Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Steil AA et al. | Platelet-activating factor and eicosanoids are mediators of local and systemic changes induced by immune-complexes in mice. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367295 |
| MartÃnez L et al. | Nitroprusside stimulates contractility and the synthesis of 14C-acetylated PAF-like substances in estrogen primed-mouse uterine horns. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367296 |
| Cahana A and Reiner O | LIS1 and platelet-activating factor acetylhydrolase (Ib) catalytic subunits, expression in the mouse oocyte and zygote. | 1999 | FEBS Lett. | pmid:10371146 |
| Diaz E et al. | Presence of platelet-activating factor in rhesus (Macaca mulatta) spermatozoa. | 1999 | J. Med. Primatol. | pmid:10372538 |
| Rosenbaum JT et al. | Intravitreally injected platelet activating factor induces retinitis in experimental animals. | 1999 | Curr. Eye Res. | pmid:10372995 |
| Xiao J et al. | Synergetic protective effects of combined blockade by two kinds of autolesion mediator receptor on neurological function after cervical cord injury. | 1998 | Chin. Med. J. | pmid:10374355 |
| Ji Z et al. | [The role of platelet activating factor in pathogenesis of acute pancreatitis in dogs]. | 1997 | Zhonghua Wai Ke Za Zhi | pmid:10374489 |
| Yi FX and Guo ZG | Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375790 |
| Wang Y et al. | Increased neutrophil-endothelial adhesion induced by placental factors is mediated by platelet-activating factor in preeclampsia. | 1999 May-Jun | J. Soc. Gynecol. Investig. | pmid:10376269 |
| Callea L et al. | Platelet activating factor is elevated in cerebral spinal fluid and plasma of patients with relapsing-remitting multiple sclerosis. | 1999 | J. Neuroimmunol. | pmid:10376955 |
| McNeil RS et al. | Neuronal cytoskeletal alterations evoked by a platelet-activating factor (PAF) analogue. | 1999 | Cell Motil. Cytoskeleton | pmid:10379835 |
| Deigner HP et al. | Novel reversible, irreversible and fluorescent inhibitors of platelet-activating factor acetylhydrolase as mechanistic probes. | 1999 | Atherosclerosis | pmid:10381281 |
| Bandeira-Melo C et al. | Suppressive effect of distinct bradykinin B2 receptor antagonist on allergen-evoked exudation and leukocyte infiltration in sensitized rats. | 1999 | Br. J. Pharmacol. | pmid:10385228 |
| Guilbert M et al. | 5-Oxo-6,8,11,14-eicosatetraenoic acid induces important eosinophil transmigration through basement membrane components: comparison of normal and asthmatic eosinophils. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10385597 |
| Fujii E et al. | Microvascular permeability change induced by platelet-activating factor is impaired in diabetic mice. | 1999 | Microvasc. Res. | pmid:10388605 |
| Forte TM et al. | Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. | 1999 | J. Lipid Res. | pmid:10393212 |
| Subramanian VS et al. | Role of lecithin-cholesterol acyltransferase in the metabolism of oxidized phospholipids in plasma: studies with platelet-activating factor-acetyl hydrolase-deficient plasma. | 1999 | Biochim. Biophys. Acta | pmid:10395969 |
| Kulikov VI and Muzya GI | Mechanisms of interaction of a plasmalogenic analog of platelet-activating factor with human platelets. | 1999 | Biochemistry Mosc. | pmid:10395976 |
| Strukova SM et al. | Modulation of mast cell activity by a peptide agonist of the thrombin receptor: role of nitric oxide. | 1999 | Biochemistry Mosc. | pmid:10395981 |
| Ishii S and Shimizu T | [Platelet-activating factor (PAF) receptor-related pathophysiology]. | 1999 | Tanpakushitsu Kakusan Koso | pmid:10396985 |