Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Archer SL and Roudebush WE | Enhancement of sperm motility using pentoxifylline and platelet-activating factor. | 2013 | Methods Mol. Biol. | pmid:22992918 |
Wang TM et al. | Alkyl and phenolic glycosides from Saussurea stella. | 2013 | Fitoterapia | pmid:23567860 |
Herndon B et al. | Urease and Helicobacter spp. antigens in pulmonary granuloma. | 2013 | J. Comp. Pathol. | pmid:22901429 |
Nasopoulou C et al. | Hen egg yolk lipid fractions with antiatherogenic properties. | 2013 | Anim. Sci. J. | pmid:23480708 |
Sato A et al. | An endothelin-3-related synthetic biotinylated pentapeptide as a novel inhibitor of platelet-activating factor. | 2013 | Eur. J. Pharmacol. | pmid:23792041 |
Ayaz G et al. | The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population. | 2013 | Gene | pmid:23816407 |
Yamazaki Y et al. | A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. | 2013 | Biochem. Pharmacol. | pmid:23817078 |
Xia SH et al. | Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. | 2013 | World J. Gastroenterol. | pmid:23840141 |
Mazereeuw G et al. | Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. | 2013 | Neurosci Biobehav Rev | pmid:23800745 |
Wang C et al. | Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain. | 2013 | Lipids Health Dis | pmid:23805935 |
Harleton E et al. | Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). | 2013 | J. Biol. Chem. | pmid:23229553 |
Detopoulou P et al. | Platelet activating factor in heart failure: potential role in disease progression and novel target for therapy. | 2013 | Curr Heart Fail Rep | pmid:23389700 |
Wang HL et al. | Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. | 2013 | Chin J Physiol | pmid:23347011 |
Motoyama N et al. | Pain-releasing action of platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action. | 2013 | Eur J Pain | pmid:23355413 |
Tsoupras AB et al. | Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor. | 2013 | J. Inorg. Biochem. | pmid:23318288 |
Krause K et al. | Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. | 2013 | Allergy | pmid:23320562 |
Vanstreels L and Merk HF | [Value of in-vitro diagnostic tools after anaphylaxis]. | 2013 | Hautarzt | pmid:23385619 |
Sato A and Ebina K | Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. | 2013 | Inflamm. Res. | pmid:23370722 |
Singh P et al. | Platelet-activating factor (PAF)-antagonists of natural origin. | 2013 | Fitoterapia | pmid:23160091 |
Costa M et al. | Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. | 2013 | Stem Cell Res | pmid:23164599 |
Sirangelo I et al. | Amyloid toxicity and platelet-activating factor signaling. | 2013 | J. Cell. Physiol. | pmid:23169529 |
Alevizos M et al. | Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. | 2013 | Ann. Allergy Asthma Immunol. | pmid:24267366 |
Cui H et al. | Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. | 2013 | J. Allergy Clin. Immunol. | pmid:24021572 |
Flasiński M et al. | Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. | 2013 | Biochim. Biophys. Acta | pmid:23906729 |
Lv XX et al. | Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. | 2013 | PLoS ONE | pmid:23869224 |
Maziero AM et al. | Inhibition of human platelet aggregation by eosinophils. | 2013 | Life Sci. | pmid:23871985 |
Borthakur A et al. | Lactobacillus acidophilus alleviates platelet-activating factor-induced inflammatory responses in human intestinal epithelial cells. | 2013 | PLoS ONE | pmid:24130731 |
Predescu S et al. | Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. | 2013 | PLoS ONE | pmid:24086643 |
Sahu RP et al. | Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. | 2013 | J. Immunol. | pmid:23355733 |
Berman B and Cockerell CJ | Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. | 2013 | J. Am. Acad. Dermatol. | pmid:23228301 |
Frost BL and Caplan MS | Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. | 2013 | Semin. Pediatr. Surg. | pmid:23611612 |
Renteria LS et al. | RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation. | 2013 | Cell Prolif. | pmid:24033386 |
Verouti SN et al. | Paricalcitol effects on activities and metabolism of platelet activating factor and on inflammatory cytokines in hemodialysis patients. | 2013 | Int J Artif Organs | pmid:23335378 |
Guerrero AT et al. | The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23187752 |
Kang JW et al. | Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. | 2013 | Phytother Res | pmid:23296979 |
Sahu RP et al. | Platelet-activating factor does not mediate UVB-induced local immune suppression. | 2012 Mar-Apr | Photochem. Photobiol. | pmid:22211638 |
Zia-ul-Haq M et al. | Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876614 |
Chini M et al. | Effects of highly active antiretroviral therapy on platelet activating factor metabolism in naive HIV-infected patients: ii) study of the abacavir/lamivudine/efavirenz HAART regimen. | 2012 Jan-Mar | Int J Immunopathol Pharmacol | pmid:22507337 |
