Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Tsuruta R et al. | Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. | 1999 | J. Leukoc. Biol. | pmid:9886248 |
Harris NR et al. | Influence of arteriovenular pairing on PAF-induced capillary filtration. | 1999 | Am. J. Physiol. | pmid:9887023 |
Longphre M et al. | Ozone-induced pulmonary inflammation and epithelial proliferation are partially mediated by PAF. | 1999 | J. Appl. Physiol. | pmid:9887149 |
Akiba S et al. | Inhibitory effect of the leaf extract of Ginkgo biloba L. on oxidative stress-induced platelet aggregation. | 1998 | Biochem. Mol. Biol. Int. | pmid:9891858 |
Yamaguchi S et al. | Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice. | 1998 | Inflamm. Res. | pmid:9892046 |
Tetta C et al. | The role of platelet-activating factor in the haemoincompatibility of haemodialytic treatments. | 1998 | Int J Artif Organs | pmid:9894743 |
Qu XW et al. | The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat. | 1999 | Gut | pmid:9895379 |
Zhang Y et al. | RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. | 1999 | J. Biol. Chem. | pmid:9915820 |
Siddiqui RA et al. | Chemotactic migration triggers IL-8 generation in neutrophilic leukocytes. | 1999 | J. Immunol. | pmid:9916736 |
Stafforini DM and Tjoelker LW | Human plasma platelet-activating factor acetylhydrolase. | 1999 | Methods Mol. Biol. | pmid:9918011 |