Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Cystitis D003556 23 associated lipids
Hypoxia D000860 23 associated lipids
Cholestasis D002779 23 associated lipids
Birth Weight D001724 23 associated lipids
Fibrosis D005355 23 associated lipids
Pulmonary Edema D011654 23 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Medulloblastoma D008527 22 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Helicobacter Infections D016481 21 associated lipids
Pleurisy D010998 20 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Brain Edema D001929 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
HIV Infections D015658 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Wounds and Injuries D014947 20 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Bronchial Spasm D001986 18 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Ischemia D007511 18 associated lipids
Albuminuria D000419 18 associated lipids
Lymphoma D008223 18 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Blister D001768 16 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Neutropenia D009503 15 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Encephalitis D004660 15 associated lipids
Hemorrhage D006470 15 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Angina, Unstable D000789 14 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Stomatitis D013280 14 associated lipids
Heart Arrest D006323 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Polycythemia Vera D011087 13 associated lipids
Hypercalcemia D006934 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Fetal Weight D020567 12 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Death, Sudden D003645 12 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Amnesia D000647 12 associated lipids
Hypertension, Portal D006975 12 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Migraine Disorders D008881 11 associated lipids
Shock D012769 11 associated lipids
Meningioma D008579 11 associated lipids
Infertility, Male D007248 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Shock, Septic D012772 11 associated lipids
Venous Thrombosis D020246 11 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Rhinitis D012220 10 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Pancreatitis D010195 10 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Leukopenia D007970 9 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Thalassemia D013789 8 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Cholecystitis D002764 8 associated lipids
Arthus Reaction D001183 8 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Lupus Nephritis D008181 8 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Tangier Disease D013631 8 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Mucositis D052016 7 associated lipids
Bronchiectasis D001987 7 associated lipids
Agranulocytosis D000380 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Kaplan R et al. Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease. 2000 Br. J. Haematol. pmid:11122160
Bussolati B et al. IL-10 stimulates production of platelet-activating factor by monocytes of patients with active systemic lupus erythematosus (SLE). 2000 Clin. Exp. Immunol. pmid:11122257
Kelly RF Current strategies in lung preservation. 2000 J. Lab. Clin. Med. pmid:11128744
Adams JM et al. G-protein receptor responses in trauma neutrophils. 2000 J Trauma pmid:11130495
Asimakopoulos G et al. Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin. 2000 Perfusion pmid:11131212
Tavakoli S et al. Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11133502
Clavijo LC et al. PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. 2001 J. Appl. Physiol. pmid:11133918
Galimi F et al. Hepatocyte growth factor is a regulator of monocyte-macrophage function. 2001 J. Immunol. pmid:11145707
Arese M et al. HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment. 2001 J. Immunol. pmid:11145723
Rabinowitz SS et al. Platelet-activating factor in infants at risk for necrotizing enterocolitis. 2001 J. Pediatr. pmid:11148517
Kwan ML et al. Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11159008
Komori M et al. PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11159026
Stojanov T and O'Neill C In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. 2001 Biol. Reprod. pmid:11159375
Roudebush WE et al. Impact of blood serum insulin-like growth factor I on platelet-activating factor in bull spermatozoa. 2001 Domest. Anim. Endocrinol. pmid:11164329
Giménez R and Aguilar J Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats. 2001 Neurosci. Lett. pmid:11165772