Chini M et al. | Effects of HAART on platelet-activating factor metabolism in naive HIV-infected patients I: study of the tenofovir-DF/emtricitabine/efavirenz HAART regimen. | 2012 | AIDS Res. Hum. Retroviruses | pmid:22050695 |
Nordin N et al. | Platelet-activating factor (PAF) receptor binding activity of the roots of Enicosanthellum pulchrum. | 2012 | Pharm Biol | pmid:22103812 |
Tanaka Y et al. | Stimulation of Ly-6G on neutrophils in LPS-primed mice induces platelet-activating factor (PAF)-mediated anaphylaxis-like shock. | 2012 | J. Leukoc. Biol. | pmid:22131343 |
Shi W et al. | The nondepolarizing, normokalemic cardioplegia formulation adenosine-lidocaine (adenocaine) exerts anti-neutrophil effects by synergistic actions of its components. | 2012 | J. Thorac. Cardiovasc. Surg. | pmid:22079877 |
Detopoulou P et al. | PAF and its metabolic enzymes in healthy volunteers: interrelations and correlations with basic characteristics. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22079887 |
Ding DD et al. | [Changes of platelet α-particle membrane protein, platelet activating factor and platelet parameters in patients with hyperuricemia]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541106 |
Camuesco D et al. | The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. | 2012 | Br. J. Pharmacol. | pmid:21790535 |
Sahu RP et al. | The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. | 2012 | Carcinogenesis | pmid:22542595 |
Sato A et al. | Synthetic biotinylated peptide compounds derived from Asp-hemolysin: novel potent inhibitors of platelet-activating factor. | 2012 | Eur. J. Pharmacol. | pmid:22542654 |
Bachi AL et al. | Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. | 2012 | Mediators Inflamm. | pmid:22577252 |
Neerhof MG et al. | The significance of endothelin in platelet-activating factor-induced fetal growth restriction. | 2012 | Reprod Sci | pmid:22534337 |
Muehlmann LA et al. | PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils. | 2012 | Res. Vet. Sci. | pmid:21820686 |
Kim HA et al. | Glutamine inhibits platelet-activating factor-mediated pulmonary tumour metastasis. | 2012 | Eur. J. Cancer | pmid:21889331 |
Werner J et al. | Multidrug strategies are effective in the treatment of severe experimental pancreatitis. | 2012 | Surgery | pmid:21982067 |
Xiong J et al. | New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation. | 2012 | Eur J Pharm Sci | pmid:22285483 |
Flaherty MM et al. | Nonclinical evaluation of GMA161--an antihuman CD16 (FcγRIII) monoclonal antibody for treatment of autoimmune disorders in CD16 transgenic mice. | 2012 | Toxicol. Sci. | pmid:22025730 |
Sharma J et al. | Lung endothelial cell platelet-activating factor production and inflammatory cell adherence are increased in response to cigarette smoke component exposure. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21984569 |
Samapati R et al. | Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22246702 |
Yao Y et al. | Platelet-activating factor receptor agonists mediate xeroderma pigmentosum A photosensitivity. | 2012 | J. Biol. Chem. | pmid:22303003 |
Du Y et al. | Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. | 2012 | Nat Commun | pmid:22910354 |
Jalil J et al. | Platelet-activating factor (PAF) antagonistic activity of a new biflavonoid from Garcinia nervosa var. pubescens King. | 2012 | Molecules | pmid:22964504 |
Kakazu A et al. | Lipoxin Aâ‚„ inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma. | 2012 | Exp. Eye Res. | pmid:22828048 |
Uomo G | Lesson from acute experimental pancreatitis: multidrug strategies is effective than single-target therapy. | 2012 | JOP | pmid:22964964 |
Huang LG et al. | [Effects of glycomacropeptide on damage to intestinal tissue and apoptosis of intestinal epithelial cells in neonatal rats with necrotizing enterocolitis]. | 2012 | Zhonghua Er Ke Za Zhi | pmid:22932017 |
Pawlowic MC and Zhang K | Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence. | 2012 | Mol. Biochem. Parasitol. | pmid:22954769 |
Nitoda E et al. | Ocular actions of platelet-activating factor: clinical implications. | 2012 | Expert Opin. Ther. Targets | pmid:22924390 |
Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils. | 2012 | Res. Vet. Sci. | pmid:21071047 |
Sahu RP et al. | Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis. | 2012 | Carcinogenesis | pmid:22223848 |
Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. | 2012 | Vet. Immunol. Immunopathol. | pmid:22226550 |
Dumas E et al. | Angiopoietin-1 but not angiopoietin-2 promotes neutrophil viability: Role of interleukin-8 and platelet-activating factor. | 2012 | Biochim. Biophys. Acta | pmid:22198097 |
López-Sagaseta J et al. | sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove. | 2012 | Blood | pmid:22167755 |
