Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Ear Diseases D004427 7 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Agranulocytosis D000380 7 associated lipids
Shock D012769 11 associated lipids
Polycythemia Vera D011087 13 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Spasm D001986 18 associated lipids
Shock, Septic D012772 11 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Conjunctivitis D003231 7 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Death, Sudden D003645 12 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Neutropenia D009503 15 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Meningioma D008579 11 associated lipids
Multiple Trauma D009104 2 associated lipids
Cluster Headache D003027 4 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Behcet Syndrome D001528 7 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Migraine Disorders D008881 11 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Thrombasthenia D013915 4 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Shock, Traumatic D012774 4 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Arthus Reaction D001183 8 associated lipids
Thrombocytosis D013922 4 associated lipids
Toxemia D014115 3 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Klebsiella Infections D007710 7 associated lipids
Ascites D001201 25 associated lipids
Albuminuria D000419 18 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Hyperinsulinism D006946 27 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Parkinson Disease D010300 53 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Bronchial Diseases D001982 3 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Tangier Disease D013631 8 associated lipids
Heart Arrest D006323 13 associated lipids
Cystitis D003556 23 associated lipids
Cholecystitis D002764 8 associated lipids
HIV Infections D015658 20 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Medulloblastoma D008527 22 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Hypertension, Portal D006975 12 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Dyslexia D004410 3 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Podolak-Dawidziak M [Role of white cells and neoplastic cells in haemostasis]. 2002 Pol. Arch. Med. Wewn. pmid:12189915
Strømgaard K et al. Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation. 2002 J. Med. Chem. pmid:12190325
Wong RK et al. Augmentation of the neutrophil respiratory burst through the action of advanced glycation end products: a potential contributor to vascular oxidant stress. 2002 Diabetes pmid:12196480
Goldring WP and Pattenden G A total synthesis of phomactin A. 2002 Chem. Commun. (Camb.) pmid:12196974
Ewer AK Role of platelet-activating factor in the pathophysiology of necrotizing enterocolitis. 2002 Acta Paediatr Suppl pmid:12200892
Göggel R et al. Platelet-activating factor-induced pulmonary edema is partly mediated by prostaglandin E(2), E-prostanoid 3-receptors, and potassium channels. 2002 Am. J. Respir. Crit. Care Med. pmid:12204861
Bazan H and Ottino P The role of platelet-activating factor in the corneal response to injury. 2002 Prog Retin Eye Res pmid:12207945
Bussolati B et al. Expression of CD154 on renal cell carcinomas and effect on cell proliferation, motility and platelet-activating factor synthesis. 2002 Int. J. Cancer pmid:12209602
Cadwallader KA et al. Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents. 2002 J. Immunol. pmid:12218155
Cuschieri J et al. Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. 2002 Surgery pmid:12219006
Colwell JA et al. Platelet adhesion and aggregation in diabetes mellitus. 1979 Metab. Clin. Exp. pmid:122293
Bussolati B et al. Nitric oxide/platelet activating factor cross-talk in mesangial cells modulates the interaction with leukocytes. 2002 Kidney Int. pmid:12234302
Weyrich AS et al. Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book. 2002 Circulation pmid:12234942
Han SJ et al. Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B). 2002 J. Biol. Chem. pmid:12235132
Akai T et al. Modulation of tissue-type plasminogen activator expression by platelet activating factor in human glioma cells. 2002 J. Neurooncol. pmid:12241114
Donnard M et al. Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. 2002 Stem Cells pmid:12351810
Leung SW et al. Platelet-activating factor enhanced the pressor response of endothelin-1. 2002 J. Cardiovasc. Pharmacol. pmid:12352314