Goudevenos J et al. Platelet-associated and secreted PAF-acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty. 2001 Eur. J. Clin. Invest. pmid:11168434
Rodrigo L et al. Hydrolysis of platelet-activating factor by human serum paraoxonase. 2001 Biochem. J. pmid:11171072
Magai RM and Shukla SD Metabolic fate of [14C]-ethanol into endothelial cell phospholipids including platelet-activating factor, sphingomyelin and phosphatidylethanol. 2001 Jan-Feb J. Biomed. Sci. pmid:11173988
Zaitseva L et al. Role of eicosanoids in regulation of macrophage phagocytic functions by platelet-activating factor during endotoxic shock. 2000 Bull. Exp. Biol. Med. pmid:11177271
Del Sorbo L et al. Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. 2001 Eur. J. Immunol. pmid:11180101
Herrero-Fresneda I et al. Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor. 2000 Transplantation pmid:11190497
Yildirim G et al. Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. 2000 Undersea Hyperb Med pmid:11191161
Kecskeméti V and Balogh I The role of platelet-activating factor (PAF) antagonists and nitric oxide in cardiac actions of PAF. Electrophysiological and morphological study. 2000 J. Physiol. Pharmacol. pmid:11192945
Karasawa K [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. 2001 Tanpakushitsu Kakusan Koso pmid:11193332
Urasaki T et al. Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. 2001 J. Leukoc. Biol. pmid:11200053
Hauser CJ et al. PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms. 2001 J. Leukoc. Biol. pmid:11200069
Jeon SY et al. Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways. 2001 Ann. Otol. Rhinol. Laryngol. pmid:11201815
Baker RR and Chang HY The regulation of CoA-independent transacylation reactions in neuronal nuclei by lysophospholipid, free fatty acid, and lysophospholipase: the control of nuclear lyso platelet-activating factor metabolism. 2000 Mol. Cell. Biochem. pmid:11204449
Mannori G et al. Interaction of tumor cells with vascular endothelia: role of platelet-activating factor. 2000 Clin. Exp. Metastasis pmid:11206844
Bassi F et al. Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. 2001 J. Periodontol. pmid:11210074
Ko TC et al. Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. 2001 Bioorg. Med. Chem. Lett. pmid:11212091
Taggart DP Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. 2001 Ann. Thorac. Surg. pmid:11216754
Lash GE and Legge M Localization and distribution of platelet activating factor receptors in the mouse ovary and oviduct during the estrous cycle and early pregnancy. 2001 Am. J. Reprod. Immunol. pmid:11216875
Sun Z et al. Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. 2001 Scand. J. Gastroenterol. pmid:11218240
Tohda Y et al. Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. 2001 Respiration pmid:11223734
Kawaguchi A et al. Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. 2001 Life Sci. pmid:11228102
Tokumura A et al. Platelet-activating factor (PAF)-like oxidized phospholipids: relevance to atherosclerosis. 2000 Biofactors pmid:11237195
Persidsky Y et al. Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. 2001 J. Neuroimmunol. pmid:11240016
Bachert C Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis. 2001 Allergy pmid:11243500
Gandhi CR et al. A23187 causes release of inositol phosphates from cultured rat Kupffer cells. 2001 Eur. J. Pharmacol. pmid:11245846
Petty HR and Kindzelskii AL Dissipative metabolic patterns respond during neutrophil transmembrane signaling. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11248046
Denis MA et al. Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. 2001 Scand. J. Gastroenterol. pmid:11252412
Wittwer T et al. Impact of PAF antagonist BN 52021 (Ginkolide B) on post-ischemic graft function in clinical lung transplantation. 2001 J. Heart Lung Transplant. pmid:11257563
Chen YG et al. Lignans from Kadsura angustifolia. 1998 J Asian Nat Prod Res pmid:11261213
Gu M et al. Role of platelet-activating factor in hepatectomy with Pringle's maneuver. 2001 J. Surg. Res. pmid:11266278
Iwazaki S et al. FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs. 2001 Jan-Feb Hepatogastroenterology pmid:11268964
Gujrati VR and Sastry BV Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation. 2001 Life Sci. pmid:11270625
Zeng S et al. Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. 1999 Zhongguo Yao Li Xue Bao pmid:11270998
Ulrich CD Lexipafant in severe acute pancreatitis: the final word? 2001 Curr Gastroenterol Rep pmid:11276374
Beales IL Effect of platelet-activating factor on gastrin release from cultured rabbit G-cells. 2001 Dig. Dis. Sci. pmid:11284466