Park J et al. | Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes. | 2012 | Int. J. Mol. Med. | pmid:22211242 |
Widgerow AD and Kalaria S | Pain mediators and wound healing--establishing the connection. | 2012 | Burns | pmid:22738827 |
Altomare A et al. | Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls. | 2012 | Neurogastroenterol. Motil. | pmid:22734465 |
Akbarshahi H et al. | Acute lung injury in acute pancreatitis--awaiting the big leap. | 2012 | Respir Med | pmid:22749752 |
Kolovou V et al. | Platelet activating factor levels and metabolism in Tangier disease: a case study. | 2012 | Lipids Health Dis | pmid:22769014 |
Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE3 on human platelet function. | 2012 | Thromb. Haemost. | pmid:22318645 |
Jia XQ et al. | [Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention]. | 2012 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22464576 |
Xu LF et al. | Protective effect of intestinal trefoil factor on injury of intestinal epithelial tight junction induced by platelet activating factor. | 2012 | Inflammation | pmid:21452036 |
Liu M et al. | Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion. | 2012 | PLoS Pathog. | pmid:22496650 |
Vadas P and Perelman B | Effect of epinephrine on platelet-activating factor-stimulated human vascular smooth muscle cells. | 2012 | J. Allergy Clin. Immunol. | pmid:22460068 |
Zheng GH et al. | Elevated plasma platelet activating factor, platelet activating factor acetylhydrolase levels and risk of coronary heart disease or blood stasis syndrome of coronary heart disease in Chinese: a case control study: a case-control study. | 2012 | Inflammation | pmid:22430230 |
Bai J et al. | Sesquiterpenes from the roots of Illicium dunnianum. | 2012 | Phytochemistry | pmid:22695122 |
Carosati E et al. | 1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 2): action in other targets and antitargets. | 2012 | Curr. Med. Chem. | pmid:22709009 |
Harpavat S et al. | Novel treatments for NEC: keeping IBD in mind. | 2012 | Curr Gastroenterol Rep | pmid:22623180 |
Flasiński M et al. | Behavior of platelet activating factor in membrane-mimicking environment. Langmuir monolayer study complemented with grazing incidence X-ray diffraction and Brewster angle microscopy. | 2012 | J Phys Chem B | pmid:22834697 |
Yuan D and He P | Vascular remodeling alters adhesion protein and cytoskeleton reactions to inflammatory stimuli resulting in enhanced permeability increases in rat venules. | 2012 | J. Appl. Physiol. | pmid:22837164 |
Gorman S and Hart PH | The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation. | 2012 | Photochem. Photobiol. Sci. | pmid:22898802 |
Zhang XT et al. | [Study on the pharmacokinetics of ginkgolide B for injection in rats]. | 2012 | Zhong Yao Cai | pmid:22876684 |
Flamm MH et al. | Multiscale prediction of patient-specific platelet function under flow. | 2012 | Blood | pmid:22517902 |
Masliakov VV et al. | [Microcirculation in the injured spleen by different operations in children]. | 2012 | Khirurgiia (Mosk) | pmid:23257700 |
Liu C et al. | Clinical significance and expression of PAF and TNF-alpha in seminal plasma of leukocytospermic patients. | 2012 | Mediators Inflamm. | pmid:23209346 |
Zhang XT et al. | [Study on pharmacokinetics of ginkgolide B injection in Beagle dogs]. | 2012 | Zhong Yao Cai | pmid:23213741 |
Mirpuri J et al. | Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit. | 2012 | PLoS ONE | pmid:23272193 |
Kim HA et al. | PTEN/MAPK pathways play a key role in platelet-activating factor-induced experimental pulmonary tumor metastasis. | 2012 | FEBS Lett. | pmid:23137704 |
Jiang Z et al. | The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. | 2012 | Respir. Res. | pmid:23140447 |
Senbagavalli P et al. | Immune complexes isolated from patients with pulmonary tuberculosis modulate the activation and function of normal granulocytes. | 2012 | Clin. Vaccine Immunol. | pmid:23100480 |
Zia-Ul-Haq M et al. | Report: Platelet aggregation inhibition activity of selected legumes of Pakistan. | 2012 | Pak J Pharm Sci | pmid:23010006 |
Petho G and Reeh PW | Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors. | 2012 | Physiol. Rev. | pmid:23073630 |
Juchem G et al. | Regulation of coronary venular barrier function by blood borne inflammatory mediators and pharmacological tools: insights from novel microvascular wall models. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22081707 |
Saadawi S et al. | Inhibitory effects of acetylmelodorinol, chrysin and polycarpol from Mitrella kentii on prostaglandin Eâ‚‚ and Thromboxane Bâ‚‚ production and platelet activating factor receptor binding. | 2012 | Molecules | pmid:22538486 |
Oh SF et al. | Resolvin E2 formation and impact in inflammation resolution. | 2012 | J. Immunol. | pmid:22450811 |