Brewer C et al. Platelet activating factor-induced apoptosis is inhibited by ectopic expression of the platelet activating factor G-protein coupled receptor. 2002 J. Neurochem. pmid:12354298
Marin V et al. Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type. 2002 Eur. J. Immunol. pmid:12355450
Beauchamp MH et al. Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. 2002 Invest. Ophthalmol. Vis. Sci. pmid:12356842
Downing SJ et al. Effect of platelet-activating factor on the electrophysiology of the human Fallopian tube: early mediation of embryo-maternal dialogue? 2002 Reproduction pmid:12361471
Teather LA et al. Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. 2002 Psychopharmacology (Berl.) pmid:12373444
Baker PR et al. Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. 2002 Biochim. Biophys. Acta pmid:12379481
Michibayashi T Platelet aggregating response to platelet activating factor participates in activation of the 12-lipoxygenase pathway in platelets from rabbits. 2002 Int Angiol pmid:12384648
Shigematsu S et al. Bradykinin-induced proinflammatory signaling mechanisms. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12388246
Maul H et al. Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. 2002 Am. J. Obstet. Gynecol. pmid:12388958
Murohisa G et al. Involvement of platelet-activating factor in hepatic apoptosis and necrosis in chronic ethanol-fed rats given endotoxin. 2002 Liver pmid:12390475
Kato M et al. Platelet-activating factor activates two distinct effector pathways in human eosinophils. 2002 J. Immunol. pmid:12391244
Ueno H et al. Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure. 2002 Crit. Care Med. pmid:12394951
Sibelius U et al. Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10. 2002 Crit. Care Med. pmid:12394960
Sakamoto H et al. Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. 2002 J. Biol. Chem. pmid:12397078
Ibe BO et al. Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. 2002 Mol. Genet. Metab. pmid:12409272
Childs EW et al. In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. 2002 Shock pmid:12412620
Farbiszewski R et al. [The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system]. 2002 Jul-Aug Neurol. Neurochir. Pol. pmid:12418143
Eikelboom JW et al. Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes. 2002 Eur. Heart J. pmid:12419297
Tanaka S and Koike T Selective inflammatory stimulations enhance release of microglial response factor (MRF)-1 from cultured microglia. 2002 Glia pmid:12420315
Maniscalco M et al. Nitric oxide attenuates platelet-activating factor induced nasal airway plasma extravasation in healthy subjects. 2002 Eur. J. Clin. Invest. pmid:12423328
Hsueh W et al. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. 2003 Jan-Feb Pediatr. Dev. Pathol. pmid:12424605
Dun Y et al. Activated polymorphonuclear leukocytes induce cardiomyocyte apoptosis and the protective effects of carvedilol. 2002 Methods Find Exp Clin Pharmacol pmid:12428428
Fallani A et al. Synthesis of platelet-activating factor (PAF) in transformed cell lines of a different origin. 2002 Prostaglandins Other Lipid Mediat. pmid:12428690
Gélinas DS et al. Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. 2002 Br. J. Pharmacol. pmid:12429574
Mahmoud FF et al. In vitro effects of ginkgolide B combined with cyclosporin A on T-lymphocyte activation and IL-5 expression in peripheral blood mononuclear cells from asthmatic subjects. 2002 Transplant. Proc. pmid:12431672
Arai H Platelet-activating factor acetylhydrolase. 2002 Prostaglandins Other Lipid Mediat. pmid:12432911
Ishii S et al. Platelet-activating factor receptor. 2002 Prostaglandins Other Lipid Mediat. pmid:12432946
Lee YM et al. Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. 2002 J. Lab. Clin. Med. pmid:12434132
Abu-Zidan FM and Windsor JA Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials. 2002 Eur J Surg pmid:12440758
Pawliczak R et al. Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway. 2002 Am. J. Respir. Cell Mol. Biol. pmid:12444032
MacKinnon AC et al. Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. 2002 J. Immunol. pmid:12444147
Marrache AM et al. Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor. 2002 J. Immunol. pmid:12444157
Pacheco P et al. Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism. 2002 J. Immunol. pmid:12444160