
| Hwang SB | Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes. | 1988 | J. Biol. Chem. | pmid:2830276 |
| Giovannini L et al. | N-acetyl-beta-glucosaminidase (NAG) and alpha-glycosidase released by PAF in isolated perfused rat kidney. | 1988 | Int J Tissue React | pmid:3294206 |
| Marquis O et al. | [3H]52770 RP, a platelet-activating factor receptor antagonist, and tritiated platelet-activating factor label a common specific binding site in human polymorphonuclear leukocytes. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2831350 |
| Domingo MT et al. | Presence of specific binding sites for platelet-activating factor (PAF) in brain. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831903 |
| Dillon PK et al. | Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action. | 1988 | Circ. Res. | pmid:2832096 |
| Ma YH and Dunham EW | Antagonism of the vasodilator effects of a platelet activating factor precursor in anesthetized spontaneously hypertensive rats. | 1988 | Eur. J. Pharmacol. | pmid:2832188 |
| Hellegouarch A et al. | Lack of effect of atrial natriuretic factor on the tone induced in rat portal vein by platelet-activating factor. | 1988 | Eur. J. Pharmacol. | pmid:2832190 |
| Valone FH | Identification of platelet-activating factor receptors in P388D1 murine macrophages. | 1988 | J. Immunol. | pmid:2832476 |
| Homma H and Hanahan DJ | Attenuation of platelet activating factor (PAF)-induced stimulation of rabbit platelet GTPase by phorbol ester, dibutyryl cAMP, and desensitization: concomitant effects on PAF receptor binding characteristics. | 1988 | Arch. Biochem. Biophys. | pmid:2833174 |
| McGowan HM et al. | Increased levels of platelet-activating factor (1-O-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip hypertension in the rat. | 1988 | Clin. Sci. | pmid:3356112 |
| Quinn MT et al. | Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3357891 |
| Rees RS et al. | Plasma components are required for platelet activation by the toxin of Loxosceles reclusa. | 1988 | Toxicon | pmid:3245050 |
| Tatsumi N et al. | Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein. | 1988 | Clin. Chim. Acta | pmid:3359655 |
| Hsueh W et al. | Sequential release of leukotrienes and norepinephrine in rat bowel after platelet-activating factor. A mechanistic study of platelet-activating factor-induced bowel necrosis. | 1988 | Gastroenterology | pmid:3360262 |
| Hasegawa T and Nakajima S | [Recent topics on platelet-activating-factor (PAF)]. | 1988 | Nippon Ika Daigaku Zasshi | pmid:3360909 |
| Chau LY and Jii YJ | Characterization of 3H-labelled platelet activating factor receptor complex solubilized from rabbit platelet membranes. | 1988 | Biochim. Biophys. Acta | pmid:2838093 |
| Kimani G et al. | Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor. | 1988 | J. Immunol. | pmid:3361129 |
| Robertson DA et al. | Negative inotropic effect of platelet-activating factor: association with a decrease in intracellular sodium activity. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361438 |
| Thelen M et al. | Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation. | 1988 | J. Clin. Invest. | pmid:2838524 |
| Terashita Z et al. | Protective action of prostaglandin E1 (PGE1) against constrictor mediators in isolated rat heart and lung. | 1988 | Biochem. Pharmacol. | pmid:2839198 |
| Prpic V et al. | Biochemical and functional responses stimulated by platelet-activating factor in murine peritoneal macrophages. | 1988 | J. Cell Biol. | pmid:2839520 |
| Kroegel C | The potential pathophysiological role of platelet-activating factor in human diseases. | 1988 | Klin. Wochenschr. | pmid:2839728 |
| Eliakim R et al. | Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. | 1988 | Gastroenterology | pmid:2901995 |
| Page CP | The role of platelet-activating factor in asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276759 |
| Barnes PJ | Platelet-activating factor and asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276760 |
| Royall JA and Levin DL | Adult respiratory distress syndrome in pediatric patients. I. Clinical aspects, pathophysiology, pathology, and mechanisms of lung injury. | 1988 | J. Pediatr. | pmid:3276861 |
| Vanhoutte PM | Platelets, endothelium and blood vessel wall. | 1988 | Experientia | pmid:3278917 |
| Lellouch-Tubiana A et al. | Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. | 1988 | Am. Rev. Respir. Dis. | pmid:3281530 |
| Chung KF and Barnes PJ | PAF antagonists. Their potential therapeutic role in asthma. | 1988 | Drugs | pmid:3281823 |
| Plante GE et al. | Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3231663 |
| Stephens LR et al. | Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. | 1988 | Biochem. J. | pmid:2845930 |
| Santos JC et al. | Effect of intrarenal infusion of synthetic PAF-acether in dogs. | 1988 | Rev. Esp. Fisiol. | pmid:3231880 |
| Ukena D and Sybrecht GW | [Function of platelet activating factor in asthma]. | 1988 | Dtsch. Med. Wochenschr. | pmid:2846251 |
| Ostermann G et al. | The degradation of platelet-activating factor in serum and its discriminative value in atherosclerotic patients. | 1988 | Thromb. Res. | pmid:3232123 |
| Croft KD et al. | The effect of dietary fish oil and long-term salt loading on blood pressure and eicosanoid metabolism in spontaneously hypertensive rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3271614 |
| Ng DS and Wong K | Effect of sulfhydryl reagents on PAF binding to human neutrophils and platelets. | 1988 | Eur. J. Pharmacol. | pmid:2846326 |
| Storch J et al. | Influence of platelet activating factor and a nonmetabolizable analogue on superoxide production by bone marrow derived macrophages. | 1988 | J. Leukoc. Biol. | pmid:2846728 |
| Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
| Fradin A et al. | Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin 's'. | 1988 | Biochim. Biophys. Acta | pmid:2848583 |
| Lohmann HF et al. | Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086. | 1988 | Lancet | pmid:2903365 |
| White HL and Faison LD | Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. | 1988 | Prostaglandins | pmid:2903520 |