| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukocyte-Adhesion Deficiency Syndrome | D018370 | 1 associated lipids |
| Chromoblastomycosis | D002862 | 2 associated lipids |
| Hemorrhagic Fever, American | D006478 | 2 associated lipids |
| Bovine Virus Diarrhea-Mucosal Disease | D001912 | 2 associated lipids |
| Ileitis | D007079 | 2 associated lipids |
| Jaundice, Obstructive | D041781 | 2 associated lipids |
| Peanut Hypersensitivity | D021183 | 2 associated lipids |
| Multiple Trauma | D009104 | 2 associated lipids |
| Amnesia, Anterograde | D020324 | 2 associated lipids |
| Soft Tissue Injuries | D017695 | 2 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Will PC et al. | Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. | 1991 | Agents Actions | pmid:1793026 |
| Vincent D et al. | Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig. | 1991 | Agents Actions | pmid:1793031 |
| Adolfs MJ et al. | PAF-acether modifies human peritoneal macrophage cAMP levels in a biphasic fashion. | 1989 | Agents Actions | pmid:2540635 |
| Neumann M and Kownatzki E | The effect of adherence on the generation of reactive oxygen species by human neutrophilic granulocytes. | 1989 | Agents Actions | pmid:2540640 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
| Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
| Taira M et al. | Lack of involvement of leukotriene and platelet activating factor in passive cutaneous anaphylaxis in rats. | 1988 | Agents Actions | pmid:3407549 |
| Perales J et al. | Neutralization of the oedematogenic activity of Bothrops jararaca venom on the mouse paw by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum. | 1992 | Agents Actions | pmid:1295374 |
| Wong CW et al. | Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor. | 1992 | Agents Actions | pmid:1414679 |
| Tran A et al. | Separate induction of human blood platelet aggregation or cytotoxicity by different concentrations of PAF-acether and thrombin. | 1992 | Agents Actions | pmid:1414687 |
| Miyagawa H et al. | The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils. | 1992 | Agents Actions | pmid:1456179 |
| Lewis AJ et al. | The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation. | 1984 | Agents Actions | pmid:6152379 |
| Boonen GJ et al. | Activation of neutrophil migration by dioctanoyl-sn-glycerol and fMet-Leu-Phe is controlled by different pathways. | 1993 | Agents Actions | pmid:8317308 |
| Jouvin-Marche E et al. | Platelet-activating factor (PAF-acether), an activator of neutrophil functions. | 1982 | Agents Actions | pmid:6299078 |
| Caillard CG et al. | Hypotensive activity of PAF-acether in rats. | 1982 | Agents Actions | pmid:6299079 |
| Bette P and Bienvenue A | Exchange of a spin-labeled analog of PAF-acether between micelles, serum albumin and model membranes. | 1982 | Agents Actions | pmid:7164940 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of PAF-acether. Preliminary results after the intravenous administration of a 3H-labelled product to the rabbit. | 1982 | Agents Actions | pmid:7164941 |
| Morgat JL et al. | Radio-labelling of 1-O-alkyl, 2-O-acetyl, sn-glycero-3-phosphorylcholine, 1-O-(9,10-di3H)-octadecyl PAF-acether. | 1982 | Agents Actions | pmid:7164942 |
| Convert O et al. | 1H NMR of PAF-acether: influence of solvent on its structure. | 1982 | Agents Actions | pmid:7164943 |
| Borrel MC et al. | Additional techniques for the total synthesis of PAF-acether. | 1982 | Agents Actions | pmid:7164944 |