Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Wasserman SI | Mediators of immediate hypersensitivity. | 1983 | J. Allergy Clin. Immunol. | pmid:6193157 |
Hartung HP | Acetyl glyceryl ether phosphorylcholine (platelet-activating factor) mediates heightened metabolic activity in macrophages. Studies on PGE, TXB2 and O2- production, spreading, and the influence of calmodulin-inhibitor W-7. | 1983 | FEBS Lett. | pmid:6309563 |
Swendsen CL et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407484 |
Billah MM and Johnston JM | Identification of phospholipid platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407483 |
Chilton FH et al. | Selective acylation of lyso platelet activating factor by arachidonate in human neutrophils. | 1983 | J. Biol. Chem. | pmid:6408071 |
Hartung HP et al. | Platelet activating factor (PAF) induces the oxidative burst in macrophages. | 1983 | Int. J. Immunopharmacol. | pmid:6874164 |
Camussi G et al. | Acute lung inflammation induced in the rabbit by local instillation of 1-0-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine or of native platelet-activating factor. | 1983 | Am. J. Pathol. | pmid:6859232 |
Sánchez-Crespo M et al. | Presence in normal human urine of a hypotensive and platelet-activating phospholipid. | 1983 | Am. J. Physiol. | pmid:6859262 |
Lumb RH et al. | Spontaneous and protein-catalyzed transfer of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) between phospholipid bilayers. | 1983 | Biochim. Biophys. Acta | pmid:6860678 |
Suquet CM and Leid RW | Aggregation of equine platelets by PAF (platelet-activating factor). | 1983 | Inflammation | pmid:6862593 |
Blank ML and Snyder F | Improved high-performance liquid chromatographic method for isolation of platelet-activating factor from other phospholipids. | 1983 | J. Chromatogr. | pmid:6863454 |
Simrock R et al. | [Reversible inhibition of thrombocyte stimulation by acetylsalicylic acid and its role in antithrombotic therapy]. | 1983 | Klin. Wochenschr. | pmid:6865264 |
Pieroni G and Hanahan DJ | Metabolic behavior of acetyl glyceryl ether phosphorylcholine on interaction with rabbit platelets. | 1983 | Arch. Biochem. Biophys. | pmid:6870274 |
Camussi G et al. | Inhibitory effect of prostacyclin (PGI2) on neutropenia induced by intravenous injection of platelet-activating-factor (PAF) in the rabbit. | 1983 | Prostaglandins | pmid:6346397 |
Iñarrea P et al. | Platelet-activating factor: an effector substance of the vasopermeability changes induced by the infusion of immune aggregates in the mouse. | 1983 | Immunopharmacology | pmid:6347969 |
Satouchi K | [Platelet activating factor (PAF)--a new chemical mediator of inflammation]. | 1983 | Seikagaku | pmid:6350499 |
McGowan EB and Detwiler TC | Characterization of the thrombin-induced desensitization of platelet activation by thrombin. | 1983 | Thromb. Res. | pmid:6356458 |
Weksler BB | Platelets and the inflammatory response. | 1983 | Clin. Lab. Med. | pmid:6360503 |
Page CP et al. | An in vivo model for studying platelet aggregation and disaggregation. | 1982 | Thromb. Haemost. | pmid:7051409 |
Borrel MC et al. | Additional techniques for the total synthesis of PAF-acether. | 1982 | Agents Actions | pmid:7164944 |