Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Kaplan R et al. | Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease. | 2000 | Br. J. Haematol. | pmid:11122160 |
Bussolati B et al. | IL-10 stimulates production of platelet-activating factor by monocytes of patients with active systemic lupus erythematosus (SLE). | 2000 | Clin. Exp. Immunol. | pmid:11122257 |
Kelly RF | Current strategies in lung preservation. | 2000 | J. Lab. Clin. Med. | pmid:11128744 |
Adams JM et al. | G-protein receptor responses in trauma neutrophils. | 2000 | J Trauma | pmid:11130495 |
Asimakopoulos G et al. | Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin. | 2000 | Perfusion | pmid:11131212 |
Tavakoli S et al. | Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133502 |
Clavijo LC et al. | PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. | 2001 | J. Appl. Physiol. | pmid:11133918 |
Galimi F et al. | Hepatocyte growth factor is a regulator of monocyte-macrophage function. | 2001 | J. Immunol. | pmid:11145707 |
Arese M et al. | HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment. | 2001 | J. Immunol. | pmid:11145723 |
Rabinowitz SS et al. | Platelet-activating factor in infants at risk for necrotizing enterocolitis. | 2001 | J. Pediatr. | pmid:11148517 |
Kwan ML et al. | Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159008 |
Komori M et al. | PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159026 |
Stojanov T and O'Neill C | In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. | 2001 | Biol. Reprod. | pmid:11159375 |
Roudebush WE et al. | Impact of blood serum insulin-like growth factor I on platelet-activating factor in bull spermatozoa. | 2001 | Domest. Anim. Endocrinol. | pmid:11164329 |
Giménez R and Aguilar J | Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats. | 2001 | Neurosci. Lett. | pmid:11165772 |
Goudevenos J et al. | Platelet-associated and secreted PAF-acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty. | 2001 | Eur. J. Clin. Invest. | pmid:11168434 |
Rodrigo L et al. | Hydrolysis of platelet-activating factor by human serum paraoxonase. | 2001 | Biochem. J. | pmid:11171072 |
Magai RM and Shukla SD | Metabolic fate of [14C]-ethanol into endothelial cell phospholipids including platelet-activating factor, sphingomyelin and phosphatidylethanol. | 2001 Jan-Feb | J. Biomed. Sci. | pmid:11173988 |
Zaitseva L et al. | Role of eicosanoids in regulation of macrophage phagocytic functions by platelet-activating factor during endotoxic shock. | 2000 | Bull. Exp. Biol. Med. | pmid:11177271 |
Del Sorbo L et al. | Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. | 2001 | Eur. J. Immunol. | pmid:11180101 |
Herrero-Fresneda I et al. | Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor. | 2000 | Transplantation | pmid:11190497 |
Yildirim G et al. | Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. | 2000 | Undersea Hyperb Med | pmid:11191161 |
Kecskeméti V and Balogh I | The role of platelet-activating factor (PAF) antagonists and nitric oxide in cardiac actions of PAF. Electrophysiological and morphological study. | 2000 | J. Physiol. Pharmacol. | pmid:11192945 |
Karasawa K | [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. | 2001 | Tanpakushitsu Kakusan Koso | pmid:11193332 |
Urasaki T et al. | Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. | 2001 | J. Leukoc. Biol. | pmid:11200053 |
Hauser CJ et al. | PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms. | 2001 | J. Leukoc. Biol. | pmid:11200069 |
Jeon SY et al. | Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways. | 2001 | Ann. Otol. Rhinol. Laryngol. | pmid:11201815 |
Baker RR and Chang HY | The regulation of CoA-independent transacylation reactions in neuronal nuclei by lysophospholipid, free fatty acid, and lysophospholipase: the control of nuclear lyso platelet-activating factor metabolism. | 2000 | Mol. Cell. Biochem. | pmid:11204449 |
Mannori G et al. | Interaction of tumor cells with vascular endothelia: role of platelet-activating factor. | 2000 | Clin. Exp. Metastasis | pmid:11206844 |
Bassi F et al. | Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. | 2001 | J. Periodontol. | pmid:11210074 |
Ko TC et al. | Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11212091 |
Taggart DP | Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. | 2001 | Ann. Thorac. Surg. | pmid:11216754 |
Lash GE and Legge M | Localization and distribution of platelet activating factor receptors in the mouse ovary and oviduct during the estrous cycle and early pregnancy. | 2001 | Am. J. Reprod. Immunol. | pmid:11216875 |
Sun Z et al. | Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. | 2001 | Scand. J. Gastroenterol. | pmid:11218240 |
Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
Kawaguchi A et al. | Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. | 2001 | Life Sci. | pmid:11228102 |
Tokumura A et al. | Platelet-activating factor (PAF)-like oxidized phospholipids: relevance to atherosclerosis. | 2000 | Biofactors | pmid:11237195 |
Persidsky Y et al. | Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. | 2001 | J. Neuroimmunol. | pmid:11240016 |
Bachert C | Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis. | 2001 | Allergy | pmid:11243500 |
Gandhi CR et al. | A23187 causes release of inositol phosphates from cultured rat Kupffer cells. | 2001 | Eur. J. Pharmacol. | pmid:11245846 |
Petty HR and Kindzelskii AL | Dissipative metabolic patterns respond during neutrophil transmembrane signaling. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248046 |
Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
Wittwer T et al. | Impact of PAF antagonist BN 52021 (Ginkolide B) on post-ischemic graft function in clinical lung transplantation. | 2001 | J. Heart Lung Transplant. | pmid:11257563 |
Chen YG et al. | Lignans from Kadsura angustifolia. | 1998 | J Asian Nat Prod Res | pmid:11261213 |
Gu M et al. | Role of platelet-activating factor in hepatectomy with Pringle's maneuver. | 2001 | J. Surg. Res. | pmid:11266278 |
Iwazaki S et al. | FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs. | 2001 Jan-Feb | Hepatogastroenterology | pmid:11268964 |
Gujrati VR and Sastry BV | Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation. | 2001 | Life Sci. | pmid:11270625 |
Zeng S et al. | Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. | 1999 | Zhongguo Yao Li Xue Bao | pmid:11270998 |
Ulrich CD | Lexipafant in severe acute pancreatitis: the final word? | 2001 | Curr Gastroenterol Rep | pmid:11276374 |
Beales IL | Effect of platelet-activating factor on gastrin release from cultured rabbit G-cells. | 2001 | Dig. Dis. Sci. | pmid:11284466 |