Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Zhang GQ et al. | [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. | 2003 | Zhonghua Er Ke Za Zhi | pmid:14751060 |
Wu B et al. | [Effects of bificobacterium longum on neonatal rat model of necrotizing enterocolitis and roles of platelet-activating factor and tumor necrosis factor-alpha]. | 2007 | Zhonghua Er Ke Za Zhi | pmid:17953818 |
Huang LG et al. | [Effects of glycomacropeptide on damage to intestinal tissue and apoptosis of intestinal epithelial cells in neonatal rats with necrotizing enterocolitis]. | 2012 | Zhonghua Er Ke Za Zhi | pmid:22932017 |
Lu H and Xue XD | [Platelet-activating factor and neonatal necrotizing enterocolitis]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15189692 |
Zhang S et al. | [Determination of platelet activating factor and platelet associated IgG in pregnancy-induced hypertension]. | 1996 | Zhonghua Fu Chan Ke Za Zhi | pmid:9206185 |
Jiang W et al. | [Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:22333285 |
Wang F et al. | [The effect of platelet activating factor on the biosynthesis of thromboxane A2 and prostaglandin I2 in human placental villi and umbilical artery]. | 1997 | Zhonghua Fu Chan Ke Za Zhi | pmid:9596897 |
Zhou X et al. | [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. | 1996 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:9387483 |
Gao F et al. | [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979844 |
Li Q | [Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects]. | 1992 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:1307517 |