Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Ferreira MG and Fonteles MC | Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8987112 |
Dupuis F et al. | Production and metabolism of platelet-activating factor by human bone marrow cells. | 1997 | Res. Immunol. | pmid:9226766 |
Denizot Y et al. | Modulation of gut wall paf-acether and precursors by intestinal microflora. | 1990 Mar-Apr | Res. Immunol. | pmid:2218055 |
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Muehlmann LA et al. | PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils. | 2012 | Res. Vet. Sci. | pmid:21820686 |
Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils. | 2012 | Res. Vet. Sci. | pmid:21071047 |
Fairbairn SM et al. | Effects of platelet activating factor on the distribution of radiolabelled leucocytes and platelets in normal horses and asymptomatic horses with chronic obstructive pulmonary disease. | 1996 | Res. Vet. Sci. | pmid:8880978 |
Foster AP et al. | Platelet activating factor is a mediator of equine neutrophil and eosinophil migration in vitro. | 1992 | Res. Vet. Sci. | pmid:1332153 |
Bailey SR et al. | Actions and interactions of ADP, 5- HT, histamine and PAF on equine platelets. | 2000 | Res. Vet. Sci. | pmid:10756136 |
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Jarvis GE and Evans RJ | Endotoxin-induced platelet aggregation in heparinised equine whole blood in vitro. | 1994 | Res. Vet. Sci. | pmid:7871251 |
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Akbarshahi H et al. | Acute lung injury in acute pancreatitis--awaiting the big leap. | 2012 | Respir Med | pmid:22749752 |
Echazarreta AL et al. | Lack of systemic oxidative stress during PAF challenge in mild asthma. | 2005 | Respir Med | pmid:15823446 |
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Marcano H et al. | Effect of dopamine on platelet activating factor induced-pulmonary edema in isolated and perfused rabbit lungs. | 2001 | Respir Physiol | pmid:11348642 |
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Raj JU et al. | Effects of endothelin, platelet activating factor and thromboxane A2 in ferret lungs. | 1992 Apr-May | Respir Physiol | pmid:1626132 |
Rastogi P and McHowat J | Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. | 2009 | Respir Physiol Neurobiol | pmid:19059366 |
Machado GB et al. | Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. | 2011 | Respir. Res. | pmid:21819560 |
Jiang Z et al. | The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. | 2012 | Respir. Res. | pmid:23140447 |
Gebremichael I and Leuenberger P | Platelet-activating factor does not induce bronchial hyperreactivity in nonasthmatic subjects. | 1992 | Respiration | pmid:1485002 |
Block LH et al. | PAF-dependent phosphatidylinositol turnover in platelets: differences between asthmatics and normal individuals. | 1990 | Respiration | pmid:2099571 |
Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
Matheson MJ et al. | Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea. | 1997 | Respirology | pmid:9424405 |
Li HP et al. | Effect of chinonin on acute hypoxic pulmonary vasoconstriction in Sprague-Dawley rats. | 1998 | Respirology | pmid:9692515 |
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Hosford D et al. | Platelet-activating factor and cytokine interactions in shock. | 1989 | Resuscitation | pmid:2555874 |
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Romero A et al. | [Effect of corticosteroids, quinacrine and L-652, 731 on experimental aggregation of polymorphonuclear leukocytes induced by complement and platelet activating factor (PAF)]. | 1988 | Rev. Esp. Fisiol. | pmid:3072620 |
Santos JC et al. | Effect of intrarenal infusion of synthetic PAF-acether in dogs. | 1988 | Rev. Esp. Fisiol. | pmid:3231880 |
Brochet B et al. | [Pilot study of Ginkgolide B, a PAF-acether specific inhibitor in the treatment of acute outbreaks of multiple sclerosis]. | 1992 | Rev. Neurol. (Paris) | pmid:1439458 |
Simmet T and Peskar BA | Eicosanoids and the coronary circulation. | 1986 | Rev. Physiol. Biochem. Pharmacol. | pmid:3520775 |
Sperling RI | Dietary omega-3 fatty acids: effects on lipid mediators of inflammation and rheumatoid arthritis. | 1991 | Rheum. Dis. Clin. North Am. | pmid:1862246 |
Tunc SE et al. | Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients. | 2005 | Rheumatol. Int. | pmid:15004723 |
Su J et al. | Natural antibodies against phosphorylcholine as potential protective factors in SLE. | 2008 | Rheumatology (Oxford) | pmid:18522961 |
Lima MC et al. | Mediators of inflammation and antagonism of experimental pleurisy in the rat by fenspiride. | 1988 | Rhinol. Suppl. | pmid:2907679 |
Ganbo T et al. | Platelet activating factor (PAF) effects on ciliary activity of human paranasal sinus mucosa in vitro. | 1991 | Rhinology | pmid:1947682 |
Ganbo T et al. | Turn-over of PAF in cultures of human paranasal sinus mucosa. | 1994 | Rhinology | pmid:7839082 |
Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
Oda M et al. | [Platelet-activating factor producing cell--target cell interactions]. | 1989 | Rinsho Byori | pmid:2754814 |
Oura Y | [The effects of platelet-activating factor (PAF) on the collagen-induced whole blood aggregation]. | 1994 | Rinsho Byori | pmid:8107285 |
Maki N et al. | [Analysis of platelet-activating factor and its effect on the lung]. | 1993 | Rinsho Byori | pmid:8361018 |
Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
Izumi T and Shimizu T | [Biological regulation with platelet activating factor--molecular cloning and signal transduction of PAF]. | 1994 | Rinsho Ketsueki | pmid:8028185 |
Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
Asada Y | [Inflammatory and immune responses in arterial thrombus formation]. | 2005 | Rinsho Ketsueki | pmid:16447700 |
Kira J | [Multiple sclerosis]. | 2005 | Rinsho Shinkeigaku | pmid:16447761 |
Debek W et al. | Luminol-chemiluminescence in free peritoneal cells in hemorrhagic shock in rats treated with PAF-receptor-antagonist BN 52021. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528982 |
Kirejczyk JK et al. | Ginkgolide BN 52021 protects against hemorrhagic shock-induced renal injury in rats. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528996 |
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Gabryelewicz A | Etiology and pathogenesis of acute pancreatitis--current view. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8834603 |
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Rylander R | Role of endotoxin and glucan for the development of granulomatous disease in the lung. | 1989 | Sarcoidosis | pmid:2623374 |
Teles de Araújo A et al. | Surfactant modifications and lipidic mediators in occupational lung diseases. | 1989 | Sarcoidosis | pmid:2623375 |
Bottecchia D et al. | Influence of the pure synthetic PAF (platelet aggregating factor) on clot retraction and platelet aggregation. | 1984 | Scand J Haematol | pmid:6695148 |
Birk-Sørensen L et al. | Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. | 1999 | Scand J Plast Reconstr Surg Hand Surg | pmid:10450571 |
Mastroroberto P et al. | Elevated circulating levels of von Willebrand factor and D-dimer in patients with heart failure and mechanical prosthesis. | 1996 | Scand J Thorac Cardiovasc Surg | pmid:8857679 |
Møller CH and Steinbrüchel DA | Platelet function after coronary artery bypass grafting: is there a procoagulant activity after off-pump compared with on-pump surgery? | 2003 | Scand. Cardiovasc. J. | pmid:12881156 |
Palmblad J et al. | Interactions between alkylglycerols and human neutrophil granulocytes. | 1990 | Scand. J. Clin. Lab. Invest. | pmid:2168089 |
Jørgensen L et al. | Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy. | 1993 | Scand. J. Clin. Lab. Invest. | pmid:8272758 |
Atuma C et al. | Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell- and platelet-activating factor receptor-dependent pathway in rats. | 1999 | Scand. J. Gastroenterol. | pmid:10636064 |
Wang LS et al. | Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. | 2002 | Scand. J. Gastroenterol. | pmid:11989839 |
Sun Z et al. | Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. | 2001 | Scand. J. Gastroenterol. | pmid:11218240 |
Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
Binnaka T et al. | Gastric hemodynamic disturbance induced by hemorrhagic shock in rats. Role of platelet-activating factor. | 1990 | Scand. J. Gastroenterol. | pmid:2359986 |
Gustafson C et al. | Phospholipase C from Clostridium perfringens stimulates formation and release of platelet-activating factor (PAF-acether) in cultured intestinal epithelial cells (INT 407). | 1991 | Scand. J. Gastroenterol. | pmid:1947765 |
Kald B et al. | Phospholipase C from Clostridium perfringens stimulates acetyltransferase-dependent formation of platelet-activating factor in cultured intestinal epithelial cells (INT 407). | 1994 | Scand. J. Gastroenterol. | pmid:8209184 |
Olanders K et al. | Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. | 2003 | Scand. J. Gastroenterol. | pmid:12825870 |
Berstad A et al. | Effect of platelet-activating factor and its receptor antagonist, SRI 63-675, on gastric bleeding in rats. | 1988 | Scand. J. Gastroenterol. | pmid:3262915 |
Binnaka T et al. | Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor. | 1992 | Scand. J. Gastroenterol. | pmid:1561532 |
Yoshida N et al. | Pathogenesis of platelet-activating factor-induced gastric mucosal damage in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2556790 |
Rachmilewitz D et al. | Platelet-activating factor--a possible mediator in the pathogenesis of ulcerative colitis. | 1990 | Scand. J. Gastroenterol. Suppl. | pmid:1972295 |
Kingsnorth AN | Platelet-activating factor. | 1996 | Scand. J. Gastroenterol. Suppl. | pmid:8865468 |
Iwai A et al. | Role of PAF in ischemia-reperfusion injury in the rat stomach. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595310 |
Binnaka T et al. | Gastric mucosal damage induced in rats by intravenous administration of platelet-activating factor. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595311 |
Hatakeyama K et al. | Platelet activating factor induced gastric damage in rats: participation of increased gastric vascular permeability. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595312 |
Renkonen R et al. | Signal transduction during platelet-activating factor-induced lymphocyte binding to endothelial cells. | 1990 | Scand. J. Immunol. | pmid:2159182 |
Geffner JR et al. | Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear leucocytes. | 1991 | Scand. J. Immunol. | pmid:1903211 |
Lindström P et al. | Rapid adhesive responses of endothelial cells and of neutrophils induced by leukotriene B4 are mediated by leucocytic adhesion protein CD18. | 1990 | Scand. J. Immunol. | pmid:1972589 |